Ingaba ulusu lwakho luyaqina kwaye luqina? Masifunde ngeScleroderma!

Ngaba ngamanye amaxesha uziva ngathi ulusu lwakho lutyebile kwaye luqinile kunesiqhelo? Okanye ngaba uneentlungu zamalungu okanye ukuqina kwasekuseni? Ezi zizinto esinokuthi singazinaki kangako. Nangona kunjalo, zisenokuba ziimpawu zesifo esingaqhelekanga esibizwa ngokuba yiScleroderma . Makhe sithethe ngale nto ngeenkcukacha ezithe vetshe namhlanje, akunjalo?

Yintoni iScleroderma?

Ngamafutshane, iScleroderma yimeko engaqhelekanga apho izicubu zomzimba wakho ziba nkulu kwaye zibe nzima kunesiqhelo. Ngokuqhelekileyo, ichaphazela ulusu. Kodwa ngamanye amaxesha, le meko inokuchaphazela nayiphi na enye izicubu emzimbeni.

Esi sisifo sokuzikhusela komzimba . Ngoku usenokuba uzibuza ukuba yintoni 'isifo sokuzikhusela komzimba'. Umzimba wethu unenkqubo efana nomkhosi esikhusela kwizifo, ebizwa ngokuba yinkqubo yokuzikhusela komzimba. Kodwa kule meko, loo nkqubo ayisebenzi kakuhle, kwaye endaweni yokulwa neentsholongwane zasemzini, iqala ukuhlasela iiseli zethu ezilungileyo. Kungathi asinakwazi ukuxelela ukuba ngubani ongowethu kwaye ngubani utshaba. Kwanoogqirha abakakwazi ukuqonda ukuba kutheni oku kusenzeka.

Ukuba une-scleroderma, inkqubo yakho yomzimba yokuzikhusela ixelela iiseli zomzimba wakho ukuba zenze iproteni eninzi ebizwa ngokuba yi-collagen . Imizimba yethu iyayifuna i-collagen. Yiyo eyenza izicwili eziqinileyo nezisempilweni ezixhasa amalungu ethu. Kodwa xa ziqokelelana kakhulu, ulusu kunye nezinye izicwili ziyatyeba kwaye zibe ne-fiber ngaphezu kwesiqhelo.

I-Scleroderma yimeko engapheliyo . Oku kuthetha ukuba unokuphila nale mpawu ixesha elide, mhlawumbi ubomi bakho bonke. Kwakhona, ukuba ichaphazela izicwili zamalungu akho angaphakathi, inokubangela iingxaki ezisongela ubomi. Ukuba uziva ngathi unesifo sentliziyo, unengxaki yokuphefumla, okanye unengxaki yokuginya, fowunela u-911 (okanye inombolo yakho yongxamiseko yasekuhlaleni) ngoko nangoko, okanye uye kwigumbi likaxakeka esibhedlele.

Ukuba uneentlungu okanye ukuqina kwamalungu akho, ingakumbi ajikeleze iminwe neenzwane zakho, ngokuqinisekileyo kuya kufuneka ubone ugqirha.

Ziziphi iintlobo eziphambili zeScleroderma?

Oogqirha bahlula i-scleroderma kwiintlobo ezimbini eziphambili:

1. I-Localized Scleroderma: 'Localized' ithetha ukuvalelwa kwindawo enye. Olu hlobo luchaphazela inxalenye enye yomzimba (ngokuqhelekileyo ulusu). Lubangela amabala okanye imicu yolusu olujiyileyo nolufana nencindi. Eyona nto ingcono kukuba i-localized scleroderma ngamanye amaxesha inokuzigqibela yodwa . Ayisasazeki nakwezinye iindawo zomzimba.

2.I-Systemic Sclerosis: Olu hlobo lunokuchaphazela amanye amalungu omzimba ukongeza kulusu. Lunokuchaphazela inkqubo yakho yokuphefumla (ilungu elikuncedayo ukuphefumla nokuvumba) kunye nenkqubo yakho yokugaya ukutya (ilungu eliguqula ukutya esikutyayo kube ngamandla). Ukuba i-scleroderma ichaphazela amandla akho okuphefumla okanye ukufunxa izondlo, unokuba neengxaki ezinkulu. Inokuba yingozi. I-Systemic Sclerosis ikwanazo nezinye iintlobo ezintathu - i-diffuse, i-limited, kunye ne-sine sclerosis.

I-Diffuse Sclerosis

'Ukusasaza' kuthetha 'ukusasazeka'. Kule meko, i-diffuse sclerosis yenzeka ngequbuliso kwiindawo ezinkulu zomzimba. Umzekelo:

• Isifuba
• Isisu
• Amathanga
• Iingalo
• Imilenze
• Ubuso

Kwakhona, inokuchaphazela amalungu amaninzi ngaxeshanye. Oko kuthetha ukuba:

• Inkqubo yokugaya ukutya (Inkqubo yokugaya ukutya - indlela yokugaya ukutya)
• Izintso
• Intliziyo
• Imiphunga

Isifo seSclerosis esiNcinci (i-CREST syndrome)

Oogqirha badla ngokubiza i-Limited Scleroderma njenge -CREST syndrome . Unobumba ngamnye kwi-CREST umele uphawu olubangelwa yiyo:

• C - ICalcinosis: Ubuninzi bekhalsiyam eluswini. Ingabonakala njengamaqhuma amancinci amhlophe eluswini.
• R - Raynaud's syndrome: Ukutshintsha kombala kunye nokungacaci kweminwe kunye neenzwane. Zinokuba mhlophe, ziluhlaza okwesibhakabhaka, okanye zibomvu xa zibekwe kwindawo ebandayo.
• E - Ukungasebenzi kakuhle kwe-Esophageal: Ubunzima bokuginya kunye ne-acid reflux.
• S - Sclerodactyly: Ukuqina kolusu kwiminwe, okwenza kube nzima ukugoba nokulungisa iminwe.
• T - IiTelangiectasias: Amabala amancinci, abomvu okanye anombala otshintshileyo eluswini. La mabala anokubonakala ngathi ziintambo zesigcawu.

Isifo seSine Sclerosis

Kwimeko yeSine Sclerosis, iimpawu zeLimited Sclerosis ezikhankanyiweyo ngaphambili ziyenzeka, kodwa ulusu aluchaphazeleki . Oko kukuthi, usenokuba nezinye zeempawu ezikhankanyiweyo kwi-CREST syndrome, kodwa akukho kuqina okubonakalayo kolusu.

Ixhaphake kangakanani iScleroderma?

I-Scleroderma sisifo esingaqhelekanga ngokwenene.Iingcali ziqikelela ukuba malunga nabantu abangama-250 kwisigidi eMelika baneentlobo ezintathu ze-scleroderma. Kulaba, malunga nabantu abayi-100,000 bane-systemic sclerosis.

Zithini iimpawu zeScleroderma?

Abanye abantu abane-scleroderma basenokungabi nazo naziphi na iimpawu kwasekuqaleni. Nangona kunjalo, kwabaninzi, uphawu oluphambili kukubonakala kwamabala aqinileyo, afana newax okanye imicu eluswini. Ukongeza, kukho nezinye iimpawu ezininzi eziqhelekileyo:

• Intlungu yamalungu
• Ukuqina , ingakumbi xa uvuka kusasa
• Ukudinwa (ukuziva udiniwe kakhulu ngalo lonke ixesha)
• Ukunciphisa umzimba ngendlela engachazekiyo

Ezinye iimpawu ozifumanayo (kwaye apho zikuchaphazela khona) zixhomekeke kuhlobo lwe-scleroderma onayo.

Iimpawu ze-Localized Scleroderma

Abantu abane-localized scleroderma badla ngokubona ukuqina kolusu kuphela . Oku kuqina kusenokuba kwindawo enye okanye kwenzeke kwiindawo ezinamabala. Kunokuchaphazela ezi ndawo zilandelayo zolusu:

• Isifuba
• Isisu (indawo ejikeleze isisu)
• Iingalo nemilenze (Iingalo nemilenze yakho)
• Izandla neminwe
• Iinyawo neenzwane

Nangona kunjalo, i-localized scleroderma, echaphazela amalungu angaphakathi, ayifumaneki rhoqo .

Iimpawu zeSystemic Sclerosis

I-systemic sclerosis inokubangela iimpawu ezahlukeneyo. Oku kubangela ukuba ulusu lube lukhuni, kodwa ngokuqhelekileyo kwiindawo ezinkulu nakwiindawo ezinamabala. Ingakumbi ebusweni nasezizandleni. Ulusu oluqinileyo lunokuqala kwiminwe nakwiinzwane luze lusasazeke emzimbeni wonke. Ukuba unesifo sikaRaynaud , iminwe neenzwane kwilungu elichaphazelekayo zinokutshintsha umbala xa zichatshazelwa yingqele (ngesiqhelo zimhlophe, zibomvu, okanye zimfusa-luhlaza okwesibhakabhaka).

I-Systemic sclerosis inokubangela iimpawu kwezinye izitho zomzimba kunye nezicubu zakho. Umzekelo:

• Izihlunu: Ukuba ndindisholo nokudumba, ingakumbi ezandleni nasezinyaweni (eziphelweni zamalungu akho).
• Amalunga: Ukuqina, ukudumba, kunye nokulahlekelwa kukuhambahamba.
• Imiphunga: Ukukhohlela kunye nobunzima bokuphefumla (ukuphelelwa ngamandla).
• Indlela yokugaya ukutya: I-Dysphagia, isitshiso sentliziyo, ukudumba, ukuqhina, kunye norhudo.
• Intliziyo:Ukubetha kwentliziyo okungaqhelekanga (i-arrhythmia), ukuqokelelana kolwelo olujikeleze intliziyo (i-pericardial effusion), kunye nokuqina kwemisipha yentliziyo (i-fibrosis).
• Izintso: Ukungasebenzi kakuhle kwezintso (oku kunokuba yingozi ebomini).
• Izitho zangasese: Ukungasebenzi kakuhle kwe-Erectile (ED) kumadoda kunye nokoma kwe-vaginal kubafazi.

Yintoni ebangela iScleroderma?

Enyanisweni, oogqirha abakayazi eyona nto ibangela i-scleroderma.

Ezinye izifundo zifumanise ukuba inokusebenza kwiintsapho ukuya kwinqanaba elithile (oko kuthetha ukuba inokudluliselwa ukusuka kubazali ukuya ebantwaneni), kodwa ayiqhelekanga kangangokuba akukho bungqina baneleyo bokungqina ngokuqinisekileyo ukuba sisifo semfuza .

Izinto Ezibangela Umngcipheko weScleroderma

Nabani na unokuba ne-scleroderma, kodwa amanye amaqela asengozini enkulu:

• Abafazi banamathuba aphindwe kane okufumana esi sifo kunamadoda.
• Ixhaphake kakhulu kubantu abaneminyaka ephakathi kwama-30 nama-50. I-Scleroderma ayifumaneki lula kubantu abangaphantsi kwama-30 eminyaka ubudala.
• Abantu abamnyama banamathuba amaninzi okuba nesifo se-scleroderma. Bakwanomkhuba wokuba nesifo kwangethuba, banamathuba amaninzi okuba neempawu ezichaphazela imiphunga, kwaye babe neempawu eziqatha zolusu.

Ziziphi iingxaki ezinokubakho zeScleroderma?

Abantu abane-scleroderma basengozini enkulu yokuhlaselwa zezinye izifo ezimbini: iRaynaud's syndrome kunye neSjögren's syndrome .

Isifo sikaRaynaud sichaphazela imithambo yegazi emincinci kwiminwe yakho nakwiinzwane zakho (iinombolo zakho). Abantu abanale meko bafumana iimpawu (ngamanye amaxesha zibizwa ngokuba 'ziintlaselo'). Kulapho imithambo yegazi kwiminwe yakho ifinyela ngequbuliso kakhulu. Oku kunokubangela ukuba ulusu kwiminwe echaphazelekayo lutshintshe lube mthubi, okanye lube mhlophe kunombala wesikhumba sakho wendalo. Ngamanye amaxesha, lunokubonakala luluhlaza okwesibhakabhaka.

I-Sjögren's syndrome ibangela ukuba ezinye zeendlala zomzimba wakho zivelise ukufuma okuncinci – uninzi lwazo ziindlala zamathe emlonyeni wakho kunye neendlala ezikrazukileyo emehlweni akho. Abanye abantu abane-Sjögren's syndrome nabo bafumana iintlungu zemisipha kunye namalungu.

Ezinye iintlobo ze-scleroderma zinokubangela iingxaki ezinkulu . Ezinye zazo ziquka:

• Ukungasebenzi kakuhle kwezintso
• Uxinzelelo lwegazi oluphezulu kwimithambo yegazi ethwala igazi lisuka entliziyweni ukuya emiphungeni)
• I-Pulmonary fibrosis (ukurhawuzelelwa kwezicubu zemiphunga)
• Isifo sentliziyo (iingxaki ezichaphazela intliziyo yakho kunye nemithambo yegazi)
• Ukungaphumeleli kwentliziyo okubangelwa kukunganyamezelani, imeko yentliziyo
• Ukunqongophala kwamandla omzimba
• Izifo zesisu (iimeko ezichaphazela indlela umzimba osebenza ngayo ekutyeni nasekufunxeni izondlo)
• Umhlaza

Ezinye zezi ngxaki zingabulala . Ukuba ubona naziphi na iimpawu ezintsha okanye ezitshintshayo, bona ugqirha ngokukhawuleza. Ukuba ucinga ukuba uneempawu zokuhlaselwa yintliziyo, ezinje ngobunzima bokuphefumla okanye ukuginya, fowunela u-911 (okanye inombolo yakho yongxamiseko yasekuhlaleni) ngoko nangoko, okanye uye kwigumbi likaxakeka esibhedlele.

Ifunyanwa njani iScleroderma?

Ugqirha uxilonga isifo se-scleroderma ngovavanyo lomzimba kunye nezinye iimvavanyo ezininzi.

Kusenokufuneka ubonane nogqirha wezifo zamathambo , ugqirha ochwephesha ekunyangeni izifo zenkqubo yomzimba yokuzikhusela. Uza kukuhlola aze akubuze ngeempawu zakho. Kufuneka uxelele ugqirha wakho ukuba zeziphi iimpawu zakho, ukuba zaqala nini, kwaye nokuba kukho into ebonakala izenza zibe mandundu na.

Kuya kufuneka wenze uvavanyo oluninzi ukuqinisekisa ukuba awunazo ezinye iimeko ezibangela iimpawu ezifanayo.

Ziziphi iimvavanyo ezisetyenziswa ngoogqirha ukuze baxilonge iScleroderma?

Ukuchonga i-scleroderma kudla ngokuba yinxalenye yenkqubo ebizwa ngokuba yi -'differential diagnosis.' Oku kuthetha ukuba ugqirha wakho usenokungazivumeli ezinye iimeko aze enze uvavanyo oluninzi ukuze afumanise ukuba yintoni ebangela iimpawu zakho ngaphambi kokuba akufumanise une-scleroderma. Nazi ezinye zeemvavanyo onokuba nazo:

• Uvavanyo lwegazi ukuze kubonwe ukuba amajoni akho omzimba asebenza njani.
• Uvavanyo lomsebenzi wemiphunga ukuze kubonwe ukuba imiphunga yakho okanye inkqubo yokuphefumla ichaphazelekile na.
• I -biopsy yinkqubo apho kuthathwa isampulu encinci yolusu oluchaphazelekayo okanye ezinye izicwili ize ivavanywe kwilebhu.
• Ukuba uneempawu zokugaya ukutya (GI), i-endoscopy luvavanyo olujonga ezantsi emqaleni okanye esiswini sakho ngekhamera encinci eqhotyoshelwe kwityhubhu ende nebhityileyo.

Ukongeza, kuya kufuneka wenze iimvavanyo ezininzi zokuthatha imifanekiso ukuze uthathe imifanekiso yangaphakathi emzimbeni wakho. Ezi ziquka:

• I-Electrocardiogram (ECG)
• I-Echocardiogram (i-Echocardiogram - i-Echo)
• I -X-reyi yesifuba
• I- CT scan (i-Computed Tomography - i-CT scan)

Iphathwa njani iScleroderma?

Akukho nyango lwe-scleroderma , kodwa ugqirha wakho unokukunceda ufumane indibaniselwano yonyango olunokukunceda ukulawula iimpawu zakho nokunciphisa impembelelo yazo kubomi bakho bemihla ngemihla.

Uhlobo lonyango olufunekayo luxhomekeke ekubeni iimpawu zakho zikuphi kwaye zinzima kangakanani. Nazi ezinye iindlela eziqhelekileyo zonyango lwe-scleroderma:

• Unyango lwesikhumba: Kuya kufuneka usebenzise iikhrimu kunye nezithambisi-mafutha ukuthintela ukoma kwesikhumba sakho.
• Ii-immunosuppressants: La mayeza athintela inkqubo yakho yomzimba yokuzikhusela ekonakaliseni iiseli kunye nezicubu ezisempilweni.
• Amayeza okulawula iimpawu ezithile: Umzekelo, unokufuna ukuthatha amayeza okulawula uxinzelelo lwegazi, ukwenza ukuphefumla kube lula, ukulawula ukungasebenzi kakuhle kwezintso, okanye ukunciphisa iimpawu zokugaya ukutya.
• Unyango lomzimba: Ingcali yonyango lomzimba inokukunceda uphucule iintshukumo zakho zomzimba.
• Unyango ngeFoto: Oku kuquka ukusebenzisa ukukhanya okukhanyayo, okugxile kwi-ultraviolet (UV) ukunyanga iingxaki zolusu. Oku kunokunceda ekunyangeni ulusu olujiyileyo.
• Ukufakelwa kweeseli ze-stem: Abanye abantu abaneempawu eziqatha banokufuna ukufakelwa iiseli ze-stem. Oku kuquka ukutshintsha iiseli zegazi ezonakeleyo ngeeseli eziphilileyo zomnikelo.

Ukuba ndineScleroderma, ndimele ndilindele ntoni?

Ufanele ulindele ukuba i-scleroderma kunye neempawu zayo ziya kulawula ubomi bakho bonke . Nangona kungekho nyango luhlala luhleli, abantu abaninzi bafumana unyango kunye notshintsho kwindlela yokuphila olunokunciphisa impembelelo yeempawu zabo kubomi babo bemihla ngemihla.

Ukuphila nesigulo esihlala ixesha elide kunokuba yinto ecaphukisayo ngamanye amaxesha. Buza ugqirha wakho malunga namaqela enkxaso okanye amathuba emfundo anokukunceda ulawule uxinzelelo lwakho kunye nempilo yengqondo.

Ngaba iScleroderma ingathintelwa?

Ngenxa yokuba unobangela ochanekileyo ungaziwa, akukho ndlela yokuthintela i-scleroderma .

Ndingazinyamekela njani? (Ukuzinyamekela)

Ukongeza kunyango lwakho oluqhelekileyo, unokukwazi ukulawula ezinye iimpawu ngokwenza utshintsho kwindlela yakho yokuphila yemihla ngemihla. Ezinye zezi ziquka:

• Ukulandela ukutya okunempilo kunye nesicwangciso sokuzilolonga esikufaneleyo.
• Ukuphepha ukwenza umthambo onzima xa ungaziva kakuhle.
• Khusela ulusu lwakho ngokunxiba ngendlela efanelekileyo kwindawo okuyo kunye nokusebenzisa i -sunscreen esemgangathweni xa uphuma ngaphandle.
• Ndwendwela ugqirha wamazinyo (umboneleli wamazinyo) ukuze ucoce amazinyo rhoqo kwaye uhlolwe.

Ndifanele ndimbone nini ugqirha wam?

I-Scleroderma inokubangela iimpawu ezahlukeneyo, ngoko ke ngamanye amaxesha kunokuba nzima ukuzazi ekuqaleni. Ukuba unentlungu entsha okanye ezinye iimpawu, ingakumbi ukuba ziya zisiba mandundu, bona ugqirha. Nokuba iimpawu zakho zibangelwa yenye into, ugqirha wakho unokuchonga unobangela aze acebise unyango lokuzilawula.

Ukuba unyango lwakho lwe-scleroderma alubonakali lusebenza kakuhle, okanye ukuba iimpawu zakho ziyatshintsha okanye ziya ziba mandundu – ingakumbi ukuba zichaphazela amandla akho okuphefumla okanye okuginya – thetha nogqirha wakho.

Ndingaya nini kwiYunithi yoNyango oluNgxamisekileyo (i-ETU) ?

Ukuba uneempawu zokuhlaselwa yintliziyo , ezinje ngeentlungu esifubeni, ubunzima bokuphefumla, okanye ukuba uziva ngathi awukwazi ukuginya, fowunela u-911 (okanye inombolo yakho yongxamiseko yasekuhlaleni) ngoko nangoko, okanye uye kwisebe likaxakeka lesibhedlele.

Ndingayibuza yiphi imibuzo ugqirha wam?

Ungalibali ukubuza le mibuzo xa ubona ugqirha:

• Ngaba ndineScleroderma okanye esinye isifo?
• Luhlobo luni lweScleroderma endinalo?
• Luhlobo luni lonyango endiludingayo?
• Ziziphi iingxaki ekufuneka ndiziqaphele ngokukodwa?

Ingakanani iminyaka yobomi bomntu oneScleroderma?

Uninzi lwabantu abane-scleroderma abanazo iingxaki ezisongela ubomi .

Nangona kunjalo, ukuba une-systemic sclerosis, echaphazela amalungu angaphakathi, usemngciphekweni omkhulu weengxaki ezinkulu. Ugqirha wakho uza kukuxelela into omawuyilindele kunye nokuba usemngciphekweni ophezulu weengxaki ezibulalayo.

Ngaba iScleroderma sisifo esiyingozi?

Njengaso nasiphi na isifo esingapheliyo, i-scleroderma yimeko ebalulekileyo neyingozi.Oku kungenxa yokuba kuya kufuneka ujongane neempawu ubomi bakho bonke. Nangona kunjalo, oko akuthethi ukuba iScleroderma iya kulawula ubomi bakho. Amava abo bonke ahlukile. Thetha nogqirha wakho malunga noloyiko lwakho, amathandabuzo kunye neenkxalabo zakho.

I-Scleroderma inokuba yimeko ekhathazayo kakhulu onokuhlala nayo. Ngenxa yokuba oogqirha abaqinisekanga ukuba yintoni ebangela oko kwaye akukho nyango lufanayo, kungathatha ixesha ukufumana unyango oluya kulawula iimpawu zakho kakuhle. Ugqirha wakho uya kukunceda kuyo yonke inyathelo.

Kholosa indlela oziva ngayo esiswini sakho, kwaye ukholelwe kwinto evakala 'ingalunganga'. Nokuba utshintsho oluncinci kwiimpawu lunokuba luphawu lwengxaki ekufuneka ihlolwe ngugqirha wakho. Ungoyiki ukubuza imibuzo kwaye wabelane ngeengcinga zakho malunga neempawu okanye unyango lwakho.

Ukuphila nesifo esinganyangekiyo kunokuba yinto edinisayo. Zinike ixesha lokuzihlonipha nokuziqonda ngenxa yomsebenzi onzima owenzayo ukulawula iimpawu zakho.

Izinto ezibalulekileyo ekufuneka uzikhumbule (Umyalezo Wokuya Ekhaya)

Kulungile, sithethe kakhulu ngeScleroderma ngoku. Ukuqukumbela, nazi izinto ezibalulekileyo ekufuneka uzikhumbule:

• I-Scleroderma sisifo esingaqhelekanga, esihlasela umzimba apho umzimba uvelisa i-collagen eninzi kakhulu, nto leyo ebangela ukuba ulusu ngamanye amaxesha amalungu angaphakathi aqine.
• Kukho iintlobo ezimbini eziphambili zale nto: eyendawo kunye neyenkqubo yomzimba. Uhlobo lwenkqubo yomzimba luyingozi ngakumbi kuba lunokuchaphazela nezitho zangaphakathi.
• Iimpawu ziyahluka. Ezona ziphambili ziquka ukuqina kolusu, iintlungu zamalungu, ukudinwa, kunye nesifo sikaRaynaud.
• Nangona kungekho nyango luhlala luhleli, kukho unyango olusebenzayo lokulawula iimpawu. Thetha nogqirha wakho kwaye wenze isicwangciso sonyango esikusebenzelayo.
• Ukuxilongwa kwangoko kunye nonyango kubaluleke kakhulu. Ngoko ke, ukuba unale mpawu, qiniseka ukuba ucela iingcebiso zonyango.
• Ekubeni le yimeko yexesha elide, kubalulekile ukuhlala uqinile engqondweni. Ukuba kuyimfuneko, funa uncedo kumaqela enkxaso.

Ungakhathazeki, awuwedwa. Ngolwazi olufanelekileyo kunye neengcebiso zonyango, ungaphila ngempumelelo nale meko.

I- Scleroderma, iScleroderma, Ukuqina kolusu, Izifo zokuzikhusela komzimba, iCollagen, isifo sikaRaynaud, iSystemic sclerosis, Izifo zolusu