Kuqhelekile ukuba nabani na azive esoyika kwaye exhalabile xa efunyaniswa ukuba unomhlaza. Kodwa eyona nto ibalulekileyo ekufuneka uyazi kukuba njengoko isayensi yezonyango iqhubeka ihambela phambili, ngoku kukho unyango olutsha nolusebenzayo lomhlaza . Namhlanje siza kuthetha ngonyango olutsha noluphambili. Igama leli yeza yiLarotrectinib. Olu lunyango olujoliswe kulo oluye lwenzelwe ngokukodwa iintlobo ezithile zomhlaza .
Ngamafutshane, yintoni iLarotrectinib?
Cinga ngeeseli zomhlaza njengohlobo lwekhula olusasazeka ngokungalawulekiyo. Kukho 'iswitshi' ekhethekileyo enceda olu khula lukhule kwaye lusasazeke. Olu 'switshi' yinto esiyibiza ngokuba yiproteni kumayeza. Eli yeza elibizwa ngokuba yiLarotrectinib lenza into ekrelekrele kakhulu. Liya ngqo 'kwiswitshi' enceda iiseli zomhlaza zikhule, oko kukuthi, loo protein ikhethekileyo. Liyayicima. Emva koko iiseli zomhlaza zilahlekelwa okanye zinciphise kakhulu amandla azo okwahlukana, ukukhula, nokusasazeka kwamanye amalungu omzimba.
Oku akufani namayeza omhlaza aqhelekileyo. Amayeza aqhelekileyo ngamanye amaxesha anokonakalisa iiseli ezisempilweni emzimbeni. Kodwa olu hlobo lonyango olujoliswe kulo luwonakalisa kakhulu iiseli zomhlaza kuphela. Ke ngoko, iziphumo ebezingalindelekanga zinokuncitshiswa. Eli yeza linokufumaneka kwimarike phantsi kwegama le- VITRAKVI .
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza
Ngaphambi kokuba ukunike eli yeza, ugqirha wakho kuya kufuneka azi imeko yakho yempilo epheleleyo. Ngoko ke, ukuba unenye yezi meko zilandelayo, qiniseka ukuba uxelela ugqirha wakho ngazo. Musa ukufihla nantoni na, kuba ibaluleke kakhulu kukhuseleko lwakho.
- Isifo sesibindi : Ukuba unesifo sesibindi esele sikhona, nceda usixelele ngaso.
- Ukuphazamiseka kwemithambo-luvo : Ukuba uziva ungenamandla kwiminwe okanye ezinzwaneni zakho, okanye ukuba unesinye isifo semithambo-luvo , nceda usazise.
- Iingxaki zokunganyamezelani komzimba :Ukuba une-allergies, kungekuphela nje kwiLarotrectinib, kodwa nakweyiphi na enye imithi, ukutya, idayi, okanye isithinteli se-preservative , qiniseka ukuba usixelele ngayo.
- Ukukhulelwa : Le yingxaki ebaluleke kakhulu ukuba ukhulelwe, uzama ukukhulelwa, okanye ukuba iqabane lakho lizama ukukhulelwa.
- Ukuncancisa: Ukuba ungumama oncancisa umntwana wakho, kufuneka uxelele ugqirha.
Khumbula, impumelelo kunye nokhuseleko lonyango lwakho kuxhomekeke ekuchanekeni kolwazi olunika ugqirha wakho.
Ndingayisebenzisa njani kanye kanye le yeza?
Emva kokuba ugqirha wakho ekunike eli yeza, kubaluleke kakhulu ukwazi kakuhle indlela yokulisebenzisa.
- Eli yeza liza likwimo yeekhaphu. Ufanele ulisele neglasi yamanzi.
- Zama ukusela amayeza akho ngexesha elifanayo yonke imihla , njengoko ugqirha wakho ekuyalele. Oku kuya kunceda ukugcina amanqanaba afanayo amayeza emzimbeni wakho.
- Ungaze uwaphule, uwatyumze, okanye uwahlafune. Ama-pods afanele aginywe aphelele.
- Eli yeza lingasetyenziswa ngaphambi okanye emva kokutya. Nangona kunjalo, ukuba ufumana ukungakhululeki esiswini okanye isicaphucaphu emva kokusela iyeza, kungcono ukulisela kunye nesidlo esincinci.
- Qhubeka usela amayeza de ugqirha wakho akuxelele ukuba uyeke. Musa ukuyeka phakathi.
- Kubaluleke kakhulu: Musa ukusela ijusi yegrapefruit ngelixa usebenzisa eli yeza. Ijusi yegrapefruit inokudibana neli yeza kwaye yonyuse inani leyeza emzimbeni wakho. Oku kunokunyusa umngcipheko weziphumo ebezingalindelekanga.
Ngaba eli yeza linokunikwa abantwana abancinci?
Ewe, kwezinye iimeko ezikhethekileyo, oogqirha banika abantwana eli yeza. Kodwa kukho amanyathelo akhethekileyo okhuseleko abandakanyekayo. Ngoko ke, ukuba unika umntwana eli yeza, thetha nogqirha ngononophelo kwaye ufumane ingcebiso.
Wenza ntoni ukuba uthatha amayeza amaninzi kakhulu?
Ukuba ukrokrela ukuba usele amayeza amaninzi kunokuba ucinga, thatha inyathelo ngokukhawuleza ngaphandle kokuthandabuza.
1. Fowunela iZiko loLwazi lweZityhefu zeSizwe kwiSibhedlele sikaZwelonke saseColombo ngoko nangoko.
2. Okanye, yiya kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane ngokukhawuleza.
Eli liyeza elinikwa wena wedwa. Ungaze unike omnye umntu amayeza akho.
Kuthekani ukuba ndiphoswa lidosi leyeza?
Ukulibala ukusela amayeza akho yinto enokwenzeka nakubani na. Ukuba oko kuyenzeka, ungakhathazeki.
- Sela idosi oyiphosileyo ngokukhawuleza nje ukuba uyakhumbula.
- Kodwa,Ukuba kungaphantsi kweeyure ezi-6 ngaphambi kokuba uthathe idosi elandelayo xa ukhumbula, yiyeke yonke idosi oyiphosileyo. Thatha nje idosi yakho elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe iidosi ezimbini ngaxeshanye, kuquka nelo uphosileyo.
- Ukuba uyahlanza emva kokusela iyeza, yiyeke loo dosi uze uthathe idosi elandelayo ngexesha elicwangcisiweyo.
Ezinye izinto ezinokusebenzisana nale mithi (Intsebenziswano)
I-Larotrectinib liyeza elinokunxibelelana namanye amayeza nokutya. Ngoko ke, xelela ugqirha wakho ngawo onke amayeza owasebenzisayo, kungekuphela nje lawo amiselwe ngugqirha, kodwa kunye neepilisi zokudambisa iintlungu, iivithamini, iziqholo zesintu, amayeza e-Ayurvedic, kunye nezongezo zokutya ozithengayo kwikhemesti. Kwakhona xelela ugqirha wakho ukuba utshaya okanye usela utywala.
Ngezantsi zezinye zezinto ezinokudibana nale mithi. Olu luhlu aluphelelanga.
| Uhlobo lweyeza/into | Imizekelo |
|---|---|
| Ezinye iintlobo zee-antibiotics | IClarithromycin, iTelithromycin |
| Amayeza osulelo lwefungus | I-Itraconazole, iKetoconazole, iVoriconazole |
| Amanye amayeza okunyanga isifo sokuwa | I-Carbamazepine, iPhenytoin, iPhenobarbital |
| Amanye amayeza okulwa ne-HIV/AIDS | Buza ugqirha. |
| Amayeza okuthintela amajoni omzimba | I-Cyclosporine, iSirolimus, iTacrolimus |
| Amanye amayeza esifo sentliziyo | IDisopyramide, iDofetilide |
| Ezinye izinto ezibalulekileyo | Ijusi yegrapefruit, iSt. John's wort |
Izinto ekufuneka uzilumkele ngakumbi xa usebenzisa amayeza
- Ukujonga ugqirha: Ugqirha wakho uza kukujonga ngokusondeleyo ngelixa usela la mayeza. Qiniseka ukuba uya ekliniki ngemihla emiselweyo kwaye wenze naluphi na uvavanyo lwegazi olufunekayo.
- Ukudinwa Nokukhathalela: Eli yeza linokubangela isiyezi, ukozela, kunye nobunzima bokugxila kwabanye abantu. Ngoko ke, ziphephe izinto ezifuna ukuphaphama, njengokuqhuba okanye ukusebenzisa oomatshini abanzima, ude wazi ukuba eli yeza likuchaphazela njani.
- Xa uphakama kwindawo ohleli kuyo okanye olele kuyo, phakama kancinci. Ukuba uphakama ngequbuliso, ungaziva unesiyezi uze uwe. Ukusela utywala kunokuyenza mandundu le meko.
- Ukukhulelwa kunye nolawulo lokuzalwa (kubaluleke kakhulu):
- Kwabasetyhini: Ukuba sele ufikelele kwiminyaka yokuzala, kufuneka wenze uvavanyo lokukhulelwa ukuqinisekisa ukuba awukhulelwanga ngaphambi kokuba uqale eli yeza. Kufuneka usebenzise uhlobo lokulawula ukukhulelwa olusebenza kakuhle kakhulu kulo lonke ixesha lonyango kwaye iveki enye emva kokuyeka ukusebenzisa eli yeza . Thetha nogqirha wakho ngendlela efanelekileyo kuwe.
- Kwabesilisa: Ukuba iqabane lakho liyakwazi ukukhulelwa, kubalulekile ukusebenzisa ikhondom ngalo lonke ixesha nisenza ucansi ngelixa nisela eli yeza kwaye iveki enye emva kokuyeka ukusebenzisa eli yeza.
- Ukuncancisa: Kuphephe ukuncancisa umntwana wakho ngelixa usebenzisa eli yeza kwaye iveki enye emva kokuba uyekile iyeza.
- Ukuzala: Eli yeza lisenokuchaphazela amandla akho okufumana abantwana (ukungazali). Ukuba uneengxaki malunga noku, thetha nogqirha wakho ngaphambi kokuba uqale unyango.
Iziphumo ebezingalindelekanga zeyeza
Njengalo naliphi na iyeza, i-larotrectinib inokubangela ezinye iziphumo ebezingalindelekanga. Ezinye zezi zinokuba yingozi, ngoko ke kubalulekile ukuba uzazi.
| Iziphumo ebezingalindelekanga ekufuneka uzixele kugqirha wakho ngoko nangoko | |
|---|---|
| Iimpendulo ze-allergy | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi okanye umqala. |
| Iimpawu zokulimala kwesibindi | Intlungu kwicala eliphezulu lasekunene lesisu, ukuphelelwa ngumdla wokutya, isicaphucaphu, indle ekhanyayo, umchamo otyheli okanye omdaka omnyama, ukutyheli kwamehlo okanye ulusu, kunye nokudinwa kakhulu. |
| Utshintsho lwengqondo kunye nokuziphatha | Ukuxhalaba okugqithisileyo, ukungazinzi, ukudideka, ukubona izinto ezingekhoyo, umsindo, iingcinga zokuzibulala, kunye noxinzelelo olukhulu. |
| Iingxaki zenkqubo yemithambo-luvo | Ukuba ndindisholo okanye iintlungu emalungeni, ubuthathaka bemisipha, utshintsho embonweni, ubunzima bokuthetha, ukulahlekelwa yibhalansi, ubunzima bokuhamba, ukuxhuzula. |
| Izinto ezingaqhelekanga ukuba zimbi, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| |
Ugcina kwaye ulahla njani amayeza?
- Indawo yokugcina: Gcina amayeza kude nabantwana nezilwanyana zasekhaya.Gcina kubushushu begumbi (phakathi kwama-20-25 degrees Celsius). Musa ukusebenzisa amayeza aphelelwe lixesha.
- Ukulahlwa: Eyona ndlela ilungileyo yokulahla amayeza aphelelwe lixesha okanye angafunekiyo kukuwanikela kwinkqubo yokubuyisela amayeza esibhedlele okanye kwiikhemesti. Ukuba oko akunakwenzeka, susa iikhaphu kwisikhongozeli, uzixube nento efana nekofu esetyenzisiweyo, umhlaba, okanye inkunkuma yekati, uze uzibeke kwibhegi okanye kwisikhongozeli esivalwe kakuhle uze uzilahle kwinkunkuma. Ungaze uzihlambe endlwini yangasese. Ukuba awuqinisekanga, buza ugqirha wakho.
Umyalezo Wokuya Ekhaya
- I-Larotrectinib lunyango oluthile, olujoliswe kwiintlobo ezithile zomhlaza.
- Sela amayeza kanye njengoko ugqirha wakho ekuyalele, ngexesha elifanelekileyo. Musa ukuwaphula, ukuwatyumza, okanye ukuwahlafuna.
- Kubalulekile ukwazisa ugqirha wakho malunga nawo onke amanye amayeza, iivithamini, kunye namayeza owasebenzisayo.
- Musa ukusela ijusi yegrapefruit ngokupheleleyo ngelixa usebenzisa eli yeza.
- Ukuba ubona naziphi na iimpawu zeziphumo ebezingalindelekanga ezinzulu (iingxaki zesibindi, iingxaki zemithambo-luvo, ukunganyamezelani okukhulu), yazisa ugqirha wakho ngoko nangoko.
- Kuphephe ukusebenzisa eli yeza ngexesha lokukhulelwa okanye ngexesha lokuncancisa. Kubalulekile ukuba omabini amaqabane asebenzise uhlobo lokulawula ukukhulelwa olusebenza kakuhle ngexesha lonyango.
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