Iqhawe elincinci lomzimba wethu: Yonke into malunga ne-Erythropoietin!

Ngaba wakha weva ngento ebizwa ngokuba yi-'Erythropoietin' okanye 'EPO'? Mhlawumbi ugqirha wakho ukhe wathetha ngayo, okanye ukuba unesifo esifana ne-anemia, eli gama lisenokuba liqhelekile kuwe. Le yi-hormone emangalisayo nebaluleke kakhulu emizimbeni yethu. Namhlanje, siza kuthetha ngayo ngendlela elula onokuyiqonda.

Yintoni i-Erythropoietin?

Ngamafutshane, i-Erythropoietin yi-hormone eveliswa ikakhulu zizintso zakho. Siyibiza ngokuba yi -EPO ngamafutshane. Umsebenzi ophambili wale EPO kukunceda ukugcina inqanaba elisempilweni leeseli ezibomvu zegazi, oko kukuthi, iiseli ezibomvu zegazi (ii-erythrocytes) . Le EPO isebenza njengomphathi oxelela umzi-mveliso weeseli ezibomvu zegazi emzimbeni wethu ukuba 'wenze okungakumbi!'

Ngamanye amaxesha, oogqirha basebenzisa uhlobo lwe-erythropoietin oluyilwe ngendlela yokwenziwa, ingakumbi ukunyanga i-anemia ebangelwa sisifo sezintso esingapheliyo (CKD) . Khawucinge nje, kuba izintso zabanye abantu zingasebenzi kakuhle, azivelisi ngokwaneleyo le hormone ye-EPO. Emva koko ziba ne-anemia. Kulapho ke le EPO yokwenziwa inceda khona.

Nangona kunjalo, abanye abadlali bayayisebenzisa kakubi ukuphucula ukusebenza kwabo. Isizathu kukuba i-EPO yonyusa ubungakanani beoksijini efikelela kwizihlunu zabo. Oko akulunganga konke konke, kuba kunokubangela iingxaki ezinkulu zempilo.

I-Erythropoietin ikwaziwa nangamanye amagama, njenge-erythropoietin, i-hematopoietin, kunye ne-hemopoietin. Nangona kunjalo, amagama asetyenziswa kakhulu yi-Erythropoietin kunye ne-EPO.

Yintoni eyenziwa yi-erythropoietin (EPO) emizimbeni yethu?

Lo ngumbuzo obaluleke kakhulu. I-EPO yi-hormone ephambili enceda imizimba yethu ukuba yenze iiseli ezibomvu zegazi . Ngoku, kutheni sizidinga iiseli ezibomvu zegazi? Xa uphefumla, ngubani othwala ioksijini engena emiphungeni yakho uye kuyo yonke indawo yomzimba wakho, kuyo yonke iseli? Yiloo nto eyenziwa ziiseli ezibomvu zegazi. Cinga ngayo njengeelori ezincinci ezithwala ioksijini emzimbeni wakho wonke. I-EPO ixelela ezi lori ukuba zizenze.

Xa ioksijini ifika kwiiseli zethu, ijika ibe ngamandla. La mandla abalulekile kuwo wonke umsebenzi wethu. Emva koko, ezi seli zibomvu zegazi zithwala ikharbon dioxide eshiya iiseli zethu zibuyele emiphungeni. Ukusuka apho, siyayikhupha.

Okuqhele ukwenzeka kukuba: Iiseli ezikhethekileyo kwizintso zakho zibona ukuba inqanaba leoksijini egazini lakho liphantsi. Xa zibona oko, ziyandisa imveliso yazo ye-EPO. Le EPO emva koko iya kwinxalenye ethambileyo yamathambo ethu, umongo wethambo , ize ithi, 'Kulungile, ngoku yenza iiseli ezibomvu zegazi ezingaphezulu!'

Nangona kunjalo, ukuba iiseli ezikwizintso zibona ukuba kukho ioksijini eyaneleyo egazini, ziyayinciphisa imveliso ye-EPO. Oku kufana nenkqubo yokubonelela ngenkxaso-mali. Zivelisa okungakumbi xa umzimba uyidinga, kwaye zivelisa kancinci xa isidingo siphantsi.

Ayimangalisi na indlela izinto ezinje ezenzeka ngayo emizimbeni yethu? Yonke into icwangcisiwe!

Ezinye iimeko zonyango zinokuchaphazela ubungakanani be-EPO eveliswa zizintso. Oku kunokubangela ukuba kuveliswe i-EPO eninzi kakhulu, okanye kunganeli. Zombini ezi zinto zinokubangela ukungalingani kwamanqanaba eeseli ezibomvu zegazi.

Kwenzeka ntoni ukuba amanqanaba e-erythropoietin (EPO) ayanda?

Ukuba amanqanaba e-EPO ayanda ngokungeyomfuneko, oko kukuthi, ukuba umzimba unyusa i-EPO ngaphandle kokuyidinga ngokwenene, inani leeseli ezibomvu zegazi nalo liyakhula. Oku sikubiza ngokuba yi -polycythemia . Ngamafutshane, kukho iiseli ezibomvu zegazi ezininzi kakhulu egazini. Oku kukwayingxaki, kuba igazi liyaqina kwaye igazi linokuqhekeka.

Kutheni amanqanaba e-erythropoietin (EPO) enyuka?

Kukho izizathu ezahlukeneyo zokuba amazinga e-EPO anokuba phezulu ngokungeyomfuneko:

• Ukuhlala kwindawo enezinga eliphantsi leoksijini ixesha elide: Khawuthelekelele, ukuba umntu uyaqhubeka nokutshaya, ubungakanani beoksijini efikelela emzimbeni wakhe buphantsi. Emva koko izintso zicinga, 'Owu, akukho oksijini yaneleyo, kufuneka senze iiseli ezibomvu ezingaphezulu,' kwaye zivelisa i-EPO engaphezulu. Ngokufanayo, ukuba umntu uhlala kwindawo ephakamileyo kakhulu njengeNuwara Eliya ixesha elide, izinga le-EPO linokunyuka ngenxa yezinga eliphantsi leoksijini emoyeni apho. Kodwa kuqhelekile ukuba i-EPO inyuke kule ndawo iphakamileyo, kukuziqhelanisa nomzimba.
• I-anemia ayibangelwa sisifo sezintso: Ngamanye amaxesha i-anemia ayibangelwa yingxaki yezintso. Kodwa ngenxa yokuba zimbalwa kakhulu iiseli ezibomvu zegazi okanye iiseli ezibomvu zegazi zingasebenzi kakuhle, izintso ziva ukuba azifumani ioksijini eyaneleyo. Nangona kunjalo, zivelisa i-EPO engaphezulu ukunceda ekwenzeni iiseli ezibomvu zegazi. Oku kukuphendula okuqhelekileyo komzimba.
• Iintlobo ezithile zeethumba: Nangona zinqabile kakhulu, ezinye iintlobo zeethumba zinokubangela ukuba izintso zikhuphe i-EPO eninzi kakhulu.

Kwenzeka ntoni ukuba amanqanaba e-erythropoietin (EPO) ehla?

Eyona nto ibangela ukuba amanqanaba e-EPO aphantsi sisifo sezintso esingapheliyo (CKD) . Njengoko bekutshiwo ngaphambili, xa izintso zonakele, azikwazi ukuvelisa i-EPO ngokufanelekileyo. Oku kubangela amanqanaba e-EPO aphantsi. Le meko, i-CKD, kunye namanqanaba e-EPO aphantsi kunokukhokelela kwi-anemia. Oku kuthetha ukuba ungaziva udiniwe, uphaphathekile, kwaye unengxaki yokuphefumla.

Kutheni amanqanaba e-erythropoietin (EPO) ehla?

Nangona unobangela oyintloko yi-CKD, kukho esinye isizathu. Leyo yimeko ebizwa ngokuba yiPolycythemia Vera . Olu luhlobo lomhlaza oluvela egazini. Ngenxa yotshintsho lwemfuza, umongo wethambo wenza iiseli ezibomvu zegazi ezininzi kakhulu. Emva koko izintso ziva, 'Owu, zininzi iiseli ezibomvu zegazi egazini, asisadingi ukwenza i-EPO.' Ngoko ke zinciphisa imveliso ye-EPO. Oku kukwangunobangela we-EPO ephantsi.

Loluphi unyango olunokwenziwa ukuba amanqanaba e-EPO aphantsi?

Ukuba amanqanaba e-EPO aphantsi, anyangwa ngokunyanga unobangela oyintloko . Oko kukuthi, ukuba sisifo sezintso, siyanyangwa, ukuba sisinye isizathu, siyanyangwa.

Nangona kunjalo, unyango oluphambili lwe-anemia olubangelwa ngamanqanaba aphantsi e-EPO yi -recombinant erythropoietin . Ezi zikwabizwa ngokuba yi -erythropoietin-stimulating agents (ESAs) . Ezi ziinguqulelo zokwenziwa ze-EPO hormone ezenziwe kwilebhu. Oogqirha badibanisa i-EPO gene baze bakunike yona njengenaliti. Emva koko ingena emzimbeni wakho kwaye ivuselele umongo wakho wethambo ukuba uqalise ukwenza iiseli ezibomvu zegazi ezingaphezulu.

Olu nyango lunikwa ikakhulu ukunyanga i-anemia ebangelwa kukungasebenzi kakuhle kwezintso okungapheliyo. Lunikwa nabantu abaneentlobo ezithile zomhlaza ezingaqhelekanga.

Kodwa ezi ESA zinokubangela ezinye iziphumo ebezingalindelekanga:

• Igazi elonyukayo
• Ifiva
• Isiyezi
• Isicaphucaphu
• Intlungu kwindawo yokutofa

Kungoko ke, kubaluleke kakhulu ukuthatha olu nyango ngomlinganiselo ochanekileyo, njengoko kucetyisiwe ngugqirha.

Amanqanaba e-erythropoietin (EPO) alinganiswa njani?

Ugqirha wakho unokulinganisa amanqanaba akho e-EPO ngovavanyo lwegazi olulula. Olu vavanyo lwegazi lunokufumanisa utshintsho kwiiseli zakho zegazi oluchaphazela ukukhululwa kwe-EPO. Oku kunokunceda ekuqinisekiseni ukuba une-polycythemia, i-anemia, okanye ezinye iimeko zomongo wethambo.

Ugqirha okanye umongikazi uza kukhetha umthambo ongalweni yakho aze acoce ulusu apho ngento efana ne-iodine okanye i-isopropyl alcohol. Emva koko, inaliti encinci kakhulu (inaliti ye-21 gauge - encinci kancinci kunencam yecici) iya kuthatha isampuli encinci yegazi emthanjeni wakho. Isampuli yegazi iya kuthunyelwa kwilebhu ukuze ihlolwe.

Nje ukuba iziphumo zelebhu zifike, ugqirha wakho uza kuthetha nawe ngazo aze aphendule nayiphi na imibuzo onokuba unayo. Khumbula, nokuba amanqanaba akho e-EPO akwinqanaba eliqhelekileyo, usenokufuna olunye unyango. Oko kuya kuxhomekeka kugqirha wakho ukuba agqibe.

Ithini inqanaba eliqhelekileyo le-erythropoietin (EPO)?

Oogqirha balinganisa i-EPO ngee -milliyunithi nge-milliliter (mU/mL) . Inqanaba le-EPO lomntu ophilileyo linokusukela kwi-4 ukuya kwi-26 mU/mL.

Kodwa la maxabiso ngawakho:

• Ubudala
• Isini
• Imeko yempilo iyonke

Ingahluka ngokuxhomekeke kwizinto ezahlukeneyo, ezinje: Ngoko ke, ngugqirha wakho kuphela onokutolika ngokuchanekileyo iziphumo zakho aze akuxelele ukuba zingaphakathi okanye zingaphandle kwazo. Ngoko ke, musa ukuzenzela uxilongo lwakho ngokusekelwe koko kufumaneka kwi-Intanethi.

Ngaba kunokwenzeka ukunyusa amanqanaba e-erythropoietin (EPO) ngokwendalo?

Ukuba unesifo sezintso esinganyangekiyo (CKD) okanye i-anemia enamanqanaba aphantsi e-EPO, utshintsho oluthile kwindlela otya ngayo nendlela ophila ngayo lunokunceda ekunyuseni kancinci amanqanaba akho e-EPO. Nangona kunjalo, oku kufuneka kwenziwe ukongeza kwiingcebiso zonyango kungekhona endaweni yonyango.

• Ukuzilolonga: Uphando lubonisa ukuba xa uzilolonga rhoqo, ngamandla aphakathi, umzimba wakho usebenzisa ioksijini engaphezulu. Ingqondo yakho emva koko ixelela umzimba wakho ukuba 'wenze i-EPO engaphezulu.' Izinto ezifana nokukhwela ibhayisekile, ukubaleka, kunye nokudada ziyimizekelo emihle yolu hlobo lokuzilolonga.
• Isinyithi esidityanisiweyo: Isinyithi yinxalenye ephambili ye -hemoglobin kwiiseli zethu ezibomvu zegazi. Le hemoglobin yiyo ethwala ioksijini. Xa sithetha ngokutya okutyebileyo kwi-iron, sithetha inyama ebomvu, amaqanda, iimbotyi, kwanemifuno eluhlaza efana nesipinatshi esinayo kwilali yethu. I-Tofu, iinkozo eziqiniswe nge-iron, umgubo, kunye nesonka nazo ziqulethe i-iron.

Ukongeza kwezi zinto, izinto ezinje ngokutya ukutya okunesondlo, ukusela amanzi aneleyo, kunye nokuphepha ukutshaya nazo zilungile kwimpilo yakho iyonke, kwaye ngokungathanga ngqo, kumanqanaba akho e-EPO.

Okokugqibela, izinto ekufuneka uzikhumbule

I-Erythropoietin (EPO) yi-hormone ebaluleke kakhulu exelela umongo wethu ukuba 'wenze iiseli ezibomvu zegazi ezingaphezulu'.

Ngamanye amaxesha, imizimba yethu yenza iiseli ezibomvu zegazi ezininzi kakhulu, okanye zinganeli. Zombini ezi zinto zinokubangela iingxaki zempilo. Ugqirha wakho angajonga ubungakanani be-EPO egazini lakho ngovavanyo lwegazi aze, ukuba kuyimfuneko, anike unyango olufanelekileyo. Ngoko ke, ukuba uneempawu ze-anemia (ukudinwa, ukuphaphatheka, ukuphefumla kancinci), okanye ukuba uneengxaki zezintso, qiniseka ukuba ufuna ingcebiso kagqirha. Baza kukunceda ngendlela eyiyo. Hlala uphilile!

I- Erythropoietin, i-EPO, iiseli ezibomvu zegazi, i-anemia, izintso, iihomoni, umongo wethambo