Ingaba uziva udiniwe ngalo lonke ixesha kuba unegazi eliphantsi? Makhe sithethe nge-Erythropoietin!

Ngaba ngamanye amaxesha uziva udiniwe kwaye ungenabomi? Esinye sezizathu zoku kukuncipha kwenani leeseli ezibomvu zegazi emzimbeni. Umzimba wethu unehomoni ebaluleke kakhulu enceda ekuvelisweni kwezi seli zibomvu zegazi. Leyo yihomoni esiza kuthetha ngayo namhlanje. Igama layo yi-Erythropoietin, okanye i-EPO ngamafutshane.

Yintoni i-Erythropoietin?

Ngamafutshane, i-Erythropoietin yi-hormone eveliswa kakhulu zizintso zethu. Ewe, uyivile kakuhle, xa sicinga ngezintso, sicinga kuphela ngokuveliswa komchamo, kodwa izintso zenza okuninzi emizimbeni yethu. Omnye umsebenzi obalulekileyo kukuvelisa le hormone (EPO). Le hormone (EPO) inceda ukugcina inani elisempilweni leeseli ezibomvu zegazi, oko kukuthi, ii-erythrocytes, emzimbeni wethu.

Ngamanye amaxesha, oogqirha basebenzisa uhlobo lwe-erythropoietin oluyilwe ngokwenziwa ukunyanga i-anemia , ingakumbi kwiimeko ezifana nesifo sezintso esingapheliyo. Kwakhona, abanye abadlali basebenzisa eli yeza kakubi ukuphucula ukusebenza kwabo. Kuba i-EPO yonyusa ubungakanani beoksijini efikelela kwizihlunu zabo. Ngaba oko akukho mthethweni? Kulungile?

Amanye amagama ale erythropoietin aquka i-erythropoietin, i-hematopoietin, kunye ne-hemopoietin. Nangona kunjalo, onke athetha into enye.

Yeyiphi inkonzo enikezelwa yi-erythropoietin (EPO) emizimbeni yethu?

Kulungile, ngoku masibone ukuba yintoni kanye kanye eyenziwa yi-EPO. Umsebenzi ophambili we-EPO kukwenza iiseli ezibomvu zegazi. Ezi seli zibomvu zezona zithwala ioksijini ziye kwizicubu zomzimba wethu. Ioksijini iguqulwa ibe ngamandla, ize emva koko i-carbon dioxide ikhutshwe kwizicubu zethu. Xa uphefumla, ezi seli zibomvu zegazi zinceda ekususeni i-carbon dioxide.

Oku kuqhele ukwenzeka: Xa uhlobo oluthile lweseli kwizintso zethu lufumanisa ukuba inqanaba leoksijini egazini lethu liphantsi, luyandisa imveliso yalo ye-(EPO). Le hormone (EPO) emva koko ixelela inxalenye ethambileyo yamathambo ethu, umongo wethambo, ukuba yenze iiseli ezibomvu zegazi ezingaphezulu. Cinga ngayo njengokunika i-odolo efektri.

Xa iiseli ezikwizintso ziqonda ukuba kukho ioksijini eyaneleyo egazini, zinciphisa ukuveliswa kwe-erythropoietin. Le yinkqubo enzima kakhulu, kodwa elawulwa kakuhle.

Nangona kunjalo, ezinye iimeko zonyango zinokuchaphazela ubungakanani be-EPO eveliswa zizintso. Zinokuvelisa kakhulu okanye zingavelisi ngokwaneleyo. Oku kunokubangela iingxaki ngeeseli ezibomvu zegazi ezininzi kakhulu okanye ezimbalwa kakhulu.

Kwenzeka ntoni ukuba amanqanaba e-erythropoietin (EPO) ayanda?

Ukuba amanqanaba e-EPO anyuka ngokungafanelekanga, oko kukuthi, ukuba umzimba une-EPO engaphezulu kuneemfuno zawo, inani leeseli ezibomvu zegazi linokunyuka ngokungeyomfuneko. Oku sikubiza ngokuba yi-polycythemia. Kufana nokuxinana kweemoto endleleni, xa kukho iiseli ezibomvu zegazi ezininzi kakhulu, ukuhamba kwegazi kunokuphazamiseka.

Zithini izizathu zokonyuka okungaka kwamanqanaba e-EPO?

Kunokubakho izizathu ezahlukeneyo zokuba amazinga e-EPO abe phezulu ngokungeyomfuneko.

• Ukuvezwa ixesha elide kumanqanaba aphantsi eoksijini: Oku kunokwenzeka kubantu abatshayayo okanye abahlala kwiindawo ezineentaba, eziphezulu ngaphezu kolwandle. Oku kungenxa yokuba umoya uneoksijini encinci njengoko unyuka. Nangona kunjalo, kuqhelekile ukuba umntu ohlala kwindawo eneentaba abe namanqanaba aphezulu e-EPO, okuyindlela umzimba onokuziqhelanisa ngayo.
• I-anemia ayibangelwa sisifo sezintso: Ngamanye amaxesha i-anemia ayibangelwa yingxaki yezintso. Nangona kunjalo, xa izintso zibona ukuba umzimba uneeseli ezibomvu zegazi ezisezantsi, zivelisa i-EPO engaphezulu ukunceda ekwenzeni iiseli ezibomvu zegazi. Oku kukwakhula okuqhelekileyo, okufunekayo kwi-EPO.
• Umhlaza ongaqhelekanga: Kunqabile kakhulu ukuba ezinye iintlobo zomhlaza zibangele ukuba izintso zivelise i-EPO eninzi ngokungafanelekanga.

Zithini izizathu zokuba amanqanaba aphantsi e-erythropoietin (EPO) abonakale?

Eyona nto iphambili neyona ixhaphakileyo yokuba amanqanaba e-EPO aphantsi sisifo sezintso esingapheliyo ( CKD ). Xa izintso zonakele, azikwazi ukuvelisa i-EPO eyaneleyo. Oku kubangela amanqanaba e-EPO aphantsi. Le meko, kunye namanqanaba e-EPO aphantsi, inokukhokelela kwi-anemia. Ungabona ukuba zingaphi iingxaki ezinokuvela ukuba izintso azisebenzi kakuhle, akunjalo?

Kwakhona, imeko ebizwa ngokuba yiPolycythemia Vera inokubangela amanqanaba aphantsi e-EPO. Olu luhlobo lomhlaza wegazi. Kule meko, utshintsho lwemfuza lubangela ukuba umongo wethu wamathambo uvelise iiseli ezibomvu zegazi ezininzi kakhulu. Emva koko, izintso ziva ukuba kukho iiseli ezibomvu zegazi ezininzi kakhulu emzimbeni, kwaye zinciphisa ukuveliswa kwazo kwe-EPO.

Amanqanaba aphantsi e-erythropoietin (EPO) anyangwa njani?

Ukuba inqanaba lakho le-EPO liphantsi, into yokuqala ekufuneka uyenze xa ulinyanga kukufumana unobangela oyintloko uze ulinyange.

Eyona ndlela iphambili yokunyanga ngokuthe ngqo i-anemia ebangelwa ngamanqanaba aphantsi e-EPO kukufaka i-erythropoietin ephinda i-recombinant. Ezi zikwabizwa ngokuba zii-erythropoietin-stimulating agents okanye ii-ESA. Ezi zombini ziyi-hormone yendalo ye-EPO kunye nohlobo lwe-EPO oluyilwe ngelabhoratri. Oogqirha bayenza i-gene ye-EPO ibe yi-clone, okanye bayikopishe baze bayinike wena njengovavanyo lokukhuthaza ukuveliswa kweeseli ezibomvu zegazi ezingaphezulu.

Ezi zitofu (ESAs) zisetyenziselwa ukunyanga isifo sezintso esinganyangekiyo.Nyanga i-anemia ebangelwa kukungasebenzi kakuhle kwezintso okungapheliyo. Zinikwa nabantu abaneentlobo ezithile zomhlaza ezingaqhelekanga.

Nangona kunjalo, ezi zitofu (ii-ESA) zinokubangela ezinye iziphumo ebezingalindelekanga. Asinguye wonke umntu ozifumanayo, kodwa abanye abantu banokuthi:

• Igazi elonyukayo
• Ifiva
• Isiyezi
• Isicaphucaphu
• Intlungu kwindawo yokutofa

Ngaphambi kokuba uqalise olu hlobo lonyango, kubaluleke kakhulu ukuxoxa ngako konke oku nogqirha wakho kwaye ubuze nayiphi na imibuzo onokuba nayo.

Oogqirha balinganisa njani amanqanaba e-erythropoietin (EPO)?

Ugqirha wakho unokulinganisa amanqanaba akho e-EPO ngovavanyo lwegazi. Olu vavanyo lwegazi lunokunceda ekuqinisekiseni ukuba utshintsho kwiiseli zakho zegazi, ezifana ne-polycythemia, i-anemia, okanye ezinye iimeko zomongo wethambo, ziyayichaphazela imveliso ye-EPO.

Nantsi into oyenzayo xa uthatha igazi:

1. Okokuqala, coca ulusu olujikeleze umthambo ongalweni yakho ngento efana ne-iodine okanye i-isopropyl alcohol.

2. Emva koko, kusetyenziswa inaliti encinci (edla ngokuba yi-21 gauge, encinci kancinci kune-earring post eqhelekileyo), kuthathwa igazi elincinci kumthambo osengalweni yakho.

3. Emva koko isampuli yegazi ithunyelwa kwilebhu ukuze ihlolwe.

Nje ukuba ilebhu igqibe ukuvavanya isampuli yegazi lakho, ugqirha wakho uza kukufowunela ukuze axoxe ngeziphumo zovavanyo aze aphendule nayiphi na imibuzo onokuba nayo. Ngamanye amaxesha, nokuba amanqanaba akho e-EPO akwinqanaba eliqhelekileyo, unokufuna olunye unyango. Oku kuya kugqitywa ngugqirha wakho.

Inqanaba eliqhelekileyo le-erythropoietin (EPO) lifanele libe lingakanani?

Oogqirha balinganisa i-EPO ngee-milliyunithi nge-milliliter (mU/mL). Inqanaba le-EPO lomntu ophilileyo linokusukela kwi-4 ukuya kwi-26 mU/mL.

Kodwa khumbula, iziphumo zakho zovavanyo (EPO) zingahluka kancinci ngokuxhomekeke kwizinto ezininzi. Umzekelo:

• iminyaka yakho
• Isini sakho sebhayoloji
• Imeko yakho yempilo iyonke

Ngoko ke, ngugqirha wakho oza kuhlalutya iziphumo zakho ngokuchanekileyo aze akuxelele ukuba amanqanaba akho (EPO) asempilweni okanye akunjalo. Musa ukujonga nje amanani uze ufikelele kwizigqibo, kulungile?

Ziziphi iindlela zokunyusa amanqanaba e-erythropoietin (EPO) ngokwendalo?

Ukuba unesifo sezintso esinganyangekiyo (CKD), okanye ukuba une-anemia enamanqanaba aphantsi e-EPO, utshintsho oluthile kwindlela otya ngayo kunye nendlela ophila ngayo lunokunceda ekunyuseni kancinci amanqanaba akho e-EPO. Nangona kunjalo, oku kufanele kwenziwe kuphela ngeengcebiso zonyango.

• Ukuzilolonga: Uphando lubonise ukuba xa uzilolonga rhoqo, ngamandla aphakathi (ukuzilolonga ngamandla), umzimba wakho usebenzisa ioksijini engaphezulu. Ingqondo yakho emva koko ixelela umzimba wakho ukuba wenze i-EPO engaphezulu. Imizekelo yolu hlobo lokuzilolonga kukukhwela ibhayisekile, ukubaleka, kunye nokudada.
• Isinyithi esifumaneka ekutyeni: Isinyithi yinxalenye ephambili ye-hemoglobin. Le hemoglobin inceda ekuthwaleni ioksijini kwiiseli zomzimba wethu. Ukutya okutyebileyo kwi-iron kuquka inyama ebomvu, amaqanda, isibindi, i-tofu, kunye nokutya okuqiniswe nge-iron (umzekelo, ezinye iinkozo, isonka kunye nepasta).

Kodwa ezi zinto zodwa zisenokungenzi mahluko mkhulu, ingakumbi ukuba imeko esisiseko imbi kakhulu. Ngoko ke kubalulekile ukulandela icebiso likagqirha wakho.

Izinto ekufuneka uzikhumbule kuzo zonke ezi zinto (Umyalezo Wokuya Ekhaya)

I-Erythropoietin yi-hormone ebaluleke kakhulu neyimfuneko exelela umongo wethu ukuba “wenze iiseli ezibomvu zegazi ezingaphezulu.” Nangona kunjalo, ngamanye amaxesha imizimba yethu ivelisa iiseli ezibomvu zegazi ezininzi ngendlela engafanelekanga, okanye inganeli. Zombini ezi zinto zinokubangela iingxaki zempilo.

Ukuba uhlala uziva udiniwe kwaye udiniwe, musa ukuyityeshela loo nto. Ungabonana nogqirha kwaye uhlolwe amanqanaba egazi lakho (i-EPO). Ugqirha angacebisa unyango olufanelekileyo kuwe. Khumbula, ibhalansi yala ma-hormone ibaluleke kakhulu kubomi obusempilweni.