Usenokuba ukhe weva nge " Cortisol " ( iCortisol ), ingakumbi xa kuxoxwa " ngoxinzelelo ." Nangona kunjalo, i-cortisol ingaphezulu kakhulu kunokuba 'yi-hormone yoxinzelelo'. Enyanisweni, yi-hormone ebalulekileyo edlala indima ebalulekileyo kwimisebenzi ebalulekileyo yomzimba wakho. Apha eNirogi Lanka, makhe sichaze ukuba yintoni kanye kanye i-cortisol kunye nendlela esebenza ngayo kuwe.
Yintoni iCortisol? Ngaba ngokwenene 'yi-hormone yoxinzelelo'?
Ngamafutshane, i-cortisol yi-hormone eveliswa zii -adrenal glands zakho ( ii-adrenal glands )—ii-glands ezincinci eziphezu kwe-kidney nganye. Luhlobo lwe- glucocorticoid , oluwela phantsi kodidi lwee -steroid hormones .
Ewe, njengoko unokucinga, i-cortisol inxulumene kakhulu noxinzelelo. Nokuba ujongene noxinzelelo olukhawulezileyo, uxinzelelo olungapheliyo oluqhubekayo, okanye uxinzelelo emva kwesiganeko esibuhlungu , umzimba wakho ukhupha i-cortisol. Yiyo kanye le nto yaziwa ngokubanzi ngokuba yi-"stress hormone".
Nangona kunjalo, nceda ukhumbule: Umsebenzi weCortisol awupheleli nje kuxinzelelo lodwa. Le hormone yenza eminye imisebenzi ebalulekileyo emzimbeni wakho.
I-cortisol iwuchaphazela njani umzimba wakho?
I-Cortisol inefuthe phantse kuzo zonke izitho zomzimba wakho, ilawula imisebenzi emininzi ebalulekileyo. Makhe sijonge ukuba zeziphi ezo zinto.
Ukulawula indlela osabela ngayo kuxinzelelo lwakho
Xa uziva usongelwa okanye usoyika, umzimba wakho ungena ngokukhawuleza kwimeko "yokulwa okanye yokubaleka". Iihormone ezifana ne-adrenaline zikhutshwa kuqala, zilandelwe yi-cortisol ukuze uhlale uphaphile. Ukongeza, i-cortisol inceda isibindi sakho sikhuphe i-glucose, ikunika amandla akhawulezileyo owadingayo.
I-Metabolism kunye namanqanaba eswekile egazini
I-Metabolism yinkqubo esetyenziswa ngumzimba wakho ukuvelisa amandla obomi bemihla ngemihla. I-Cortisol ilawula oku ngokulawula indlela umzimba wakho osebenzisa ngayo i-glucose.
Umzekelo:
- Isebenzisana nepancreas yakho ukunciphisa ukuveliswa kwe-insulin kunye nokwandisa ukuveliswa kwe-glucagon. Ngelixa i-insulin yehlisa iswekile egazini, i-glucagon iyasebenza ukuyinyusa.
- Ikwalawula indlela i-glucose esetyenziswa ngayo zizicubu zakho zamafutha, isibindi kunye nezicubu zemisipha.
Ukuthintela ukudumba
Ngexesha elifutshane, i-cortisol inokunyusa amandla akho okusebenza.ukuzikhusela komzimba ngokunciphisa ukudumba (ukudumba okanye ukuba bomvu). Nangona kunjalo, ukuba amanqanaba akho e-cortisol ahlala ephakanyisiwe ixesha elide, umzimba wakho unokuqhelana nawo, nto leyo enokubangela isiphumo esahlukileyo: ukwanda kokudumba kunye nobuthathaka benkqubo yomzimba yokuzikhusela .
Ukulawula uxinzelelo lwegazi
Nangona indlela esebenza ngayo le nkqubo iyinkimbinkimbi, uphando lubonisa ukuba amanqanaba aphezulu e-cortisol anokubangela uxinzelelo lwegazi oluphezulu, ngelixa amanqanaba aphantsi ngokungaqhelekanga anokubangela uxinzelelo lwegazi oluphantsi.
Ukunceda ukulawula umjikelo wokulala nokuvuka
Ngokwesiqhelo, amanqanaba akho e-cortisol aphantsi kakhulu ebusuku kwaye afikelela kwinqanaba eliphezulu xa uvuka. Oku kubonisa ukuba i-cortisol idlala indima ebalulekileyo kwisigqi sakho se-circadian , okanye kumjikelo wakho wendalo wokulala nokuvuka.
Umzimba wakho ulawula njani amanqanaba e-cortisol?
Umzimba wakho unenkqubo enobuchule yokulawula amanqanaba e-cortisol, elawulwa ikakhulu yi- hypothalamus kunye ne- pituitary gland engqondweni yakho. Ezi nxalenye zimbini zilawula ukuveliswa kwe-cortisol ngamadlala akho e-adrenal.
Nantsi indlela esebenza ngayo le nkqubo:
- Xa amanqanaba e-cortisol egazini lakho ehla, i-hypothalamus yakho ikhupha i-CRH (i-corticotropin-releasing hormone) .
- Le CRH inika i-pituitary gland yakho imiqondiso yokuba ivelise i-ACTH (i-adrenocorticotropic hormone) .
- Emva koko i-ACTH ivuselela amadlala akho e-adrenal ukuba avelise i-cortisol aze ayikhuphele egazini lakho.
Ukuze ugcine amanqanaba e-cortisol asempilweni, i-hypothalamus yakho, i-pituitary gland, kunye ne-adrenal glands kufuneka zonke zisebenze ngoxolo. Ukuba ufumana iimpawu eziqatha, nceda unxibelelane neenkonzo zongxamiseko ezikufutshane nawe okanye isibhedlele ngokukhawuleza.
Kuthekani ukuba amanqanaba akho e-cortisol aphezulu kakhulu?
Xa umzimba wakho ugcina amanqanaba aphezulu e-cortisol ixesha elide, oko kukhokelela kwimeko ebizwa ngokuba yi- hypercortisolism . Oku kuqhele ukunxulunyaniswa nesifo esaziwa ngokuba yi -Cushing's syndrome .
Yintoni ebangela amanqanaba aphezulu e-cortisol?
- Amayeza e-corticosteroid: Ukusetyenziswa kwexesha elide kweedosi eziphezulu (umz., i-prednisone, i-prednisolone, i-dexamethasone).
- Iithumba ezikhupha i-ACTH: Ezi zihlala zikhula kwi-pituitary gland.
- Ii-adrenal tumors: Ukukhula kwamadlala akho e-adrenal okuvelisa i-cortisol eninzi kakhulu.
Iimpawu ze-cortisol ephezulu
Ukuba une-cortisol ephezulu okanye i-Cushing's syndrome, ungabona ezi mpawu zilandelayo:
- Ukwanda kobunzima: Ngokuyintloko kufutshane nobuso bakho naphakathi kwesinqe.
- Amanqatha: Akhula phakathi kwamagxa akho, adla ngokubizwa ngokuba yi "buffalo hump."
- Utshintsho lolusu:Amabala abanzi, amfusa okunwebeka esiswini sakho.
- Ubuthathaka bemisipha: Ingakumbi kwiingalo zakho zangasentla nasemathangeni (okunxulunyaniswa nokuwohloka kwemisipha ).
- Iswekile ephezulu egazini: Ihlala isiya kwisifo seswekile sohlobo lwesibini.
- Uxinzelelo lwegazi: Uxinzelelo lwegazi oluphezulu.
- I-Hirsutism: Ukukhula kweenwele emzimbeni ngokugqithisileyo kubafazi.
- Ukulahlekelwa bubunzima bamathambo: I-Osteoporosis, eyonyusa kakhulu umngcipheko wakho wokuqhekeka kwamathambo.
Kuthekani ukuba amanqanaba akho e-cortisol aphantsi kakhulu?
Xa amanqanaba e-cortisol ehla ngaphantsi komlinganiselo oqhelekileyo, oogqirha babiza oku ngokuthi yi-hypocortisolism okanye i-adrenal insufficiency . Kukho iintlobo ezimbini eziphambili.
Yintoni ebangela i-cortisol ephantsi?
- Ukungasebenzi kakuhle kwe-adrenal: Kudla ngokwenzeka xa amajoni omzimba wakho ehlasela amadlala akho e-adrenal; oku kwaziwa ngokuba sisifo sika-Addison .
- Ukungasebenzi kakuhle kwe-adrenal yesibini: Kwenzeka ngenxa yokusebenza kakubi kwe-pituitary (hypopituitarism) okanye i-tumor ye-pituitary.
Iimpawu ze-cortisol ephantsi
Ukuba amanqanaba akho e-cortisol aphantsi, unokufumana oku kulandelayo:
- Ukudinwa okungapheliyo: Ukuziva udiniwe ngokuqhubekayo.
- Ukunciphisa umzimba ngendlela engachazekiyo.
- Ukulahlekelwa yintliziyo.
- Uxinzelelo lwegazi oluphantsi (hypotension).
Ungawulawula njani amanqanaba akho e-cortisol?
Ukuba unesifo esifana ne-Cushing's syndrome, kuya kufuneka unyango lobuchwephesha, olunokubandakanya amayeza okanye utyando. Nangona kunjalo, ungawuxhasa umzimba wakho ekulawuleni i-cortisol ngale mikhwa isempilweni:
- Beka ubuthongo obusemgangathweni kwindawo yokuqala: Ukungalali kakuhle okanye amaxesha angacwangciswanga, njengokusebenza ebusuku, kunokunyusa i-cortisol.
- Ukuzilolonga rhoqo: Ukuzilolonga rhoqo kuphucula umgangatho wokulala kwaye kunciphisa uxinzelelo ngokufanelekileyo.
- Ukuzilolonga ngokuphefumla nzulu: Ukuphefumla okulawulwayo kuvuselela inkqubo yakho ye-parasympathetic nervous system — inkqubo "yokuphumla nokugaya" enceda ukuzola umzimba wakho.
- Gxila kuvuyo nokuhleka: Ukuhleka kukhupha ii-endorphins, ezinceda ngokwendalo ukunciphisa amanqanaba e-cortisol.
- Yakha ubudlelwane obusempilweni: Uxinzelelo oluqhubekayo kubudlelwane bomntu lunokubangela uxinezeleko olungapheliyo.
Inqaku lokugqibela: Oko kufuneka ukukhumbule
Nangona i-cortisol idla ngokubonwa njengengalunganga, yi-hormone ebalulekileyo kwimisebenzi emininzi yomzimba. Ukulawula uxinzelelo sisixhobo esinamandla sokugcina i-cortisol ilungelelene. Nangona kunjalo, ngamanye amaxesha amanqanaba angaqhelekanga angaphaya kwamandla akho kwaye abonisa ingxaki yempilo engaphantsi.
Ukuba ufumana iimpawu ze-cortisol ephezulu okanye ephantsi, kubalulekile ukuba udibane nogqirha. Ngovavanyo olulula lokuxilonga, banokubona ukuba iimpawu zakho zinxulumene ne-adrenal okanye i-pituitary glands yakho kwaye banike unyango olufanelekileyo.
