Mhlawumbi wena okanye umntu osapho lwakho unikwe iyeza elibizwa ngokuba yi-'Ruxolitinib' ngugqirha wakho. Eli gama lisenokuvakala liyinkimbinkimbi. Kodwa ungoyiki. Eyona nto ibalulekileyo kukwazi ngokupheleleyo ngala mayeza akhethekileyo kwaye uwasebenzise. Ngoko ke namhlanje, masithethe ngokuba yintoni eli yeza, yintoni eliyenzayo, kunye nento ekufuneka siyilumkele xa silisebenzisa.
Yintoni iRuxolitinib?
Ngamafutshane, iRuxolitinib liyeza elijolise kwiiproteni ezithile ngaphakathi kwiiseli zomzimba wethu kwaye lilawula umsebenzi wazo, oko kuthetha ukuba liyayithintela iseli ekukhuleni. Oku kubizwa ngokuba yi-target therapy .
Eli yeza lisetyenziswa kakhulu ukunyanga iimeko ezintathu:
- I-Myelofibrosis: Oku kwenzeka xa izicubu ezinee-fibrous ziqokelelana kumongo wethambo, ziphazamisa ukuveliswa kweeseli zegazi ezisempilweni.
- I-Polycythemia Vera: Kule meko, umzimba uvelisa iiseli ezibomvu zegazi ezingaphezulu kunokuba kuyimfuneko.
- Isifo se-graft-versus-host: Oku kwenzeka emva kokuba into efana nokufakelwa umongo wethambo, xa iiseli ezifakelweyo ziqala ukuhlasela imizimba yethu.
Ugqirha wakho angacebisa eli yeza nakwezinye iimeko.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza
Ngaphambi kokuba uqalise eli yeza, kubaluleke kakhulu ukuxelela ugqirha wakho ngazo naziphi na iingxaki zempilo onazo. Ukuba unayo nayiphi na kwezi zilandelayo, qiniseka ukuba umxelela ngayo.
| Imeko | Inkcazo |
|---|---|
| Isifo sentliziyo kunye neengxaki zemithambo yegazi | Ukuba ukhe wahlaselwa yintliziyo okanye wafa yistroke ngaphambili, wakha waneengxaki zokujiya kwegazi, okanye wakha wanezinga eliphezulu le-cholesterol. |
| Iintsholongwane | Imbali yangoku okanye yangaphambili yeSifo sePhepha (TB), iHepatitis, okanye naluphi na olunye usulelo lwebhaktiriya, intsholongwane, okanye ifungus. |
| Isifo sezintso okanye sesibindi | Ukuba unesifo sezintso okanye ukwi-dialysis, okanye unesifo sesibindi. |
| Iingxaki zegazi kunye nomhlaza | Ukuba unegazi eliphantsi, iiseli ezimhlophe zegazi ezisezantsi, iiseli ezibomvu zegazi ezisezantsi, okanye iiplatelets ezisezantsi, okanye ukuba unomnye umhlaza. |
| Amanye amanqaku | Xelela ugqirha wakho ukuba uyatshaya, uzama ukukhulelwa, ukukhulelwa, okanye uncancisa. Xelela ugqirha wakho ukuba unayo nayiphi na i-allergies kwi-ruxolitinib okanye naliphi na elinye iyeza okanye ukutya. |
Ndingayisebenzisa njani le yeza?
Eli yeza lifanele lithathwe ngomlomo neglasi yamanzi. Lingathathwa nokutya okanye ngaphandle kokutya. Nangona kunjalo, ukuba uziva uphazamisekile esiswini, kungcono ukulithatha kunye nokutya.
Kubaluleke kakhulu: Kuphephe ukusela ijusi yegrapefruit ngokupheleleyo ngelixa usela eli yeza, kuba ijusi yegrapefruit ingayichaphazela indlela eli yeza elisebenza ngayo.
Zama ukusela amayeza akho ngexesha elifanayo yonke imihla. Thatha idosi kanye njengoko ugqirha wakho ekuyalele. Ukuba uneziphumo ebezingalindelekanga, ugqirha wakho angakuxelela ukuba utshintshe idosi okanye uyeke ukuyisebenzisa. Ungaze utshintshe idosi okanye uyeke ukuyisebenzisa ngaphandle kwengcebiso kagqirha wakho.
Kuthekani ukuba uphoswe yidosi yeyeza?
Thatha idosi oyiphosileyo ngokukhawuleza xa ukhumbula. Nangona kunjalo, ukuba sele kuza kufuneka uthathe idosi elandelayo, yitsibe idosi oyiphosileyo uze uthathe idosi elandelayo ngexesha elicwangcisiweyo. Musa ukuthatha idosi ephindwe kabini nangasiphi na isizathu.
Kuthekani ukuba ndithatha amayeza amaninzi kakhulu?
Ukuba ucinga ukuba uthathe amayeza amaninzi kakhulu, fowunela iZiko loLwazi lweePoison kwiSibhedlele sikaZwelonke saseColombo ngoko nangoko. Okanye yiya kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
Amanye amayeza anokusebenzisana neRuxolitinib
Xelela ugqirha wakho ngawo onke amayeza owasebenzisayo, kuquka amayeza kagqirha namayeza athengiswa ngaphandle kwemvume kagqirha, amayeza esintu, iivithamini, kunye neemveliso zezityalo (ezifana ne-St. John's wort). Amanye amayeza anokusebenzisana ne-Ruxolitinib.
Nazi imizekelo embalwa nje:
- Amanye amayeza okulwa neentsholongwane asetyenziswa kwi-HIV okanye kwi-AIDS
- Amayeza osulelo lwefungus (umz. i-fluconazole, i-ketoconazole)
- Amanye amayeza okubulala iintsholongwane (umz. i-clarithromycin, i-erythromycin)
- Amanye amayeza okuxhuzula/ ukuxhuzula (umz. i-carbamazepine, i-phenytoin)
- I-Rifampin (iyeza lesifo sephepha)
- Imveliso yemifuno iSt. John's wort
Olu luhlu aluphelelanga, ngoko ke kubaluleke kakhulu ukuxelela ugqirha wakho ngayo yonke into oyithathayo .
Zeziphi izinto ezikhethekileyo ekufuneka uzilumkele xa usebenzisa iyeza?
Kungcono ukuqaphela utshintsho olusemzimbeni wakho ngelixa usebenzisa eli yeza.
- Uvavanyo lwegazi: Ugqirha wakho uhlala eyalela uvavanyo lwegazi ukujonga izinto ezifana notshintsho kubungakanani beeseli zakho zegazi.
- Umngcipheko wokosuleleka: Eli yeza linokunciphisa amandla omzimba okulwa nezifo, oko kukuthi, amasosha omzimba. Ngoko ke, ukuba ufumana iimpawu ezinje ngomkhuhlane, umkhuhlane, umphimbo obuhlungu, ukukhwehlela, musa ukuzenza unyango, kodwa xelela ugqirha wakho. Nciphisa ukuya kwiindawo apho abantu abagulayo bafumaneka khona kangangoko.
- Ukopha nokudumba: Ukuba unesilonda esingachazwanga emzimbeni wakho, okanye ukuba ukopha akupheli nokuba kungenzakalanga okuncinci, yazisa ugqirha wakho.
- Umngcipheko womhlaza: Abanye abantu abasebenzisa eli yeza banokuba nomngcipheko okhulayo wokufumana ezinye iintlobo zomhlaza, njengomhlaza wolusu. Ngoko ke gquma ulusu lwakho xa uphuma elangeni, sebenzisa i-sunscreen, kwaye uthethe nogqirha wakho ngale nto.
- Ukosuleleka kwengqondo okunzulu: Akuqhelekanga ukuba abanye abaguli babe nosulelo lobuchopho olunzima. Xelela ugqirha wakho ngoko nangoko ukuba unengxaki yokubona, yokuthetha, yokucinga, yokuhamba, okanye yokuma, okanye ukuba udidekile.
- Oomama abancancisayo: Musa ukuncancisa umntwana wakho ngelixa usebenzisa eli yeza kwaye kangangeeveki ezimbini emva kokuba uyekile ukusebenzisa eli yeza.
Zeziphi iziphumo ebezingalindelekanga endinokuzifumana?
Njengalo naliphi na iyeza, iRuxolitinib inokubangela iziphumo ebezingalindelekanga. Ezinye ziyingozi, ngelixa ezinye zixhaphakile. Kubalulekile ukuzazi ezi zinto.
| Imiphumela | Inkcazo |
|---|---|
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha wakho ngoko nangoko | |
| Iimpendulo ze-allergy | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe okanye ulwimi. |
| Ihlwili legazi | Intlungu esifubeni, ubunzima bokuphefumla, intlungu, ukudumba, okanye ukuziva ufudumele emlenzeni. |
| Ukuhlaselwa yintliziyo | Ubunzima bokuphefumla, iintlungu okanye ukuqina esifubeni, entanyeni, emqolo, okanye ezingalweni, ukudinwa kakhulu. |
| Istroke | Ukutshintsha kombono, ukudideka, ubunzima bokuthetha okanye ukuqonda, intloko ebuhlungu, ukudinwa okanye ubuthathaka ngequbuliso ebusweni, engalweni, okanye emlenzeni. |
| Ukopha okungaqhelekanga okanye ukukrweleka | Imivumbo engachazekiyo, ukopha okungapheliyo. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| Ezinye izifo ezincinci | Urhudo, intloko ebuhlungu, ukuqaqamba kwemisipha, ukudumba kwamalungu omzimba. |
Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ufumana nantoni na engaqhelekanga, thetha nogqirha wakho.
Umyalezo Wokuya Ekhaya
- Qiniseka ukuba uxelela ugqirha wakho malunga nawo onke amayeza, iivithamini, kunye neemveliso zezityalo ozisebenzisayo.
- Musa ukusela ijusi yegrapefruit ngelixa usebenzisa eli yeza.
- Ukuba ubona iimpawu zosulelo ezifana nomkhuhlane nokukhwehlela, okanye ukopha okungaqhelekanga okanye ukukrweleka, funa ingcebiso kagqirha ngoko nangoko.
- Ukuba ufumana iimpawu ezinzulu ezifana neentlungu esifubeni, ubunzima bokuphefumla, okanye ubunzima bokuthetha, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) esibhedlele ngoko nangoko.
- Ungaze uyeke ukuthatha amayeza okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho.
- Ukuba unenkxalabo malunga nale mithi, ungoyiki ukuthetha nogqirha wakho ngayo.
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