Ngaba kukho umntu kusapho lwakho, mhlawumbi umama wakho, utata wakho, okanye umntu omthandayo, onesifo sikaParkinson? Ngoko mhlawumbi uyazi ukuba ngamanye amaxesha umzimba wakhe uba lukhuni ngequbuliso, baqala ukungcangcazela, kwaye abakwazi ukwenza nto. Kufana nemoto eyeka ngequbuliso. Namhlanje sithetha ngenaliti ekhethekileyo esetyenziselwa ukubonelela ngoncedo olukhawulezileyo kwezi zinto zibizwa ngokuba "zii-off-periods." Leyo yinaliti ye-Apomorphine.
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Yintoni i-Apomorphine?
Ngamafutshane, i-Apomorphine liyeza elisetyenziselwa ukunyanga iimpawu zesifo sikaParkinson. Lisebenza ngendlela efanayo nekhemikhali ebizwa ngokuba yi-dopamine engqondweni yethu. Ubusazi ukuba isifo sikaParkinson sibangelwa kukulahlekelwa ziiseli engqondweni yethu ezivelisa le khemikhali ebizwa ngokuba yi-dopamine. Le dopamine inceda ukulawula iintshukumo zomzimba wethu kunye nokulungelelaniswa kwazo.
Ngoko ke, xa i-dopamine ingekho ngokwaneleyo, iimpawu ezifana nokuqina kunye nokungcangcazela ziyavela. Inaliti ye-apomorphine isebenza njenge-dopamine, igcwalisa okwethutyana loo ntsilelo, kwaye inceda ukubuyisela iintshukumo zomzimba. Oku kudla ngokufumaneka kwimarike phantsi kwegama elithi Apokyn .
Khawuthelekelele ukuba isifo sikaParkinson sishiye umzimba wakho ubambekile, njengocango olutshixiweyo olungenasitshixo. Inaliti ye-apomorphine ifana nesitshixo esikhethekileyo esivula loo mnyango. Ibuyisela umzimba wakho esiqhelweni ngokukhawuleza. Kodwa ingasetyenziselwa nezinye izinto, ngoko ke ukuba unemibuzo, buza ugqirha wakho.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokusebenzisa eli yeza
Ngaphambi kokuba ukunike eli yeza, ugqirha wakho kuya kufuneka azi imbali yakho epheleleyo yempilo. Oku kungenxa yokuba ezinye iimeko zifuna unonophelo olukhethekileyo xa usebenzisa eli yeza. Qiniseka ukuba uxelela ugqirha wakho ngayo nayiphi na kwezi zilandelayo:
- Ukuba une-asthma.
- Ukuba unesithukuthezi sokulala rhoqo emini okanye ulale ngequbuliso.
- Ukuba usela rhoqo.
- Ukuba ukhe waba nestroke ngaphambili.
- Ukuba unesifo sentliziyo .
- Ukuba unembali yokusoloko ungena engxakini .
- Ukuba kukho ukubetha kwentliziyo okungahambelaniyo okanye utshintsho kwisigqi.
- Ukuba unesifo sezintso okanye sesibindi .
- Ukuba uxinzelelo lwegazi luphantsi .
- Ukuba uneengxaki zempilo yengqondo (ezifana nokudakumba).
- Ukuba ukhe waba ne-allergy kwi-apomorphine, i-sulfites, okanye nayiphi na enye iyeza, ukutya, okanye idayi ngaphambili.
- Ukuba ukhulelwe okanye uzama ukukhulelwa .
- Ukuba ungumama oncancisayo .
Ukunika ugqirha wakho olu lwazi ngokuchanekileyo kubaluleke kakhulu kukhuseleko lwakho.
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Check Availability →Ungayisebenzisa njani i-vaccine ngokuchanekileyo?
Le yinaliti efakwa ngaphantsi kwesikhumba. Xa uqala ukuthatha eli yeza, ugqirha okanye umongikazi wakho uza kukunika imiyalelo eneenkcukacha malunga nendlela yokulungiselela inaliti kunye nendlela yokuyijova ngokwakho. Kubaluleke kakhulu ukulandela le miyalelo ngokuchanekileyo.
- Sebenzisa kanye njengoko ugqirha wakho ekuxelela: Musa ukusebenzisa ngaphezu kwedosi emiselweyo okanye rhoqo.
- Musa ukuyeka ukuthatha eli yeza ngequbuliso: Musa ukuyeka ukulithatha eli yeza ngaphandle kokuba ugqirha wakho ekuxelele ukuba uliyeke. Ukuliyeka ngequbuliso kunokubangela iziphumo ebezingalindelekanga ezibi kwaye kwenze imeko yakho ibe mandundu.
- Lahla iinaliti kunye neesirinji ngokukhuselekileyo: Ungaze ulahle iinaliti kunye neesirinji ezisetyenzisiweyo enkunkuma. Zifanele zibekwe kwisikhongozeli esikhethekileyo esibukhali esinikiweyo. Ukuba awunayo, ungacela ugqirha wakho akunike enye.
- Funda incwadana yemiyalelo: Funda incwadana yemiyalelo eza nale yeza ngononophelo. Ukuba unemibuzo, buza ugqirha wakho.
Kuthekani ukuba ndisebenzisa i-overdose?
Ukuba ucinga ukuba uthathe amayeza amaninzi kunokuba ucinga, yiya kwiSebe lezeMpilo eziNgxamisekileyo (i-ETU) esibhedlele esikufutshane okanye utsalele umnxeba iZiko loLwazi lweeTyhefu leSizwe kwiSibhedlele sikaZwelonke saseColombo .
Eli yeza limiselwe wena wedwa. Ngoko ke, ungaze ulinike omnye umntu.
Ngawaphi amanye amayeza angafanele asetyenziswe kunye nale mithi?
Amanye amayeza anokusebenzisana ne-apomorphine aze abangele iingxaki ezinkulu. Ngoko ke, kufuneka uxelele ugqirha wakho ngawo onke amayeza owasebenzisayo, kuquka iivithamini, amayeza emifuno, kunye nezongezo.
| Udidi lweziyobisi | Inkcazo kunye nemizekelo |
|---|---|
| Amayeza ekungafanele athathwe ngokuqinisekileyo | |
| Amanye amayeza okunyanga isicaphucaphu/ukuhlanza | Umzekelo: i-dolasetron, i-granisetron, i-ondansetron, i-palonosetron |
| Amanye amayeza | I-Dronedarone, iKetoconazole, iLevoketoconazole, iPimozide, iThioridazine |
| Izinto onokuzisebenzisa ngononophelo/unxibelelwano olunokwenzeka | |
| Utywala | Iziphumo ebezingalindelekanga zichatshazelwa kakhulu kukwanda. |
| Amayeza okunyanga ixhala okanye ukulala | Umzekelo: IiBenzodiazepines ezifana ne-alprazolam, i-diazepam, i-lorazepam |
| Amanye amayeza oxinzelelo lwegazi | Qiniseka ukuba ubuza ugqirha wakho ngale nto. |
| I-Nitroglycerin | Uxinzelelo lwegazi lunokwehla ngendlela eyingozi (oku kuchazwe ngezantsi). |
| Amanye amayeza | IHaloperidol, iMetoclopramide, iiOpioids, amanye amayeza achaphazela isigqi sentliziyo, iiPhenothiazines. |
Olu luhlu aluphelelanga, ngoko ke kungcono ukuxelela ugqirha wakho ngayo yonke into oyithathayo.
Izinto ekufuneka uzikhumbule xa uthatha olu gonyo
Kukho izinto ezininzi ekufuneka uziqwalasele malunga nokhuseleko lwakho ngelixa usebenzisa eli yeza.
Bona ugqirha rhoqo.
Bona ugqirha wakho rhoqo ukuze ujonge imeko yakho kwaye ubone ukuba iimpawu zakho ziyaphucuka okanye ziya ziba mandundu na. Ukuba iimpawu zakho aziphucuki okanye ziya ziba mandundu, xelela ugqirha wakho .
Isicaphucaphu nokuhlanza
Eli yeza linokubangela isicaphucaphu nokuhlanza, ngamanye amaxesha linokuba qatha kakhulu. Ugqirha wakho uza kukunika elinye iyeza loku. Musa ukuthatha naliphi na iyeza lokunyanga isicaphucaphu ngokwakho. Oku kungenxa yokuba amanye amayeza okunyanga isicaphucaphu anokusebenzisana ne-apomorphine.
Ukozela nokuqhuba
Eli yeza linokuchaphazela ixesha lakho lokulungelelanisa kunye nexesha lokuphendula. Ke ngoko, de wazi kakuhle indlela eli yeza elikuchaphazela ngayo , kuphephe ukwenza imisebenzi efuna ukuphaphama, njengokuqhuba okanye ukusebenzisa oomatshini. Kwakhona, yima kancinci xa usukuma ngequbuliso, okanye xa uvuka kwindawo yokuhlala. Kungenjalo, ungaziva unesiyezi kwaye unomsindo. Le ngozi inkulu ngakumbi ukuba usela utywala.
Kubalulekile! Xa usebenzisa eli yeza, abanye abantu banokulala ngequbuliso ngaphandle kwesilumkiso . Oku kunokwenzeka ngelixa uqhuba, uthetha, okanye usitya. Ukuba oku kuyenzeka kuwe, xelela ugqirha wakho ngoko nangoko.
Impendulo nge-nitroglycerin
Ukuba usela i-nitroglycerin yesifo sentliziyo, kufuneka ulumke kakhulu. Ukuyisebenzisa kunye nale mithi kunokubangela ukuba uxinzelelo lwakho lwegazi lwehle kakhulu. Oku kunokubangela isiyezi, ukuquleka, kunye nokuwa.
Ngoko ke, ukuba ufuna ukuthatha i-nitroglycerin,
1. Okokuqala, lala phantsi.
2. Emva koko beka ithebhulethi phantsi kolwimi lwakho.
3. Hlala ulele phantsi ubuncinane imizuzu engama-45.
Zithini iziphumo ebezingalindelekanga ezinokubakho?
Njengalo naliphi na iyeza, i-apomorphine inokubangela iziphumo ebezingalindelekanga. Ezinye zimbi kakhulu, ezinye zixhaphakile.
| Imiphumela | Inkcazo |
|---|---|
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha ngoko nangoko | |
| Iimpendulo eziqatha ze-allergy (iimpendulo ze-allergy okanye i-angioedema) | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, amehlo, imilebe, ulwimi, izandla okanye iinyawo, ubunzima bokuginya okanye ukuphefumla. |
| Intlungu yesifuba (i-Angina) | Ukuva iintlungu, ukuqina, okanye uxinzelelo esifubeni, entanyeni, emqolo, okanye ezingalweni. |
| Ukulala ngequbuliso | Ukulala ngaphandle kwesilumkiso ngelixa usebenza emini. |
| Ukungaboni | Ukubona okanye ukuva izinto ezingekhoyo. |
| Iimpawu zokuhlaselwa yintliziyo | Intlungu esifubeni, emagxeni, engalweni okanye emhlathini, isicaphucaphu, ubunzima bokuphefumla, ukubila okubandayo, isiyezi. |
| Utshintsho kwisantya sentliziyo | Ukubetha kwentliziyo ngokukhawuleza okanye ngokungangqalanga, isiyezi, ukuquleka, iintlungu zesifuba. |
| I-Hemolytic anemia | Ukudinwa okungaqhelekanga, isiyezi, intloko ebuhlungu, ubunzima bokuphefumla, umchamo omnyama, ukutyheli kolusu okanye amehlo. |
| Iipateni zokuziphatha ezingaqhelekanga | Umnqweno ongalawulekiyo wokungcakaza, ukutya kakhulu, ukwenza umkhwa wesondo, okanye ukuchitha imali ngokungeyomfuneko. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| Ukudinwa, ukozela | Ezi zinokwenzeka rhoqo. |
| Isicaphucaphu, ukuhlanza | Kuqhelekile kwizigaba zokuqala zokuqalisa amayeza. |
| Impumlo egobhozayo okanye impumlo exineneyo | Kusenokuvakala ngathi ziimpawu zomkhuhlane. |
| Ukudumba kwamaqatha, izandla, okanye iinyawo | Isenokuba ngenxa yokugcinwa kolwelo emzimbeni. |
Ukuba ufumana naziphi na ezinye iziphumo ebezingalindelekanga ezingadweliswanga kolu luhlu, nceda wazise ugqirha wakho.
Ugcina kwaye ulahla njani amayeza?
- Gcina kude nabantwana kunye nezilwanyana zasekhaya.
- Gcina kubushushu begumbi (phakathi kwama-20-25 degrees Celsius).
- Musa ukusebenzisa amayeza aphelelwe lixesha.
- Xa ulahla amayeza angasetyenziswanga okanye aphelelwe lixesha, buza ugqirha wakho ngendlela ekhuselekileyo.
Umyalezo Wokuya Ekhaya
- Inaliti ye-apomorphine liyeza elinceda ngokukhawuleza ekuqaliseni ngequbuliso kokuqina kunye nokungcangcazela ("ngaphandle kwexesha") kwisifo sikaParkinson.
- Soloko uxelela ugqirha wakho ngazo zonke ezinye iindlela zonyango ozisebenzisayo kunye nezinye iingxaki zempilo onazo.
- Kuphephe ukuqhuba okanye ukusebenzisa oomatshini ude wazi ukuba eli yeza likuchaphazela njani. Khumbula ukuba ungaziva ulele ngequbuliso.
- Funa uncedo lwezonyango ngokukhawuleza ukuba ufumana iziphumo ebezingalindelekanga ezinzulu ezifana neentlungu zesifuba, ukusabela okunamandla kokunganyamezelani, okanye utshintsho kwisantya sentliziyo.
- Soloko ulahla iinaliti kunye neesirinji ezisetyenzisiweyo ngokukhuselekileyo kwisikhongozeli esikhethekileyo "sezinto ezibukhali".
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