Mhlawumbi ukhe weva ngamayeza afana neViagra. Uninzi lwabantu luyazi ukuba la ngamayeza anikwa ukungasebenzi kakuhle ngokwesondo. Kodwa ubusazi na ukuba amayeza akwiqela elahlukileyo, abizwa ngokuba yiPhosphodiesterase Inhibitors, asetyenziselwa ukunyanga iimeko ezahlukeneyo, ukusuka kwisifo sentliziyo ukuya kwisifo semiphunga, isifo solusu, kunye nesifo samalungu? Namhlanje, masithethe ngolu hlobo lumangalisayo lwamayeza. Masiqonde nje ukuba ayintoni, asebenza njani, kwaye zeziphi izinto ezilungileyo nezingalunganga.
Ngamafutshane, zithini iiPhosphodiesterase Inhibitors (ii-PDE inhibitors)?
Olu luhlobo lwamayeza andisa imithambo yegazi emzimbeni wethu, anciphise ukuqina kwayo, kwaye enze ukuhamba kwegazi kube lula. Khawuthelekelele ukuba xa umbhobho wamanzi uvalekile, ukuba uwenza ube mkhulu kancinci, amanzi ahamba lula. Oku kunciphisa uxinzelelo lwegazi kwaye kuphucula ukuhamba kwegazi kwiindawo ezahlukeneyo zomzimba. Ngenxa yolu buchule, olu hlobo lwamayeza lusetyenziswa njengonyango lwezifo ezahlukeneyo.
Lisebenza njani eli yeza?
Ukuze sikuqonde oku, kufuneka siqale sazi ngesithunywa esincinci seekhemikhali emzimbeni wethu. Igama laso yiPhosphodiesterases , okanye iPDE ngamafutshane. Le PDE luhlobo lwe -enzyme . Ii-enzymes zifana nabancedisi abancinci abakhawulezisa kwaye baququzelele ezinye iinkqubo zekhemikhali emzimbeni wethu.
Kukho iintlobo ezahlukeneyo zezi enzymes ze-PDE emizimbeni yethu. Izazinzulu zisebenzise amanani ukuze ziwahlule. Into ekhethekileyo kukuba uhlobo ngalunye lwe-PDE lusebenza kakhulu kwiindawo ezithile zomzimba.
- I-PDE-3: Olu hlobo lufumaneka kakhulu entliziyweni yakho nakwinkqubo yokujikeleza kwegazi . Lukwabandakanyeka kwinkqubo yokujiya kwegazi.
- I-PDE-4: Oku kufumaneka kakhulu emiphungeni . Kusebenza ngokuqinisa izihlunu kwindlela yomoya.
- I-PDE-5: Olu hlobo lufumaneka kwimiphunga nakwizitho zangasese zamadoda .
Ngoko ke, amayeza abizwa ngokuba yiPhosphodiesterase Inhibitors (PDE inhibitors) asebenza ngokuthintela umsebenzi wee-enzymes zePDE ezikhankanyiweyo apha ngasentla. Kufana nokuvala ucango. Amanye amayeza okuthintela iPDE asebenza ngokukhetha kakhulu. Oko kukuthi, ajolise kuhlobo oluthile kuphela, njengePDE-5. Kukho amanye amayeza asebenza ngaphandle kokukhetha . Oko kukuthi, anokuchaphazela zonke iintlobo zePDE ukuya kwinqanaba elithile.
Zeziphi iimeko ezinyangwa ngale mithi?
Udidi lwamayeza abizwa ngokuba yi-PDE inhibitors luvunyiwe ziiarhente ezifana ne-U.S. Food and Drug Administration (FDA) ukunyanga izifo ezingaphezu kweshumi elinesibini. Nazi ezinye zazo.
| Udidi lwezifo | Imeko yezonyango kunye nenkcazo elula |
|---|---|
| Intliziyo kunye nokujikeleza kwegazi |
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| Izifo ezivuthayo |
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| Izifo zenkqubo yokuzala yamadoda |
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| Izifo zenkqubo yokuphefumla |
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Zithini iingenelo zePDE Inhibitors?
Olu hlobo lweyeza luluncedo kakhulu ekunyangeni izifo ezithile. Kukho izizathu ezahlukeneyo zoku.
- Kulula ukuyisebenzisa: La mayeza eza ngeendlela ezahlukeneyo. Afumaneka njengeepilisi zomlomo, iikhrimu zomlomo, kunye neenaliti ze-IV. Amanye amayeza kufuneka athathwe yonke imihla, ngelixa amanye anokuthathwa kuphela xa kufuneka.
- Unyango olujoliswe kulo: Njengoko benditshilo ngaphambili, amanye amayeza ajolise kuphela kuhlobo oluthile lwe-PDE, ngoko ke akunakwenzeka ukuba abangele iziphumo ezingafunekiyo (iziphumo ebezingalindelekanga) kwamanye amalungu omzimba. Kufana nokuba iyeza lisebenza kanye apho isifo sikuyo.
- Iingenelo ezininzi zeyeza elinye: Ngamanye amaxesha iimeko ezimbini ezinxulumeneyo zinokwenzeka kumntu omnye. Umzekelo, i-benign prostatic hyperplasia (BPH) kunye ne-erectile dysfunction (ED) zinokwenzeka zombini kunye. I-PDE-5 inhibitor tadalafil ivunyiwe ukunyanga zombini ezi meko. Ngokufanayo, kukho amayeza anokunyanga zombini i-gout kunye ne-arthritis ehambelana nayo.
Zithini iziphumo ebezingalindelekanga kunye neengozi zale mithi?
Eyona nto ibalulekileyo kukuba onke la mayeza afanele athathwe kuphela phantsi kwengcebiso kagqirha. Imiphumo emibi enokubakho inokwahluka ngokwamayeza nangokweengcali.
Iziphumo ebezingalindelekanga eziphambili zixhomekeke ekubeni iyeza liloluphi uhlobo lwe-PDE inhibitor.
| Uhlobo lwe-PDE Inhibitor | Iziphumo ebezingalindelekanga ezincinci neziphakathi | Iziphumo ebezingalindelekanga ezinokuba yingozi (xelela ugqirha wakho ngoko nangoko) |
|---|---|---|
| Izithinteli ze-PDE-3 (ichaphazela intliziyo nemithambo yegazi) | Intloko ebuhlungu, ubuthathaka, ukudumba, isicaphucaphu, ukuhlanza, iintlungu zesisu, isiyezi, ukurhawuzelelwa lusu. | Ukungahambi kakuhle kwesingqisho sentliziyo (i-arrhythmia), iintlungu zesifuba, uxinzelelo lwegazi oluphantsi, ukopha okanye ukukrweleka okungaqhelekanga, umonakalo wesibindi. |
| Izithinteli ze-PDE-4 (ichaphazela imiphunga kunye nokudumba) | Ukunciphisa umzimba, isicaphucaphu, ukuhlanza, urhudo, usulelo oluphezulu lwendlela yokuphefumla, intloko ebuhlungu, ukungalali, ukudumba kwindawo efakwe inaliti. | Ukuwohloka koxinzelelo olukhoyo, iingcinga zokuzibulala, iimpendulo ze-hypersensitivity (ukurhawuzelela, ukudumba, irhashalala). |
| Izithinteli ze-PDE-5 (ichaphazela ukungabi namandla okwabelana ngesondo kunye noxinzelelo lwegazi oluphezulu emaphaphu) | Intloko ebuhlungu, ukurhawuzelela, impumlo exineneyo, umqolo obuhlungu, iintlungu zemisipha, isicaphucaphu, isiyezi, mhlawumbi nokubona ukukhanya okuluhlaza okwesibhakabhaka (okwethutyana). | Ukuqandusela: Ukuqina okubuhlungu okuhlala iiyure ezingaphezu kwe-4 ngaphandle kokukhuthazwa ngokwesondo. Le yingxamiseko yezonyango. Utshintsho/ukulahlekelwa ngumbono okanye ukuva ngequbuliso, umonakalo wesibindi. |
| Izithinteli ezingakhethiyo (umz. i-caffeine, i-theophylline) | Ukungazoli, ukungalali, ukungcangcazela, isicaphucaphu, ukuhlanza, urhudo, isiyezi, intloko ebuhlungu. | Ukubetha kwentliziyo ngokukhawuleza, ukubetha kwentliziyo okungahambelaniyo, iintlungu zesifuba, ukuxhuzula. |
Isilumkiso esikhethekileyo: Ukuba usela amayeza afana ne -nitroglycerin phantsi kolwimi ngenxa yentlungu yesifuba, kwaye uqalwa ziintlungu zesifuba kwiiyure ezingama-24 emva kokuthatha i-PDE-5 inhibitor (umz. iSildenafil, iTadalafil), yiya kwicandelo likaxakeka lesibhedlele (ETU) ngoko nangoko. Ukudibanisa la mayeza mabini kunokubangela uxinzelelo lwegazi oluphantsi ngendlela eyingozi.
Ngubani ongafanele athathe eli yeza?
Kwabanye abantu, olu hlobo lwamayeza abizwa ngokuba yi-PDE inhibitors lusenokungafaneleki ngenxa yezinye iimeko zabo zonyango okanye amanye amayeza abawasebenzisayo. Oku sikubiza ngokuba zii-contraindications . Kukho iintlobo ezimbini zala mayeza:
1. Izichaso ezipheleleyo:
- Kuyo nayiphi na inhibitor ye-PDE: Ukuba ukhe waba ne-allergy enzima (hypersensitivity) kule yeza okanye efanayo.
- KwiCilostazol: Ukuba unayo nayiphi na uhlobo lokusilela kwentliziyo.
- Kwimithi yokuthintela i-PDE-5 (efana neSildenafil, iTadalafil): isifo sentliziyo esibi, iintlungu zesifuba ezingazinzanga (i-angina engazinzile), uhlaselo lwentliziyo okanye isifo sohlangothi kutshanje.
2. Izithintelo ezinxulumene noko:
- Kwi-PDE-5 inhibitors: Ukuba uthatha ii-nitrate okanye ii-alpha-blockers, kufuneka uthethe nogqirha wakho kuba zinokubangela ukuba uxinzelelo lwakho lwegazi lwehle ngendlela eyingozi.
- KwiCilostazol: Ukuba unengxaki yokopha.
- KwiPentoxifylline: Ukuba usandul' ukopha engqondweni okanye emehlweni.
Ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa, soloko uthetha nogqirha wakho ngaphambi kokuba uthathe naluphi na unyango. Kukho ubungqina bokuba ezinye izithinteli ze-PDE zinokuchaphazela umntwana ongekazalwa kwizifundo zezilwanyana.
Ufanele uye nini kugqirha?
Ukuba iimpawu zakho ziyatshintsha okanye zichaphazela imisebenzi yakho yemihla ngemihla, kungcono ukuxelela ugqirha wakho. Nangona kunjalo, ukuba ufumana nayiphi na kwezi zilandelayo , yiya esibhedlele okanye kwigumbi likaxakeka (ETU) ngokukhawuleza.
- Iimpawu zokuhlaselwa yintliziyo: iintlungu zesifuba, ukuphefumla nzima, ukubila, isiyezi, isicaphucaphu.
- I-Priapism: Ukuqina okubuhlungu okuhlala iiyure ezingaphezu kwe-4 ngaphandle kokukhuthazwa ngokwesondo. Oku kunokubangela umonakalo ongunaphakade ukuba akunyangelwa ngokukhawuleza.
- Ukulahlekelwa ngumbono okanye ukuva ngequbuliso: Ukuba ufumana ukulahlekelwa ngumbono ngequbuliso, ukulahlekelwa ngumbono, okanye ukulahlekelwa kukuva, funa uncedo lwezonyango ngoko nangoko. Ukulibaziseka kunokubangela umonakalo ongunaphakade.
Umyalezo Wokuya Ekhaya
- Ii-Phosphodiesterase inhibitors (PDE inhibitors) ziluhlobo oluluncedo kakhulu lwamayeza angasetyenziswanga kuphela kwizifo ezingasebenzi kakuhle ngokwesondo, kodwa nakwizifo ezininzi zentliziyo, imiphunga, ulusu kunye namalungu.
- Onke la mayeza afanele athathwe kuphela ngokwengcebiso kagqirha.Xelela ugqirha wakho ngezinye izifo onazo kunye nezinye amayeza owasebenzisayo.
- Iziphumo ebezingalindelekanga zinokwenzeka, ngoko ke ziqaphele ngaphambi kokuba uqale amayeza.
- Ukuba ufumana iimpawu ezinzima ezifana neentlungu zesifuba, ukuphefumla okunzima okuhlala ixesha elingaphezu kweeyure ezi-4, okanye ukulahleka ngequbuliso kokubona/ukuva, yiya kwiSebe leNgxamiseko (ETU) ngoko nangoko.
- Ukusebenzisa eli yeza ngaphandle kwemvume kagqirha, ngokubuza abanye okanye ngokubuza kwiikhemesti, kunokuba nemiphumo emibi, esongela ubomi.
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