Ngaba wena okanye umntu omthandayo unikwe iyeza iDasatinib njengonyango lomhlaza? Kuqhelekile ukuba uzive usoyika kwaye unexhala xa oko kusenzeka. Usenokuba nemibuzo emininzi malunga nokuba loluphi uhlobo lonyango, indlela yokulisebenzisa, kunye nento ekufuneka uyilumkele. Ngoko ke namhlanje, masifunde yonke into malunga nalo nyango ngendlela elula kakhulu, ngokungathi sithetha nomhlobo.
Lithini eli yeza libizwa ngokuba yiDasatinib?
Ngamafutshane, i-dasatinib liyeza elikhethekileyo elithintela ukukhula kweeseli zomhlaza. Lisebenza 'njengonyango olujoliswe kulo'. Oku kuthetha ukuba eli yeza alihlaseli nje kuphela iiseli emzimbeni. Endaweni yoko, lichonga iiproteni ezithile ezikhethekileyo ezinceda iiseli zomhlaza zahlukane kwaye zisasazeke, kwaye lijolise kwaye limise umsebenzi wazo. Lisebenza njengomdubuli onobuchule.
Eli yeza lisetyenziswa kakhulu ukunyanga iintlobo ezimbini ze-leukemia.
- I-Chronic Myeloid Leukemia (CML)
- I-Acute Lymphoblastic Leukemia (YONKE)
Ngamanye amaxesha ugqirha wakho angakunika eli yeza nakwezinye iimeko zonyango. Ngoko ke, buza ugqirha wakho ukuba kutheni unikwe eli yeza.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza
Ugqirha wakho kufuneka abe nomfanekiso opheleleyo wempilo yakho ngaphambi kokuba aqalise eli yeza. Oku kubalulekile ukuze ukhuseleke. Ke ngoko, ukuba unenye yezi meko zilandelayo, qiniseka ukuba uxelela ugqirha wakho ngazo.
- Ukuba unengxaki yokopha okanye utyekele ekuphumeni kwegazi.
- Ukuba unesifo sentliziyo okanye ukubetha kwentliziyo okungaqhelekanga.
- Ukuba unobuthathaka kwinkqubo yakho yomzimba yokuzikhusela.
- Ukuba ukhe waxelelwa ngaphambili ukuba amanqanaba akho e-potassium okanye i-magnesium egazini aphantsi.
- Ukuba une-allergy kule dasatinib yeza, i-lactose, okanye naliphi na elinye iyeza, ukutya, okanye idayi.
- Oku kubaluleke kakhulu ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa .
Ukuthetha ezi zinto ngaphandle kokuzifihla kuya kunceda kakhulu kwimpumelelo yonyango kunye nokhuseleko lwakho.
Ungayisebenzisa njani le yeza ngokuchanekileyo?
Le yinxalenye ebaluleke kakhulu. Ukuze ufumane okuninzi kwiyeza, kufuneka ulisebenzise ngokuchanekileyo.
- Indlela yokuthatha: Ginya le pilisi yonke ngeglasi yamanzi. Musa ukuyiqhekeza, ukuyityumza, okanye ukuyihlafuna. Ukwenza njalo kunokuchaphazela indlela elisebenza ngayo iyeza.
- Ngokutya: Ungalithatha eli yeza nokuba utya okanye ungenalo. Akukho ngxaki ngaloo nto.
- Ixesha lokuthatha amayeza: Zama ukuthatha amayeza akho ngexesha elifanayo yonke imihla, njengoko kuyalelwe ngugqirha wakho. Ukuba uphoswe yidosi, thatha idosi elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe iidosi ezimbini ngaxeshanye ukuze ubuyisele idosi elibalekileyo.
- Ingcebiso kagqirha: Musa ukuyeka ukuthatha amayeza akho ngaphandle kwengcebiso kagqirha wakho.
- Kubaluleke kakhulu: Musa ukusela ijusi yegrapefruit okanye yegrapefruit ngelixa usela eli yeza. Igrapefruit inokutshintsha indlela umzimba wakho ofunxa ngayo eli yeza, nto leyo enokubangela iziphumo ebezingalindelekanga eziyingozi.
- Ii-antacids: Sela ii-antacids ezine-aluminium, i-calcium, okanye i-magnesium (umz., i-Digene, i-Gelusil) kwiiyure ezi-2 ngaphambi okanye kwiiyure ezi-2 emva kokuthatha eli yeza. Musa ukulisebenzisa kunye. Kwakhona, xelela ugqirha wakho ukuba usebenzisa amanye amayeza anciphisa i-acid esiswini (umz., i-Omeprazole, i-Famotidine).
Ukuba unika abantwana eli yeza, kufuneka uthethe nogqirha wakho wabantwana ngalo. Nangona licetyiswa kubantwana abangaphezu konyaka omnye ubudala phantsi kweemeko ezithile, kukho izinto ekufuneka uzilumkele.
Yintoni omawuyenze ukuba ugqithisile?
Ukuba ucinga ukuba uthathe ngaphezu komlinganiselo omiselweyo, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele esikufutshane ngoko nangoko . Okanye utsalele umnxeba iZiko loLwazi lweePoison kwiSibhedlele sikaZwelonke saseColombo ukuze ufumane ingcebiso. Musa ukuthatha oku lula.
Amanye amayeza anokusebenzisana ne-dasatinib (i-Drug Interactions)
Xa usebenzisa eli yeza, kufuneka uqaphele nezinye iiyeza ozisebenzisayo. Amanye amayeza anokusebenzisana ne-dasatinib, nto leyo enciphisa ukusebenza kwayo okanye ibangele iziphumo ebezingalindelekanga eziyingozi.
Nantsi imizekelo embalwa. Xelela ugqirha wakho ngayo yonke imithi oyithathayo (kuquka iivithamini, iimveliso zezityalo, kunye nezithomalalisi zentlungu).
| Amachiza anokusebenzisana ne-dasatinib | |
|---|---|
| Udidi lweziyobisi | Imizekelo |
| Musa ukuzithatha ezi zinto kunye nantoni na. | |
| Amayeza kunye nezinye ezichaphazela isigqi sentliziyo | ICisapride, iDronedarone, iPimozide, iThioridazine |
| I-Antifungal | I-Fluconazole, iPosaconazole |
| Ezi zisenokusabela (funa ingcebiso kagqirha) | |
| Izibulali-ntlungu | I-Acetaminophen (iParacetamol), i-Aspirin, i-Ibuprofen, i-Naproxen (i-NSAIDS) |
| Ii-antibiotics | IClarithromycin, iErythromycin, iRifampin |
| Izinto ezilwa nokungunda | I-Itraconazole, iKetoconazole |
| Amayeza e-HIV/AIDS | Amayeza okulwa nentsholongwane |
| Amayeza e-migraines | I-Carbamazepine, iPhenobarbital, iPhenytoin |
| Izinto ezilwa nokugabha kwegazi | I-Warfarin |
| Iimveliso zezityalo | I-St. John's Wort |
Iziphumo ebezingalindelekanga ekufuneka uzazi xa uthatha eli yeza
Njengalo naliphi na iyeza, i-dasatinib inokubangela iziphumo ebezingalindelekanga. Ezinye zincinci, kodwa ezinye zifuna unyango olukhawulezileyo.
| Iziphumo ebezingalindelekanga ekufuneka uzixele kugqirha wakho ngoko nangoko | |
|---|---|
| Iimpendulo ze-Allergic | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe okanye ulwimi. |
| Ukopha okungaqhelekanga | Indle emnyama engapheliyo, ukuhlanza okufana nekofu egayiweyo, umchamo obomvu/omdaka omnyama, amabala abomvu eluswini, ukopha empumlweni nasezintsinini. |
| Iimpawu zoHlaselo lweNtliziyo | Ubunzima bokuphefumla, iintlungu/ukuqina esifubeni, entanyeni, emqolo, okanye ezingalweni, ukudinwa kakhulu. |
| Iimpawu zestroke | Ukutshintsha kombono, ukudideka, ubunzima bokuthetha, ukuba ndindisholo okanye ubuthathaka ngequbuliso ebusweni/engalweni/emlenzeni, ubunzima bokuhamba. |
| Iimpawu zosulelo | Umkhuhlane, ukubanda, ukukhohlela, umphimbo obuhlungu. |
| Ukudumba komzimba/ukwanda kobunzima | Ukudumba emilenzeni, emaqatheni, okanye kwezinye iindawo zomzimba, ukunyuka kobunzima ngequbuliso. |
| Ezinye iimpawu ezinzulu | Ukukhohlela okomileyo, ukubetha kwentliziyo okukhawulezayo okanye okungahambelaniyo, iintlungu zamathambo, ukushukuma kwemisipha, ukudumba/ukuxobuka kwesikhumba, kuquka nomlomo, ukuxhuzula. |
| Ngokwesiqhelo ayisiyongozi (kodwa xelela ugqirha wakho ukuba iyaqhubeka) | |
| Iingxaki zenkqubo yokugaya ukutya | Intlungu yesisu, isicaphucaphu, ukuhlanza, ukurhawuzelela, ukuqhina kwesisu. |
| Ezinye izifo ezincinci | Intloko ebuhlungu, ukuphelelwa ngumdla wokutya, iintlungu zemisipha. |
Ukwaziswa okukhethekileyo malunga nokukhulelwa nokuncancisa
Oku kubaluleke kakhulu. Kuphephe ukukhulelwa ngelixa usela eli yeza kwaye kangangeentsuku ezingama-30 emva kokuyeka eli yeza. Amadoda afanele akuphephe ukuba nguyise womntwana ngelixa esela eli yeza kwaye kangangeentsuku ezingama-30 emva kokuliyeka. Oku kunokubangela ingozi enkulu kusana olungekazalwa. Kwakhona, kuphephe ukuncancisa ngelixa usela eli yeza kwaye kangangeeveki ezi-2 emva kwedosi yokugqibela.
Umyalezo Wokuya Ekhaya
- I-Dasatinib liyeza elinamandla elijolise kwiiseli zomhlaza. Landela imiyalelo kagqirha wakho ngononophelo.
- Xelela ugqirha wakho malunga nawo onke amayeza, iivithamini, kunye nazo naziphi na iimeko zempilo ozisebenzisayo ngaphambi kokuba uqalise amayeza.
- Ginya ipilisi yonke ngaphandle kokuyiqhekeza, ukuyityumza, okanye ukuyihlafuna.
- Musa ukusela ijusi yegrapefruit ngokupheleleyo ngelixa usebenzisa eli yeza.
- Kuphephe ukuthatha ii-antacids xa uthatha isitshiso sentliziyo xa sele usondele ixesha lokuthatha iyeza.
- Ukuba ufumana naziphi na iziphumo ebezingalindelekanga ezinje ngokopha okungaqhelekanga, ubunzima bokuphefumla, iintlungu zesifuba, okanye ukudumba komzimba, funa ingcebiso kagqirha ngokukhawuleza.
- Kuphephe ukukhulelwa nokuncancisa ngelixa uthatha eli yeza kwaye ngexesha elimiselweyo.
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