Umhlaza Webele: Masingoyiki kodwa masiqaphele!

Xa sisiva igama elithi umhlaza webele, sonke siyoyika kancinci. Kodwa ubusazi na ukuba ayizizo zonke iintlobo zomhlaza webele ezifanayo? Kukho iintlobo ezithile, ukuba zifunyenwe kwangethuba kwaye zinyangwa ngokufanelekileyo, ezinokuthi zinyangeke. Ngoko ke, olunye uhlobo lomhlaza webele esiza kuthetha ngalo namhlanje, oluyintuthuzelo kancinci, kodwa esifanele siluqaphele ngokuqinisekileyo, lubizwa ngokuba yi-'Luminal A'. Ngoko ke, ngaba singathetha ngale nto ngokweenkcukacha?

Yintoni umhlaza webele weLuminal A?

Ngamafutshane, olu luhlobo lomhlaza webele oluxhomekeke kwiihomoni (iHormone Receptor-Positive okanye iHR+) . Ngoku ucinga, "Ithetha ukuthini le hormone?" Sineehomoni ezimbini emizimbeni yethu ezibizwa ngokuba yi-estrogen kunye ne-progesterone. Ngaphakathi kwezi seli zomhlaza, kukho iiproteni ezikhethekileyo ezinokubophelela kwezi homoni, njengesitshixo esingena kwisitshixo. Sizibiza ezi receptors . Ngoko ke, xa ezi homoni zifika zibophelele kwezo receptors, zinceda iiseli zomhlaza zikhule. Igama elithi 'luminal' libhekisa kumaleko weeseli ngaphakathi kwimibhobho yobisi yebele. Kulapho uninzi lomhlaza webele luqala khona.

Iiseli zomhlaza zeLuminal A zineempawu ezikhethekileyo ezahlukeneyo:

• I-Estrogen Receptor-Positive (ER+): Oku kuthetha ukuba ezi seli zinezinga eliphezulu le-estrogen receptors (ERs), ezikwaziyo ukubopha kwi-hormone estrogen. Oku kuthetha ukuba iiseli zomhlaza zinokukhula kwi-hormone estrogen.
• I-Progesterone Receptor-Positive (PR+): Ezi seli zikwanazo nee-receptors ezingaphezulu (PR) ezibopha kwi-hormone ye-progesterone. Oku kunceda ukukhula kweeseli zomhlaza.
• I-HER2-Negative okanye i-HER2-: Oku kunzulu ngakumbi. I-HER2 (i-Human Epidermal Growth Factor Receptor 2) yenye iproteni ekhethekileyo. Inokufumaneka ngobuninzi kumphezulu weeseli ezithile zomhlaza, nto leyo enokunceda umhlaza usasazeke ngokukhawuleza. Nangona kunjalo, iiseli zeLuminal A zihlala zineproteni ye-HER2 encinci okanye azinazo kwaphela . Yinto elungileyo leyo. (Ezinye iintlobo zomhlaza wamabele, njengeLuminal B, zinokuba ne-HER2-positive okanye negative.)
• Iproteni yeKi-67 ephantsi: I-Ki-67 yiproteni efumaneka kuphela kwiiseli ezahlulahlula ngokukhawuleza. Umhlaza weLuminal A unezinga eliphantsi kakhulu lale proteni. Oku kuthetha ukuba ezi seli zomhlaza zahlukana ngesantya esicothayo, oko kuthetha ukuba umhlaza ukhula kancinci . Lo ngumahluko omkhulu phakathi kolu hlobo lomhlaza nezinye iintlobo ezifana neLuminal B.
• Udidi olusezantsi: Ngamafutshane, iiseli zeLuminal A azinazo iintsholongwane njengezinye iintlobo zomhlaza. Kwakhona azinakwenzeka ukuba ziphinde zivele emva konyango kuneeseli zeLuminal B.

Olu lwazi lusenokubonakala lunzima kancinci kuwe. Usenokuba uzibuza, "Zithini ii-ER, ii-PR, ii-HER2, ii-Ki-67?" Kodwa ezi zibaluleke kakhulu .Ezi zizinto ezibonelela ngolwazi olukwinqanaba leemolekyuli malunga neeseli zomhlaza ezisemabeleni akho. Ngokusekelwe kolu lwazi, ugqirha wakho angenza isicwangciso sonyango esilungele wena kwaye aqikelele indlela oza kusabela ngayo kunyango olwahlukeneyo.

Ixhaphake kangakanani i-Luminal A yomhlaza webele?

Enyanisweni, olu lolona hlobo luqhelekileyo lomhlaza webele. Kubikwa ukuba phakathi kwama -50% nama-60% abo bonke abaguli abanomhlaza webele banalo olu hlobo, olubizwa ngokuba yiLuminal A. Oku kuthetha ukuba xa kuthethwa ngomhlaza webele, kubaluleke kakhulu ukwazi ngolu hlobo.

Zithini iimpawu zomhlaza webele weLuminal A?

Ngamanye amaxesha lo mhlaza ungavela ngaphandle kweempawu. Yiyo loo nto oogqirha besoloko becebisa ukuba uhlolwe rhoqo amabele (iiRoutine Cancer Screenings). Ukuba ufunyenwe kwangethuba, kulula ukunyanga. Nangona kunjalo, abanye abantu banokufumana iimpawu ezifana nezi:

• Iqhuma okanye i-cyst ebeleni: Le yeyona mpawu ixhaphakileyo. Isenokuvakala ngathi yiqhuma elinokuvakala kodwa lingekho ngaphambili.
• Iintlungu zebele: Abanye abantu banokuba neentlungu emabeleni okanye emakhwapheni.
• Ukuphuma kwengono: Ngamanye amaxesha, ukuphuma kwengono okungekho bisi kodwa okubonakala ngathi ligazi kunokuphuma kwingono.
• Ukuqina okanye ukufiphala kolusu lwebele: Utshintsho kulusu lwebele, njengokubonakala okufiphele kwezinye iindawo, okanye ukubonakala okufana nexolo loorenji.
• Ukudumba kwebele okanye kwekhwapha: Elinye ibele lisenokubonakala likhulu kunelinye, okanye indawo yekhwapha nayo isenokuba luphawu.

Khumbula, ukuba nezi mpawu akuthethi ukuba unomhlaza webele. Nangona kunjalo, ukuba ufumana naziphi na kwezi mpawu, kusoloko kububulumko ukubona ugqirha ukuze akuhlole.

Yintoni ebangela umhlaza webele weLuminal A?

Enyanisweni, umhlaza webele uyenzeka xa iiseli zebele ezisempilweni zitshintsha ngequbuliso zize ziqale ukukhula ngendlela engalawulekiyo. Iingcali azikayazi kakuhle ukuba kutheni oku kusenzeka. Nangona kunjalo, zichonge ezinye izinto ezibangela umngcipheko wokufumana umhlaza webele. Ziquka:

• Imbali yosapho yomhlaza webele okanye wesibeleko: Ukuba umama wakho, udadewenu, okanye intombi yakho ikhe yaba nomhlaza webele, nawe usemngciphekweni omkhulu kancinci.
• Ukuba neminyaka engaphezu kwama-50 ubudala: Le ngozi iyanda xa ukhula.
• Ukuba nezicubu ezixineneyo zebele: Abo banezicubu ezixineneyo zebele kwi-mammogram basengozini enkulu.
• Ukusetyenziswa kotywala: Abantu abasela utywala rhoqo basengozini enkulu.
• Ekubeni sele ndifumene unyango lwe-radiation kwindawo yesifuba ngaphambili:Ukuba ufumene unyango lwe-radiation kwindawo yesifuba ngenxa yesifo esithile.
• Ukuchatshazelwa ixesha elide zii-hormone ezifana ne-estrogen okanye i-progesterone: Zininzi izizathu ezinokubangela oku. Umzekelo, ukuya exesheni kwangoko (ukuya exesheni kokuqala) , ukuya exesheni kade (ukuya exesheni kade) , okanye ukuthatha unyango oluthile lokutshintshwa kwee-hormone (HRT) ixesha elide.

Ayinguye wonke umntu onezi zinto ezinobungozi oza kuba nomhlaza. Kwakhona, umntu ongenazo ezi zinto unokuba nawo. Yiyo loo nto ukuxilongwa rhoqo kubalulekile.

Ufunyaniswa njani umhlaza webele weLuminal A?

Umhlaza webele udla ngokufunyanwa okokuqala ngokuhlolwa kweemammogram . Ukuba i-mammogram yakho ibonisa into ekrokrisayo, ugqirha wakho uya kuyalela iimvavanyo ezongezelelweyo. Ezi zinokuquka:

• I-Diagnostic Mammogram: I-mammogram ejongeka ngokucacileyo kwindawo ekrokrisayo.
• Uvavanyo lwe-MRI (Magnetic Resonance Imaging): Oku kunokuvelisa imifanekiso ecacileyo yebele.
• Uvavanyo lwe-ultrasound: Oku kunokunceda ukubona izinto ezifana namaqhuma ngcono.

Emva kwezi mvavanyo, kuya kufuneka wenze i-biopsy yebele . Oku kuquka ukuthatha isampuli encinci yezicubu kwindawo erhanelekayo yebele, uyithumele elebhu kwaye uyihlole phantsi kwe-microscope. Olu vavanyo lunokubonisa ngokuqinisekileyo ukuba kukho iiseli zomhlaza okanye azikho.

Ukuba ingcali yezifo ifumene iiseli zomhlaza, iya kwenza ezinye iimvavanyo ukuqinisekisa ukuba ezi seli zezohlobo lweLuminal A. Oko kuthetha ukuba iya kujonga izinto ezifana ne-ER, i-PR, i-HER2, kunye ne-Ki-67 ezikhankanyiweyo ngaphambili.

Ukwazi kakuhle uhlobo lomhlaza onalo kunokunceda ugqirha wakho we-oncologist ukuba agqibe ukuba loluphi unyango olusebenzayo . Kungakunika nombono wamathuba okuba umhlaza uphinde ubuye emva konyango.

I-Luminal A isetyenziswa njani ukunyanga umhlaza webele?

Umhlaza webele ubuthathaka kwiihomoni (HR+), ngoko ke uhlala usabela kakuhle kunyango lokuthintela iihomoni . Le yenye yezona nzuzo ziphambili zolu hlobo lomhlaza. Kukho iindlela ezahlukeneyo zonyango:

• Unyango lweHormone-Blocker: Oku kuquka ukunika amayeza athintela ukusebenza kweehomoni (i-estrogen, i-progesterone) ezinceda ukukhula kweeseli zomhlaza. Amayeza afana neTamoxifen kunye neAromatase Inhibitors asetyenziswa kakhulu koku.Unyango lokuSuswa kwamaqanda lunokwenziwa.
• Utyando: Kule meko, iiseli zomhlaza ziyasuswa ebeleni. Oku kungenziwa ngeendlela ezimbini:
• Ukususwa kwethumba elinomhlaza: Ukususwa kwethumba elinomhlaza kuphela kunye nenani elincinci lezicubu eziphilileyo ezijikeleze lona.
• Ukususwa kwebele lonke: Ukususwa kwebele lonke.

Ukuba loluphi utyando olufanelekileyo luxhomekeke kwizinto ezifana nobukhulu kunye nokusasazeka komhlaza.

• Unyango lweMisebe: Emva kotyando, unyango lweMisebe lunokunikezelwa ukutshabalalisa naziphi na iiseli zomhlaza ezinokuthi zihlale kuloo ndawo.
• Unyango lweKhemotherapy: Amayeza eKhemotherapy adla ngokusebenza kakuhle kwimihlaza ekhula ngokukhawuleza. Umhlaza weLuminal A ukhula kancinci, ngoko ke ayinguye wonke umntu ofuna ikhemotherapy. Nangona kunjalo, abanye abantu (umzekelo, ukuba umhlaza usasazeke kwi-lymph nodes okanye ukuba umhlaza mkhulu kakhulu) banokungenelwa yikhemotherapy. Ugqirha wakho we-oncologist uza kukuxelela ukuba uyayifuna na le nto.

Rhoqo, kudityaniswa olunye okanye ngaphezulu kwezi ndlela zonyango. Ngokusekelwe kulwazi olukwingxelo yakho ye-biopsy, ugqirha wakho uya kudala isicwangciso sonyango esifanelekileyo kuwe.

Ithini ingqikelelo yabo banomhlaza webele weLuminal A?

Nazi iindaba ezithuthuzelayo. Xa kuthelekiswa nezinye iintlobo zomhlaza webele, umhlaza webele iLuminal A unembono engcono kakhulu .

Nangona kunjalo, uqikelelo lwakho luxhomekeke kubungakanani bomhlaza xa ufunyaniswa, ukuba ukhula ngokukhawuleza kangakanani, nokuba usasazeke na kwamanye amalungu omzimba. Okukhona unyango luqalwa ngokukhawuleza, kokukhona uqikelelo luba ngcono.

Umhlaza webele unganyangwa ngokupheleleyo ngonyango (remission). Kwakhona, ukuba ufunyenwe kwangethuba (amatyala akwinqanaba lokuqala), unganyangwa ngokupheleleyo (uyanyangeka).

Amanqanaba okusinda kwabasindileyo kumhlaza webele weLuminal A

Izinga lokusinda kweminyaka emihlanu kolu hlobo lomhlaza webele limalunga nama -95% . Oko kuthetha ukuba abantu abangama-95 kwabayi-100 abafunyaniswe benale sifo baya kube bephila emva kweminyaka emihlanu.

Nangona kunjalo, la mazinga okusinda asekelwe kuphela kwiziphumo zabanye ababenaso esi sifo ngaphambili. Azichazi imeko yakho. Thetha nogqirha wakho ukuze ufumane indlela la mazinga asebenza ngayo kwimeko yakho.

I-Luminal A iyinciphisa njani ingozi yokuba nomhlaza webele?

Asinakuthintela ezinye izinto ezinobungozi, njengembali yosapho yomhlaza. Nangona kunjalo, ukwenza ezi zinto kunokunceda ukunciphisa umngcipheko wakho womhlaza:

• Kuphephe ukutshaya nokutshaya nge-vaping.
• Yitya iziqhamo, imifuno, kunye neenkozo ezipheleleyo ezininzi.
• Yandisa umthambo. Kulungile ukuzilolonga ubuncinane imizuzu engama-30 ngosuku.
• Nciphisa ukusetyenziswa kotywala.
• Gcina ubunzima bakho busempilweni.

Ndingazinyamekela njani?

Kuqhelekile ukuba neemvakalelo ezahlukeneyo xa unomhlaza. Kulungile ukuva nantoni na oyivayo. Ngezinye iintsuku ungaziva uphilile. Ngezinye iintsuku ungasafuni nokuvuka ebhedini. Kubalulekile ukumamela umzimba wakho. Ezi ngcebiso zinokukunceda:

• Yitya iziqhamo, imifuno, kunye neenkozo ezipheleleyo ezininzi.
• Lala kamnandi.
• Lawula uxinzelelo ngezinto ezifana neyoga, ukucamngca, okanye unyango lobugcisa.
• Phumla xa ufuna ukuphumla.
• Funa inkxaso kwiiNkqubo zoLondolozo loMhlaza.
• Thetha nabanye abantu abanesifo esifana nesakho. Oku kungaba ngumthombo omkhulu wamandla.

Ndifanele ndimbone nini ugqirha wam?

Uza kubona ugqirha wakho rhoqo ukuze ahlolwe rhoqo. Nangona kunjalo, ukuba ufumanisa naziphi na iimpawu ezintsha , okanye ukuba iimpawu zakho zangoku ziya zisiba mandundu, qiniseka ukuba wazise ugqirha wakho.

Ndingayibuza yiphi imibuzo ugqirha wam?

Ukuba unomhlaza webele weLuminal A, ungabuza ugqirha wakho le mibuzo:

• Leliphi inqanaba (ibanga okanye inqanaba) lomhlaza endinalo?
• Ingaba umhlaza usasazeke nakwezinye iindawo?
• Loluphi unyango olucebisa uhlobo lomhlaza webele endinalo?
• Ingaba unyango luza kuthatha ixesha elingakanani?
• Kuza kufuneka ndize kangaphi kuvavanyo?
• Ngaba kukho naziphi na iziphumo ebezingalindelekanga zonyango?

Sithini isigidimi esifuna ukusithatha sibuyele ekhaya kweli bali?

I-Luminal Umhlaza webele luhlobo lomhlaza olunesimo esihle kakhulu sokuqikelela ukuba uza kuqatshelwa xa unyangwa . Yiyo loo nto. Nangona kunjalo, ukufunyanwa unomhlaza sisiganeko esitshintsha ubomi. Ngelo xesha, unokufumana iimvakalelo ezahlukeneyo, kuquka uloyiko kunye nosizi. Konke kuqhelekile.

Eyona nto ibalulekileyo kukuhlala uzolile, ufumane ulwazi olufanelekileyo, kwaye ulandele iingcebiso zikagqirha wakho. Fumana inkxaso kusapho lwakho nakubahlobo bakho, abakuthandayo. Thetha nogqirha wakho malunga naluphi na uloyiko okanye iinkxalabo onokuba nazo. Angachaza uhlobo lomhlaza onalo kunye neendlela ezilungileyo zonyango kuwe.

Khumbula, awuwedwa. Ukuba ufunyenwe kwangethuba kwaye unyangwa ngokufanelekileyo, umhlaza webele weLuminal A unethuba eliphezulu lokunyangeka!

"I-Luminal A, Umhlaza Webele, Unyango LweeHormone, Iimpawu Zomhlaza, Unyango Lomhlaza, Impilo Yabasetyhini, Ukwazisa Ngomhlaza