Ingaba unengxaki yokuba ne-methotrexate ephezulu emzimbeni wakho kwaye izintso zakho zibuthathaka? Ngoko makhe sifunde ngesi sitofu seGlucarpidase!

Usenokuba ucinga, "Hayi bo, loluphi uhlobo lonyango olungaqhelekanga endithetha ngalo?" Ewe, eli liyeza elikhethekileyo. Ngamanye amaxesha, xa amayeza amaninzi abizwa ngokuba yiMethotrexate, asetyenziselwa ukunyanga izifo ezifana nomhlaza, eqokelelana emzimbeni, anokubangela iingxaki, ingakumbi ukuba izintso zakho azisebenzi kakuhle. Kulapho ke esi sitofu sibizwa ngokuba yiGlucarpidase siza kusihlangula khona. Ngaba singathetha ngakumbi ngale nto?

Lithini eli yeza libizwa ngokuba yiGlucarpidase? Ngamafutshane...

Cinga ngayo njengeqhawe elincinci, iGlucarpidase . Enyanisweni yienzyme . Iienzyme zifana nabancedisi abancinci abakhawulezisayo nabanceda kwiinkqubo ezahlukeneyo zeekhemikhali emizimbeni yethu. Ngoko ke, into eyenziwa yile enzyme ebizwa ngokuba yiGlucarpidase kukunciphisa ubungakanani beyeza elibizwa ngokuba yiMethotrexate endilikhankanyileyo ngaphambili emizimbeni yethu.

Ngoku ubuza, "Kutheni kufuneka kuncitshiswe i-methotrexate? Ayiloyeza na elo?" Ewe, i-methotrexate liyeza elibaluleke kakhulu nelinamandla elinikwa ukulawula ukukhula kweeseli zomhlaza kunye neemeko ezifana ne-arthritis. Nangona kunjalo, eli yeza likhutshwa kakhulu emzimbeni ngezintso. Ngoko ke, ukuba izintso zomntu zibuthathaka kancinci, ukuba azisebenzi kakuhle, le methotrexate ikhutshwa kancinci emzimbeni. Emva koko kwenzeka ukuba iqokelelane emzimbeni ize ifikelele kumanqanaba anobuthi . Oko kuyingozi. Kulapho kunikwa le injection ikhethekileyo ebizwa ngokuba yi-glucarpidase, i-methotrexate egqithisileyo eqokelelene emzimbeni iyancipha ngokukhawuleza, kwaye isigulane siyakhuseleka.

Ungalifumana eli yeza phantsi kwegama le- VORAXAZE , kodwa ngugqirha wakho kuphela oya kwazi ngokuqinisekileyo ukuba uyalidinga okanye awuyidingi.

Ngubani onikwe eli yeza leGlucarpidase?

Oku akuyonto yokuphelisa zonke iingxaki. Kuluncedo kakhulu kwezi zinto zilandelayo:

• Iyeza i- methotrexate lenzelwe abantu abafikelele kumanqanaba ayingozi obutyhefu emizimbeni yabo.
• Kwakhona, izintso zabo kufuneka zingasebenzi kakuhle , kuba ukuba izintso zisebenza kakuhle, i-methotrexate idla ngokukhutshwa emzimbeni ngokuqhelekileyo.

Eli yeza linokunikwa abantu abadala kunye nabantwana . Ngamanye amaxesha, lingasetyenziswa kwiimeko ezikhethekileyo, kwanakwiintsana ezineminyaka eyi-1 ubudala. Nangona kunjalo, xa ulinika abantwana abancinci, oogqirha balisebenzisa ngononophelo olukhulu nangokulandela imiyalelo ekhethekileyo . Ke ngoko, ukuba uthetha nomntwana wakho ngale yeza, kungcono ukuthetha nogqirha ngayo ngokupheleleyo uze uchaze yonke into.

Zeziphi izinto ezibalulekileyo ekufuneka ndizixelele ugqirha ngaphambi kokuba ndisebenzise eli yeza?

Ngaphambi kokuba wena okanye umntu omaziyo anikwe olu gonyo lweGlucarpidase, nazi izinto ekufuneka uzixelele iqela lakho lezonyango (oko kukuthi oogqirha kunye nabahlengikazi):Zininzi. Akulunganga ukuzifihla ezi, kuba zingaba yingxaki yokhuseleko kuwe.

• Ukuba une-allergies:
• Ukuba une-aleji kweli yeza le-glucoparidase.
• Ukuba une-allergies kwezinye amayeza, ukutya, iidayi, okanye izithinteli, xelela ugqirha wakho. Ngamanye amaxesha, i-allergies kwinto ethile inokuchaphazela enye.
• Ukuba ukhulelwe okanye uzama ukukhulelwa: Oku kubaluleke kakhulu kuba amanye amayeza anokuchaphazela umntwana.
• Ukuba ungumama oncancisayo: Amanye amayeza anokudluliselwa kumntwana ngobisi lwebele, ngoko ke kubalulekile ukuxelela ugqirha wakho ngale nto.

Khumbula: Ukuxelela ugqirha wakho inyaniso yonke malunga nolwazi lwakho lwempilo kuya kukunceda kakhulu ekufumaneni unyango olukhuselekileyo nolufanelekileyo.

Ulisebenzisa njani eli yeza?

Eli yeza libizwa ngokuba yiGlucarpidase asinto onokuya nayo ekhaya usele okanye uzitofe ngayo.

• Olu luhlaselo olungena emthanjeni . Ngokuchanekileyo, eli yeza linikwa emzimbeni ngomthanjeni, njengokuba kusenziwa ityuwa.
• Oku kwenziwa yingcali yezempilo eqeqeshiweyo esibhedlele okanye ekliniki . Oku kuthetha ukuba kwenziwa ngugqirha okanye umongikazi oqeqeshwe ngokukodwa.

Kuza kwenzeka ntoni ukuba uthatha kakhulu? (Ukusebenzisa kakhulu):

Ekubeni eli yeza linikwa esibhedlele phantsi kweliso likagqirha, ukugqithisa amayeza kunqabile kakhulu. Nangona kunjalo, ukuba ucinga ukuba oku kwenzekile, oko kukuthi, ukuba uvakalelwa kukuba umthamo weyeza unyusiwe, kufuneka wazise ngokukhawuleza iziko lolawulo lwetyhefu okanye igumbi likaxakeka.

Inqaku elibalulekileyo: Eli yeza limiselwe wena ngqo . Ugqirha wakho uza kulibhalela wena ngokusekelwe kwizinto ezininzi, ezifana nemeko yakho yempilo, amanqanaba e-methotrexate, kunye nokusebenza kwezintso. Ngoko ke, musa ukunika okanye ukwabelana ngeli yeza nabanye abantu.

Kuthekani ukuba ndiphoswa yidosi?:

Ekubeni eli liyeza elinikwa esibhedlele, akunamsebenzi ukuba uliphosile ixesha elibekiweyo. Iqela lezonyango liza kujongana nalo mba.

Ziziphi ezinye izinto ezinokusebenzisana nale mithi?

Amanye amayeza "anokuphazamisa" ezinye izinto esizisebenzisayo. Oko kukuthi, isenzo sesinye sinokuchaphazela isenzo sesinye. Esona siphambili esichongiweyo ukuza kuthi ga ngoku esinokuphazamisana ne-glucarpidase sisiyobisi esibizwa ngokuba yiLeucovorin .

ILeucovorin lelinye iyeza elibalulekileyo elisetyenziswa kunyango lwe-methotrexate. Inceda ekunciphiseni iziphumo ebezingalindelekanga ze-methotrexate. Ngoko ke, xa benika zombini i-glucoparidase kunye ne-leucovorin, oogqirha bayalumkela kakhulu ixesha kunye nomthamo. Kuba xa i-glucoparidase yehlisa amanqanaba e-methotrexate, inokuchaphazela nokusebenza kwe-leucovorin.

Nangona kunjalo, olu luhlu aluphelelanga. Xelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo (amiselwe ngugqirha okanye athengiswa ngaphandle kwemvume kagqirha), amayeza emifuno, iivithamini (izongezo zokutya), kunye nokuba uyatshaya, usela utywala, okanye usebenzisa ezinye iziyobisi ezingekho mthethweni. Ngamanye amaxesha, izinto ezingalindelekanga zinokudibana namayeza akho.

Zeziphi izinto ekufuneka sizilumkele ngakumbi xa sithatha amayeza?

Xa ufumana le injection yeGlucarpidase, iqela lezonyango liza kukujonga ngononophelo . Oku kuthetha ukuba baza kuhlala bejonga imeko yakho.

• Uvavanyo lwegazi: Kuya kufuneka uvavanywe igazi rhoqo ngelixa usebenzisa eli yeza. Uyazi ukuba kutheni? Eyona nto iphambili kukujonga ukuba amanqanaba akho e-methotrexate aphantsi kangakanani . Olu vavanyo lwegazi lunokujonga nokusebenza kwezintso zakho kunye nezinye izinto ezibalulekileyo. Le yindlela oogqirha abagqiba ngayo ukuba unyango luyasebenza na kwaye ukuba kukho enye into ekufuneka yenziwe.
• Ukudinwa: Abanye abantu banokuziva benesizunguzi emva kokusela eli yeza. Ngoko ke, de ube uyazi kakuhle indlela eli yeza elikuchaphazela ngayo, kuphephe ukuqhuba, ukusebenza ngoomatshini, okanye ukwenza eminye imisebenzi efuna ukuba uqaphele kakhulu .
• Lumka xa uvuka ngokukhawuleza: Xa uvuka uhleli okanye ulele, musa ukuvuka ngequbuliso, kodwa kancinci . Oku kubaluleke kakhulu ukuba ukhulile. Kungenjalo, ungaziva unesiyezi uze uwe.
• Kuphephe utywala: Ukusela utywala kunokubangela ukuba isiyezi sakho sibe sibi ngakumbi. Kungoko ke, kungcono ukukuphepha ngokupheleleyo utywala ngelixa usebenzisa eli yeza.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengalo naliphi na iyeza, iGlucarpidase inokubangela ezinye iziphumo ebezingalindelekanga. Kodwa ayinguye wonke umntu ozifumanayo. Bambalwa abantu abazifumanayo. Musa ukukhathazeka, kodwa kubalulekile ukuba uzazi ezi.

Iziphumo ebezingalindelekanga ekufuneka uzixelele ugqirha wakho ngoko nangoko:

Ukuba ufumana naziphi na kwezi mpawu, kufuneka uxelele ugqirha wakho okanye ingcali yezonyango ngokukhawuleza ngaphandle kokulibazisa.

• Iimpendulo ze-allergy:
• Ukuqhambuka kwesikhumba
• Ukurhawuzelela okanye ukurhawuzelela
• Ukudumba kobuso, imilebe, okanye ulwimi – Oku kuyingozi kakhulu kuba kunokubangela ubunzima bokuphefumla.
• Utshintsho embonweni: Ukufiphala ngequbuliso kombono, utshintsho olufana nokubona kwiindawo ezimbini.
• Intlungu, ukurhawuzelela, ukungaziva kakuhle ezandleni okanye ezinyaweni: Kuvakala ngathi ilungu lilele, okanye kuvakala nje ngathi yintlungu ehlabayo.
• Ukungcangcazela: Ukungcangcazela okungalawulekiyo kwamalungu omzimba.

Iziphumo ebezingalindelekanga ezingezizo ezinzulu, kodwa ekufuneka zixelwe kugqirha wakho ukuba ziyaqhubeka:

Ezi zifo zihlala ziphela emva kweentsuku ezimbalwa. Nangona kunjalo, ukuba ziyaqhubeka okanye zikukhathaza kakhulu, xelela ugqirha wakho .

• Urhudo: Ukuphuma kwendle.
• Ukudinwa: Ukuziva ngathi ujikeleza entloko.
• Ukurhawuzelela kobuso: Ukubomvu ngequbuliso kobuso kunye nobushushu obuphuma kubo.
• Intloko ebuhlungu : Intloko ebuhlungu.
• Isicaphucaphu, ukuhlanza: Ukuziva unesicaphucaphu esiswini sakho, uzive ngathi uza kuhlanza.

Olu luhlu alunazo zonke iziphumo ebezingalindelekanga. Ukuba ubona enye into engaqhelekanga, thetha nogqirha wakho ngayo. Ngamanye amaxesha isenokungabi ngenxa yamayeza, kodwa kulungile ukuba uqaphele.

Uligcina phi iyeza?

Akunyanzelekanga ukuba ukhathazeke ngale nto. Kuba, awuyi kuvunyelwa ukuba uyithathe le gonyo yeGlucarpidase uye nayo ekhaya. Isetyenziswa esibhedlele okanye ekliniki. Ngoko ke, abasebenzi bezonyango baya kuyigcina ikhuselekile.

Eyona nto ibalulekileyo ekufuneka uyikhumbule (Umyalezo Wokuya Ekhaya)

Kulungile, ngoko ke, ngokwezinto esithethe ngazo, ezi zezona zinto zibalulekileyo ekufuneka uzikhumbule:

• I-Glucarpidase yi-enzyme ekhethekileyo enikwa xa inqanaba letyhefu leyeza i- Methotrexate lisanda emzimbeni, ingakumbi kubantu abanezintso ezingasebenzi kakuhle.
• Oku kunikwa njengenaliti emthanjeni , esibhedlele, yingcali yezonyango eqeqeshiweyo.
• Kubalulekile ukuba uxelele ugqirha wakho ngazo zonke izinto ezibangela ukuba ungabi naso isifo, ukuba ukhulelwe okanye uncancisa, kunye nazo zonke iziyobisi ozisebenzisayo .
• Ngelixa usela amayeza, uza kuhlolwa ngokusondeleyo kwaye kuza kwenziwa uvavanyo lwegazi.
• Lumka kuba kusenokubakho izinto ezifana nesiyezi.
• Ukuba ufumana naziphi na iziphumo ebezingalindelekanga ezinzulu , xelela ugqirha wakho ngoko nangoko.
• Eli liyeza elikhethekileyo, ngoko ke thetha nogqirha uze umchazele yonke into.

Esi sisishwankathelo nje. Ukuba unemibuzo engaphezulu malunga nale yeza, nceda ungathandabuzi ukubuza ugqirha wakho, ikhemisti, okanye omnye umboneleli wezempilo. Baya kukwazi ukukunceda.

i- glucarpidase, i-methotrexate, isifo sezintso, ii-enzymes, ukusebenzisana kwamayeza, iziphumo ebezingalindelekanga, ugonyo