Ngaba umama wakho, utata wakho, okanye umntu omaziyo uyalibala ngakumbi? Ukulibala izinto ezincinci ezifana nokuba izitshixo zakho zikuphi okanye igama lomntu kunokuba luphawu lokuqala lwesifo sika-Alzheimer. Nangona kungekho nyango lwesi sifo sinzima, iyeza elitsha elinokunciphisa ukuqhubela phambili kwesi sifo livunyiwe ngokupheleleyo yi-US FDA (uLawulo lokutya namayeza). Eli lithemba elikhulu kakhulu kwizigulana kwihlabathi liphela. Ngoko masithethe kancinci ngeli yeza litsha, iLeqembi.
Yintoni le yeza litsha elibizwa ngokuba yiLeqembi?
Into yokuqala ekufuneka uyiqonde kukuba oku akuyonyango lwesifo sika-Alzheimer. Kodwa kuyanceda. Kungacothisa ukuqhubela phambili kwesi sifo. Uphando lubonise ukuba kunokucothisa ukuqhubela phambili kwesi sifo malunga ne-27% kwixesha leenyanga ezili-18.
Ngoku usenokuba ucinga, 'Ngaba kuya kwenza umahluko ngenene?' Ewe, ngokuqinisekileyo kuya kwenza njalo. Cinga nje, umntu osebenzisa eli yeza uya kukwazi ukuphila iinyanga ezi-5 ngaphezulu ngaphandle kokuba iimpawu zibe mandundu kunomntu ongalisebenzisiyo eli yeza, kwaye uya kukwazi ukwenza umsebenzi wakhe, onwabe nosapho lwakhe, aye kubona umzukulwana wakhe ophumeleleyo... Lixabiseke kangakanani elo xesha longezelelweyo lokwenza izinto ezinje? Elo xesha lelona ncedo likhulu leli yeza.
Kodwa kubalulekile ukukhumbula oku: I-Leqembi icetyiswa kuphela kubantu abakwinqanaba lokuqala lesifo sika-Alzheimer , oko kuthetha abo babonisa ukungasebenzi kakuhle kwengqondo. Ayizukusebenza kumntu onesifo esiphambili.
Lisebenza njani eli yeza?
Ukuze siqonde oku, masithathe umzekelo omncinci. Kwiingqondo zabantu abane-Alzheimer's, kufakwa iproteni engafunekiyo ebizwa ngokuba yi -amyloid plaques . Kufana nothuli olunamathela kumbhobho wamanzi luze lunamathele kancinci kancinci kumbhobho. Ngenxa yokufakwa kwezi proteni, unxibelelwano phakathi kweeseli zengqondo luyaphazamiseka, kwaye iiseli ziqala ukufa kancinci kancinci. Yiyo loo nto inkumbulo ilahleka kwaye ukuziphatha kuyatshintsha.
Eli yeza, elibizwa ngokuba yiLeqembi, lihlasela kwaye lisuse ii-amyloid plaques eziqokelelene engqondweni. Likwiqela lamayeza abizwa ngokuba yi-monoclonal antibodies. Eli yeza lidla ngokunikezelwa kwisigulana kabini ngenyanga ngokufakwa kwe-IV.
Makhe sijonge ezinye izinto ezibalulekileyo malunga nale yeza kwitheyibhile.
| Isishwankathelo esifutshane seLeqembi (lecanemab) | |
|---|---|
| Uhlobo lweyeza | Iyeza lohlobo lwe-monoclonal antibody. |
| Ifanelekile kubani? | Kuphela kubantu abakwinqanaba lokuqala lesifo sika-Alzheimer, abanokuphazamiseka kwengqondo okuncinci. |
| Inzuzo ephambili | Ukusasazeka kwesi sifo kuyehla nge-27% kwiinyanga ezili-18. |
| Indlela yokunika | Inikwa ngemithambo (i-IV infusion) kabini ngenyanga. |
| Umda obaluleke kakhulu | Oku akusinyangi esi sifo. Akuncedi nganto abo sele bekwinqanaba elibi lesi sifo. |
Ngaba kukho umngcipheko wokusebenzisa oku?
Ewe. Njengazo zonke amayeza, le ineengozi kunye nemiphumo emibi. Enyanisweni, i-FDA ikhuphe "isilumkiso sebhokisi emnyama" sale yeza, elilona nqanaba liphezulu lesilumkiso sokhuseleko . Isizathu saloo nto yimeko ebizwa ngokuba yi-ARIA.
Yintoni i-ARIA?
I-ARIA sisishunqulelo segama elithi Amyloid-Related Imaging Abnormalities. Ngamafutshane, eli yeza linokubangela ukuba abanye abantu baphuke ingqondo okanye baphume igazi elincinci (microbleeds) . Nangona ezi zinto zihlala zingeyongozi kangako, ngamanye amaxesha zinokuba yingozi ebomini.
- I-APOE4 gene: Abantu abaneekopi ezimbini ze-APOE4 gene mutation basengozini enkulu yokuphuhlisa le meko ye-ARIA kunabanye.
- Izinto Zokunciphisa Igazi: Enye into ebaluleke kakhulu kukuba oogqirha bayalumkisa kakhulu malunga nokusebenzisa eli yeza kumntu othatha amayeza okunciphisa igazi. Kuba ukuba wenza njalo, kukho ithuba elikhulu lokuba ukopha okuncinci kuya kuba kukopha okukhulu, okusongela ubomi (macro-bleed). Ngamanye amaxesha oku kunokukhokelela ekuxhuzuleni, esibhedlele, okanye nasekufeni.
Ngoko ke, ngaphambi kokuba uqale eli yeza, kubalulekile ukuxoxa ngokucacileyo ngazo zonke ezi ngozi nogqirha wakho, wenze uvavanyo olufunekayo, kwaye uqinisekise ukuba oku kulungile na kuwe.
Ngoko ke ndimele ndenze ntoni?
Ukuba wena, mfundi weli nqaku, unento encinci yokucinga ukuba wena okanye umntu osondeleyo kuwe uneempawu zokuqala zesifo sika-Alzheimer, eyona nto ingcono onokuyenza kukubona ugqirha ngokukhawuleza uze ufumane ukuxilongwa ngokuchanekileyo.
Kuba njengoko besitshilo ngaphambili, amayeza afana neLeqembi aluncedo kuphela kwizigaba zokuqala zesifo. Ukuba uyalibazisa, ungaphoswa lithuba lonyango. Kwakhona, amayeza amatsha afana nala adla ngokubiza kakhulu. Ngoko ke licebo elihle ukuthetha nogqirha wakho ngaloo nto ngaphambi kokuba uqale unyango.
Iingcali zikholelwa ukuba kungekudala, kuya kubakho unyango olunokufumanisa nokuthintela izifo ngaphambi kokuba abantu babonise naziphi na iimpawu. Kanye njengokuba sinokufumanisa nokunyanga umhlaza webele kunye nomhlaza weprostate kwangethuba, ngenye imini siya kukwazi ukufumanisa nokuthintela isifo se-Alzheimer kwangethuba. Kude kube ngoko, amayeza afana neLeqembi anika ithemba elikhulu kuthi sonke.
Umyalezo Wokuya Ekhaya
- ILeqembi ayilonyango lwesifo sika-Alzheimer. Inciphisa kuphela ukuqhubela phambili kwesi sifo kwizigaba zaso zokuqala.
- Eli yeza lisebenza ngokususa ii-amyloid plaques eziyingozi eziqokelelana engqondweni.
- Kukho umngcipheko weziphumo ebezingalindelekanga ezinzulu ezifana nokudumba kobuchopho okanye ukopha okuncinci (ARIA), ngoko ke kubalulekile ukuxoxa ngazo zonke iingozi nogqirha.
- Eli yeza alifanelekanga kwabo bathatha amayeza okunciphisa igazi okanye abo banesifo esibi kakhulu.
- Ukuba wena okanye umntu osondeleyo kuwe uneengxaki zokukhumbula, funa ingcebiso kugqirha ngokukhawuleza. Ukuxilongwa kwangoko kubalulekile ukuze ufumane unyango.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho