Ulusu lwethu luyinto entle kakhulu, akunjalo? Ngamanye amaxesha amaqhuqhuva amancinci namabala ayavela adlule. Kodwa ngamanye amaxesha usenokuba norhano malunga nendawo entsha okanye iqhuqhuva eluswini lwakho, okanye elidala elingazange liphole. Ngamaxesha anjalo, kufuneka silumke kancinci. Kuba, nangona kunqabile kakhulu, olo tshintsho lolusu lunokuba luphawu lwesifo esibi. Namhlanje siza kuthetha ngesifo solusu esingaqhelekanga, kodwa esibaluleke kakhulu ekufuneka siqaphele. Leyo yimeko ebizwa ngokuba yi-cutaneous B-cell lymphoma, okanye `(Cutaneous B-Cell Lymphoma)`.
Yintoni i-Cutaneous B-Cell Lymphoma?
Ngamafutshane, i-Cutaneous B-Cell Lymphoma (CBCL) luhlobo lomhlaza oluqala eluswini lwakho. Lunqabile kancinci. Lukwiqela lomhlaza olubizwa ngokuba yi-lymphoma. Kodwa into ekhethekileyo kukuba luqala ngaphandle kwama-lymph nodes ethu, eluswini. Yiyo loo nto lubizwa ngokuba yi-extranodal lymphoma.
Amaxesha amaninzi, le `(CBCL)` ibonakala njengebala, irhashalala, okanye iqhuma eluswini. Ezi zikhula kancinci kakhulu. Kungathatha iinyanga, kwaneminyaka, ukuba zikhule. Kwakhona, azisasazeki kwamanye amalungu omzimba. Abanye abantu bayibiza ngokuba yi-`(B-cell skin lymphoma)`. Ngoko ke, ukuba ubona into entsha okanye eyahlukileyo eluswini lwakho, licebo elihle ukuyiqwalasela.
Ikhula njani le lymphoma? Zithini ii-B-cells?
Ngoku usenokuba uzibuza ukuba kutheni into efana nale isenzeka. Inyaniso kukuba, izazinzulu azikafumani unobangela ochanekileyo wale `(CBCL)`. Kodwa kukho into enye ecacileyo: ayilofuzo okanye ayisuleli.
Iqala ngeeseli ezimhlophe zegazi ezibizwa ngokuba zii-lymphocytes. Ezi lymphocytes zingamalungu abalulekileyo kwinkqubo yethu yokuzikhusela. Zifana nomkhosi okhusela ilizwe lethu. Kukho iintlobo ezimbini eziphambili zee-lymphocytes: ii-T-cells kunye nee-B-cells. Xa ii-B-cells ziqala ukukhula kakhulu ngaphandle kokulawulwa, le meko ebizwa ngokuba yi-B-cell lymphoma iyenzeka. Ngamafutshane, iiseli zethu ziyaphambana kancinci kwaye zibe ziiseli zomhlaza.
Ziziphi iintlobo eziphambili ze-cutaneous B-cell lymphoma?
Kukho iintlobo ezine eziphambili zale ``(CBCL)``. Ezi zahlulwe ngokwendlela ezibonakala ngayo iiseli phantsi kwemakroskopu. Uhlobo ngalunye lunokubonakala lwahlukile eluswini kwaye lunokufuna unyango olwahlukileyo.
1. I-lymphoma yesikhumba esiphambili se-follicle center:
- Olu lolona hlobo luqhelekileyo lwe-`(CBCL)`.
- Amaxesha amaninzi, zenzeka entloko, entanyeni, okanye esifubeni/emzimbeni.
- Kubonakala ngathi ziimpundu ezibomvu-mdaka, eziphakanyisiweyo okanye amaqhuqhuva eluswini .
- Oku kubi kakhulu, kukhula ngokuhamba kweenyanga, mhlawumbi iminyaka.
2. I-B-cell lymphoma yesikhumba esiphambili:
- Olu luhlobo olukhula kakuhle.
- Ihlala ibonakala njengezilonda ezibomvu-pinki, amaqhuqhuva, okanye iithumba .
- Ihlala isenzeka emzimbeni okanye ezingalweni.
3. I-lymphoma enkulu ye-B-cell diffuse yesikhumba, uhlobo lomlenze:
- Le incinci kancinci kunezinye iintlobo ezimbini, kodwa inobundlongondlongo ngakumbi. Oko kuthetha ukuba ikhula ngokukhawuleza, kwiiveki okanye kwiinyanga ezimbalwa.
- Idla ngokubonakala njengethumba elinye okanye ngaphezulu okanye amaqhuqhuva emilenzeni, ezingalweni, okanye esifubeni/esiqwini.
4. I-lymphoma enkulu ye-B-cell diffuse yesikhumba, enye:
- Olu luhlobo olunqabileyo kakhulu nolunobundlongondlongo.
- Inkangeleko ingahluka, kodwa ngokuqhelekileyo iqala entloko, esiqwini, nasemaphethelweni.
Ngubani onokuba sengozini enkulu yokuhlaselwa sesi sifo? Sixhaphake kangakanani?
Enyanisweni, le meko ibizwa ngokuba yi-``(CBCL)`` inokukhula nakubani na. Akukho mahluko ngokwesini, akukho mahluko ngeminyaka, kwaye ifunyenwe ukuba ikhula kwiintlanga ezahlukeneyo. Ngoko ke, kunzima ukucinga ukuba, "Oku akuyi kwenzeka kum."
Kodwa, musa ukoyika. Le yimeko engaqhelekanga kakhulu. Cinga ngayo, ukuba uthatha umyinge wabantu abasisigidi, bane kuphela kubo abaya kuba nale meko. Ngoko ke, akufuneki ukhathazeke uze ucinge ukuba oku "(CBCL)" xa ubona into engaqhelekanga eluswini lwakho. Nangona kunjalo, ukuba unamathandabuzo, kububulumko ukufuna ingcebiso kagqirha.
Zithini iimpawu? Jonga ukuba unazo na ezi mpawu
Uphawu oluphambili lwe-`(CBCL)` lutshintsho eluswini. Olu tshintsho lunokuvela ngeendlela ezahlukeneyo:
- Urhashalala
- Iqhuma okanye iqhuma eluswini
- Iqhuma elincinci (iqhubu okanye ithumba)
Ezi zinokuba bomvu, zimfusa, okanye zibe mdaka. Ezinye ziphakanyisiwe kwaye ziqinile, kodwa zigudile. Ezi zibizwa ngokuba zii-papules. Ezinye zithe tyaba, njengeziqwenga zesikhumba esityebileyo. Ezi zibizwa ngokuba zii-plaque. Amaqhuma amakhulu akwabizwa ngokuba zii-nodules okanye ii-tumor.
Kusenokuba nebala/iqhubu elinye nje, okanye kunokubakho ezininzi. Kwakhona, zinokuvela kwindawo enye emzimbeni okanye kwiindawo ezininzi. Zisenokuba kufutshane, okanye ziqelelene kakhulu.
Khawucinge nje, uMalume uSunil wayenebala elibomvu esandleni sakhe kangangeenyanga. Wayecinga ukuba ngumkrwelo nje. Kodwa lakhula kancinci kancinci laza laba njengeqhubu. Yiloo nto enokuba luphawu lokuqala lwale nto.
Kunqabile kakhulu, abanye abantu banokubona ezinye iimpawu. Ezi zikwabizwa ngokuba "ziimpawu ze-B". Ezi ziquka:
- Umkhuhlane oza ngaphandle kwesizathu.
- Ukubila kakhulu ebusuku.
- Ukudumba kwama-lymph nodes entanyeni, emakhwapheni, okanye emqolo.
- Ukunciphisa umzimba ngaphandle kwesizathu.
Ukubakho kwezi "mpawu ze-B" kuthetha ukuba esi sifo sisenokuba sisasazeke ngakumbi. Nangona kunjalo, ezi zinqabile kakhulu kwi-`(CBCL)`.
Oogqirha bayixilonga njani le nto?
Abantu abaninzi bayalibazisa ukufuna iingcebiso zonyango kuba amabala kunye namaqhuma avela eluswini kwi-CBCL anokubonakala njenge-acne eqhelekileyo, ukulunywa zizinambuzane, i-allergies, imikrwelo, okanye ezinye iimeko zesikhumba ezifana ne-eczema okanye i-psoriasis. Nangona kunjalo, ukuba unento engaqhelekanga eluswini lwakho engaphiliyo, ngokuqinisekileyo kuya kufuneka ubone ugqirha, ngakumbi ingcali yesikhumba.
Ugqirha uza kuqala enze uvavanyo olucokisekileyo lolusu lwakho. Baza kujonga zonke iindawo zomzimba wakho baze bahlole naziphi na iingxaki.
Emva koko, ukuze kufunyanwe isifo ngokuqinisekileyo, kufuneka i-"skin biopsy", oko kuthetha ukuthatha iqhekeza elincinci lesikhumba kwindawo engaqhelekanga uze ulihlolisise. Eli qhekeza lincinci lesikhumba lihlolwa phantsi kwe-microscope yingcali (''pathologist'') ukuze kubonwe ukuba kukho iiseli zomhlaza, kwaye ukuba kunjalo, zeziphi iintlobo zazo. I-"biopsy" yeyona ndlela yokwazi ukuba ingaba yi-"skin lymphoma" kwaye loluphi uhlobo.
Ukuze ubone ukuba umhlaza usasazekile na, ugqirha wakho unokuyalela ezinye iimvavanyo (`iimvavanyo zokulinganisa`). Ezi zinokubandakanya:
- Uvavanyo lwegazi.
- Uvavanyo lwemifanekiso olufana ne-CT scan okanye i-PET scan.
- I-biopsy yomongo wethambo.
- I-biopsy ye-lymph node.
Masifunde ngamanqanaba kunye nokusasazeka kwesi sifo.
Inqanaba lesi sifo (CBCL) liyindlela yokulinganisa ukuba umhlaza usasazeke kangakanani na kwaye usasazeke kangakanani na. Eli nqanaba libaluleke kakhulu kuba limisela unyango. Ugqirha wakho uza kukuchazela ukuba esi sifo sikuliphi inqanaba kwaye siza kukuchaphazela njani.
- Inqanaba 1E: Igama elithi "E" limele "i-extranodal," oko kuthetha ukuba ngaphandle kwee-lymph nodes. Kweli nqanaba, umhlaza uhlala eluswini kwaye awukasasazeki kwenye indawo. Ukuba akukho zimpawu zongezelelweyo "B", ezinje ngomkhuhlane okanye ukwehla kobunzima, oku kukwabizwa ngokuba "yinqanaba 1AE."
Ukuba i-"CBCL" isasazekile, oogqirha basebenzisa inkqubo ebizwa ngokuba yi-"TNM staging system".
- Ithumba (T): Unobumba "T" ubhekisa kwinani leepapules, ii-nodules, okanye ii-tumor eluswini, ukuba zinkulu kangakanani, kunye nokuba ziphi. Oku kubalwa ukusuka ku-1 ukuya ku-3 (ukusuka kowona mncinci ukuya kowona unzima).
- AmaNode (N):Unobumba "N" ubonisa ukuba ii-lymph nodes zichaphazelekile na, zingaphi, kwaye ziphi. Oku kukwabalwa ukusuka ku-0 ukuya ku-3.
- I-Metastasis (M): Unobumba "M" ubonisa ukuba i-lymphoma isasazeke ngaphaya kolusu okanye ii-lymph nodes (`M1`) okanye akunjalo (`M0`). `(I-Metastasis)` ithetha ukuba umhlaza usasazeke kwizitho ezikude.
Zithini iindlela zonyango? Ngaba zinokunyangeka?
Unyango lwe-`(CBCL)` luxhomekeke kuhlobo lwesifo kunye nenqanaba laso. Sinokuphiliswa rhoqo, ingakumbi kwiindlela eziphambili. Nangona kunjalo, ngamanye amaxesha isifo sinokuphinda sibuye.
Kukho iindlela ezahlukeneyo zonyango:
- Ukubeka esweni okusebenzayo: Kwezinye iimeko apho isifo sikhula kwaye singabangela iingxaki ezinkulu, oogqirha banokusebenzisa indlela "yokulinda nokulinda". Oko kukuthi, babeka esweni isifo de kuqalwe unyango.
- Unyango lweKhemotherapy: Ukunika amayeza abulala iiseli zomhlaza. La mayeza angathathwa njengeepilisi okanye anikwe njengeenaliti.
- Amayeza asetyenziswa ngaphandle okanye afakwa ngenaliti: Amayeza anjenge-corticosteroids anokusetyenziswa eluswini okanye afakwe ngqo kwiqhuma.
- Ii-antibodies ze-Monoclonal: Amayeza afana ne-`(Rituximab)` akweli qela. La asebenza njengonyango olujoliswe kulo kwaye atshabalalisa ii-B-cells.
- Unyango ngemitha: Ukusetyenziswa kwemitha enamandla aphezulu ukutshabalalisa iiseli zomhlaza. Oku kudla ngokusebenza kakuhle kwiithumba ezikwindawo ethile.
- Ukususwa ngotyando: Ngamanye amaxesha, ukuba kukho iqhuma elinye, lingasuswa ngokupheleleyo ngotyando.
Ugqirha wakho uza kuxoxa nawe ngendlela yonyango efanelekileyo kuwe.
Ngaba ikho indlela yokuthintela oku ukuba kungenzeki?
Ngelishwa, ekubeni unobangela ochanekileyo we-`(CBCL)` ungaziwa, akukho ndlela ziqinisekisiweyo zokukuthintela. Ke ngoko, eyona nto ingcono esinokuyenza kukwazi naluphi na utshintsho olungaqhelekanga eluswini lwethu size sifune ingcebiso yezonyango ngokukhawuleza ukuba sibona nantoni na.
Ithini ingqikelelo yokuchacha? (Ingqikelelo)
I-prognosis, okanye imbono, ixhomekeke kwizinto ezininzi, ikakhulu uhlobo lwe-lymphoma kunye nesigaba sesifo.
- Iintlobo ezimbini eziqhelekileyo (`i-Primary cutaneous follicle center lymphoma` kunye ne`Primary cutaneous marginal zone B-cell lymphoma`): Ezi zinezinga lokusinda leminyaka emihlanu elimalunga nama-95%. Oko kuthetha ukuba emva kweminyaka emihlanu yokufunyaniswa, ama-95 kwabali-100 abaguli basaphila. Olu lutyekelo oluhle kakhulu.
- Iintlobo ezinobundlongondlongo (`I-Primary cutaneous diffuse large B-cell lymphoma, uhlobo lomlenze` kunye ne`other`): Ezi zinezinga lokusinda leminyaka emihlanu elimalunga nama-60%.
La manani angumndilili nje. Imeko yakho isenokuba ngcono okanye ibe mbi, ngoko ke kungcono ukuthetha nogqirha wakho ngale nto.
Ndingabuya emva konyango?
Ewe, i-cutaneous lymphoma inokuphinda ivele emva konyango. Amaqhuma anokubuya kwindawo enye okanye kwindawo entsha. Ngokuqhelekileyo, uhlobo olufanayo lubuya. Nangona kunjalo, kunqabile kakhulu, i-CBCL ephinde yabuya ingaba sisifo esiqhelekileyo okanye olunye uhlobo lwe-lymphoma.
Kungoko ke, kubaluleke kakhulu ukujonga ulusu lwakho rhoqo (`ukuhlolwa kolusu`) kwaye uhlolwe rhoqo ngugqirha wesikhumba okanye enye ingcali.
Uyinyamekela njani impilo yakho njengomntu one-CBCL?
Ukuba unayo (i-CBCL) okanye sele unayo ngaphambili waza waphila, kubaluleke kakhulu ukulandela imiyalelo kagqirha wakho. Kuya kufuneka uqhubeke novavanyo ukuqinisekisa ukuba isifo asiphindanga savela.
Ukuba ezi mvavanyo zenziwa kangaphi kuya kwahluka ngokuxhomekeke kuhlobo lwe-CBCL kunye nokuba inamandla kangakanani na. Isenokuba rhoqo emva kweeveki ezimbalwa, rhoqo emva kweenyanga ezimbalwa, okanye kube kanye ngonyaka. Ezi zihlandlo zokulandelela zinokubandakanya uvavanyo lolusu, uvavanyo lwegazi, ii-x-ray, okanye ii-biopsy.
Imibuzo ekufuneka uyibuze ugqirha wakho ngokuqinisekileyo
Ukuba ufunyaniswe une-`(Cutaneous B-Cell Lymphoma)`, ungalibali ukubuza ugqirha wakho le mibuzo:
- Yeyiphi i-subtype `(CBCL)` endinayo?
- Le ikweliphi inqanaba?
- Luhlobo luni lonyango olucetyiswayo?
- Zithini iziphumo ebezingalindelekanga kunye neengozi zalo nyango?
- Ithini ingqikelelo yam?
- Kuthatha ixesha elingakanani ukwazi ukuba unyango luphumelele okanye akunjalo?
- Ndifanele ndikubone kangaphi ukuqinisekisa ukuba i-lymphoma ayibuyanga?
Iimpendulo zale mibuzo ziya kukunceda ukuba uqonde ngcono esi sifo kunye namanyathelo alandelayo.
Umyalezo Wokubuyela Ekhaya Ovela Kwinto Esithetha Ngayo
I-Cutaneous B-Cell Lymphoma luhlobo olungaqhelekanga lomhlaza oluqala kwiiseli ezibizwa ngokuba zii-lymphocytes eluswini.
- Iimeko ezininzi zikhula kancinci kwaye azisasazeki kwezinye iindawo zomzimba. Nangona kunjalo, ezinye iintlobo zinokuba ndlongondlongo kwaye zisasazeke.
- Ukuba ubona iqhuma elitsha, elingapholiyo, ibala, okanye irhashalala eluswini lwakho, musa ukulibetha ngoyaba. Yiya kugqirha, ingakumbi ugqirha wesikhumba, ngoko nangoko.
- Iintlobo ezininzi ze-CBCL zinokunyangwa ngokufunyaniswa kwangoko kunye nonyango olufanelekileyo.
- Ngenxa yokuba isifo sinokuphinda sibuye emva konyango,Kubalulekile ukuba uhlolwe ngamaxesha amiselweyo njengoko ugqirha emyalele.
Khumbula, olu lwazi lujolise ekunikeni ulwazi kuphela. Ukuba uneengxaki zempilo, kungcono ukufuna ingcebiso kagqirha.
👩🏽⚕️ Imibuzo eyongezelelweyo (Ii-FAQ)
💬 Ngaba i-Cutaneous B-Cell Lymphoma (CBCL) ngumhlaza wolusu?
Ewe, kodwa lo asingomhlaza wesikhumba oqhelekileyo (iMelanoma) obangelwa kukutshiswa lilanga. Lo ngumhlaza onxulumene nohlobo lweeseli ezimhlophe zegazi (ii-B-lymphocytes). Ezo seli zomhlaza azihlali engqondweni okanye kumongo wethambo, kodwa zihlasela ulusu ngqo zize zihlale eluswini (uhlobo lwe-Non-Hodgkin Lymphoma).
💬 Injani le mhlaza yolusu?
Zidla ngokuqala njengeziqhuqhuva ezincinci ezibomvu okanye ezimfusa okanye iithumba entlokweni, entanyeni, okanye emqolo. Azirhawuzeli okanye zibuhlungu. Azivakali ngathi yindawo eqhelekileyo, kodwa zivakala ngathi liqhuqhuva elingaphantsi kolusu.
💬 Ngaba oku kuza kusasazeka emzimbeni wonke kuze kube yingozi ebomini?
Iindaba ezimnandi zezokuba uninzi lweentlobo zomhlaza ze-'CBCL' zikhula kancinci kakhulu (azinamdla) kwaye azinabungozi (azisasazeki kumalungu angaphandle kolusu). Kwiimeko ezininzi, zinokunyangwa ngokupheleleyo ngonyango lwemitha okanye utyando lokususa ithumba.
I- Lymphoma ye-B-Cell ekhuhlayo, umhlaza wolusu, i-Lymphoma, ii-B-Cell, amaqhuma olusu, isifo solusu
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