Ngaba une -gout ? Okanye ngaba kukho umntu omaziyo onale meko? Ngoko ke mhlawumbi uqhelene kakhulu nentlungu enzima emalungeni. Ngoko ke, elinye lamayeza acetyiswa ngoogqirha ukulawula i- gout ixesha elide yiProbenecid. Kweli nqaku, siza kuthetha ngale pilisi yeProbenecid, kwenzeka ntoni ngayo, kunye nezinto ekufuneka uzilumkele xa uyithatha.
Kwenzeka ntoni ngokwenene ngeli yeza leProbenecid?
Ngamafutshane, eli yeza libizwa ngokuba yiProbenecid lisebenza ngokukhawulezisa ukukhutshwa kwe-uric acid egqithisileyo emzimbeni wethu ngomchamo. Njengoko usazi, i-gout yenzeka xa ubungakanani be-uric acid emzimbeni busanda kwaye ifakwa kumalungu njengeekristale. Ngoko ke, ngokunciphisa amanqanaba e-uric acid, eli yeza linokuthintela ukuphinda kuhlaselwe yi -gout ebuhlungu.
Eli yeza likwanomsebenzi omnye. Linceda amanye amayeza okubulala iintsholongwane, anjengepenicillin, ukuba ahlale emzimbeni ixesha elide, nto leyo eyenza ukuba amayeza okubulala iintsholongwane asebenze ngakumbi.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uthathe amayeza
Ngaphambi kokuba uqale iProbenecid, kubaluleke kakhulu ukunika ugqirha wakho inkcazo epheleleyo yemeko yakho yempilo. Qiniseka ukuba ubaxelela ngayo nayiphi na kwezi meko zilandelayo onazo:
- Ukuba okwangoku uhlaselwa yi-gouty acute: Eli yeza lisetyenziselwa ukuthintela iintlungu ukuba zingaveli, hayi ukuzinciphisa xa sele zikhona. Ke ngoko, aliqalwa ngelo xesha.
- Ukuba unesifo segazi okanye iingxaki zegazi .
- Ukuba unesifo sezintso okanye amatye ezintso : Ekubeni eli yeza lisebenza kwizintso, ukuba uneengxaki zezintso, ugqirha wakho kufuneka azi ngalo.
- Ukuba usandul' ukufumana unyango lwe-radiation.
- Ukuba unezilonda esiswini .
- Ukuba une-allergy kwi-probenecid, amayeza e-sulfa, okanye naliphi na elinye iyeza, ukutya, okanye idayi.
- Ukuba ukhulelwe okanye uzama ukukhulelwa.
- Ukuba ungumama oncancisayo.
Ngokusekelwe kolu lwazi, ugqirha wakho uya kugqiba ukuba eli yeza lifanelekile kuwe okanye ukuba kufuneka kutshintshwe idosi.
Ulisebenzisa njani kanye kanye eli yeza?
Indlela yokusebenzisa oku ilula kakhulu, kodwa ibaluleke kakhulu.
- Le pilisi ineglasi enkulu yamanziSela. Kubaluleke kakhulu ukusela amanzi amaninzi imini yonke.
- Sela idosi echanekileyo, kanye njengoko ugqirha wakho ekuyalele. Sela amayeza akho ngamaxesha amiselweyo, ngaphandle kokutsiba naziphi na iidipozithi.
- Musa ukuyeka ukuthatha amayeza de ugqirha wakho akuxelele ukuba uwathathe. Qhubeka uwathatha nokuba uzive ungcono.
- Ukuba linikwa abantwana: Eli yeza alinikwa abantwana abangaphantsi kweminyaka emi-2 ubudala. Ukuba linikwa abantwana abadala kunalo, thetha nogqirha wabantwana ngalo uze ulandele imiyalelo yakhe.
- I-Overdose: Ukuba ucinga ukuba uthathe ngaphezu kwedosi emiselweyo, fowunela iZiko loLwazi lweePoisons kwiSibhedlele sikaZwelonke saseColombo ngoko nangoko . Okanye yiya kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
Eli yeza lelakho kuphela. Musa ukulinika nabani na oneempawu ezifanayo nezakho. Iyeza elifanelekileyo kumntu ngamnye linokwahluka.
Amanye amayeza anokusebenza kunye nale mayeza
I-Probenecid inokunxibelelana namanye amayeza. Ngoko ke xelela ugqirha wakho ngawo onke amayeza owasebenzisayo, kuquka neevithamini. Itheyibhile engasezantsi iza kucacisa oku ngokucacileyo.
| Unxibelelwano olunokwenzeka neProbenecid | |
|---|---|
| Amayeza angafanele asetyenziswe kunye | |
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| Amayeza afanele asetyenziswe ngononophelo kwaye axelwe kugqirha | |
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Olu luhlu aluphelelanga. Ngoko ke xelela ugqirha wakho ngazo zonke iziyobisi ozisebenzisayo, ukuba uyatshaya, okanye ukuba usela utywala.
Izinto ezikhethekileyo ekufuneka uzazi xa usebenzisa iProbenecid
- Kuthatha ixesha ukubona iziphumo: Kungathatha iinyanga ezininzi ukubona iziphumo ezipheleleyo zale yeza. Ngoko ke, nokuba uneentlungu ze-gout okanye awunazo, qhubeka usela iyeza ixesha elide njengoko ugqirha wakho ekuxelela. Ukuba uneentlungu ezingalindelekanga, ugqirha wakho uya kukunika iyeza elahlukileyo.
- Lumka ngeepilisi zokudambisa iintlungu:
- Akukho tywala: Utywala bunokuphazamisa ukusebenza kakuhle kwale mithi. Ngoko ke, kuphephe ukusela utywala.
- Sela amanzi amaninzi: Kubaluleke kakhulu ukusela ubuncinane iiglasi ezisi-8 ukuya kwezili-10 zamanzi ngosuku ukunceda ukukhupha i-uric acid emzimbeni nokuthintela amatye ezintso. Musa ukuzivumela ukuba uphelelwe ngamanzi emzimbeni.
- Iziphumo kwezinye iimvavanyo: Eli yeza lisenokuchaphazela iziphumo zezinye iimvavanyo ezijonga iswekile kumchamo. Ukuba wenza uvavanyo olunjalo, xelela ugqirha wakho kwangaphambili.
- Ukurhawuzelelwa lusu, ukurhawuzelelwa, ii-hives (Iimpendulo ze-allergic)
- Ukudumba kobuso, imilebe, okanye ulwimi
- Ubunzima bokuphefumla
- Umkhuhlane, ukubanda, iimpawu zosulelo
- Igazi kumchamo
- Intlungu esiswini esisezantsi okanye emqolo (enxulumene nezintso)
- Intlungu okanye ubunzima bokuchama
- Ukudumba kwamalungu kunye nentlungu
- Ukopha okungaqhelekanga okanye ukukrweleka
- Ukudinwa okanye ukudinwa okungaqhelekanga
- Isiyezi
- Ukuhlanjwa ngamanzi
- Ukuchama rhoqo
- Ukulahleka kweenwele
- Intloko ebuhlungu
- Umnqweno wokutya
- Isicaphucaphu, ukuhlanza
- Intlungu yentsini
- I-Probenecid liyeza elisetyenziselwa ukulawula i-gout ixesha elide, hayi ukuhlaselwa ngequbuliso.
- Xa usela eli yeza, kubaluleke kakhulu ukusela amanzi amaninzi imini yonke.
- Musa ukuthatha i-aspirin okanye ezinye iintlungu (ingakumbi ii-NSAID) ngaphandle kokubonisana nogqirha wakho.
- Nika ugqirha wakho inkcazo epheleleyo ngayo yonke eminye imithi, iivithamini, kunye nezongezo ozithathayo.
- Ukuba ufumana naziphi na iziphumo ebezingalindelekanga (umz. ukurhawuzelela eluswini, ubunzima bokuphefumla, iintlungu eziqatha), funa ingcebiso kagqirha ngoko nangoko.
Ii-NSAID painkillers ezifana ne-aspirin kunye ne-ibuprofen zinokunciphisa ukusebenza kweli yeza. Ngoko ke, musa ukuzisebenzisa ii-painkillers ezithengiswa ngaphandle kwemvume kagqirha xa uneentloko ezibuhlungu okanye ezinye iintlungu. Buza ugqirha wakho ngaphambi kokuba uthathe naliphi na iyeza leentlungu.
Zithini iziphumo ebezingalindelekanga ezinokubakho?
Njengalo naliphi na iyeza, iProbenecid inokubangela iziphumo ebezingalindelekanga kwabanye abantu. Ezinye zezi ziyingozi, ngelixa ezinye zincinci.
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha wakho ngoko nangoko | |
|---|---|
| Iziphumo ebezingalindelekanga ezingaqhelekanga, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
Umyalezo Wokuya Ekhaya
👩🏽⚕️ Imibuzo eyongezelelweyo (Ii-FAQ)
💬 Zisetyenziselwa ntoni iipilisi zeProbenecid?
Eli liyeza elisebenzayo nelinamandla kakhulu kwisifo esibi samathambo esibizwa ngokuba yi-'Gout' (i-Uricosuric agent)! Izigulane ezine-gout zihlushwa ziintlungu ezinganyamezelekiyo kunye nokudumba ngenxa yeekristale ze-'Uric Acid' ezinamathela njengeenaliti ngaphakathi kwamalungu. Into eyenziwa yile pilisi kukukhukulisa yonke i-uric acid eyingozi emzimbeni ize iyikhuphe.
💬 Xa eli yeza (iProbenecid) lingena emzimbeni, liyisusa njani 'i-uric acid' ebangela iintlungu ze-gout?
Ngokwesiqhelo, emva kokuba umzimba wethu ukhuphe i-uric acid ngezintso ukuya kumchamo, izintso ziphinda ziyifunxe enye yayo emzimbeni/egazini (Reabsorption/URAT1). Oko kwenziwa yile pilisi (Probenecid) kukuthintela ngokupheleleyo 'ukuphinda ifunxe'. Ekubeni ingenakufunxwa, yonke i-uric acid egazini lakho iphuma emzimbeni wakho njengomlambo (Excretion) ngaphandle kokuphazamiseka.
💬 Kutheni kufuneka usele amanzi amaninzi xa usela ezi pilisi? Zithini iingozi?
Le pilisi ityhala yonke i-uric acid emzimbeni iye kwizintso/umchamo, ngoko ke ukuba awuseli 'iilitha ezi-2-3 zamanzi ngosuku', loo uric acid iya kuqokelelana kwizintso ize yenze 'amatye (amatye ezintso e-Uric acid)'. Oko kuyabulala! Enye into ekhethekileyo kukuba ukuba uthatha i-antibiotic ebulala iintsholongwane (ezifana nePenicillin) ngelixa uthatha le pilisi, oku kunokunyusa ubungakanani be-antibiotic ehlala emzimbeni (ukuya kwinqanaba lokuba yityhefu) kwaye kwandise iziphumo ebezingalindelekanga zeyeza (Ukusebenzisana kwamayeza).
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