Xa ugqirha ekuxelela okanye umntu omthandayo ukuba "unesifo somhlaza webele ," kuyinto eqhelekileyo ukuziva ngathi ihlabathi lakho lonke liwile. Kunye noloyiko kunye nokuxhalaba okufika engqondweni, unemibuzo emininzi malunga nonyango kunye namayeza anikwa ngugqirha. "Ngaba eli yeza lilungile emzimbeni?", "Ngaba liza kubangela iziphumo ebezingalindelekanga ?", "Ngaba oku kuya kusebenza ngokwenene?" Izinto ezinjalo mhlawumbi zidlula entlokweni yakho. Yile ndlela esiza kuthetha ngayo ngeTamoxifen, iyeza elibaluleke kakhulu elisetyenziswa kakhulu kunyango lomhlaza webele, ngendlela elula neyobuhlobo namhlanje.
Ngamafutshane, yintoni iTamoxifen?
I-Tamoxifen liyeza elisetyenziselwa ukunyanga umhlaza webele one- hormone receptor-positive . Liza njengepilisi (Nolvadex®) okanye ulwelo (Soltamox®).
Ngoku usenokuba ucinga, "Yintoni le mhlaza ixhomekeke kwiihomoni?" Kulula kakhulu. Ezinye iiseli zomhlaza emzimbeni wethu zifana nesityalo esincinci. Njengokuba isityalo sifuna amanzi kunye nesondlo ukuze sikhule kwaye sikhule, ezi seli zomhlaza zifuna iihomoni ezibizwa ngokuba yi-estrogen okanye i-progesterone ukuze zikhule kwaye zisasazeke. Yiloo nto siyibiza ngokuba 'ngumhlaza oxhomekeke kwiihomoni.'
Into eyenziwa liyeza i-tamoxifen kukuthintela ukusebenza kwe-hormone ye-estrogen efunekayo kwiiseli zomhlaza. Kufana nokucima ipompo yamanzi yesityalo. Emva koko iiseli zomhlaza azifumani myalezo ekufuneka zikhule.
Kwakhona, oogqirha ngamanye amaxesha bacebisa eli yeza ukuthintela umhlaza kubantu abasengozini enkulu yokuba nomhlaza webele (umzekelo, ukuba kukho umntu kusapho lwakhe obenomhlaza ).
Ngubani ocebisa eli yeza?
I-Tamoxifen ayinikwa bonke abantu abanomhlaza webele. Ugqirha wakho uza kuqwalasela izinto ezininzi, kuquka imbali yakho yezonyango kunye nohlobo lomhlaza, ukuze agqibe ukuba eli yeza likulungele na. Lisetyenziswa kakhulu kwezi meko zilandelayo:
- Abo banembali yosapho yomhlaza okanye utshintsho lwezakhi zofuzo ze-BRCANjengenyathelo lokuthintela umhlaza kwabo basengozini enkulu yokuba nomhlaza webele ngenxa yezinto ezifana nezi:
- Ukuthintela ukuphinda komhlaza kumntu osele enomhlaza webele kwaye oye wafumana unyango olufana notyando , i-chemotherapy , okanye unyango lwe-radiation .
- Thintela umhlaza kwelinye ibele eliphilileyo kumntu onomhlaza kwelinye ibele.
- Kumntu onesigaba sokuqala somhlaza, njenge -DCIS (ductal carcinoma in situ) , thintela ukuba ungasasazeki ngakumbi kwaye ube ngumhlaza onzima ngakumbi.
Eyona nto ibalulekileyo kukuba isigqibo sokuba uza kusela okanye awuthathi eli yeza, kunye nexesha elingakanani, kufuneka senziwe ngugqirha wakho ngokupheleleyo. Ngoko ke ungoyiki ukuxoxa ngayo nayiphi na imibuzo onayo malunga noku nogqirha wakho.
Ziziphi iingenelo eziphambili zeTamoxifen?
I-Tamoxifen liyeza eliye lanceda ekusindiseni ubomi bezigidi zabasetyhini kwihlabathi liphela kangangeminyaka emininzi. Iingenelo zalo azibalulekanga kangako.
- Inciphisa ukuphinda umhlaza: Eli yeza linokunciphisa umngcipheko wokuphinda umhlaza emva konyango ngama- 30% ukuya kuma-50% .
- Ikhusela elinye ibele: Kumntu okhe waba nomhlaza kwelinye ibele, umngcipheko wokuba nomhlaza kwelinye ibele uncitshiswa malunga nama-50% .
- Ithintela umhlaza: Kumntu osengozini enkulu, umngcipheko wokuba nomhlaza kwasekuqaleni ungancitshiswa malunga ne-40% .
- Yomeleza amathambo: Eli yeza linceda ekuthinteleni i-osteoporosis , isifo sokuncipha kwamathambo esiba khona ingakumbi emva kokuya exesheni.
- Inciphisa i-cholesterol: I-Tamoxifen ikwanako nokunciphisa izinga le-cholesterol embi emzimbeni.
Zithini iziphumo ebezingalindelekanga ezinokubakho xa usebenzisa iTamoxifen?
Njengayo nayiphi na iyeza, iTamoxifen inokubangela ezinye iziphumo ebezingalindelekanga. Kodwa oku akuthethi ukuba uza kuzifumana zonke. Abanye abantu basenokungaziboni kwaphela. Abanye banokufumana enye okanye ezimbini. Ukuzazi ezi zinto kwangaphambili kuya kukunceda ujongane nazo.
Masiwahlule la miphumo ibe ngamacandelo amabini.
| Uhlobo lwesiphumo esibi | Inkcazo |
|---|---|
| Iziphumo ebezingalindelekanga eziqhelekileyo, ezingabalulekanga kangako | |
| Iimpawu zokuya exesheni | Ubushushu obugqithisileyo, ukubila ebusuku, kunye nokoma kwelungu lobufazi zezinye zezona zinto zinzima abantu abaninzi abazivayo. |
| Utshintsho kwinyanga yokuya exesheni | Umjikelo wokuya exesheni usenokuba ngongahambelaniyo okanye uyeke ngokupheleleyo. |
| Ukunyuka kobunzima okanye ukudumba | Abanye abantu banokufumana ubunzima obuncinci. Abanye banokufumana ukudumba (ukudumba) ngokungathi imizimba yabo izele ngamanzi. |
| Ezinye iingxaki ezincinci | Ukuphuma kwamanzi kwi-vaginal, isicaphucaphu, irhashalala eluswini, ukudinwa, intloko ebuhlungu, ukudumba kwemilenze, kunye nokungasebenzi kakuhle kwe-erectile kumadoda kunokwenzeka. |
| Iingozi ezingaqhelekanga kodwa ezinzulu | |
| Amahlwili egazi | Kukho umngcipheko omncinci kakhulu wokukhula kweemeko ezifana nokuqhekeka kwegazi kwimithambo yemilenze (i-deep vein thrombosis - DVT) okanye istroke. |
| Umhlaza wesibeleko | I-Tamoxifen iyandisa kancinci umngcipheko womhlaza we-endometrial, olu luhlu lwesibeleko. Yiyo loo nto kufuneka uxelele ugqirha wakho ngoko nangoko ukuba ufumana ukopha okungaqhelekanga kwilungu lobufazi. |
| Iingxaki zamehlo | Umngcipheko wokuba ne-cataracts unokwanda kancinci. |
Kubalulekile ukukhumbula ukuba ezi ziphumo zimbi azixhaphakanga , kodwa bubulumko ukuzazi kwaye wazise ugqirha wakho ngoko nangoko ukuba kukho naziphi na kwezi mpawu.
Kunini apho kufuneka ufowunele ugqirha ngokukhawuleza?
Ukuba usebenzisa iTamoxifen kwaye ufumana naziphi na iimpawu ezilandelayo, kufuneka wazise ugqirha wakho ngoko nangoko okanye uye kwiSebe leNgxamiseko (ETU) lesibhedlele esikufutshane nawe.
- Ukuba uva iintlungu esifubeni okanye ubunzima bokuphefumla .
- Ukuba ufumana umkhuhlane .
- Ukuba uneempawu zestroke - umzekelo, intetho engacacanga, umbono ofipheleyo, okanye ukuba ndindisholo ngequbuliso kwelinye icala lomzimba (ingalo, umlenze, okanye ubuso).
- Ukuba imilenze yakho, amaqatha, okanye iinyawo zakho zidumba ngequbuliso (ingakumbi umlenze omnye kuphela).
- Ukuba awukwazi ukuyeka ukuhlanza .
- Ukuba uphuma igazi ngendlela engaqhelekanga kwilungu lobufazi .
Eminye imibuzo eqhelekileyo malunga neTamoxifen
Ngaba iTamoxifen yi-chemotherapy?
Hayi. Kulapho abantu abaninzi badideka khona. I-Tamoxifen lunyango lwe-hormone . Ikwiqela lamayeza abizwa ngokuba yi -Selective Estrogen Receptor Modulators (SERMs) . I-Chemotherapy lunyango olubulala iiseli ezahlulahlula ngokukhawuleza (iiseli zomhlaza kunye neeseli eziphilileyo). Kodwa i-Tamoxifen isebenza ngendlela eyahlukileyo, kwinqanaba le-hormone.
Ngaba kukhuselekile ukuthatha iTamoxifen ngexesha lokukhulelwa?
Akunjalo konke konke. Ukukhulelwa ngelixa usebenzisa i-tamoxifen kunokubangela iziphene ezinkulu zokuzalwa . Ngoko ke ukuba usebenzisa eli yeza, kufuneka uphephe ukukhulelwa . Ulawulo lokuzala olusebenzisa iihomoni (njengeepilisi zokulawula ukuzalwa) alufanelekanga ngeli xesha, ngoko ke thetha nogqirha wakho malunga nokusebenzisa indlela yokulawula ukuzalwa engeyiyo ihomoni (njengeekhondom okanye ii-IUD). Kubalulekile ukusebenzisa ulawulo lokuzala ubuncinane iinyanga ezimbini emva kokuyeka ukusebenzisa iyeza.
Zeziphi iziselo kunye nokutya omele uziphephe xa usebenzisa iTamoxifen?
Ewe. Ukutya nezinye iziselo zinokunciphisa ukusebenza kweTamoxifen. Ngoko ke, kungcono ukuziphepha ezi zinto zilandelayo:
- I-grapefruit
- Iitangerines
- Utywala balo naluphi na uhlobo
Ingaba iziphumo ebezingalindelekanga ziyenzeka kwangoko emva kokuba uqalile ukuthatha iyeza?
Oku kuyahluka kumntu nomntu. Abanye abantu basenokuqala ukuqaphela utshintsho oluncinci ukususela ngomhla abasela ngawo ipilisi yokuqala. Abanye basenokungaqapheli nto kangangeenyanga.
Lihlala ixesha elingakanani iyeza emzimbeni emva kokuba liyekile?
I-Tamoxifen ihlala isebenza emzimbeni kangangeeveki ezimbini emva kokuba usele ipilisi yokugqibela, kodwa kungathatha malunga neenyanga ezintathu ukuba iphume ngokupheleleyo emzimbeni wakho.
Umyalezo Wokuya Ekhaya
- I-Tamoxifen lunyango olusebenzayo kakhulu lwe-hormone kumhlaza webele oxhomekeke kwi-hormone.
- Eli yeza linciphisa kakhulu umngcipheko wokuphinda umhlaza kunye nokukhula okutsha.
- Musa ukukhathazeka ngemiphumo emibi yokusela amayeza. Uninzi lwazo lunokulawulwa. Kodwa qaphela iimpawu ezinzulu kwaye uxelele ugqirha wakho ngokukhawuleza ukuba ziyavela.
- Kubaluleke kakhulu ukuqhubeka nokusela eli yeza ixesha lonke elichazwe ngugqirha wakho.
- Zive ukhululekile ukuxoxa ngayo nayiphi na imibuzo okanye iinkxalabo onazo nogqirha wakho. Lilungelo lakho.
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