Ngaba wena okanye umntu omaziyo unikwe iTamoxifen ngugqirha wakho ngenxa yomhlaza webele? Okanye unikwe iTamoxifen kuba usengozini enkulu yokuba nomhlaza? Kuqhelekile ukuba uzive usoyika kancinci, unomdla, kwaye unemibuzo emininzi xa usiva igama lale yeza. "Ngaba le nto iza kuyiphilisa ngokwenene umhlaza? Zithini iziphumo ebezingalindelekanga?" Mhlawumbi uyazibuza. Ngoko ke, namhlanje siza kuthetha ngokuba yintoni iTamoxifen, yintoni eyenzayo emzimbeni, kunye noko kufuneka sikuqaphele, ngokulula, ngokungathi sithetha nomhlobo.
Ngamafutshane, yintoni iTamoxifen?
I-Tamoxifen liyeza eliqhelekileyo elisetyenziswa kunyango lomhlaza webele. Nangona kunjalo, ayinikwa zonke iintlobo zomhlaza webele. Inikwa ngokukodwa abantu abanomhlaza webele one-hormone receptor-positive .
Kuthetha ukuthini oko? Cinga ngako, ezinye iiseli zomhlaza wamabele zifana neentsana ezilambileyo. Zifuna iihomoni ezimbini eziveliswa yimizimba yethu ngokwendalo ukuze zikhule kwaye zisasazeke. Ziyi -estrogen kunye ne -progesterone . Into eyenziwa liyeza i-tamoxifen kukuba lithintela ezo seli zomhlaza ekufumaneni "ukutya" ezikufunayo, okuyihomoni i-estrogen.
Ukongeza, oogqirha bakwacebisa eli yeza ukuthintela umhlaza kwabo basengozini enkulu yokuba nomhlaza webele (umzekelo, ukuba umntu kusapho lwakhe wayenomhlaza, okanye ukuba uneziguquguquko zemfuza ezifana ne-``(BRCA)```).
Ziziphi iingenelo eziphambili zonyango lwe-tamoxifen?
Eli yeza lincede ekusindiseni ubomi bezigidi zabasetyhini kwihlabathi liphela. Ezinye zezibonelelo zalo eziphambili zezi:
- Ukuthintela ukuphinda umhlaza: Umngcipheko wokubuya komhlaza emva kotyando, i-chemotherapy, okanye unyango lwemitha uncitshiswa ngama-30% ukuya kuma-50%.
- Ukukhusela elinye ibele: Kumntu onomhlaza kwelinye ibele, umngcipheko wokuba nomhlaza kwelinye ibele eliphilileyo uncitshiswa ngama-50%.
- Ukuthintela umhlaza ohlaselayo: Kumntu onomhlaza okwinqanaba lokuqala (iDuctal Carcinoma in Situ okanye iDCIS), ohlala kwimibhobho yobisi yebele, kunciphisa umngcipheko wokuba ngumhlaza ohlaselayo malunga ne-50%.
- Ukuqinisa amathambo: Eli yeza likwanceda ekuthinteleni i-osteoporosis nokuqinisa amathambo, anokwenzeka emva kokuya exesheni.
- Ukunciphisa i-cholesterol: Ikwanceda ngandlela ithile ekunciphiseni amanqanaba e-cholesterol embi egazini.
Masifunde nendlela yokusebenzisa amayeza kunye neziphumo zawo ezingalindelekanga.
Ugqirha wakho uya kukuxelela ukuba uthathe i-tamoxifen njengepilisi (`Nolvadex®`) okanye njengolwelo (`Soltamox®`) ngexesha elifanayo yonke imihla. Ixesha lonyango linokuba yiminyaka emi-5 okanye eli-10. Oku kuya kugqitywa ngugqirha wakho kuxhomekeke kwimeko yakho.
Njengayo nayiphi na imithi, i-tamoxifen inokubangela ezinye iziphumo ebezingalindelekanga. Uninzi lwazo azibi kakhulu, kwaye ayinguye wonke umntu ozifumanayo. Kodwa kubalulekile ukuba uzazi.
| Uhlobo lwesiphumo esibi | Inkcazo kunye neempawu |
|---|---|
| Iziphumo ebezingalindelekanga eziqhelekileyo | |
| Iimpawu ezifana nokuya exesheni | Ubushushu obugqithisileyo, ukubila ebusuku, kunye nokoma kwelungu lobufazi. |
| Ukunyuka/ukudumba kobunzima | Abanye abantu basenokutyeba okanye bavuvuke (ukudumba) kwiindawo ezifana nemilenze. |
| Ukuya exesheni okungaqhelekanga | Ukungahlali ixesha elide okanye ukuyeka ngokupheleleyo ukuya exesheni. |
| Ezinye izifo ezincinci | Ukudumba kwemilenze, isicaphucaphu, ukukhupha ulwelo kwilungu lobufazi, ukurhawuzelelwa lusu, ukudinwa, intloko ebuhlungu. Kumadoda, ukungasebenzi kakuhle kwe-erectile kunokubakho. |
| Iingozi ezinzulu kodwa ezingaqhelekanga ezifuna unyango olukhawulezileyo | |
| Amahlwili egazi | Iimeko ezinje ngokuqhekeka kwegazi kwimithambo yemilenze (iDeep Vein Thrombosis - DVT) okanye isifo sohlangothi. |
| IiCataracts | Iingxaki zamehlo ezifana nokungaboni kakuhle. |
| Umhlaza wesibeleko | Kukho umngcipheko omncinci kakhulu wokuba nomhlaza we-endometrial. |
Ezi ngozi zinkulu azixhaphakanga, kodwa kubalulekile ukuba uzazi. Ugqirha wakho unika eli yeza kuba iingenelo zalo yeza zingaphezulu kakhulu kuneengozi.
Xa kufuneka ubone ugqirha ngokukhawuleza!
Ukuba usebenzisa i-tamoxifen kwaye ufumana naziphi na iimpawu ezilandelayo, xelela ugqirha wakho ngoko nangoko okanye uye kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele ngaphandle kokulibazisa.
- Intlungu yesifuba ngequbuliso okanye ubunzima bokuphefumla .
- Ifiva .
- Iimpawu zestroke ziquka ukuthetha okungaqondakaliyo , ukubona okufipheleyo , kunye nokungaziva mnandi ngequbuliso kwelinye icala lengalo, umlenze, okanye ubuso .
- Ukudumba okugqithisileyo emilenzeni, emaqatheni, okanye ezinyaweni .
- Ukuhlanza okungapheliyo.
Lumka kwezi zinto xa usebenzisa amayeza.
Ndingalithatha eli yeza ngexesha lokukhulelwa?
Hayi. Akunjalo konke konke. Ukuba ukhulelwa ngelixa usela i-tamoxifen, umntwana wakho unokuba neziphene ezinkulu zokuzalwa. Ngoko ke, ngokuqinisekileyo kufuneka ukuphephe ukukhulelwa ngelixa usela eli yeza kwaye emva kweenyanga ezimbini uyekile iyeza. Thetha nogqirha wakho malunga nokusebenzisa indlela yokulawula ukuzalwa engeyiyo i-hormone (njengeekhondom).
Ngaba i-tamoxifen yi-chemotherapy?
Hayi. Ezi zizinto ezimbini ezahlukeneyo. I-Tamoxifen lunyango lweehomoni . Ngokukodwa, ikudidi lwamayeza abizwa ngokuba yi-"Selective Estrogen Receptor Modulators - SERMs." I-Chemotherapy lunyango olubulala iiseli ezahlulahlula ngokukhawuleza (iiseli zomhlaza kunye neeseli eziphilileyo). Kodwa i-tamoxifen ijolise kuphela kumsebenzi weehomoni.
Ngaba kukho ukutya okanye iziselo endifanele ndiziphephe xa ndisebenzisa eli yeza?
Ewe. Ukutya nezinye iziselo zinokunciphisa ukusebenza kwe-tamoxifen, ngoko ke kububulumko ukuziphepha.
- I-grapefruit
- Iitangerines
- Nasiphi na isiselo esinotywala
Umyalezo Wokuya Ekhaya
- I-Tamoxifen lunyango olusebenzayo kakhulu nolusindisa ubomi kumhlaza webele oxhomekeke kwiihomoni.
- Kubalulekile ukuthatha amayeza akho njengoko ugqirha wakho emyalele, ngexesha elifanelekileyo, kwaye ixesha elifanelekileyo.
- Musa ukoyika iziphumo ebezingalindelekanga, kodwa ziqaphele. Qaphela ngakumbi iimpawu zokuqhekeka kwegazi okanye isifo sohlangothi (ukudumba emilenzeni, iintlungu zesifuba, intetho engavakaliyo). Ukuba ufumana nayiphi na kwezi, funa ingcebiso kagqirha ngokukhawuleza.
- Musa ukukhulelwa ngelixa usela eli yeza kwaye emva kweenyanga ezimbini uyekile. Thetha nogqirha wakho malunga nokusebenzisa indlela yokulawula ukukhulelwa ekhuselekileyo.
- Thetha ngokukhululekileyo nogqirha wakho ngayo nayiphi na imibuzo, uloyiko, okanye amathandabuzo onokuba nawo. Bahlala bekulungele ukukunceda.
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