Mhlawumbi ukhe weva ngehomoni ethi "estrogen," akunjalo? Yihomoni ebalulekileyo edlala indima ebaluleke kakhulu emzimbeni womfazi. Kodwa ubusazi ukuba ngamanye amaxesha, i-estrogen, eluncedo kakhulu emzimbeni wethu, inokusebenza njenge "fertilizer" kwezinye iiseli zomhlaza, izincede zikhule ngokukhawuleza? Ungakhathazeki. Le yingongoma enzima kancinci, kodwa masithethe ngayo ngendlela elula kakhulu onokuyiqonda.
Ngamafutshane, zithini ezi cancer ezixhomekeke kwi-estrogen?
Okokuqala, kufuneka sikucacise oku. I-estrogen hormone ayibangeli umhlaza. Oko kukuthi, i-estrogen ayisiyo i-carcinogen. Nangona kunjalo, ukuba iseli yomhlaza ikhula emzimbeni ngesizathu esithile, ezinye zezo seli zomhlaza zifumana amandla kunye nokukhuthaza ezikufunayo ukuze zikhule, zahlule, kwaye zisasazeke kwi-estrogen hormone emizimbeni yethu. Njengokuba isichumisi sisetyenziselwa ukukhulisa isityalo, ezi seli zomhlaza zisebenzisa "isichumisi" esibizwa ngokuba yi-estrogen ukuze zikhule ngokukhawuleza.
Cinga ngale ndlela. Iseli yomhlaza ifana nomnyango. Kukho indawo apho isitshixo sibekwa khona kuloo mnyango (siwubiza ngokuba yi-receptor). Ihomoni i-estrogen ifana neso sitshixo. Xa ihomoni i-estrogen ifika ize ibophelele kwi-receptor kuloo seli yomhlaza, kufana nokufaka isitshixo uze uvule ucango, kwaye iseli yomhlaza ifumana umyalezo othi, "Ngoku yahlulahlula, yanda, kwaye isasazeke." Umhlaza oxhomekeke kwihomoni i-estrogen kwaye wondliwa yiyo yile nto siyibiza ngokuba yi-estrogen-dependent cancers .
Le meko ibonakala kakhulu kwiintlobo ezahlukeneyo zomhlaza ezichaphazela abafazi.
- Umhlaza webele
- Umhlaza wesibeleko
- Umhlaza wesibeleko/we-Endometrial
Xa benyanga olu hlobo lomhlaza, iingcali zomhlaza zisebenzisa unyango (unyango lweehomoni) oluthintela ihomoni ye-estrogen ukuba ingafikeleli kwiiseli zomhlaza.
Yeyiphi i-cancer exhaphake kakhulu kule meko?
Nangona kunjalo, oku kudla ngokuxoxwa ngako ngokunxulumene nomhlaza webele . Ayizizo zonke iintlobo zomhlaza webele ezixhomekeke kwi-estrogen. Kodwa kukho iintlobo ezithile ezifana kakhulu ne-estrogen. Usenokuba uwabonile la mazwi kwiingxelo zakho zomhlaza webele.
- Umhlaza webele one-ER-positive (ER+): Oku kuthetha ukuba iiseli zomhlaza zine-estrogen receptors.
- Umhlaza webele one-HR-positive (HR+): Oku kuthetha ukuba iiseli zomhlaza zine-hormone receptors. Oku kuthetha ukuba zisabela kwi-hormone enye okanye zombini i-estrogen okanye i-progesterone.
- Umhlaza webele weLuminal A
- Umhlaza webele weLuminal B
- Umhlaza webele oneempawu ezintathu
Oku kunzima kancinci, kodwa oko kuthetha ukuba iihomoni zinceda umhlaza ukuba ukhule. Ukwazi oku kubaluleke kakhulu ekucwangciseni unyango.
Kutheni oku kusenzeka? Zeziphi izinto ezandisa umngcipheko?
Njengoko besitshilo ngaphambili, oku kungenxa yeeproteni ezikhethekileyo kwiiseli zomhlaza (ii-receptors zehomoni). Iiseli eziphilileyo nazo zinazo ezi receptors. Xa i-estrogen ifika kwaye ibopha kuzo, ezo seli zisebenza ngokuqhelekileyo. Kodwa iiseli zomhlaza "ziyithimba" le nkqubo kwaye ziyisebenzisele ukwahlukana nokukhula ngeendlela ezizifunayo.
Khumbula, i-estrogen ayifani nomlilo otshisayo. Kufana nokongeza i-parafini emlilweni otshayo. Kwenza umlilo ube mkhulu nangakumbi.
Kukho izinto ezininzi ezibangela umngcipheko wokufumana olu hlobo lomhlaza. Eyona nto iphambili kukwanda kwexesha umzimba womfazi ofumana ngalo i-hormone ye-estrogen ebomini bakhe.
Ungafumana umbono ocacileyo ngezi zinto zinobungozi kwitheyibhile engezantsi.
| Into Engumngcipheko | Ingcaciso elula |
|---|---|
| Ukufikisa ngaphambi kokuba ube neminyaka eli-12 ubudala | Ukuqala kwakho exesheni kwangethuba kuthetha ukuba umzimba udibana ne-hormone ye-estrogen ixesha elide. |
| Ukuya exesheni kwenzeka emva kweminyaka engama-55 ubudala. | Ukuyekiswa kokuya exesheni okulibazisekileyo kuthetha ukuba umjikelo wokuya exesheni ude, nto leyo eyandisa ixesha lokufumana i-estrogen. |
| Ukuthatha unyango lokutshintshwa kwehomoni (HRT) ngexesha lokuya exesheni | Iihormone zinikwa ngaphandle ukulawula ukungakhululeki kokuya exesheni (umz., ubushushu). Oku kwandisa amanqanaba e-estrogen. |
| Ulawulo lwe-estrogen | Ibhalansi phakathi kweehomoni ze-estrogen kunye ne-progesterone emzimbeni iyaphazamiseka, nto leyo ebangela ukuba amanqanaba e-estrogen anyuke ngokuthe ngcembe. |
| Ukutyeba kakhulu | Iiseli zamafutha emzimbeni zivelisa i-hormone ye-estrogen, ngoko ke njengoko ubunzima bomzimba busanda, amanqanaba e-estrogen nawo anokunyuka. |
| I-Polycystic ovary syndrome (i-PCOS) | I-PCOS inokubangela ukungalingani kwamahomoni, okunokubangela utshintsho kumanqanaba e-estrogen. |
Into ekhethekileyo malunga neziyobisi iTamoxifen
Kukho ityala elikhethekileyo apha. I-Tamoxifen liyeza elisebenza kakhulu kumhlaza webele oxhomekeke kwiihomoni. Isebenza ngokuthintela i-estrogen ukuba ingafikeleli kwiiseli zebele. Nangona kunjalo, kwisibeleko somfazi oye wadlula kwixesha lokuya exesheni, eli yeza liqala ukusebenza ngendlela eyahlukileyo ngokupheleleyo, njenge-estrogen. Ke ngoko, kunqabile kakhulu, kukho umngcipheko wokufumana umhlaza wesibeleko oxhomekeke kwi-estrogen xa usebenzisa eli yeza. Nangona oku kungaqhelekanga kakhulu, ugqirha wakho uya kukwazisa ngale nto kwaye uya kwenza uvavanyo olufunekayo ngexesha elifanelekileyo.
Oogqirha bayifumana njani le nto?
Ukuba ukrokrela ukuba unomhlaza, into yokuqala ugqirha wakho aya kuyenza kukuthatha isampuli encinci yeeseli zomhlaza aze azithumele kwilebhu. Oku kubizwa ngokuba yi-biopsy .
Kwilabhoratri, le sampuli yeseli iyathathwa ize ivavanywe ukuze kubonwe ukuba inazo na ii-receptors ezinokubophelela kwiihomoni ze-estrogen kunye ne-progesterone.
- Ukuba ingxelo yovavanyo ithi HR+ (Hormone Receptor-Positive) , oko kuthetha ukuba i-estrogen, i-progesterone, okanye zombini ii-hormone zinceda umhlaza wakho ukuba ukhule.
- Ukuba ingxelo yovavanyo ithi HR- (Hormone Receptor-Negative) , oko kuthetha ukuba la mahormone awachaphazeli ukukhula komhlaza wakho.
Olu lwazi lubalulekile ekucwangciseni unyango.
Zithini iindlela zonyango?
Xa umhlaza uqinisekisiwe ukuba uxhomekeke kwiihomoni (HR+), oogqirha baya kucebisa unyango olubizwa ngokuba yi-hormone therapy . Oku kuquka ukuthintela i-hormone estrogen ekubeni "kukutya" kweeseli zomhlaza. Oku kungenziwa ngeendlela ezahlukeneyo.
- Ukuthintela i-estrogen ekufikeleleni kwiiseli zomhlaza: Njengokufaka into emngxunyeni womnyango uze uyivale, iziyobisi zithintela ii-receptor ze-estrogen. Emva koko i-estrogen ayinakuza ize izibophe.
- Ukuyeka ukuveliswa kwe-estrogen emzimbeni: Kunikwa amayeza anciphisa okanye amisa ukuveliswa kwe-estrogen.
- Ukutshintsha i-estrogen ngenye into: Ngamanye amaxesha, i-hormone "yobuxoki" eyenziwe kwilebhu ebonakala ngathi yi-estrogen kodwa engasetyenziswa ziiseli zomhlaza inikwa umzimba. Iiseli zomhlaza emva koko zithatha i-hormone yobuxoki zize zikhohliswe ukuba zikhule, kodwa azikwazi ukwenza njalo.
Unyango lwehomoni alusoloko lunikezelwa lodwa. Lunikezelwa kunye nezinye iindlela zonyango, ezinje ngotyando , i-chemotherapy, okanye unyango lwemitha, kuxhomekeke kuhlobo kunye nobungakanani bomhlaza.
Ngaba ii-estrogens (ii-phytoestrogens) ezivela ekutyeni naseziseloni zinempembelelo?
Oku kukwayingxaki kubantu abaninzi. Ezinye izidlo zezityalo ziqulathe iikhemikhali ezisebenza njenge-estrogen emizimbeni yethu. Ezi sizibiza ngokuba zii-phytoestrogens . Imizekelo yezi zinto zifana nesoya, ubisi, kunye nengqolowa epheleleyo.
Abaphandi abakavumelani nokuba ezi phytoestrogens ziyawuchaphazela na umngcipheko womhlaza oxhomekeke kwi-estrogen. Ezinye izifundo zibonisa ukuba zinokuba luncedo kubantu abanamanqanaba aphantsi e-estrogen emzimbeni. Kodwa akukacaci ukuba zichaphazela njani abantu abasele benamanqanaba aphezulu e-estrogen emzimbeni. Ngoko ke, ukuba unolu hlobo lomhlaza okanye usemngciphekweni, kungcono ukuthetha nogqirha wakho okanye ingcali yesondlo malunga nokutya kwakho.
I-estrogen yi-hormone ebalulekileyo ekusindeni komzimba womfazi. Inceda kuyo yonke into ukusuka kwinkqubo yethu yokuzala ukuya kumandla amathambo. Kodwa le hormone ibalulekileyo inokubangela ezinye iintlobo zomhlaza. Ukuba unomhlaza webele, wesibeleko, okanye wesibeleko, ugqirha wakho uya kufuna ukwazi ukuba uxhomekeke kwi-estrogen na. Olo lwazi luya kubanceda bakhethe unyango olufanelekileyo nolusebenzayo kuwe.
Umyalezo Wokuya Ekhaya
- I-hormone i-estrogen ayisiyonto ibangela umhlaza. Oko kuthetha ukuba i-estrogen ayibangeli umhlaza.
- Nangona kunjalo, ezinye iintlobo zomhlaza (ingakumbi umhlaza wamabele, wesibeleko, kunye nomhlaza wesibeleko) zisebenzisa i-hormone i-estrogen "njengesiphehli" sokukhula kwazo.
- I-biopsy inokumisela ukuba umhlaza wakho uxhomekeke kwi-hormone (HR+) okanye akunjalo.
- Ukuba umhlaza yi-HR+, unokulawulwa ngempumelelo kakhulu ngonyango lweehomoni.
- Ukuba unemibuzo malunga nezinto ezikubangela umngcipheko, ukutya, okanye unyango, umntu ofanelekileyo nofanelekileyo onokuthetha naye ngugqirha wakho.
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