Ngaba uyayazi i-HER2-Negative Breast Cancer? Masithethe!

Mhlawumbi ukhe weva okuninzi malunga nomhlaza webele. Kodwa ngaba uyazi ngokwenene ukuba olu hlobo lomhlaza lubizwa ngokuba yi-'HER2-negative'? Luziphatha ngendlela eyahlukileyo kunezinye iintlobo zomhlaza webele, kwaye unyango lunokwahluka. Ungakhathazeki, namhlanje siza kuthetha ngalo mhlaza webele 'HER2-Negative' ngendlela elula onokuyiqonda, kulungile?

Yintoni i-HER2-Negative Breast Cancer?

Ngamafutshane, 'umhlaza webele ongengowakhe uHER2' uthetha ukuba iiseli zomhlaza ebeleni lakho azinazo iiproteni ezininzi okanye ezincinci kakhulu ezibizwa ngokuba yi-'human epidermal growth factor 2 (HER2). Ubusazi na ukuba umhlaza webele uhlala ukhula ngenxa yeehomoni (ingakumbi i-estrogen kunye ne-progesterone) okanye ngenxa yale protein ye-'HER2'? Umzekelo, kumhlaza webele ongengowakhe uHER2, iproteni ye-'HER2' ikhona kumphezulu weeseli, nto leyo ebangela ukuba iiseli zomhlaza zahlukane ngokukhawuleza kwaye zenze iithumba.

Kodwa kwiimeko ze-`HER2-negative`, umhlaza awuphuhli kuba kukho iproteni ye-`HER2` eninzi kakhulu. Oko kukuthi, kukho nezinye izinto ezibandakanyekayo.

Xa ugqirha wakho ekuxilonga ukuba unomhlaza webele, ngokuqinisekileyo uya kujonga imeko yakho ye-'HER2' (oko kukuthi, eyakhayo okanye engeyiyo). Ezi ziimpawu ezikhethekileyo zeeseli zomhlaza, esizibiza ngokuba yi -'biomarkers' , kwaye xa ziqondwa ngokuchanekileyo, oogqirha banokugqiba ukuba loluphi unyango olufanelekileyo nolusebenzayo kuwe. Uyifumene?

Ziziphi iintlobo eziphambili zomhlaza webele we-HER2-negative?

Uninzi lwemihlaza yamabele efunyenweyo ngoku yeyohlobo lwe-'HER2-negative'. Kukho iintlobo ezimbini eziphambili zale mihlaza, makhe sijonge ukuba zeziphi:

1. Umhlaza webele one-hormone receptor kunye ne-HER2-negative (HR+/HER2-) :

Olu lolona hlobo luqhelekileyo lomhlaza webele, lumalunga nama-70 ekhulwini (70%) azo zonke iintlobo zomhlaza webele. Kule meko, iiseli zomhlaza zinee-receptors ezivakalelwa yi-estrogen hormone (ER+), i-progesterone hormone (PR+), okanye zombini. Ngamafutshane, xa ezi hormone zibopha kwezi receptor, iiseli zomhlaza ziqala ukukhula. Nangona kunjalo, ezi ntlobo zomhlaza azinamanqanaba aphezulu eproteni ye-HER2. Yiyo loo nto zibizwa ngokuba yi-HR+/HER2-.

2. Umhlaza webele one-hormone receptor-negative kunye ne-HER2-negative (HR-/HER2-) :

Olu hlobo lubandakanya malunga ne-11% (11%) yazo zonke iintlobo zomhlaza wamabele. Ezi seli zomhlaza azinazo ii-receptors ze-estrogen okanye i-progesterone. Kwakhona, njengoko bekutshiwo ngaphambili, iproteni ye-'HER2' ayiphezulu. Oku kuthetha ukuba iihomoni okanye iproteni ye-'HER2' azinawo amandla okukhulisa lo mhlaza . Elinye igama lale nto yi -'Triple-Negative Breast Cancer' . Oku kungenxa yokuba i-estrogen receptor, i-progesterone receptor, kunye neproteni ye-'HER2' zonke azinawo amandla okukhula kweli tyala.

Zithini iimpawu zomhlaza webele we-HER2-negative?

Enyanisweni, iimpawu zomhlaza webele ongengowe-HER2 zifana kakhulu nezo zomnye umhlaza webele. Kufuneka uqaphele oku kulandelayo:

• Ukuba ubona utshintsho olungaqhelekanga kubungakanani okanye kwimo yebele elinye okanye omabini.
• Ukuba ubona iqhuma elitsha, iqhuma, okanye ukuqina esifubeni sakho okanye ekhwapheni, ingakumbi ukuba iqhuma alitshintshi ngomjikelo wakho wenyanga wokuya exesheni.
• Utshintsho kulusu lwebele okanye ingono. Umzekelo:
• Ukufiphala kwesikhumba, njengexolo leorenji
• Ulusu luyashwabana, luyaqhuma
• Ulusu olunezikhwebu
• Ukurhawuzelela okungapheliyo
• Utshintsho lombala wolusu (obomvu, omfusa, omdaka, okanye omnyama ngokungaqhelekanga).
• Ukuphuma kweengono . Oku kungaba bomvu njengegazi, ulwelo olucacileyo, okanye umbala omhlophe ofana nobisi (ukuba awukhulelwe okanye awuncancisi).
• Ukuguqulwa kweengono (ukuba bekungenjalo ngaphambili).

Kubalulekile ukuqaphela ukuba umhlaza webele awusoloko ubangela utshintsho olucacileyo kwindlela okhangeleka ngayo . Kwakhona, uninzi lwale nguqu lunokubonwa nakwiimeko ezingezizo neziqhelekileyo (umz. ii-cysts, i-fibroadenoma). Yiyo loo nto kubaluleke kakhulu ukujonga amabele akho rhoqo kwaye ufumane uhlolo lomhlaza webele olufanelekileyo kwiminyaka yakho . Ukuba unenkxalabo malunga notshintsho, qiniseka ukuba ubona ugqirha ukuze ufumane ukuba luphawu lomhlaza okanye enye imeko.

Yintoni ebangela umhlaza webele ongengowakho we-HER2?

Ngamafutshane, umhlaza webele ongengowe-HER2 ubangelwa lutshintsho kwiijini, okanye i-DNA, kwiiseli zebele, ezibizwa ngokuba zii-mutations , ezibangela ukuba ezo seli zibe ziiseli zomhlaza. Ezi seli zomhlaza emva koko zahlukane kwaye zande ngokukhawuleza ngaphandle kokulawulwa, zenze iithumba.

Izinto Ezinobungozi

Iingcali azikaqiniseki ukuba yintoni kanye kanye imbangela yolu tshintsho lwemfuza kwi-HER2-negative breast cancer. Nangona kunjalo, zichonge izinto ezininzi ezinokunyusa umngcipheko wokuba nomhlaza webele ngokubanzi. Ezi ziquka:

• Utshintsho lwemfuza oluzuzwe njengelifa : Akukho tshintsho luthile lwemfuza olunxulunyaniswa nomhlaza webele onxulumene ne-HER2. Nangona kunjalo, ukuba umntu ufumana utshintsho kwimfuza efana ne-BRCA1 okanye i-BRCA2, usemngciphekweni omkhulu wokuba nomhlaza webele (kunye neminye imifuza) ngokubanzi.
• Wena okanye umntu osapho lwakho ukhe waba nomhlaza webele ngaphambili.: Ukuba ukhe waba nomhlaza webele ngaphambili, usemngciphekweni othile wokuba ubuye. Kwakhona, ukuba izalamane zakho zegazi (ingakumbi umama wakho, utata wakho, abantakwenu, abantwana bakho) bakhe baba nomhlaza webele, nawe usemngciphekweni omkhulu kancinci.
• Ukuvezwa ixesha elide kwiihomoni ze-estrogen okanye ze-progesterone : Ukuba uqale ukuya exesheni lakho lokuqala usemncinci (umz., ngaphambi kweminyaka eli-12), okanye ukuba uye waphela ukuya exesheni kade (umz., emva kweminyaka engama-55), umzimba wakho uye wavezwa kwezi homoni zesini ixesha elide. Oku kunokuba yinto enobungozi. Ezinye iindlela zonyango zokutshintsha iihomoni zinokwandisa umngcipheko wakho xa zithathwa ixesha elide.
• Ukusetyenziswa kotywala : Uphando lufumanise ukuba ukusela isiselo esiqhelekileyo esingaphezu kwesinye ngosuku kwandisa umngcipheko womhlaza webele.

Ukongeza koku, izinto ezinje ngokwanda kweminyaka, ukutyeba kakhulu, kunye nokungazilolongi nako kunokunyusa umngcipheko womhlaza wamabele ngokubanzi.

Ufunyaniswa njani umhlaza webele ongengowe-HER2?

Oogqirha badla ngokuxilonga umhlaza webele ongengowe-HER2 nge- biopsy yebele . Oku kuquka ukuthatha isampuli encinci (iqhekeza) lesicwili kwiqhuma okanye kwindawo erhanelekayo baze bayithumele kwilebhu. Apho, ingcali yezifo ihlola isampuli phantsi kwe-microscope ukuze ibone ukuba kukho iiseli zomhlaza.

Ukuba iiseli zomhlaza ziqinisekisiwe, kwenziwa uvavanyo olukhethekileyo ukuze kubonwe ukuba ingakanani na iproteni ye-`HER2` ekhoyo kumphezulu wezo seli zomhlaza, okanye zingaphi iikopi zejini ye-`HER2` ekhoyo.

• Ukuba unezixa eziqhelekileyo (eziphantsi) zeproteni okanye i-gene ethi `HER2`, unomhlaza webele othi `HER2-negative`.

Uvavanyo oluphambili lwelabhoratri olwenziweyo ngenxa yale njongo zezi:

1. I-Immunohistochemistry (IHC) : Olu vavanyo lusebenzisa ii-antibodies ezithile kunye needayi ukufumanisa iproteni ye-HER2 kumphezulu weeseli zomhlaza. Ukuba iziphumo ze-IHC ziyi-0 okanye i-1+, umhlaza uthathwa njenge-HER2-negative. Ukuba iziphumo ziyi-2+ (ngamanye amaxesha zibizwa ngokuba "zii-equivocal" okanye "zii-borderline"), uvavanyo olubizwa ngokuba yi-FISH nalo lwenziwa ukuqinisekisa imeko ye-HER2.

2. I-Fluorescence in situ hybridization (FISH) : Olu vavanyo lujonga ukuba zingaphi iikopi ze-HER2 gene, ezenza iproteni ye-HER2, ezikhoyo kwiiseli zomhlaza. Oku kusebenzisa imakroskopu ekhethekileyo kunye nee-fluorescent (light-emitting markers). Kwimeko apho iziphumo zovavanyo lwe-IHC zingaphelelanga, ezifana ne-2+, uvavanyo lwe-FISH lunokuqinisekisa ngokuqinisekileyo imeko ye-HER2 (engalunganga okanye engalunganga).

Ukongeza kwezi mvavanyo ze-`HER2`, ingcali yezifo iza kuhlola isampuli ye-biopsy ize ijonge ubukho bee-estrogen receptors (ETU) kunye nee-progesterone receptors (PR) kumhlaza.

Kusenokufuneka ukuba wenze iinkqubo zokuthatha imifanekiso ezifana ne-mammogram, i-ultrasound, i-CT scan, okanye i-MRI scan ukuze ufumane inqanaba lomhlaza wakho (oko kukuthi, ukubona ukuba ithumba likhulu kangakanani kwaye nokuba lisasazeke na kwii-lymph nodes okanye kwezinye iindawo ezikude zomzimba).

Ugqirha wakho uza kudibanisa lonke olu lwazi (imeko ye-HER2, imeko ye-HR, inqanaba lomhlaza, kunye neempawu zomhlaza) ukuze enze isicwangciso sonyango esifanelekileyo kuwe.

Ziziphi iindlela zonyango zomhlaza webele ongengowakho we-HER2?

Unyango olungcono lomhlaza webele one-HER2-negative lunokwahluka kumntu nomntu. Kuxhomekeke kwizinto ezininzi, kuquka inqanaba lomhlaza wakho, nokuba yi-hormone receptor-positive okanye negative (HR+/HER2- okanye HR-/HER2-), kunye nempilo yakho iyonke.

Ngokubanzi, unyango lungabandakanya:

• Utyando lomhlaza webele : Ukususwa kwethumba elinomhlaza kunye nezicubu eziphilileyo ezijikeleze lona. Oku kungaba kukususwa kwe-lumpectomy, esusa inxalenye yebele, okanye i-mastectomy, esusa lonke ibele.
• Unyango ngemitha : Imitha enamandla aphezulu isetyenziselwa ukutshabalalisa naziphi na iiseli zomhlaza ezinokuthi zihlale emva kotyando, okanye ukunciphisa ithumba ngaphambi kotyando.

Ukongeza kwezi ndlela zonyango zisisiseko, kukho ezinye iindlela zonyango ezithile ezixhomekeke kuhlobo lomhlaza:

Unyango lomhlaza webele we-HR+/HER2- (i-hormone receptor-positive, i-HER2-negative)

Ngenxa yokuba olu hlobo lomhlaza luxhomekeke kwiihomoni, olu nyango lubalulekile ukongeza kutyando kunye/okanye unyango lwemitha:

• Unyango lweehomoni : Olu nyango lusebenza ngokunciphisa amanqanaba eehomoni ze-estrogen okanye ze-progesterone ezinceda ukukhula komhlaza, okanye ngokuthintela ezo homoni ekubeni zibophelele kwiiseli zomhlaza. Umzekelo:
• Izithinteli zeAromatase (umz. iAnastrozole, iLetrozole, iExemestane)
• Ii-agonists ze-Gonadotropin-releasing hormone (GnRH) (ziyekisa ukuveliswa kweehomoni ezivela kuma-ovari)
• `Ii-modulators ze-estrogen receptor ezikhethiweyo (ii-SERM)` (umz. iTamoxifen, iRaloxifene)

Kwezinye iimeko, kunokufuneka utyando (oophorectomy) ukuze kususwe ama-ovari akho, avelisa i-estrogen. Unyango lwehomoni lunokunikwa lodwa okanye ludityaniswe nonyango olujoliswe kulo kangangeminyaka eliqela.

• Unyango olujoliswe kulo : Olu nyango lujolise kubuthathaka obuthile kwiiseli zomhlaza kwaye luzihlasele ukuze luyekise ukukhula nokusasazeka kweeseli zomhlaza. Kwi-HR+/HER2- cancers, amayeza abizwa ngokuba yi-CDK4/6 inhibitors (umz. iPalbociclib, iRibociclib, i-Abemaciclib) asetyenziswa kunye nonyango lweehomoni. La mayeza athintela i-enzyme elawula ukwahlukana kweeseli zomhlaza.
• Unyango lweKhemotherapy: Kwabanye abantu abanomhlaza wamabele i-HR+/HER2-, ingakumbi ukuba umhlaza usasazeke okanye unamandla, oogqirha banokucebisa unyango lwekhemotherapy kunye nonyango lwehomoni kunye/okanye unyango olujoliswe kulo.

Unyango lomhlaza webele we-HR-/HER2- (triple-negative)

Ngenxa yokuba umhlaza webele one-triple-negative awuxhomekekanga kwiihomoni, unyango lweehomoni alusebenzi. Ukongeza kutyando kunye/okanye unyango lwemitha, olu hlobo lonyango lulandelayo lusetyenziswa kakhulu:

• Unyango lweKhemotherapy : Unyango lweKhemotherapy lunyango olubaluleke kakhulu kumhlaza one-triple-negative. Oogqirha basebenzisa iintlobo ezahlukeneyo zamayeza ekhemotherapy. Banokunika iyeza elinye okanye indibaniselwano yamayeza amaninzi.
• Unyango lwe-Immunotherapy : Olu lonyango olutsha. Lusebenza ngokuvuselela amasosha omzimba wakho ukuba aqaphele kwaye atshabalalise iiseli zomhlaza. I-Pembrolizumab (Keytruda®) liyeza le-immunotherapy elivunyiweyo yi-Food and Drug Administration (FDA) kwaye linikwa kunye ne-chemotherapy kwiintlobo ezithile zomhlaza webele one-triple-negative.
• Unyango olujoliswe kuko : Kwimihlaza eneentsholongwane ezintathu ene-BRCA gene mutation, kusetyenziswa amayeza ajoliswe kuko abizwa ngokuba yi-PARP inhibitors (umz., i-Olaparib, i-Talazoparib). Kwakhona, kwisifo esisasazekayo, iintlobo ezintsha zonyango olujoliswe kuko (umz., ii-antibody-drug conjugates) ngoku ziyafumaneka.

Zithini iziphumo ebezingalindelekanga zonyango?

Nangona unyango lomhlaza lunokulwa ngempumelelo nomhlaza, zonke iindlela zonyango, kuquka i-chemotherapy, unyango ngemitha, unyango lweehomoni, unyango olujoliswe kulo, kunye nonyango lwe-immunotherapy, zinokubangela ezinye iziphumo ebezingalindelekanga. Ezi zinokuba zezexeshana okanye zexesha elide. Umzekelo, ukudinwa, isicaphucaphu, ukuhlanza, ukulahleka kweenwele, ukungabi namdla wokutya, izilonda zomlomo, utshintsho lolusu, urhudo okanye ukuqhina, kunye nokubalwa kweeseli zegazi ezisezantsi.

Qiniseka ukuba uthetha nogqirha wakho malunga nokuba zeziphi ezi ziphumo ebezingalindelekanga, ukuba ziya kuhlala ixesha elingakanani, kunye nendlela yokuzilawula. Banokukuthumela kwiingcali zokhathalelo lwentlungu . Ukhathalelo lwentlungu alupheleli nje kwizigaba zokugqibela zomhlaza, kodwa lukwakunceda ugcine umgangatho wobomi bakho ngokulawula iimpawu kunye neziphumo ebezingalindelekanga kulo lonke unyango.

Ingakanani izinga lokunyangwa komhlaza webele ongenayo i-HER2?

Kuzo zonke iintlobo zomhlaza webele ze-HER2-negative, izinga lokusinda liphezulu kakhulu xa umhlaza uphelele esifubeni kwaye ungasasazekanga (kwinqanaba lendawo) kunaxa umhlaza usasazeke kwizitho ezikude emzimbeni (umz., isibindi, imiphunga, ubuchopho, amathambo) (umhlaza osasazekayo okanye inqanaba elikude).Izinga lokusinda komhlaza osasazeke kwiindawo ze-lymph ezikufutshane kuphela kodwa ongazange usasazeke kwiindawo ezikude (inqanaba lengingqi) liphakathi nendawo.

Nangona kunjalo, kubalulekile ukukhumbula ukuba amathuba akho okuchacha, okanye ukubikezela kwangaphambili, axhomekeke kwizinto ezithile ezichaphazela ukuxilongwa kwakho. Ezi ziquka ukuba umhlaza usasazeke kangakanani (inqanaba), nokuba umhlaza unesimo se-hormone receptor (HR+/HER2- okanye HR-/HER2-), ukuba iiseli zomhlaza zinobundlongondlongo kangakanani (ibanga), ubudala bakho, impilo iyonke, kunye nendlela osabela ngayo kunyango. Ezi zizinto ugqirha wakho anokuthetha nawe ngazo aze akuchazele into omawuyilindele. Izibalo zingumyinge nje, kwaye aziyi kufana kuye wonke umntu.

Ndingazinyamekela njani? (Ukuzinyamekela)

Nokuba ungumntu onomhlaza webele we-HER2-negative okwinqanaba lokuqala okanye umntu ophila nomhlaza oqhubele phambili, kubalulekile ukuzinika ixesha lokuzinyamekela. Oku kuya kukunceda ngokwasemzimbeni nangokwengqondo. Nazi ezinye izinto onokuzenza:

• Phumla xa kufuneka : Kuqhelekile ukuziva udiniwe kwaye udiniwe, kokubini ngenxa yomhlaza kunye nonyango lomhlaza. Xa uziva udiniwe, thatha ikhefu uphumle. Mamela umzimba wakho.
• Yitya ukutya okunempilo nokunesondlo : Ezinye iindlela zonyango lomhlaza zinokuchaphazela umnqweno wakho wokutya kunye nemvakalelo yokungcamla. Kodwa zama ukutya ukutya okunesondlo ukuze ufumane izondlo ezifunwa ngumzimba wakho. Faka iziqhamo, imifuno, ifayibha, kunye nokutya okutyebileyo kwiproteni. Ukuba awuqinisekanga malunga nokutya omawukutye okanye okungekho, thetha nogqirha wezondlo ukuze akunike iingcebiso.
• Ukuzilolonga (kodwa ungagqithisi) : Kubalulekile ukwenza umthambo rhoqo kwinqanaba elifanelekileyo kuwe, njengoko kucetyiswa ngugqirha wakho. Nokuba kukuhamba kancinci okanye i-yoga kunokuba yinto elungileyo. Kunokunyusa amandla akho, kuphucule imo yakho, kwaye kuncede ekunciphiseni iziphumo ebezingalindelekanga. Nangona kunjalo, buza ugqirha wakho ukuba loluphi uhlobo lomthambo olufanelekileyo kuwe kunye nokuba kufuneka ulwenze kangakanani, ngokusekelwe kwisifo sakho kunye nonyango.
• Lawula uxinzelelo : Kuqhelekile ukuziva uxinezelekile, uxhalabile, kwaye usoyika xa unesifo esifana nesi. Fumana iindlela zokulawula esi sifo sikusebenzelayo. Nangona ukucamngca kunye nokuzilolonga ngokuphefumla kusebenza kwabanye, abanye banokukhetha ukuzibandakanya kwimisebenzi yokuyila efana nokufunda incwadi, ukumamela umculo, ukuzoba, okanye ukulima igadi. Beka ecaleni ixesha elithile yonke imihla kuyo nayiphi na imisebenzi ekunceda uzive uzolile kwaye ukhululekile.
• Fumana inkxaso yengqondo: Kubalulekile ukuthetha ngeemvakalelo zakho nosapho kunye nabahlobo abasondeleyo. Kunokuba namandla kakhulu ukunxibelelana nabanye abajongene nokuxilongwa komhlaza kunye nokwabelana ngamava abo. Buza ugqirha wakho malunga namaqela enkxaso okanye iinkqubo zokusinda kumhlaza.

Ndifanele ndimbone nini ugqirha?

Kubaluleke kakhulu ukuba uhlale unxibelelana nogqirha wakho, ngexesha lonyango nasemva kwalo.

• Ukuba ufumanisa iimpawu ezintsha (umz., intlungu engapheliyo, iqhuma elitsha, ubunzima bokuphefumla, ukwehla kobunzima obungachazekiyo), okanye ukuba iimpawu zakho zangoku zibonakala zisiba mandundu , bona okanye wazise ugqirha wakho ngoko nangoko .
• Emva konyango, ugqirha wakho uza kucwangcisa amaxesha okulandela emva kwexesha elithile. Qinisekisa ukuba uyawagcina la ma- aphoyintimenti. La ma-aphoyintimenti okujonga ukuba aphinde abuye na, ukulawula iziphumo ebezingalindelekanga zonyango ixesha elide, kunye nokujonga impilo-ntle yakho iyonke. La ma-aphoyintimenti okulandela emva kwexesha abaluleke kakhulu kwiminyaka emihlanu yokuqala emva konyango . Kulapho umhlaza uhlala uphinda ubuye khona.

Ndingayibuza yiphi imibuzo ugqirha wam?

Xa uthetha nogqirha wakho, ungoyiki ukubuza nayiphi na imibuzo onayo, nokuba mincinci kangakanani na. Nazi ezinye zemibuzo onokuzibuza ukuze zikuncede:

• Ingaba i-receptor yehomoni yomhlaza yam ilungile okanye ayilunganga?
• Yintoni uhlobo oluthile kunye nesigaba somhlaza wam?
• Undicebisa ukuba ndinyangwe ngaluphi unyango? Ngoba?
• Zithini iziphumo ebezingalindelekanga zexesha elifutshane nezexesha elide onokuzilindela kwezi ndlela zonyango? Yintoni enokwenziwa ukunciphisa ezo ziphumo?
• Unyango luthatha ixesha elingakanani?
• Ungandixelela ntoni ngesifo sam?
• Ndingaqhubeka nemisebenzi yam yemihla ngemihla (umsebenzi, imisebenzi yasekhaya) ngexesha lonyango?
• Ngaba kukho izinto ezikhethekileyo ekufuneka ndiziqwalasele malunga nokutya kwam kunye nokuzilolonga?
• Ndingenza ntoni ukunciphisa umngcipheko wokubuya komhlaza?
• Ukuba ndifuna iinkonzo zenkxaso okanye ingcebiso, ndingafumana umntu oza kundinceda?

Kungcono ukubhala phantsi le mibuzo uze uyibuze, ukuze ungalibali nto.

Ngaba kungcono ukuba ne-HER2-positive okanye i-negative?

Lo ngumbuzo obuzwa ngabantu abaninzi. Kodwa kunzima ukunika impendulo elula kulo mba, kuba inyani kukuba 'uxhomekeke' .

Umzekelo, umhlaza webele one-HER2-positive ukhula ngokukhawuleza kwaye ube nolaka ngakumbi kunomhlaza one-HER2-negative. Nangona kunjalo, kukho inzuzo koku. Kukho unyango oluthile olunokuthi lujolise kwiiproteni ze-HER2, umz., iHerceptin, iPerjeta, kwaye zisebenza kakhulu kumhlaza one-HER2-positive. Olu nyango alusebenzi kumhlaza one-HER2-negative, kuba loo mhlaza awunayo iproteni ye-HER2 eninzi.

Kwelinye icala, ukuba umhlaza we-`HER2-negative` ungowohlobo lwe-`HR+` (olune-receptor ye-hormone), oko kukuthi, uhlobo lwe-`HR+/HER2-`, kukho unyango olusebenzayo kakhulu lweehomoni kunye nonyango olujoliswe kulo olufana ne-`CDK4/6 inhibitors`. Enyanisweni, umhlaza webele we-`HR+/HER2-` uthathwa njengowona mhlaza ubalaseleyo phakathi kweentlobo zomhlaza webele ezikhoyo.

Kodwa ukuba umhlaza 'une-HER2-negative' (HR-) (i-hormone-receptor-negative), oko kukuthi, une-triple-negative, unokuba ndlongondlongo ngakumbi kunezinye iintlobo, kwaye unyango lunokuba nzima ngakumbi. Kodwa ngoku kukho i-chemotherapy, i-immunotherapy, kunye nonyango olutsha olujoliswe kuloo nto.

Ngoko ke, akunakwenzeka ukuthi enye "ingcono" okanye "imbi" kunenye. Eyona nto ibalulekileyo kukuchonga ngokuchanekileyo uhlobo oluthile lomhlaza wakho kwaye ufumane unyango olufanelekileyo olufanelekileyo kuwo.

Okokugqibela, kufuneka ndikuxelele... (Umyalezo Wokuya Ekhaya)

Xa ufunyaniswa ukuba unomhlaza webele othi `HER2-negative`, kuyinto eqhelekileyo ukuba uzive usoyika kwaye uxhalabile. Kodwa khumbula, oku akupheleli apha. Isayensi kunye netekhnoloji yezonyango zihambele phambili kakhulu namhlanje, kwaye kukho unyango oluninzi olusebenzayo lolu hlobo lomhlaza.

Eyona nto ibalulekileyo yile:

• Ukwaziswa ngokufanelekileyo ngale meko.
• Hlala uqaphela utshintsho emzimbeni wakho, ingakumbi amabele akho.
• Ukuba unamathandabuzo, bonana nogqirha ngexesha kwaye uhlolwe.
• Thetha ngokukhululekileyo nangokunyaniseka nogqirha wakho, ubuze yonke imibuzo yakho, kwaye ufumane ukuqonda okuhle ngeendlela zonyango.

Khumbula, awuwedwa kolu hambo. Kukho oogqirha abanetalente, abahlengikazi, usapho lwakho, kunye nabahlobo bakho abasondeleyo abakhoyo ukukunceda nokukuxhasa. Gcina isimo sengqondo esihle, landela imiyalelo yoogqirha bakho ngokuchanekileyo, kwaye ufumane inkxaso oyifunayo, kwaye ngokuqinisekileyo uya kukwazi ukujongana nale meko ngempumelelo kwaye uphile. Ngamana ungaqina!

Umhlaza webele, i-HER2-negative, iimpawu zomhlaza, unyango lomhlaza, impilo yabasetyhini, unyango lweehomoni, i-triple-negative