Ndiyazi ukuba kunzima ukuchaza ngamazwi indlela ovakalelwa ngayo xa ugqirha wakho ekuxelela ukuba unomhlaza webele. Kuqhelekile ukuba nemibuzo emininzi kunye noloyiko oluza engqondweni yakho. Kodwa enye yezona zinto zibalulekileyo ezinokukunceda kolu hambo lunzima kukuqonda uhlobo lomhlaza wakho. Ukwazi inqanaba lomhlaza, uhlobo lwawo, ubungakanani bawo, kunye nezinye zeeproteni ezikwiiseli zakho zomhlaza kubaluleke kakhulu ekuthatheni isigqibo ngonyango.
Ngamafutshane, yintoni i-HER2-Negative?
Masiqonde oku ngolu hlobo. Iiseli emzimbeni wethu zifana nezindlu ezincinci. Ezi zindlu zine-'antenna' ezikhethekileyo ezifumana imiyalezo evela ngaphandle. Kwizonyango, sizibiza ezi receptors. Kukwezi antenna apho iseli ifumana imiyalezo efana 'nokukhula' kunye 'nokwahlulwa'.
I-HER2 (i-Human Epidermal Growth Factor Receptor 2) yenye yee-antenna ezikhethekileyo. I-HER2 inceda ukulawula ukukhula kweeseli eziphilileyo. Nangona kunjalo, iiseli zomhlaza ngamanye amaxesha zenza kakhulu le antenna ye-HER2, ngaphezu kwesiqhelo. Emva koko umhlaza ufumana umyalezo oqhubekayo othi 'ukhule', kwaye umhlaza uqala ukusasazeka ngokukhawuleza. Le meko siyibiza ngokuba yi -HER2-Positive .
Ngoko ke, ukuba ugqirha wakho uthi umhlaza wakho webele awunayo i-HER2 , oko kuthetha ukuba iiseli zakho zomhlaza azinalo olu phawu lwe-HER2. Ngamafutshane, umhlaza wakho awunayo into ebalulekileyo ewenza ukhule ngokukhawuleza.
Ezi ziindaba ezimnandi ngokwenene, kuba umhlaza we-HER2-negative awudla ngokuba yingozi kangako kune-HER2-positive cancers. Uninzi lomhlaza webele ehlabathini luhlelwa njenge-HER2-negative.
Ungazi njani kanye kanye imeko yomhlaza wakho we-HER2?
Iimpawu zomhlaza we-HER2-negative kunye ne-HER2-positive ziyafana. Ugqirha wakho akanakukuxelela ukuba loluphi uhlobo onalo ngokukuxilonga nje. Kuya kufuneka athathe isampuli encinci yethumba lakho (i-biopsy) aze alivavanye. Olu vavanyo luya kuqinisekisa ukuba ingakanani na iproteni ye-HER2 ekwiiseli zomhlaza.
Sifanele sijonge okungaphezulu kune-HER2 kuphela!
I-HER2 ayisiyonto yodwa echaphazela ukukhula komhlaza. Kukho ezinye iintlobo ezimbini zee-receptors ( ii-hormone receptors - i-HR) emzimbeni wethu ezivakalelwa zii-hormone.
- Ii-Estrogen Receptors (ER)
- IiReceptors zeProgesterone (PR)
Ukuba ezi receptors zikhona kwiiseli zomhlaza, iihormone i-estrogen kunye ne -progesterone zinokunceda umhlaza ukhule. Oogqirha bathetha ngazo zonke ezi receptors kunye. Oku kuthetha ukuba umhlaza wakho we-HER2-negative unokwahlulwahlulwa ube ziintlobo ezimbini:
1. HR-Positive / HER2-Negative: Oku kuthetha ukuba umhlaza awuchaphazeleki yiHER2, kodwa uchaphazeleka yihomoni. Olu lolona hlobo luqhelekileyo lomhlaza webele.
2. I-HR-Negative / I-HER2-Negative: Oku kuthetha ukuba umhlaza awunangxaki kwi-HER2 okanye kwiihomoni. Ngenxa yokuba zonke ezi receptors zintathu (i-HER2, i-ER, i-PR) azikho, olu hlobo lukwabizwa ngokuba yi- Triple Negative .
Ukwazi zonke ezi zinto kuya kukunceda wena nogqirha wakho nifumane umfanekiso ocacileyo wendlela umhlaza wakho oziphatha ngayo, nto leyo eya kukunceda ukhethe unyango olufanelekileyo nolusebenzayo kuwe.
Ziziphi iindlela zonyango zomhlaza we-HER2-negative?
Ngenxa yokuba umhlaza wakho awunayo i-HER2, awuyi kunikwa unyango olujoliswe kulo, olujolise kwiproteni ye-HER2. Kungenxa yokuba amayeza kufuneka abe ne-antenna ye-HER2 kwiiseli zomhlaza ukuze asebenze. Endaweni yoko, ezinye iindlela zonyango ziya kukhethwa ngokusekwe kwinqanaba lomhlaza wakho kunye nokuba ingaba uvakalelwa na ngamahomoni.
- Utyando kunye nemitha: Ukuba umhlaza ufunyenwe kwangethuba, utyando lunokuwususa ngokupheleleyo. Unyango ngemitha lunokucetyiswa ngaphambi okanye emva kotyando.
- Unyango lwe-Endocrine/ Hormone : Olu nyango lubaluleke kakhulu ukuba umhlaza wakho une-HR-Positive/HER2-Negative. Lusebenza ngokunciphisa amanqanaba eehomoni ezifana ne-estrogen emzimbeni. Xa iihomoni ziphelile, iiseli zomhlaza zilahlekelwa ngumyalezo wokukhula, kwaye umhlaza unokuncipha okanye uyeke ukukhula.
- Unyango lweKhemotherapy: Unyango lweKhemotherapy ngamanye amaxesha lunokunikwa kunye nonyango lwehomoni kubantu abane-HR-positive/HER2-negative cancers. Oku kuxhomekeke kwizinto ezifana nenqanaba kunye nenqanaba lomhlaza, ubudala bakho, kunye nempilo yakho iyonke. Ngamanye amaxesha iziphumo ebezingalindelekanga zekhemotherapy zinokuba ngaphezu kweenzuzo, ngoko ke kubalulekile ukuthetha nogqirha wakho malunga nokuba yintoni ekulungeleyo.
- Unyango lwe-Immunotherapy: Ukuba umhlaza wakho awunayo imiphumo emihle kwaye uphucukile, kwaye unenye iproteni ebizwa ngokuba yi-PD-L1, olu nyango lunokuba lukhetho. Lusebenza ngokuvuselela amasosha omzimba wakho ukulwa nomhlaza.
Imbono kunye nokuqikelela
Eyona nto ibalulekileyo ngomhlaza webele kukuwufumana ngaphambi kokuba usasazeke kwezinye iindawo zomzimba. Ukuba umhlaza wakho we-HER2-negative ufumaneka ebeleni, izinga lokusinda kweminyaka emi-5 liphezulu kakhulu. Oku kuyinyani ngakumbi ukuba umhlaza wakho une-HR-positive.
Umhlaza one-triple-negative kunzima ukuwunyanga kuba awusabeli kunyango lwe-hormone okanye kunyango olujoliswe kwi-HER2. Usenokuba nomsindo ngakumbi.
Apha ngezantsi kukho amazinga okusinda eminyaka emi-5 ngokusekwe kwinqanaba lomhlaza. Le yimilinganiselo nje, khumbula ukuba imeko yakho isenokuba yahlukile.
| Uhlobo lomhlaza | Indlela esasazeke ngayo | ukusinda kweminyaka emi-5 |
|---|---|---|
| I-HR-Positive / HER2-Negative (Uhlobo oluqhelekileyo) | Kulinganiselwe kwibele (Eyasekhaya) | 100% |
| Sasaza kwiindawo ze-lymph ezikufutshane (zengingqi) | 90% | |
| Kude | 31% | |
| I-Triple-Negative (HR-Negative / HER2-Negative) | Kulinganiselwe kwibele (Eyasekhaya) | 91% |
| Sasaza kwiindawo ze-lymph ezikufutshane (zengingqi) | 65% | |
| Kude | 12% |
Musa ukoyika ngala manani. La ngamanani aphakathi nje avela kumawaka abantu. Imbono yakho iya kuxhomekeka kwizinto ezininzi, kuquka indlela umzimba wakho osabela ngayo kunyango kunye nempilo yakho iyonke. Ngoko ke, vuleleka kugqirha wakho malunga nemeko yakho kunye nazo naziphi na iimvavanyo ezongezelelweyo onokuzifuna.
Umyalezo Wokuya Ekhaya
- I-HER2-Negative ithetha ukuba iiseli zakho zomhlaza azinazo iiproteni ezibalulekileyo ezenza zikhule ngokukhawuleza. Oku kudla ngokwenza ezi cancer zingabi namandla kangako.
- Nokuba umhlaza wakho awunayo i-HER2, ukwazi ukuba unovelwano kwiihomoni (HR-positive) okanye akunjalo (HR-negative) kubalulekile ekumiseleni unyango.
- Iindlela zonyango zixhomekeke kuhlobo kunye nenqanaba lomhlaza, kunye nempilo yakho. Utyando, unyango ngemitha, unyango lwehomoni, kunye ne-chemotherapy zezona ndlela ziphambili zonyango.
- Olu dabi nomhlaza akuyonto omele uyenze wedwa. Thetha nogqirha wakho ngayo yonke imibuzo yakho kunye noloyiko lwakho. Ukuba nolwazi olufanelekileyo yeyona nto inokukunceda kakhulu kolu hambo.
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