Xa ugqirha wakho ekuxelela okanye umntu omaziyo ukuba unomhlaza webele, kusenokwenzeka ukuba bakhankanye unyango lweehomoni njengonyango. Usenokuba nexhala kancinci xa usiva oku. Kodwa ungakhathazeki. Namhlanje sithetha ngohlobo olusebenzayo kakhulu lwamayeza olunikwa abantu abaneeseli zomhlaza ezibuthathaka kwihomoni ye-estrogen (`Estrogen Receptor-Positive` okanye `ER+`). Ezi zibizwa ngokuba yiAromatase Inhibitors.
Ngamafutshane, zithini ezi Aromatase Inhibitors?
Kulungile, masiyihlalutye le nto. Ii-Aromatase inhibitors, okanye ii-AI ngamafutshane, ziindidi zamayeza asetyenziswa kakhulu kunyango lweehomoni. Zisetyenziselwa ukunyanga umhlaza webele we-ER+, ingakumbi kubasetyhini abasele begqithile exesheni .
Ngoku, khangela, i-estrogen yi-hormone ebalulekileyo emizimbeni yethu, ingakumbi kwimpilo yokuzala yabasetyhini. Nangona kunjalo, kwezinye iiseli zomhlaza wamabele, le hormone ye-estrogen ifana nokutya. Oko kukuthi, xa i-estrogen ikhona, ezo seli zomhlaza zikhula ngokukhawuleza.
Kulapho ke amayeza e-'AI' angena khona. Oko kwenziwa ngala mayeza kukuthintela i-enzyme ebizwa ngokuba yi-aromatase emzimbeni wethu. Le enzyme ye-aromatase iguqula amanye ama-hormone abe yi-estrogen. Ngoko ke, xa eli yeza lithintela i-enzyme ye-aromatase ukuba isebenze, amanqanaba e-estrogen emzimbeni ayancipha. Emva koko ezo seli zomhlaza zilahlekelwa "kukutya" kwazo, ziyayeka ukukhula, kwaye umhlaza uyalawuleka. Uyaqonda?
Ngamafutshane, into eyenziwa leli yeza kukuthintela iiseli zomhlaza ekufumaneni "ipetroli" eziyidingayo.
Kuphantsi kweziphi iimeko apho eli yeza licetyiswa khona?
Kukho iimeko ezininzi apho ugqirha wakho angacebisa olu nyango lwe-"AI":
- Ukuba ukhe watyandwa umhlaza webele we-ER+, eli yeza linikwa ukunciphisa umngcipheko wokuba umhlaza uphinde ubuye .
- Ukuba umhlaza usasazeke kwiindawo ze-lymph ezikufutshane.
- Ukuba umhlaza usasazeke nakwamanye amalungu omzimba (umz. imiphunga, amathambo, ingqondo, isibindi), lo mhlaza siwubiza ngokuba yi-metastatic cancer.
- Ukuba unomhlaza we-`ER+` ngaphambi kokuba uyeke ukuya exesheni. Ngeli xesha, ama-ovari akho asavelisa i-estrogen, ngoko ke unokunikwa olunye unyango lokulawula loo hormone ye-estrogen kunye namayeza e-`AI`.
- Ukuba indoda ifumana umhlaza webele othi `ER+`. (Ewe, amadoda nawo afumana umhlaza webele, kwaye akwanamanqanaba aphantsi e-estrogen emizimbeni yawo).
- Ezinye izifundo zibonise ukuba abantu abasengozini enkulu yokuba nomhlaza webeleKuthiwa eli yeza liyanceda ekunciphiseni loo mngcipheko, kodwa alikafumani mvume esemthethweni.
Iindidi ezisetyenziswa kakhulu ze-aromatase inhibitors
Kukho iintlobo ezahlukeneyo zala mayeza e-"AI" athengiswayo. Ugqirha wakho uza kukhetha elona lifanelekileyo kwimeko yakho.
| Igama leziyobisi |
|---|
| I-Letrozole |
| I-Anastrozole |
| I-Exemestane |
Ndingalufumana njani olu nyango kwaye luthatha ixesha elingakanani?
Eli yeza elithi "AI" lipilisi ekufuneka ulithathe yonke imihla . Ngamanye amaxesha, unyango luqala ngeli yeza. Ngamanye amaxesha, ugqirha wakho angakunika elinye iyeza lehomoni elibizwa ngokuba yi-tamoxifen iminyaka embalwa aze akutshintshele kwiyeza elithi "AI".
Ngokwesiqhelo, olu nyango luqhubeka kangangeminyaka emihlanu . Emva kweminyaka emihlanu, ukuba awunazo iimpawu zomhlaza kwaye uvavanyo luqhelekile, ungaluyeka unyango.
Nangona kunjalo, ezinye izifundo zibonise ukuba umhlaza ungabuyela emva kweminyaka engama-20 emva konyango. Oku kubizwa ngokuba 'kukubuyela emva kwexesha'. Ke ngoko, kubaluleke kakhulu ukuthetha ngokukhululekileyo nogqirha wakho malunga neengozi ezithile kwimeko yakho.
Iingenelo zonyango kunye nemiphumo enokubakho
Eyona nzuzo inkulu yolu nyango kukuba lunokunyanga phantse ngokupheleleyo umhlaza webele we-ER+. Izifundo zibonise ukuba ama-95% abantu abafumana olu nyango lwe-AI emva kotyando abayi kubuya umhlaza wabo kwisithuba seminyaka emi-5 . Ziindaba ezimnandi ezo, akunjalo?
Kodwa, njengazo zonke amayeza, le inokuba nemiphumo emibi. Kuba, njengoko besitshilo ngaphambili, i-estrogen yi-hormone ekwanceda ukugcina amathambo neentliziyo zethu ziphilile. Ngoko ke, xa unciphisa amanqanaba e-estrogen nge-'AI', ezinye iziphumo ebezingalindelekanga zinokwenzeka.
| Imiphumela | Kalula nje... |
|---|---|
| I-Osteoporosis kunye nokuqhekeka kwamathambo | Amathambo aba buthathaka kwaye umngcipheko wokuqhekeka uyanda ngokulula. |
| Intlungu yemisipha (iMyalgia) | Iintlungu zemisipha. |
| Intlungu yamalungu | Iintlungu zamalungu, ezinje ngamadolo neengqiniba. Le yeyona miphumo ixhaphakileyo. |
| Ubushushu obugqithisileyo | Ngequbuliso ndiziva ndishushu kakhulu kwaye ndibila. |
| Ukoma kwesisu | Intlungu inokubakho ngexesha lokwabelana ngesondo. |
| Umngcipheko wesifo sentliziyo | Umngcipheko wesifo sentliziyo uyanda kancinci. |
Ungayinyamezela njani imiphumo emibi?
Musa ukoyikiswa zezi ziphumo ebezingalindelekanga. Eyona nto ibalulekileyo kukuthetha nogqirha wakho ngazo. Ingakumbi ukuba izinto ezifana neentlungu zamalungu zinzima, akufuneki uzinyamezele. Ugqirha wakho angakunika izisombululo. Umzekelo:
- Iipilisi zokunciphisa iintlungu, ingakumbi ii-NSAID (umz., i-ibuprofen), zinokunikwa.
- Ukuba kunzima ukunyamezela, ungatshintshela kolunye uhlobo lwe-AI endaweni ye-AI oyithathayo ngoku.
- Kwezinye iimeko, i-tamoxifen inokutshintshwa endaweni ye-AI.
Eyona nto ibalulekileyo kukwazisa ugqirha wakho ngayo nayiphi na ingxaki, kunokuba wenze izigqibo wedwa.
Kufuneka uthethe nini nogqirha?
Kwiimeko ezilandelayo, qiniseka ukuba uthetha nogqirha wakho.
- Ukuba iziphumo ebezingalindelekanga zimbi kakhulu kunokuba ubulindele.
- Ukuba amayeza anikwe ngugqirha awaniki ncedo kwimiphumo emibi.
- Ukuba ubona iimpawu zokubuyela komhlaza (umz., amaqhuma amatsha, iintlungu ezingapheliyo, ubunzima bokuphefumla) , buza ugqirha wakho ukuba zeziphi iimpawu ekufuneka uziqwalasele.
Umyalezo Wokuya Ekhaya
- Izithinteli ze-Aromatase ziyindlela ebaluleke kakhulu nesebenzayo yonyango lwe-hormone kumhlaza webele obuthathaka kwi-estrogen (ER+).
- La mayeza asebenza ngokunciphisa amanqanaba e-estrogen emzimbeni kunye nokuthintela ukukhula kweeseli zomhlaza.
- Olu nyango lunciphisa kakhulu umngcipheko wokuphinda umhlaza.
- Iziphumo ebezingalindelekanga ezifana neentlungu zamalungu kunye nokuncitshiswa kwamathambo zinokwenzeka, kodwa uninzi lwazo zinokulawulwa.
- Okubaluleke kakhulu: Ungaze uyeke ukuthatha amayeza akho okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho. Thetha naye ngokukhululekileyo malunga nokungonwabi okuzivayo.
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