Ngaba nawe ukhe waba nezinga le-cholesterol eliphakamileyo kancinci kwaye ugqirha ukhe wakunika amayeza? Xa uthatha amayeza e-statin adla ngokunikwa, abanye abantu banengxaki yokuthatha amayeza kuba abangela iintlungu emzimbeni, ingakumbi kwimisipha. Abanye abantu bayayeka ukuwathatha amayeza ngenxa yokungakhululeki. Ngaba oku kuye kwenzeka nakuwe? Ukuba kunjalo, eli nqaku liza kuba libaluleke kakhulu kuwe. Kuba, namhlanje sithetha ngeyeza elitsha elibonelela ngokhuseleko oluhle kwintliziyo, eliye laziswa kwabo bangenakuthatha amayeza e-cholesterol ngenxa yeziphumo ebezingalindelekanga ezinjalo.
Yintoni le yeza litsha kwaye lenza ntoni?
Eli yeza litsha libizwa ngokuba yiBempedoic acid. Linokufumaneka phantsi kwamanye amagama athengiswayo. Eli yeza linikwa abantu, njengoko besitshilo ngaphambili, abafumana iziphumo ebezingalindelekanga ezifana neentlungu zemisipha xa besebenzisa amayeza e-statin.
Uphando olukhulu lwakutshanje lufumanise ukuba ukusebenzisa eli yeza kunciphisa "i-cholesterol embi" yomzimba, okanye i-LDL (low-density lipoprotein) cholesterol, malunga ne-21% kwiinyanga ezi-6.
Ngamafutshane, le cholesterol imbi ebizwa ngokuba yi-LDL yiyo ehlala eludongeni lwemithambo yegazi yethu, izivale kancinci kancinci. Njengothuli olubhajwa kumbhobho wamanzi. Oku kuvaleka kwemithambo yegazi yikona okubangela izifo ezininzi eziyingozi ezifana nokuhlaselwa yintliziyo kunye nokubetha.
Ngoko ke eli yeza litsha alinciphisi nje kuphela amanqanaba e-LDL, kodwa likwanciphisa nomngcipheko wokuhlaselwa sisifo sentliziyo ngama-23% , kunye nomngcipheko wokufumana imeko enzima efana nokuhlaselwa sisifo sentliziyo, isifo sohlangothi, okanye ukufuna unyango lomthambo wegazi ovalekileyo ngama-13%, olu phononongo luqinisekisile.
Ngaba eli yeza lingcono kunee-statins esizisebenzisayo ngoku?
Lo ngumbuzo obaluleke kakhulu. Kukho into ekufuneka siyiqonde ngokucacileyo sonke apha.
Impendulo ithi, hayi . Udidi lwamayeza angcono, asebenzayo, kwaye akhethwa kuqala akhoyo ngoku kwihlabathi lokulawula i-cholesterol yiklasi ye-statin.
Kutheni ke eli liyeza elitsha? Cinga ngalo mzekelo. Iistatin zifana 'neqhawe elikhulu' elihlisa i-cholesterol. Eli yeza litsha, i-Bempedoic acid, lifana 'nomncedisi okrelekrele' weqhawe. Lo gama nje iqhawe likho, singazenzela umsebenzi ngokwethu. Kodwa ngamanye amaxesha kukho abantu abangakwaziyo ukumelana namandla alo qhawe. Ngaloo maxesha, kungcono kakhulu ukufumana uncedo lwalo mncedisi okrelekrele kunokuba ungabi nakhuseleko. Unayo?
Oko kuthetha ukuba, ukuba ugqirha wakho ukunike i-statin, kwaye awufumani miphumo mibi ibalulekileyo, ngokuqinisekileyo kuya kufuneka uqhubeke nokusela loo mayeza . Ungaze ucinge nangokuyeka ukusebenzisa i-statin yakho kuba nje unale mayeza matsha.
Ixabiso lokwenyani leli yeza litsha kukuba libonelela ngenye indlela ekhuselekileyo kwabo basengozini yesifo sentliziyo kwaye abangakwaziyo ukuthatha naluphi na unyango ngenxa yeziphumo ebezingalindelekanga ze-statins.
Masijonge nje iziphumo zophando.
Olu asilulo nje uphando oluncinci. Luphononongo olubaluleke kakhulu olwenziwe kwiminyaka emithathu, kusetyenziswa iqela elikhulu labantu, malunga ne-14,000, abangazange bakwazi ukuthatha ii-statins. Makhe sijonge iziphumo eziphambili kwitheyibhile efana nale.
| Isiphumo | Inkcazo elula |
|---|---|
| Ukunciphisa i-cholesterol embi (LDL) | Yehlisa amanqanaba e-cholesterol embi ngama-21% kwiinyanga ezi-6. |
| Umngcipheko wokuhlaselwa yintliziyo | Inciphisa umngcipheko wokuba nesifo sentliziyo ngama-23%. |
| Umngcipheko wesifo sentliziyo iyonke | Inciphisa umngcipheko wezifo ezinzulu zentliziyo ezifana nokuhlaselwa yintliziyo kunye nesifo sohlangothi nge-13%. |
| Ukuthelekisa neStatin | Amayeza e-statin asebenza ngokuphindwe kabini ekulawuleni i-cholesterol kune-Bempedoic acid. |
Ngoko ke ngubani ofanelekileyo ngokwenene kweli yeza?
Eli yeza alilungelanga wonke umntu. Lifaneleke kakhulu kubantu abalandelayo:
- Kwabo bafumana iintlungu zemisipha ezinganyamezelekiyo okanye ezinye iingxaki xa besebenzisa amayeza e-statin.
- Kwabo baye bacetyiswa ngugqirha wabo ukuba bayeke ukuthatha ii-statins ngenxa yezinye iziphumo ebezingalindelekanga ezibi.
- Kwabo basengozini enkulu yokuba nesifo sentliziyo ukuba i-cholesterol yabo ayilawulwa, kodwa abanakuthabatha ii-statins phantsi kwayo nayiphi na imeko.
- Ukuba sele uthatha i-statin kodwa kufuneka ulawule ngakumbi amanqanaba akho e-cholesterol, ugqirha wakho unokucebisaUkuba ugqiba ekubeni uyongeze njengeyeza lesibini .
Eyona nto ibalulekileyo kukuba, musa ukwenza izigqibo ngokwakho, nokuba uza kusela eli yeza okanye uyeke ukuthatha ii-statins. Qiniseka ukuba uxoxa ngale nto nogqirha wakho onyangayo kwaye wenze isigqibo sakho ngokusekelwe kwingcebiso yakhe.
Ndiyekile ukuthatha ii-statins ngaphambili. Ngaba kufuneka ndiqale kwakhona?
Lo ngumbuzo olungileyo. Mhlawumbi ubukhe waba neengxaki ngee-statins ngaphambili waza wayeka ukuzisebenzisa. Kodwa uluvo lweengcali luthi kufanelekile ukuqala kwakhona ii-statins, ukuba kunokwenzeka, phantsi kwengcebiso kagqirha, ngaphambi kokuba uqhubekele kwezinye iindlela ezifana neBempedoic acid. Kuba, njengoko besitshilo ngaphambili, ukhuseleko kunye neenzuzo zee-statins zinkulu kakhulu.
Ugqirha wakho angakutshintshela kolunye uhlobo lwe-statin okanye atshintshe umthamo. Ngoko ke, ukuba ubunengxaki nge-statin yakho yangaphambili, thetha nogqirha wakho ngayo loo nto.
Umyalezo Wokuya Ekhaya
- Iyeza elingcono nelibaluleke kakhulu lokulawula i-cholesterol liseliqela lamayeza e-statin . Anezinga eliphezulu lokhuseleko.
- I-asidi ye-bempedoic yindlela exabisekileyo yokusetyenziswa endaweni ye-statins, ayithathi indawo yayo.
- Eli yeza litsha licetyiswa kakhulu kubantu abangakwaziyo ukunyamezela iziphumo ebezingalindelekanga ze-statins (ingakumbi iintlungu zemisipha).
- Endaweni yokuthatha umngcipheko wokungathathi naluphi na unyango kwaphela, eli yeza libonelela ngokhuseleko olukhulu lwentliziyo kwabo bangenako ukuthatha ii-statins.
- Yenza naziphi na izigqibo malunga namayeza e-cholesterol, nokuba uqala, uyeke, okanye utshintshe amayeza, nogqirha wakho. Kuphephe ukwenza izigqibo wedwa.
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