Ingaba umzimba wakho awusabeli kakuhle kwiParathyroid Hormone? Makhe sithethe ngale meko ingaqhelekanga (iPseudohypoparathyroidism)!

Ngaba ngamanye amaxesha ukhe uzive ngathi kukho into engasebenzi kakuhle emzimbeni wakho? Kukho izifo ezingaqhelekanga, amagama azo anokuba yinto eyoyikisayo. Esinye sezifo ezinjalo esingavakaliyo rhoqo, kodwa kubalulekile ukwazi ngaso, yiPseudohypoparathyroidism (PHP). Nangona igama lisenokubonakala lide kancinci, masiligcine lilula.

Yintoni i-pseudohypoparathyroidism?

Ngamafutshane, le yimeko engaqhelekanga yemfuza . Sinee-glands ezincinci emizimbeni yethu ezibizwa ngokuba zii-parathyroid glands. Ezi zivelisa i-hormone ebizwa ngokuba yi-Parathyroid Hormone (PTH). Le hormone ye-PTH ibaluleke kakhulu emizimbeni yethu. Kuba, le hormone inceda ukugcina amanqanaba afanelekileyo eCalcium, iPhosphorus, kunye neVithamin D egazini lethu.

Ngoku, uyazi ukuba kwenzeka ntoni kumntu one-pseudohypoparathyroidism (PHP)? Nangona amadlala abo e-parathyroid evelisa i-PTH hormone ngokuqhelekileyo, iiseli emzimbeni wabo aziphenduli kakuhle kuyo, oko kuthetha ukuba azikwazi "ukuyiqonda". Kufana nomntu othetha nawe kodwa awukwazi ukumva. Oku sikubiza ngokuba yi -Parathyroid Hormone Resistance .

Kwenzeka ntoni ngenxa yoko? Amanqanaba e-calcium egazini ayancipha, ngelixa amanqanaba e-phosphorus enyuka. Oku kungalingani kunokubangela ukuxhuzula kwemisipha, ukuba ndindisholo, ukuxhuzula, kunye neengxaki zamazinyo.

Okubalulekileyo kukuba, le meko ibizwa ngokuba yi-PHP yahlukile kwimeko ebizwa ngokuba yi-Hypoparathyroidism. Abantu abane-hypoparathyroidism abayivelisi i-PTH hormone eyaneleyo kwasekuqaleni. Nangona kunjalo, kwi-PHP, i-hormone iyaveliswa, kodwa umzimba awuyisebenzisi.

Ziziphi iintlobo eziphambili ze-PHP?

Kukho iintlobo ezininzi eziphambili zale meko ye-PHP. Masibone ukuba zeziphi.

Uhlobo lwe-PHP-1

Olu lolona hlobo luqhelekileyo lwe-PHP . Ukongeza kwi-PTH hormone resistance ekhankanyiweyo ngaphambili, utshintsho oluthile kwinkqubo yamathambo lunokubonwa. Umzekelo:

• Ubuso obujikelezayo
• Ukuncipha kobude (ubufutshane bobude)
• Intlungu yentamo
• Ukophuka kwezandla neenyawo

Oogqirha babiza olu didi lweempawu ngokuthi yi-Albright Hereditary Osteodystrophy (AHO) . Abantu abane-PHP-1 banale meko ngenxa yohlobo oluthile lwe-gene olubizwa ngokuba yi-'GNAS' abalufumana kumzali wabo.

I-PPHP (Pseudopseudohypoparathyroidism)

Olu luhlobo olulinganiselweyo lwe-PHP-1. Abantu abane-PPHP (Pseudopseudohypoparathyroidism) banokuba neempawu zomzimba ezibonakala kwi-AHO (njengobuso obungqukuva kunye nobude obufutshane), kodwa abanayo i-PTH hormone resistance . Oku kuthetha ukuba amanqanaba abo e-calcium kunye ne-phosphorus aqhelekile.

Uhlobo lwe-PHP-2

Abantu abane-PHP-2 banokumelana ne-PTH hormone, oko kuthetha ukuba bane-calcium ephantsi kunye ne-phosphorus ephezulu. Kodwa abanazo iimpawu zomzimba (ezifana nobuso obungqukuva kunye nobude obufutshane) ezibonakala kwi-AHO. Abaphandi abakafumani ukuba zeziphi iziphene zemfuza ezibangela olu hlobo lwe-PHP-2.

Zithini iimpawu ze-PHP?

Iimpawu ze-PHP zingahluka kumntu nomntu . Oku kuthetha ukuba ayinguye wonke umntu oza kuba neempawu ezifanayo. Ezinye zeempawu eziqhelekileyo ziquka:

• Ukuqaqamba kwemisipha
• Ukuqaqamba kwemisipha rhoqo : Ukuziva ngathi umlenze uyatsalwa.
• Ukungaziva okanye ukurhawuzelela kwamalungu
• Ukuxhuzula
• Ukulibaziseka kokuqaqanjelwa kwamazinyo
• Ubuthathaka be-enamel yamazinyo
• Uxinzelelo lwegazi oluphantsi
• Iinwele ezibuthathaka kunye neenzipho
• Ixhala
• Uxinzelelo

Abantu abane-PHP-1 banokufumana iimpawu ezongezelelweyo ezihamba nemeko ye -Albright hereditary osteodystrophy (AHO) ekhankanyiweyo ngaphambili. Abanye abantu abane-PHP banokufumana ezi mpawu:

• Ubuso obujikelezayo
• Ubufutshane (ubufutshane bobude)
• Intlungu yentamo
• Amathambo ezandleni nasezinyaweni : Amaqhubu, ingakumbi lawo eminwe yesine neyesihlanu, anokubonakala ngathi ajikelezwe ngaphakathi.
• Ukutyeba kakhulu : Kuthetha ukuba utyebile kakhulu.
• Ukuphazamiseka kokubona : izinto ezifana ne-cataracts, ukubona okufipheleyo, kunye nokuziva ukukhanya.
• Amaqhubu amathambo phantsi kolusu lwakho
• Ukulibaziseka kokukhula : Abanye abantwana banokufumana ukulibaziseka kokukhula.

Zithini izizathu ze-PHP?

Eyona nto ibangela esi sifo kukwahluka kwezakhi zofuzo zethu, ingakumbi kwizakhi zofuzo ezibizwa ngokuba yi-'GNAS' . Abanye abantu basifumana kubazali babo . Oko kuthetha ukuba silifa. Kodwa ngamanye amaxesha esi sifo sinokwenzeka ngaphandle kwembali yosapho kwaye akukho sizathu sifumanekayo.

I-PHP idla ngokuchongwa ebuntwaneni okanye ebuntwaneni , kodwa ngamanye amaxesha inokuvela ebudaleni.

Ziziphi iingxaki ezinokubakho ze-PHP?

Ukuba une-PHP, kusenokwenzeka ukuba ube nezinye iingxaki zenkqubo ye-endocrine . Ezi ngxaki zinxulumene nama-hormone zinokubangela iimpawu ezifana nokungabikho kwamandla kunye nokungabi namandla okwabelana ngesondo.

Abanye abantu abane-PHP basengozini enkulu yokuhlaselwa zizifo ezifana nezi:

• I-Parkinsonism: Ukubonisa iimpawu ezifana nesifo sikaParkinson.
• Ubunzima ngezakhono zomzimba ezicothayo : Oku kuthetha ubunzima ngemisebenzi ecothayo efana nokucinezela okanye ukubhala.
• I-Carpal Tunnel Syndrome : Ingakumbi kwabo bane-PHP-1. Le yimeko apho umthambo osesihlahleni ucinezelwa khona, nto leyo ebangela ukuba umntu angabi nanto kwaye abuhlungu esandleni.
• I-stenosis yomgogodla
• I-sleep apnea : Ingakumbi ebantwaneni.

Oogqirha bayixilonga njani i-PHP?

Ukuba ukrokrela ukuba une-PHP, ugqirha wakho uya kuqala enze uvavanyo lomzimba . Baya kukubuza nangembali yosapho lwakho. Emva koko banokwenza ezinye iimvavanyo ezininzi ukuqinisekisa ukuxilongwa. Ezi ziquka:

• Uvavanyo lwegazi : Linganisa amanqanaba eehomoni, ingakumbi i-calcium, i-phosphorus, kunye namanqanaba e-PTH.
• Uvavanyo lomchamo : Jonga amanqanaba e-calcium kunye ne-phosphorus kumchamo.
• Uvavanyo lwemfuza : Jonga utshintsho kwimfuza ethi `GNAS`.
• I-Electrocardiogram (EKG) : Ijonga iingxaki kwintliziyo.
• Ii-X-reyi zesandla : Jonga ukuba amathambo aphukile na kunye nolunye utshintsho.
• I-CT Scan (CT - I-Computed Tomography scan) : Ukubona ukuba kukho naluphi na utshintsho engqondweni.

Kusekelwe kulwazi olufunyenwe kwezi mvavanyo ukuba ugqirha unokuqinisekisa ngokuchanekileyo imeko ye-PHP.

Iphathwa njani i-PHP?

Akukho nyango lwale meko okwangoku . Kodwa ungakhathazeki. Ngonyango olufanelekileyo nolawulo, ungazilawula iimpawu zakho kwaye uphile ubomi obuqhelekileyo.

Injongo ephambili yonyango kukugcina amanqanaba afanelekileyo e-calcium kunye ne-phosphorus egazini lakho . Ukugcina la manqanaba kunokunciphisa kakhulu iimpawu. Olu lunyango oluhlala ubomi bonke .

Iindlela zonyango zingabandakanya:

• Izongezo zeCalcium kunye neVitamin D : kwifomu yepilisi okanye yolwelo.
• Iikhaphu zeCalcitriol : Eli liyeza elonyusa ubungakanani bekhalsiyam emzimbeni.
• Inaliti yeCalcitriol
• Unyango lokutshintshwa kwehomoni yokukhula okanye i-thyroid hormone : ukuba kuyimfuneko.
• Ukutya okune-calcium eninzi kunye ne-phosphorus ephantsi : Njengoko kucetyiswa yingcali yesondlo.

Eyona nto ibalulekileyo kukulandela iingcebiso zonyango ngononophelo kwaye uhlolwe ngexesha.

Ndifanele ndimbone nini ugqirha?

Ukuba une-PHP, kubalulekile ukubona ugqirha wakho rhoqo ukuze ahlolwe amanqanaba akho e-calcium kunye ne-phosphorus . Olu hlolo oluqhelekileyo luya kunceda ukugcina yonke into ilawulwa.

Ukuba ufumana iimpawu ezinzima ezifana nobunzima bokuphefumla ngequbuliso, ukuxhuzula okukhulu kwemisipha, okanye ukuxhuzula , yiya kwigumbi likaxakeka lesibhedlele esikufutshane ngoko nangoko okanye utsalele umnxeba ku-1990.

Yintoni onokuyilindela xa uphila nemeko ye-PHP?

Ukuba une-PHP, kufuneka uqhubeke usebenza noGqirha wakho woNyango oluPhambili . Ngenxa yokuba i-PHP inokuchaphazela iindawo ezahlukeneyo zomzimba, unokufuna ukubona iingcali ezahlukeneyo ukulawula iimpawu zakho ezithile. Iqela lakho lezonyango lingabandakanya:

• Iingcali ze-Endocrinologists : Iingcali kwiihomoni.
• Oogqirha bamathambo : Ngeengxaki ezinxulumene namathambo.
• Iingcali zabantwana : Ukuba ngumntwana.
• Iingcali ze-Neurologists : Ngeengxaki ezinxulumene nenkqubo ye-nervous.
• Iingcali zonyango lomzimba
• Iingcali zonyango emsebenzini
• Iingcali zezondlo
• Iingcali zamazinyo
• Iingcali zemfuza
• Iingcali zolawulo lweentlungu

Kuza kufuneka uzithathe ezo zongezo ubomi bakho bonke .

Izakhono zokukhula nezengqondo zinokwahluka kakhulu ngokuxhomekeke kuhlobo kunye nobunzima besifo. Nangona kunjalo , kwiimeko ezininzi, abantu abane-PHP banobomi obuqhelekileyo xa kuthelekiswa nabantu abangenayo i-PHP . Ugqirha wakho angakuxelela into omawuyilindele ngokusekelwe kwimeko yakho.

Ngenxa yokuba i-PHP yimeko engaqhelekanga, kunokuba nzima ukufumana abanye abanemeko efana neyakho . Ingaziva inesizungu ngamanye amaxesha. Ukuba wena okanye umntwana wakho nifunyaniswe ukuba ninayo i-PHP, thetha nogqirha wakho malunga namaqela enkxaso kunye nezixhobo zemfundo . Ezi zinokukunceda ufumane iindlela zokuphucula iimpawu zakho kunye nomgangatho wobomi ngokubanzi.

Umyalezo Wokuya Ekhaya

Kulungile, makhe sijonge ezinye izinto ekufuneka sizikhumbule malunga ne-pseudohypoparathyroidism (PHP) ebesithetha ngayo.

• I-PHP yimeko engaqhelekanga yemfuza apho umzimba ungaphenduli ngokufanelekileyo kwi-hormone ye-parathyroid (PTH).
• Oku kubangela ukuba i-calcium egazini inciphe kwaye i-phosphorus inyuke.
• Kukho iintlobo ezininzi eziphambili : i-PHP-1, i-PHP-2, kunye ne-PHP-3.Ewe. I-PHP-1 inokubangela utshintsho emathanjeni olubizwa ngokuba yi-AHO.
• Iimpawu ezahlukeneyo zinokuvela, ezinje ngokuxhuzula kwemisipha, ukuba ndindisholo, ukuxhuzula, iingxaki zamazinyo, ukufutshane komzimba, kunye nobuso obungqukuva .
• Isizathu esiphambili kukuguquka kwejini ye-`GNAS` .
• Nangona kungekho nyango lupheleleyo, iimpawu zingalawulwa ngonyango lobomi bonke (i-calcium, i-vitamin D, ukutya okukhethekileyo).
• Ukuhlolwa rhoqo kwezonyango kunye nenkxaso yoogqirha abaziingcali kubalulekile.
• Uninzi lwabantu lunokuphila ubomi obuqhelekileyo .
• Uncedo oluvela kumaqela enkxaso lubaluleke kakhulu ukuze uhlale uqinile engqondweni.

Ungalibali, awuwedwa. Nangona le yimeko engaqhelekanga, inokulawulwa kakuhle ngeengcebiso zonyango ezifanelekileyo kunye nenkxaso. Khumbula ukuba oogqirha, usapho, kunye nabahlobo bakulungele xa ufuna amandla.

I- Pseudohypoparathyroidism, i-PHP, i-parathyroid hormone, i-calcium, i-phosphorus, izifo zemfuza, i-AHO