Ngamanye amaxesha, utshintsho oluncinci kwiijini zethu lunokubangela iingxaki ezinkulu zempilo. I-hATTR amyloidosis yenye yeengxaki ezingaqhelekanga, kodwa ezinzulu kakhulu zemfuza. Kule meko, iproteni eveliswa sisibindi sethu iqokelelana ngendlela engafanelekanga kwaye yonakalise imithambo-luvo. Oku kunokubangela iingxaki ezininzi ezinje ngobunzima bokuhamba, iintlungu, kunye nokungaziva. Kodwa ngoku kukho unyango olutsha loku. Namhlanje, masithethe ngeli yeza litsha elibizwa ngokuba yiWainua.
Isebenza njani iyeza iWainua?
Ukuze siqonde oku, masiqale sijonge isifo se-hATTR. Umzimba wethu uneproteni ebizwa ngokuba yi-transthyretin (TTR). Oku kwenziwa sisibindi sethu. Ngenxa yotshintsho oluncinci kwi-gene ye-TTR kumntu onesifo se-hATTR, le proteni ayisongi kakuhle, ihlangana, ize ihlale emzimbeni njengee-clumps ezibizwa ngokuba yi-'amyloid'. Kufana nobisi olugobileyo. Ezi clumps ze-amyloid zihlala kakhulu kwinkqubo yemithambo-luvo. Emva koko imithambo-luvo yonakele kwaye umsebenzi wayo uyaphazamiseka.
Ngoku makhe sijonge ukuba i-Wainua vaccine yenza ntoni. Eli yeza iWainua lijolise ngqo kwi-gene eyenza i-TTR protein engalunganga. Ngamafutshane, 'liyayithulisa' i-gene enika imiyalelo engalunganga.
Oku kunciphisa ubungakanani beprotheyini ye-TTR engaqhelekanga eveliswa sisibindi. Oku kunciphisa ukubekwa kwe-amyloid kwimithambo-luvo, kunceda ukulawula ukuqhubela phambili komonakalo wemithambo-luvo.
Le yinaliti yenyanga nganye efakwa phantsi kolusu. Okukhethekileyo kukuba ifika 'kwi-auto-injector' eyenzelwe ukuba isigulana okanye umntu osinyamekelayo ayisebenzise ekhaya.
Ndingazi njani ukuba olu nyango lufanelekile kum?
Ugqirha wakho uya kugqiba ukuba iWainua ikulungele na. Olu nyango ludla ngokufanelekela abantu abalandelayo:
- Ukuba ungumntu omdala oqinisekisiweyo ukuba une -ATTR Amyloidosis .
- Ukuba esi sifo sibangele umonakalo kwimithambo-luvo .
Ugqirha wakho uza kuqwalasela izinto ezininzi ngaphambi kokuba enze esi sigqibo.
- Imbali yosapho : Jonga ukuba kukho umntu kusapho lwakho okhe waba nesi sifo.
- Ukuhlolwa kweempawu: Iimpawu zakho ziya kuhlolwa kakuhle.
- Uvavanyo lwemfuza: Uvavanyo lwegazi lwenziwa ukuqinisekisa utshintsho lwemfuza lwe-TTR.
- Uvavanyo lwemifanekiso: I-MRI scanUvavanyo olufana nolu lunokujonga nokugcinwa kwe-amyloid kwimithambo-luvo nakwezinye izitho zomzimba.
Ivavanywe njani impumelelo yamayeza aseWainua?
Ngaphambi kokuba naliphi na iyeza elitsha likhutshwe kwimarike, kwenziwa uphando olunzulu ukuze kuqinisekiswe umgangatho walo, ukhuseleko lwalo, kunye nokusebenza kwalo. Iyeza laseWainua likwavavanywe ngokwezonyango elibizwa ngokuba yiNEURO-TTTransform.
Olu phando lujonge ikakhulu oku:
1. Iyeza leWainua litshintsha njani inqanaba leprotheyini ye-TTR egazini?
2. Oku kuya kuzichaphazela njani iimpawu ezinxulumene nomonakalo wemithambo-luvo kwizigulane ze-hATTR?
Basebenzise iindlela ezikhethekileyo zokulinganisa ezi zinto.
- Amanqaku okukhubazeka kwe-Neuropathy (NIS): Le yinkqubo ekhethekileyo yokulinganisa amanqaku. Ilinganisa amandla emisipha, ii-reflexes, kunye neemvakalelo. Okukhona amanqaku ephantsi, kokukhona imeko yemithambo-luvo iba ngcono.
- Umgangatho woBomi (QOL-DN): Oku kulinganisa ukudinwa kwesigulana, amandla okwenza imisebenzi yemihla ngemihla, kunye nesimo sengqondo. Nalapha, amanqaku aphantsi abonisa umgangatho wobomi ongcono.
Impumelelo yeWainua yaqinisekiswa ngokuthelekisa iziphumo zolu phononongo neziphumo zezigulane kolunye uphando ezanikwa i-placebo engenamayeza.
| Indlela abakhethwe ngayo abathathi-nxaxheba kuphando | |
|---|---|
| Iikhrayitheriya zokubandakanywa | Iikhrayitheriya zokungabandakanywa |
| - Iminyaka eyi-18-82 - Abantu abanesigaba soku-1 (abahamba ngaphandle koncedo) okanye isigaba sesi-2 (abahamba ngoncedo) abanomonakalo wemithambo-luvo ngenxa ye-hATTR - Abo bane-mutation eqinisekisiweyo kwi-gene ye-TTR | - Abantu abanezinye iintlobo ze-Amyloidosis - Abantu abanomonakalo wemithambo-luvo ngenxa yezinye izizathu ezifana nesifo seswekile - Abo baye batyandwa okanye baza kufakelwa isibindi - Abantu abafumana ezinye iindlela zonyango lwe-hATTR |
Zithini iziphumo eziphambili zophando?
Iziphumo zolu phononongo bezikhuthaza kakhulu. Abo bafumana unyango lwaseWainua kangangeeveki ezingama-66 babeneziphumo ezingcono kakhulu kunabo bafumana i-placebo.
- Amanqanaba eprotheyini ye-TTR eyingozi egazini labo ayehlile kakhulu.
- Iimpawu ze-neurological (amanqaku e-NIS) zilawulwe kakhulu.
- Kwakhona, umgangatho wobomi babo wawucacile ukuba uphucukile.
Zithini iziphumo ebezingalindelekanga zeWainua kwaye zingalawulwa njani?
Njengayo nayiphi na imithi, iWainua inokubangela ezinye iziphumo ebezingalindelekanga ezincinci. Ezona zixhaphakileyo zezi:
| Imiphumela | Indlela yokulawula |
|---|---|
| Amanqanaba e-vitamin A anciphileyo | Thatha isongezelelo sevithamini A kanye njengoko ugqirha wakho ekuyalele. Ungaze uthathe okungaphezulu koko ugqirha wakho akuyalele kona. Ukuba ubona naluphi na utshintsho ekuboneni kwakho, njengokuncipha kokubona ebusuku okanye amehlo omileyo, xelela ugqirha wakho ngoko nangoko. |
| Ukuhlanza | Sela amanzi amaninzi kunye nolwelo. Kuphephe ukutya okunamafutha kunye nokutya okunzima. Yitya kancinci. Ukuba ukuhlanza akuyeki emva kweentsuku ezimbalwa, thetha nogqirha wakho ngokuqinisekileyo. |
Ezi zezona ziphumo ziphambili. Ukongeza, thetha nogqirha wakho malunga nazo naziphi na iimpawu ezikukhathazayo.
Uyazi njani ukuba unyango luphumelele?
Ugqirha wakho uza kujonga impilo yakho rhoqo. Oku kuza kuquka uvavanyo lwegazi ukujonga amanqanaba akho e-TTR. Baza kujonga nokuba iimpawu zakho zemithambo-luvo ziphucuka kangakanani na. Ekuhambeni kwexesha, ungaqala ukuqaphela ukuphucuka kwamandla emisipha yakho, amandla okwenza imisebenzi yemihla ngemihla, kunye neemvakalelo zakho.
Eyona nto ibalulekileyo kukuba, musa ukuyeka ukugonya ngenxa yaso nasiphi na isizathu okanye utshintshe ishedyuli yokugonya ngaphandle kwengcebiso kagqirha.
Ngaba kukho naziphi na iingxaki ngamanye amayeza okanye ukutya?
Ngokophando lwangoku, akukho ntsebenziswano imbi ifunyenweyo phakathi kweWainua kunye nezinye iziyobisi okanye ukutya. Nangona kunjalo, ulwazi olutsha lusenokuvela kwixesha elizayo.
Ngoko ke, ngaphambi kokuba uqale olu nyango kwaye ngexesha lalo, nika ugqirha wakho inkcazo epheleleyo yazo zonke ezinye iziyobisi, iivithamini, izongezo, kunye neemveliso ze-Ayurvedic ozisebenzisayo. Oku kubaluleke kakhulu kukhuseleko lwakho.
Umyalezo Wokuya Ekhaya
- I-Wainua lunyango olutsha, oluvunyiweyo rhoqo ngenyanga lwesifo esingaqhelekanga semfuza i-hATTR Amyloidosis.
- Oku kunciphisa ukuveliswa kweproteni engaqhelekanga emzimbeni eyonakalisa imithambo-luvo.
- Oku kunceda ukulawula umonakalo wemithambo-luvo obangelwa sisifo kwaye kuphucule umgangatho wobomi bezigulana.
- Ekubeni ukwehla kwamanqanaba evithamini A kuyimpembelelo embi kakhulu, kubalulekile ukuthatha isongezelelo sevithamini A esichazwe ngugqirha wakho njengoko kumiselwe.
- Soloko uthetha nogqirha wakho ngaphambi kokuba uqale okanye uyeke naluphi na unyango, kwaye ukuba kukho naziphi na iziphumo ebezingalindelekanga ezinokubakho.
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