Ngaba wena okanye umntu omaziyo une -hemolytic anemia ebangelwa kukungabikho kwe-enzyme ebizwa ngokuba yi-pyruvate kinase deficiency? Le yimeko engaqhelekanga. Kwiimeko ezinjalo, ugqirha wakho usenokuba ukunike ipilisi ebizwa ngokuba yiMitapivat. Usenokuziva udidekile xa usiva eli gama. Ngoko ke, namhlanje siza kuthetha ngokulula nangobubele ngale yeza ebizwa ngokuba yiMitapivat (igama lophawu elithi PYRUKYND).
Kalula nje, yintoni le Mitapivat?
I-Mitapivat liyeza elikhethekileyo elinikwa ukunyanga i-hemolytic anemia ebangelwa yimeko ebizwa ngokuba yi-pyruvate kinase deficiency. Ngoku usenokuba uzibuza, "Yintoni i-hemolytic anemia?"
Kulula kakhulu. Sinohlobo lweeseli zegazi ezibizwa ngokuba ziiseli zegazi ezibomvu emzimbeni wethu. Ezi seli zithwala ioksijini emzimbeni wethu wonke. Ngokwesiqhelo, ezi seli zibomvu zegazi ziphila malunga neentsuku ezili-120. Nangona kunjalo, emzimbeni womntu onesifo se-pyruvate kinase, ezi seli zibomvu zegazi ziyaqhekeka kwaye zitshatyalaliswe kwangoko, ngokukhawuleza. Yiloo nto ibizwa ngokuba yi-hemolytic anemia.
Ngoko ke, into eyenziwa yiMitapivat kukuthintela ukuqhekeka ngokukhawuleza kweeseli ezibomvu zegazi. Ngokuchanekileyo, inika ezo seli amandla kwaye yandisa ubomi bazo. Oku kwenza ntoni?
- Inani leeseli ezibomvu zegazi emzimbeni liyanda.
- Iimpawu ze- anemia ezifana nokudinwa, ukudinwa rhoqo, kunye nokuphefumla kancinci ziyancitshiswa.
- Isidingo sokutofelwa igazi rhoqo sinciphile.
Oko kuthetha ukuba eli yeza liza kunceda ukuphucula umgangatho wobomi bakho.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba usebenzise eli yeza
Ngaphambi kokuba usebenzise naliphi na iyeza, kubaluleke kakhulu ukunika ugqirha wakho inkcazo epheleleyo yemeko yakho yempilo. Ngaphambi kokuba uqale ukusebenzisa iMitapivat, qiniseka ukuba uxelele ugqirha wakho ukuba unenye yezi meko zilandelayo:
- Isifo sesibindi: Ukuba unesifo sesibindi esele sikhona, nceda usixelele ngaso.
- Iingxaki zokunganyamezelani komzimba :Ukuba une-allergy kwiMitapivat, naluphi na olunye unyango, ukutya, iidayi, okanye izithinteli, qiniseka ukuba usazise.
- Ukukhulelwa : Ukuba ukhulelwe okanye uzama ukukhulelwa kungekudala, thetha nogqirha wakho ngaloo nto.
- Ukuba ungumama oncancisayo: Ukuba ungumama oncancisayo, kufuneka uxelele ugqirha.
Ngokusekelwe kolu lwazi, ugqirha wakho uya kugqiba ukuba eli yeza lifanelekile kuwe okanye ukuba kufuneka kutshintshwe idosi.
Indlela yokusebenzisa amayeza ngokuchanekileyo?
Ukuze ufumane unyango olungcono kakhulu, kubaluleke kakhulu ukulusebenzisa ngokuchanekileyo.
- Eli yeza lipilisi olisela ngomlomo. Zama ukulisela ngexesha elifanayo yonke imihla , kanye njengoko ugqirha wakho ekuyalele.
- Ginya ipilisi yonke ngamanzi. Ungaze uyiqhekeze, uyityumze, okanye uyihlafune.
- Qhubeka usela eli yeza de ugqirha wakho akuxelele ukuba uyeke. Musa ukuyeka ngequbuliso, nokuba uzive ungcono.
- Kunokufuneka unonophelo olukhethekileyo ukuba eli yeza linikwa abantwana. Ngoko ke, landela imiyalelo kagqirha ngokufanelekileyo.
Yintoni omawuyenze ukuba uthatha amayeza amaninzi kakhulu? (Ukusebenzisa amayeza amaninzi kakhulu)
Khawucinge ukuba ngempazamo usele eli yeza elingaphezulu kunelo limiselweyo. Ukuba oko kuyenzeka, ungalibazisi. Yiya kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane ngoko nangoko. Okanye, fowunela iZiko loLwazi lweePoison kwiSibhedlele sikaZwelonke saseColombo ukuze ufumane ingcebiso.
Eli yeza limiselwe wena wedwa. Ungaze ulinike omnye umntu, nokuba lineempawu ezifanayo nezakho.
Kuthekani ukuba ndiphoswa lidosi leyeza?
Ngenxa yokuxakeka kobomi, ngamanye amaxesha ungaphoswa liyeza elithile. Ukuba oko kuyenzeka, nantsi into omawuyenze:
- Sela amayeza akho ngokukhawuleza xa ukhumbula.
- Nangona kunjalo, ukuba uphoswe yidosi ngaphezulu kweeyure ezi-4, yitsibe loo dosi ngokupheleleyo. Thatha idosi yakho elandelayo ngexesha elicwangcisiweyo.
- Musa ukuthatha idosi ephindwe kabini ukuze ubuyisele idosi oyiphosileyo nangasiphi na isizathu.
Amanye amayeza anokusebenza kunye nale mayeza
Amanye amayeza owasebenzisayo anokusebenzisana neMitapivat. Oku kunokutshintsha indlela esebenza ngayo iMitapivat okanye konyuse iziphumo ebezingalindelekanga. Ngoko ke, qiniseka ukuba uxelela ugqirha wakho ngawo onke amayeza owasebenzisayo (kuquka iivithamini, amayeza esintu, kunye namayeza amiselwe ngabanye oogqirha).Xelela ugqirha wakho.
Ngezantsi kukho amayeza anokusebenzisana neMitapivat.
| Udidi lweziyobisi | Imizekelo |
|---|---|
| Amanye amayeza osulelo lwefungus | I-Fluconazole, i-Itraconazole, iKetoconazole |
| I-Efavirenz (iyeza le-HIV) | I-Efavirenz |
| Iihomoni ze-estrogen kunye ne-progestin | Iipilisi zokulawula ukuzala, unyango lweehomoni |
| I-Midazolam | Iyeza elisetyenziselwa ukuthomalalisa okanye ukuthomalalisa i-anesthesia |
| I-Rifampin | I-antibiotic enikwa izifo ezifana nesifo sephepha |
Kubalulekile: Olu luhlu aluphelelanga. Xelela ugqirha wakho ukuba uyatshaya, usela utywala, okanye usebenzisa ezinye iziyobisi.
Izinto ekufuneka uzilumkele xa usebenzisa amayeza
Ngelixa usela eli yeza, ugqirha wakho uza kujonga impilo yakho rhoqo.
- Yiya ekliniki ngexesha elicwangcisiweyo. Oku kubaluleke kakhulu ukuze ubone ukuba uqhuba njani kwaye ukuba amayeza ayasebenza na.
- Ukuba iimpawu zakho aziphucuki, okanye ukuba ziya zisiba mandundu, xelela ugqirha wakho.
- Ungacelwa ukuba wenze uvavanyo lwegazi ngelixa usebenzisa eli yeza. Musa ukulibaleka eli vavanyo kwaye ulwenze rhoqo.
Zithini iziphumo ebezingalindelekanga ezinokubakho?
Njengazo zonke iziyobisi, iMitapivat inokubangela iziphumo ebezingalindelekanga, nangona kungengabo bonke abantu abazifumanayo. Ezinye iziphumo ebezingalindelekanga zinokuba yingozi, ngoko ke kubalulekile ukuba uzazi.
| Imiphumela | Ingcaciso |
|---|---|
| Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha wakho ngoko nangoko | |
| Iimpendulo ze-allergy | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi okanye umqala, ubunzima bokuphefumla. |
| Ukwanda kwe-hemolytic anemia | Ukuziva udiniwe/udiniwe ngaphezu kwesiqhelo, isiyezi, intloko ebuhlungu, ubunzima bokuphefumla, umchamo omnyama, ukutyheli kolusu okanye amehlo. |
| Iimpawu zokulimala kwesibindi | Intlungu kwicala eliphezulu lasekunene lesisu, ukuphelelwa ngumdla wokutya, isicaphucaphu, isitulo esihlala ixesha elide, umchamo otyheli okanye omdaka, ukutyheli kolusu okanye amehlo, ubuthathaka obungaqhelekanga. |
| Xelela ugqirha wakho ukuba iyaqhubeka okanye iyakukhathaza. | |
| Umqolo obuhlungu | |
| Intlungu yamalungu | |
Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ufumana ezinye iimpawu ezingaqhelekanga, thetha nogqirha wakho ngazo.
Ungayigcina njani amayeza ngokukhuselekileyo?
- Gcina kude nabantwana kunye nezilwanyana zasekhaya .
- Gcina kubushushu begumbi (phakathi kwama-20 nama-25 degrees Celsius).
- Gcina iyeza kwisikhongozeli sokuqala elalifunyenwe kuso.
- Ungaze usebenzise amayeza aphelelwe lixesha . Lahla ngokukhuselekileyo.
Xa ususa amayeza aphelelwe lixesha okanye angafunekiyo, kungcono udibane nogqirha wakho. Kungcono ukuwalahla enkunkuma. Ukuba kunjalo, khupha iipilisi ebhotileni, uzixube nento efana nekofu esetyenzisiweyo, umhlaba, okanye inkunkuma yeekati, uze uzifake ebhegini evalwe kakuhle uze uzilahle enkunkuma.
Umyalezo Wokuya Ekhaya
- I-Mitapivat liyeza elikhethekileyo elinyanga i-hemolytic anemia ebangelwa kukungabikho kwe-pyruvate kinase.
- Soloko usela eli yeza kanye njengoko ugqirha wakho ekuyalele, ngexesha elifanelekileyo. Musa ukuphula, ukutyumza, okanye ukuhlafuna iipilisi.
- Nika ugqirha wakho inkcazo epheleleyo ngayo yonke eminye imithi, iivithamini, kunye nezinye iimeko zempilo ozisebenzisayo.
- Funa uncedo lwezonyango ngokukhawuleza ukuba ufumana naziphi na iziphumo ebezingalindelekanga, ezinje ngokugula okanye iimpawu zokonakala kwesibindi.
- Eli yeza limiselwe wena wedwa. Ungaze wabelane ngalo nabanye.
- Ukuba unenkxalabo malunga nale yeza, thetha nogqirha wakho.
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