Ingaba inkumbulo yakho kunye neentshukumo zakho ziya ziwohloka kancinci kancinci? Masifunde ngale nto ((Corticobasal Degeneration)!

Ngaba ngamanye amaxesha uyalibala izinto? Okanye ngaba ufumana kunzima ukushukumisa iingalo nemilenze yakho? Ngaba uyawathetha amazwi arhabaxa xa uthetha? Ukuba ezi zinto zibonakala zisanda, mhlawumbi kubalulekile ukuba uqaphele le meko sithetha ngayo namhlanje ebizwa ngokuba yi-`(Corticobasal Degeneration)`. Ungakhathazeki, masithethe ngale nto ngokulula.

Yintoni `(Ukonakala kweCorticobasal)`?

Ngamafutshane, `(Corticobasal Degeneration)` yimeko yemithambo-luvo echaphazela ubuchopho bethu. Abanye abantu bayibiza ngokuba yi`(Corticobasal Syndrome).` Okwenzekayo koku kukuba ezinye iiseli engqondweni yethu zonakala kwaye zitshatyalaliswa kancinci kancinci. Kanye njengokuba ezinye izixhobo ziwohloka ngokuhamba kwexesha. Ngenxa yoku, amandla ethu okuthetha, ukuginya ukutya, ukuhambisa imizimba yethu, nokukhumbula izinto zinokuncipha kancinci kancinci. Into ebuhlungu kukuba ezi mpawu ziyanda kancinci kancinci (inkqubela phambili) ngokuhamba kwexesha.

Igama elithi "corticobasal" kweli gama libhekisa kwiindawo ezimbini zobuchopho ezonakele kakhulu sesi sifo:

• I-cerebral cortex: Le yingqimba engaphandle yezicubu zemithambo-luvo engqondweni yethu. Le nxalenye ibaluleke kakhulu kwinkumbulo yethu, ekufundeni, kwiintshukumo zokuzithandela, nakwiimvakalelo.
• I-Basal ganglia: Le yingqokelela yeeseli zemithambo-luvo ezikwindawo enzulu engqondweni. Ibalulekile ekufundeni nasekusebenzeni kwemisipha.

Igama elithi "ukonakala" lithetha "ukuwohloka" okanye "ukulahlekelwa kukusebenza kakuhle." Ngoko ke okwenzekayo kwesi sifo kukuba ukusebenza kwezi ndawo zimbini zobuchopho kuyehla kancinci kancinci.

Le meko, ethi ``Corticobasal Degeneration``, inokunciphisa ubomi bomntu kwaye ibangele iingxaki ezisongela ubomi. Njengoko iimpawu zisasazeka emzimbeni wonke, kunokuba nzima ukusebenza ngokwahlukeneyo.

Zithini iimpawu ze-`(Corticobasal Degeneration)`?

Iimpawu zale meko zingahluka kumntu nomntu, kodwa ubuchule obunokuchaphazeleka ngokubanzi zezi:

• Ubunzima bokushukuma (`Apraxia`): Oku kuthetha ukuba izinto ezinje ngokucinezela iqhosha okanye ukubamba icephe ukuze utye ziba nzima. Nangona ingqondo ithumela imiyalezo ezandleni, azikwazi ukuyenza kakuhle.
• Ukukhubazeka kwenkumbulo: Kuba nzima ukukhumbula izinto ezintsha, kwaye izinto ezindala ziyalibaleka kancinci kancinci.
• Ukuphazamiseka kokubona: Abanye abantu banokuba neengxaki zokubona.
• Ubunzima bokuthetha (`Aphasia`): Ubunzima bokufumana amagama, ukungathethi kakuhle into ofuna ukuyithetha, kwaye ngamanye amaxesha ulahlekelwe ngokupheleleyo kukuthetha.
• Ubunzima bokuginya: Usenokuziva ngathi uyakrwitshwa xa uginya ukutya nesiselo.

Ukongeza koku, ezinye iimpawu ezinjalo zinokubonakala:

• Ukuqaqamba kwemisipha, ukushukuma, ukuqina kwemisipha, okanye ukungcangcazela.
• Ubunzima bokwenza imisebenzi emincinci nebuthathaka (umz., ukuqhobosha ihempe, ukubhala ngepeni).
• Isifo sesandla sasemzini: Ukungakwazi ukulawula ingalo okanye umlenze omnye njengoko uthanda (`isifo sesandla sasemzini`). Khawuthelekelele ukuba enye yeengalo zakho yenza izinto ongafuniyo ukuba izenze, kwaye uzive ngathi awukwazi ukuzilawula.
• Ukuziva ngathi kukho into engathi yindindisholo kwelinye icala lomzimba.
• Iintshukumo zihamba kancinci kakhulu (`Bradykinesia`) okanye ukungakwazi ukuhambisa amalungu omzimba (`Akinesia`).
• Ukuncipha kokusebenza kwengqondo, oko kukuthi, ukuncipha kwengqondo (i-Dementia).
• Ubunzima bokuhamba ngaphandle koncedo.
• Utshintsho kwimo yengqondo nakwindlela yokuziphatha (ukungakhathaleli, umsindo okhawulezileyo, ukungakhathali).

Esi sifo asibachaphazeli bonke abantu ngendlela efanayo. Sidla ngokukhula kancinci kancinci. Ngamanye amaxesha iimpawu ziqala engalweni enye, zize zisasazeke kwenye ingalo nemilenze. Usenokuqala ukuziva ngathi uyakhubeka xa uhamba, uze ungakwazi ukuhamba ngaphandle koncedo. Usenokuqala ukukrwela amagama xa uthetha, kwaye ekuhambeni kwexesha, usenokungakwazi ukuthetha isivakalisi esinye esinentsingiselo.

Njengoko esi sifo sichaphazela iindawo ezininzi zobuchopho, iimpawu ziya ziba mandundu kancinci kancinci. Oku kwenzeka kancinci kancinci.

Ziqala nini iimpawu ze-`(Corticobasal Degeneration)`?

Iimpawu zihlala ziqala phakathi kweminyaka engama-50 ukuya kwengama-70. Uninzi lwabantu luneempawu zabo malunga neminyaka engama-64 ubudala. Nangona kunqabile ukuba ziqale kwangethuba xa zineminyaka engama-40 ubudala, akukho ngxelo yokuba esi sifo siqala xa umntu eselula.

Zithini izizathu `(Ukuwohloka kweCorticobasal)`?

Eyona sizathu soku kukuba iiseli zobuchopho kunye nezicubu ziyaqhekeka kancinci kancinci zize zife. Ixesha elininzi, lo monakalo uqala kwiindawo ebesithethe ngazo ngaphambili ezibizwa ngokuba yi-cerebral cortex kunye ne-basal ganglia. Njengoko esi sifo siqhubeka, sinokuchaphazela nezinye iindawo zobuchopho.

Abaphandi bakholelwa ukuba iproteni ebizwa ngokuba yi-"Tau" ibandakanyeka kwesi sifo. Le proteni idla ngokufumaneka kwiiseli zobuchopho. Kodwa kwesi sifo, le proteni ihlangana ngokungaqhelekanga ize yenze ii-clumps. Ezi clumps zibizwa ngokuba yi-"neurofibrillar tangles." Ezi clumps zibangela ukuba iiseli zobuchopho ziwohloke zize zife. Ngenxa yoko, kubakho iingxaki zokuhamba, intetho kunye nenkumbulo.

Isizathu esichanekileyo sokuba iproteni yeTau ihlangane asikaziwa okwangoku. Kufunyenwe ukuba abantu abaninzi abaneCorticobasal Degeneration bane-genetic variant (mutation) ebizwa ngokuba yi-H1 haplotype kwi-chromosome 17. Olu tshintsho lwe-genetic lunokubangela ukuba iproteni yeTau iveliswe ngokugqithisileyo kwaye ihlangane, okanye kusenokwenzeka ukuba iqela le-methyl linamathele kwi-gene yeTau, nto leyo echaphazela umsebenzi wayo.

Kodwa abaphandi bayazi ukuba esi sifuzo asiso sodwa esibangela oku. Ngenxa yokuba abantu abaninzi kuluntu ngokubanzi banaso esi sifuzo, ababi nazimpawu zokubola kweCorticobasal. Ngoko ke uphando lusaqhubeka ukuze kufunyanwe unobangela ochanekileyo wale meko.

Ingaba `(Corticobasal Degeneration)` ifuzwa njengelifa?

Iingcali zonyango azikayazi ukuba kutheni abanye abantu benesifo sokuwohloka kwe-corticobasal. Kunqabile kakhulu ukuba amalungu osapho olunye afumane esi sifo. Oko kuthetha ukuba kunzima ukuthi sisifo esizuzwe njengelifa.

Ziziphi iingxaki ezinokubakho?

Njengoko isifo siqhubeka, umngcipheko wokufumana iingxaki ezisongela ubomi ezifana nezi:

• Usulelo lweebhaktheriya
• Amahlwili egazi kunye ne-pulmonary embolisms
• Iingozi zomzimba (ezifana nokuwa)
• Ukukrala kwemiphunga
• I-Sepsis (usulelo olubi olubangelwa ziintsholongwane ezingena egazini)

Oogqirha bayixilonga njani le sifo? (`Uxilongo`)

Eyona nto ingaqhelekanga yokuxilonga `(Corticobasal Degeneration)` kukuba inokuqinisekiswa ngokuqinisekileyo kuphela ngokuhlola ubuchopho emva kokufa. Kulapho ke kuphela apho ugqirha okanye ingcali yezifo enokuthi imisele ngokuchanekileyo ubungakanani bokonakala kobuchopho.

Nangona kunjalo, ngexesha lobomi bakho, ugqirha wakho angabiza le meko ngokuthi "yiCorticobasal Syndrome" ngokusekelwe kwiimpawu zakho.

Ukuze axilonge, ugqirha wakho uza kuqala enze uvavanyo lomzimba. Baza kujonga ngononophelo iimpawu zakho.

Ngenxa yokuba izifo ezininzi zineempawu ezifanayo, ugqirha wakho unokwenza uvavanyo olwahlukeneyo ukuze afumanise unobangela. Ezi zingabandakanya:

• Uvavanyo lwegazi
• Uvavanyo lwemifanekiso yobuchopho (`Imifanekiso yeskena`) - umzekelo `(MRI)` okanye `(CT scan`)
• Uvavanyo lwe-neuropsychological ukuvavanya ukusebenza kwengqondo kunye nenkumbulo

Ukongeza, ugqirha unokuyalela iiskeni zamayeza enyukliya ezifana ne-`(FDG-PET (Fluorodeoxyglucose Positron Emission Tomography))` kunye ne-`(DAT (Dopamine Transporter))`. Ngamanye amaxesha, i-`skin biopsy` inokunceda ekuxilongweni.

Ziziphi iindlela zonyango `(Corticobasal Degeneration)`?

Ugqirha wakho unokukunika amayeza ahlukeneyo okulawula iimpawu ezahlukeneyo zesi sifo.

Khumbula, okwangoku akukho nyango lwesi sifo okanye unyango lokuthintela ukuqhubeka kweempawu. Nangona kunjalo, kukho izinto ezinokunceda ukunciphisa ukungakhululeki okubangelwa ziimpawu.

Amayeza eempawu ezinxulumene nemisipha angaquka:

• Iintshukumo ezicothayo okanye ukuqina kwemisipha: `(Levodopa)`
• Kwiintlungu zemisipha: I-Clonazepam (iBenzodiazepines)
• Ukuqinisa izihlunu okanye ukulawula intshukumo: `(Ityhefu yeBotulinum)` (Iinaliti zeBotox)
• Ukuqina kwemisipha: `(Cyclobenzaprine)`, `(Levetiracetam)` okanye `(Baclofen)`

Xa uneengxaki zokukhumbula, ugqirha wakho angakunika enye yezi ntlobo zamayeza abizwa ngokuba yi-"Cholinesterase inhibitors":

• `(Donepezil)`
• `(I-Rivastigmine)`
• `(Galantamine)`

Amanye amayeza awasebenzi kakuhle ngokulinganayo kwiimpawu zomntu wonke, ngoko ugqirha wakho unokuzama iintlobo ezahlukeneyo ukufumana elona lilungele wena.

Kwakhona, njengayo yonke imithi, kukho iziphumo ebezingalindelekanga. Ugqirha wakho uza kuthetha nawe ngale nto. Baza kukujonga rhoqo ukuqinisekisa ukuba amayeza asebenza kakuhle kwaye ukuba kukho naziphi na iingxaki. Ukuba ufumana naziphi na iziphumo ebezingalindelekanga, kufuneka uxelele ugqirha wakho ngoko nangoko.

Eyona nto ibalulekileyo kukuba okwangoku akukho nyango lokuthintela ukuqhubeka kwezi mpawu okanye lokunyanga ngokupheleleyo esi sifo.

Ungazilawula njani iimpawu?

Xa uphila neempawu ze-"Corticobasal Syndrome," ezi ndlela zonyango zilandelayo zinokunceda ekulawuleni ezi mpawu:

• Unyango lomsebenzi: Oku kunokukunceda ufunde iindlela ezintsha zokwenza imisebenzi yemihla ngemihla kwaye ugcine ukuzimela kwakho ixesha elide kangangoko unako. Ukuba kuyimfuneko, ungafunda nendlela yokusebenzisa izixhobo zokuncedisa ukuhamba.
• Unyango lomzimba: Oku kunceda ukugcina intshukumo yomzimba kunye nokunciphisa ukungonwabi okubangelwa ziimpawu ezinxulumene nemisipha. Ukuzilolonga kunokunceda ukuqinisa izihlunu kunye nokugcina ukuguquguquka.
• Unyango lokuthetha: Oku kunceda kwiingxaki zokuthetha nokuginya. Kunokunceda kwizinto ezifana nendlela yokuveza izimvo, indlela yokubiza amagama, kunye nendlela yokuginya ukutya ngokukhuselekileyo.

Ugqirha wakho uza kusebenza nawe ukuze afumane amaqhinga okulawula iimpawu zakho. La maqhinga anokwahluka kumntu nomntu, kwaye anokufuna ukulungiswa njengoko imeko yakho itshintsha ngokuhamba kwexesha.

Ufanele uye nini kugqirha?

Ukuba wena okanye umntu omthandayo uneempawu ze-`(Corticobasal Degeneration)`, bona ugqirha ngokukhawuleza:

• Ukuba unengxaki yokuhamba okanye ukulawula amalungu akho omzimba.
• Ukuba uneengxaki zokukhumbula okanye iimpawu ze-dementia.
• Ukuba unengxaki yokuthetha, yokuginya, okanye yokuphefumla.
• Ukuba kukho ukungcangcazela.

Ithini ingqikelelo ye-`(Corticobasal Degeneration)`?

Inyaniso kukuba, ikamva le-Corticobasal Degeneration alithembisi kangako. Sisifo esiqhubekayo, nto leyo ethetha ukuba iimpawu ziya zisiba mandundu ngokuhamba kwexesha.Kodwa oku kudla ngokwenzeka kancinci, ngokuhamba kweminyaka. Ugqirha wakho uza kukunika unyango oluza kukunceda ukwazi ukumelana nokulawula iimpawu zakho. Nangona olu nyango lunokunciphisa ubukhali beempawu zakho, alunakukuthintela ukuba zingabi mandundu. Njengoko iimpawu zakho zisiba mandundu, kunokuba nzima ngakumbi ukuzilawula wedwa.

Ngenxa yokuba esi sifo siqhubeka kancinci, unexesha lokuceba ikamva lakho. Akunyanzelekanga ukuba wenze ezi zinto kwangoko xa uxilongwa. Kufuneka uzinike ixesha lokucinga ngeyona nto ikulungeleyo. Kufuneka usebenzisane noogqirha bakho kunye nabantu obathembayo ukuze bahlele iminqweno yakho kunye nonyango olufunekayo.

Lingakanani ixesha lokuphila komntu ono-`(Corticobasal Degeneration)`?

Ngokomyinge, uninzi lwabantu luphila malunga neminyaka emithandathu ukuya kwesibhozo emva kokuba iimpawu zokuqala zeCorticobasal Degeneration zibonakale. Nangona kunjalo, oku akufani kuye wonke umntu, kwaye abanye abantu baphila ixesha elide. Imeko yakho isenokungahambelani nezibalo, ngoko ke umntu ongcono onokuthetha naye ngale nto ngugqirha wakho.

Ziziphi ezinye iimeko ezineempawu ezifanayo?

Ezinye zeempawu ze-`(Corticobasal Degeneration)` zinokufana neempawu zezinye izifo, ezifana:

• Umhlaza wobuchopho (`Umhlaza wobuchopho / ithumba lobuchopho`)
• `(Isifo sengqondo esixhalabisayo sangaphambili)`
• Isifo sika-Alzheimer
• `(Ukuphelelwa ngamandla kwenkqubo ezininzi)`
• Isifo sikaParkinson
• `(I-Progressive supranuclear palsy)`
• Istroke

Kungoko ke, kubaluleke kakhulu ukubona ugqirha ngokukhawuleza ukuba ufumana naziphi na iimpawu, njengoko unyango lwasekuqaleni lunokusindisa ubomi, ingakumbi kwiimeko ezifana nokukhubazeka.

Kunokuba nzima ukulawula iimvakalelo eziza nokuxilongwa okufana `(Corticobasal Degeneration)`. Usenokuziva usoyika kwaye uxhalabile ngekamva. Njengoko iimpawu zikhula ngokuhamba kweminyaka, usenokuzibuza ukuba ungayisebenzisa njani yonke into. Kunokuba nzima ukusingatha konke oku ngaxeshanye. Usenokufuna ukuthetha neengcali zempilo yengqondo ukuze ufumane inkxaso ngeli xesha linzima.

Khumbula, awuwedwa kuyo yonke le nto. Ukuba ufuna uncedo, ungaze ungathandabuzi ukuqhagamshelana neqela lakho lezonyango.

Okokugqibela, izinto ekufuneka uzikhumbule

Kulungile, ke nazi ezinye zezinto esithethe ngazo `(Corticobasal Degeneration)` endicinga ukuba ziya kuba zibalulekile kuwe:

• Le yimeko echaphazela ingqondo kwaye iimpawu ziyanda kancinci kancinci ngokuhamba kwexesha.
• Isizathu esichanekileyo soku asikafunyanwa, kodwa kucingelwa ukuba sinxulumene neproteni ebizwa ngokuba yi-`(Tau)`.
• Okwangoku akukho nyango lokunyanga ngokupheleleyo esi sifo.
• Nangona kunjalo, kukho unyango lokulawula iimpawu nokwenza ubomi bube lula.(Njengeyeza, unyango lomzimba, unyango lomsebenzi, unyango lokuthetha).
• Kubalulekile ukufuna iingcebiso zonyango ngokukhawuleza.
• Cwangcisa ikamva kwaye ufumane inkxaso oyifunayo.
• Awuwedwa. Kubaluleke kakhulu ukuhlala uqinile engqondweni. Fumana uncedo koogqirha, kusapho nakubahlobo.

Ndiyathemba ukuba olu lwazi luza kukunceda. Ukuba unemibuzo, ungathandabuzi ukuthetha nogqirha wakho.

Ukonakala kweCorticobasal , Izifo zoBuchongo, Izifo zeNeurological, Iingxaki zokuHamba, Ukuphazamiseka kweMemori, Iingxaki zokuThetha, iTau Protein, i-CBS, iBrain Atrophy, iApraxia, iAphasia, iDementia