Xa oogqirha baqinisekisa ukuba unomhlaza webele, ndingayicinga indlela omele ukuba waziva ngayo woyika, wothuka, kwaye ulusizi. Kukho imibuzo emininzi efika engqondweni ngexesha elinjalo. Kodwa xa ugqirha wakho esithi igama elifana nelithi 'HER2-Positive', kumele ukuba lenza ingqondo yakho ixhalabe ngakumbi. "Lithini elo gama? Lithetha ukuba imeko yam imbi kakhulu?" Kuqhelekile ukuba kufike izinto eziliwaka engqondweni. Yiyo loo nto namhlanje siza kuthetha ngokuba yintoni le mhlaza webele 'HER2-Positive', ithetha ukuthini, kwaye zeziphi iindlela zokuwunyanga ngendlela elula kakhulu onokuyiqonda.
Yintoni 'iHER2'?
Ngamafutshane, i-HER2 yiproteni enceda ekukhuleni kweeseli zebele emzimbeni wethu. Igama layo elipheleleyo yi-``Human Epidermal Growth Factor Receptor 2``. Le proteni ikhona kwiiseli zebele zomntu ophilileyo ngomlinganiselo othile, olawulwayo. Inceda iiseli zahlulwe kwaye zikhule ngendlela ehlelekileyo.
Nangona kunjalo, kwezinye ii-cancer zamabele, ngenxa yesiphene kwi-gene eyenza i-HER2 protein, le protein iveliswa ngokugqithisileyo. Kufana nokunyathela i-accelerator yemoto. Emva koko, ngokungathi imoto ihamba ngokukhawuleza, ezi seli zomhlaza ziqala ukwahlukana kwaye zikhule ngokukhawuleza, ngaphandle kolawulo. Isizathu esiphambili sokuba umhlaza ube mandundu kukuveliswa kweproteni ngokugqithisileyo.
Ngoko ke, ukuba umhlaza wakho 'une- HER2-positive ', oko kuthetha ukuba kukho iproteni yokukhula engaphezulu ebizwa ngokuba yi-HER2 kumphezulu weeseli zomhlaza wakho.
Ndingayazi njani ukuba ine-HER2-positive?
Xa ukrokrela ukuba unomhlaza webele, ugqirha wakho usenokucebisa ukuba kwenziwe i-biopsy. Njengoko usenokuba ukhumbula, oku kuquka ukuthatha iqhekeza elincinci lesicwili uze ulithumele kwilebhu ukuze livavanywe. Le sampulu yesicwili emva koko iyahlolwa ukuze kufunyaniswe uhlobo lomhlaza oluchanekileyo.
Eyona nto iphambili ejongwayo kolu vavanyo yimeko ye-HER2. Kwakhona, enye into ebalulekileyo iyajongwa. Oko kukuthi, ingaba umhlaza uyachaphazeleka na zii-hormone. Oko kukuthi, ingaba umhlaza ukhula ngenxa yee-hormone `(Estrogen)` kunye `(Progesterone)`. Emva kokujonga konke oku, ugqirha ugqiba ukuba yeyiphi indlela yonyango efanelekileyo nephumelelayo kuwe.
Masichaze ngakumbi ngento esiyivavanyayo.
| I-Marker | Ithini loo nto? |
|---|---|
| Imeko ye-HER2 | Iiseli zomhlaza ziyavavanywa ukuze kubonwe ukuba zineproteni yeHER2 eninzi (eyakhayo) okanye azinayo (eyakhayo). Ukuba ilungile, oko kuthetha ukuba le proteni inceda iiseli zomhlaza zikhule ngokukhawuleza. |
| Isimo seHormone Receptor | Bajonga ukuba iiseli zomhlaza zinazo na ii-receptors zeehomoni ze-estrogen okanye ze-progesterone. Ukuba ezi zilungile, ezo homoni zinceda umhlaza ukuba ukhule. |
Iziphumo zezi mvavanyo ziya kumisela uhlobo lomhlaza onawo. Umzekelo, i-HER2-positive okanye i-Hormone Receptor-negative. Lonke olu lwazi lubalulekile ekukuncedeni uphuhlise isicwangciso sakho sonyango .
Ngubani ofumana umhlaza one-HER2-positive? Ingaba uyingozi?
Umhlaza webele one-HER2-positive unokwenzeka kwabasetyhini kunye nakumadoda, kwaye unqabile kakhulu kumadoda. Uxhaphake kakhulu kubafazi abangaphantsi kweminyaka engama-50. Isizathu esichanekileyo asikaziwa okwangoku.
Ngoku masingene kumbuzo obalulekileyo engqondweni yakho: Ngaba oku kuyingozi?
Inyaniso kukuba, umhlaza we-HER2-positive unokuba nesantya sokukhula esiphezulu kancinci. Oku kuthetha ukuba ezi seli zomhlaza zinotyekelo oluphezulu lokuqhekeka okanye ukusasazeka ngokukhawuleza.
Kodwa, ungoyiki! Oku kufuneka ukukhumbule. Ewe, olu hlobo lomhlaza lunokukhawuleza. Kodwa iindlela zonyango ezisebenzayo nezijolise kuzo ziphuhlisiwe namhlanje ezilungele loo nto. Ngoko ke, akukho sizathu sokoyika igama elithi "ukukhawuleza".
Unyango kunye nethemba lokuchacha
Ezi zezona ndaba zibalaseleyo kweli nqaku. Kwiminyaka emalunga nama-20 eyadlulayo, umhlaza webele one-HER2-positive wawuthathwa njengemeko enzima nenzima ukunyanga. Kodwa ngokuhambela phambili kwesayensi yezonyango, imeko itshintshe ngokupheleleyo namhlanje.
Izazinzulu zifumene inani lamayeza akhethekileyo anokujolisa kwaye athintele umsebenzi wale protein ye-HER2. Oku kubizwa ngokuba yi-" targeted therapy.")`. Ukuchaneka, la mayeza aya ngqo kwiproteni ye-HER2 ekhoyo ngokugqithisileyo, ethintela uphawu olufunyanwa ziiseli zomhlaza ukuze "zikhule ngokukhawuleza." Oku kufana nokufaka iibhuleki kwimoto ebaleka ngesantya esiphezulu.
Ngenxa yezi ndlela zonyango ezijoliswe kuzo, ithuba lokuba umntu onomhlaza webele one-HER2 aphiliswe ngokupheleleyo ngoku liphezulu kakhulu, xa kuthelekiswa namazinga okunyangwa komhlaza oqhelekileyo oxhomekeke kwiihomoni.
Kwenzeka ntoni emva konyango?
Emva kokugqiba unyango, ugqirha wakho uya kuqhubeka ekujonga. Amaxesha amaninzi, umhlaza ungabuya okanye usasazeke kwezinye iindawo zomzimba. Ukuba oku kuyenzeka, ugqirha wakho uya kwenza olunye uvavanyo. Oku kungenxa yokuba uhlobo lomhlaza lunokutshintsha ngamanye amaxesha ngokuhamba kwexesha. Umzekelo, umhlaza owawune-HER2-positive ngaphambili unokubuya kwaye ube yi-HER2-negative. Ke ngoko, unyango luhlala lusekelwe kwimeko yamva nje.
Ngoko ke, susa uloyiko lwakho. Ewe, igama elithi umhlaza liyoyikisa. Kodwa i-HER2 -Positive yimeko enyangekayo nenyangekayo namhlanje.
Umyalezo Wokuya Ekhaya
- Umhlaza webele one-HER2-positive uyenzeka xa iiseli zomhlaza zivelisa iproteni eninzi (HER2) ekhawulezisa ukukhula.
- Le meko ifunyaniswa ngokuhlola isampuli yezicubu kwi-biopsy yakho.
- Nangona olu hlobo lomhlaza lukhula ngokukhawuleza, akukho mfuneko yokuloyika.
- Kule mihla, kukho iindlela zonyango ezijolise ngqo eziphumelele kakhulu ezenzelwe le njongo. Ngenxa yoko, amathuba okuchacha aphezulu kakhulu.
- Thetha ngokukhululekileyo nogqirha wakho ngayo nayiphi na imibuzo, uloyiko, okanye amathandabuzo onokuba nawo. Kulapho uza kufumana khona ulwazi oluchanekileyo kunye noncedo olungcono.
- Awuwedwa. Ukuba unengqondo eqinileyo kwaye ufumene unyango olufanelekileyo, ungayoyisa le ngxaki.
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