Ngaba ukhe weva ngesifo seswekile sohlobo loku-1? Le yimeko apho amasosha omzimba wethu ehlasela iiseli ezivelisa i-insulin kwi-pancreas. Oku kuyoyikisa kancinci. Kodwa ngokuhambela phambili kwesayensi yezonyango, kuvela iindlela ezintsha zokulawula ezi meko. Elinye ithemba elitsha liyeza elibizwa ngokuba yiTeplizumab. Yile nto liyenzayo, libambezela ukuqala kwesifo seswekile sohlobo loku-1. Ngoko masithethe ngale nto namhlanje ngendlela elula onokuyiqonda.
Luhlobo luni lweyeza iTeplizumab?
Ngamafutshane, iTeplizumab liyeza elivumela abantu abasengozini yokufumana isifo seswekile sohlobo loku-1 ukuba balibazise ukuqala kwaso ngeminyaka embalwa. Asilonyango lwesifo seswekile, kodwa liyalibazisa ukuqala kwaso. Yinto enkulu leyo, akunjalo?
Eli yeza likwiqela elibizwa ngokuba yiMonoclonal Antibody . Musa ukoyika xa usiva elo gama. Khawuthelekelele ukuba amajoni (ii-antibodies) kwinkqubo yethu yokuzikhusela yomzimba ayaphambuka aze aqale ukuhlasela iiseli zethu ezilungileyo. Ngelo xesha, ukulawula la majoni enza iimpazamo, olunye uhlobo lweprotheyini olwenziwe ngokukodwa kwilebhu lubizwa ngokuba yiMonoclonal Antibody. Into eyenziwa yiTeplizumab kukucinezela kancinci isenzo senkqubo yokuzikhusela ehlasela iiseli ezenza i-insulin ngempazamo. Ke ngoko, uphuhliso lwesifo seswekile luyalibaziseka.
Eli yeza lidla ngokufumaneka kwimarike phantsi kwegama lebrendi iTzield .
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale olu nyango
Oku kubaluleke kakhulu. Ngaphambi kokuba uqale unyango ngeTeplizumab, kubalulekile ukuxelela ugqirha wakho olu lwazi lulandelayo. Ezi zinto zichaphazela ngokuthe ngqo impumelelo yonyango kunye nokhuseleko lwakho.
| Imeko ekufuneka uyixele | Kutheni oko kubalulekile? |
|---|---|
| Imeko yokosuleleka ngoku (umz. umkhuhlane, umkhuhlane, ukukhwehlela) | Ngenxa yokuba eli yeza linciphisa ukusebenza kwenkqubo yomzimba yokuzikhusela, usulelo olukhoyo lunokuba mandundu. |
| Isifo sesibindi | Ekubeni isibindi sibalulekile kwinkqubo yokususa amayeza emzimbeni, kufuneka wazise ugqirha wakho ukuba uneengxaki zesibindi. |
| Ukuncipha kwezakhi zegazi (iiseli ezibomvu zegazi, iiseli ezimhlophe zegazi, iiplatelets) | Eli yeza linokubangela ukuba iinxalenye zegazi zehle ngakumbi, ngoko ke liyingozi ukuba amanqanaba sele esezantsi. |
| Isitofu sokugonya sakutshanje okanye esizayo | Iigonyo zentsholongwane ephilayo ngokukodwa zinokusebenzisana nale mithi. Ke ngoko, nceda unike inkcazo epheleleyo yegonyo. |
| Ukunganyamezelani kwamanye amayeza, ukutya, okanye izinto | Oku kubalulekile ukuze wazi ukuba une-allergy kwiTeplizumab okanye nakweyiphi na izithako zayo. |
| Ukuba uzama ukukhulelwa okanye ukhulelwe | Akukabikho datha ipheleleyo malunga nokhuseleko lwale mithi ngexesha lokukhulelwa, ngoko ke kufuneka uthethe nogqirha wakho ngale nto. |
| Ukuba ungumama oncancisayo | Olu lwazi lubalulekile ekuqinisekiseni ukuba iyeza lidlulela ebantwaneni ngobisi lwebele. |
Eli yeza linikwa njani emzimbeni?
I-Teplizumab ayiloyeza onokulithatha ekhaya ulisebenzise.
- Oku kunikwa njengokufakwa kwe-intravenous (IV) .
- Kwenziwa esibhedlele okanye ekliniki phantsi kweliso leqela lezonyango.
- Olu nyango ludla ngokwenziwa imihla ngemihla kangangeentsuku ezili-14.
- Ngaphambi kokuba uqale unyango, uza kunikwa incwadana ekhethekileyo (iMedGuide) eneenkcukacha malunga nale yeza. Soloko ulifunda ngononophelo.
- Eli yeza linokunikwa nabantwana abangaphezu kweminyaka esi-8 phantsi kweemeko ezithile. Nangona kunjalo, kukho izinto ezithile ekufuneka ziqwalaselwe. Thetha nogqirha wakho ngale nto.
Kubalulekile:Ukuba ucinga ukuba ngempazamo uthathe eli yeza kakhulu, fowunela iZiko loLwazi lweePoisons kwiSibhedlele sikaZwelonke saseColombo ngoko nangoko okanye uye kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
Kuthekani ukuba ndiphoswa lidosi leyeza?
Kubaluleke kakhulu ukuthatha idosi nganye yolu nyango ngexesha. Ukuba awukwazi ukuya kunyango olucwangcisiweyo, fowunela iqela lakho lezempilo ngoko nangoko.
Izinto ekufuneka ziqwalaselwe ngexesha lonyango
Iqela lakho lezonyango liza kukujonga ngononophelo olukhulu ngelixa usela eli yeza.
- Uvavanyo lwegazi: Kuya kufuneka wenze uvavanyo lwegazi rhoqo. Olu vavanyo luya kujonga amanqanaba ezinto ezifana neeseli ezimhlophe zegazi, iiseli ezibomvu zegazi, kunye nokusebenza kwesibindi egazini lakho.
- Umngcipheko wokosuleleka: Eli yeza linciphisa ukusebenza kwenkqubo yomzimba yokuzikhusela, nto leyo eyonyusa umngcipheko wokufumana usulelo. Ukuba ufumana iimpawu ezinje ngomkhuhlane, ukubanda, umphimbo obuhlungu, okanye ukukhwehlela, musa ukuzinyanga kwaye utsalele umnxeba ugqirha wakho ngoko nangoko. Kukwangumbono olungileyo ukunciphisa ukuya kwiindawo apho abantu bagula khona ngeli xesha.
- Iigonyo: Oku kubaluleke kakhulu. Phakathi kweeveki ezi-6 nezingama-52 emva kokuthatha iTeplizumab, umzimba wakho usenokungasabeli kakuhle kwiigonyo ozifumanayo. Ngoko ke ukuba ufuna ukufumana igonyo, xelela ugqirha wakho ukuba uthathe iTeplizumab. Kusenokufuneka ufumane iidosi zokunyusa okanye utshintshe ishedyuli yakho yokugonya.
Iziphumo ebezingalindelekanga ezinokubakho ngenxa yamayeza
Njengalo naliphi na iyeza, iTeplizumab inokubangela iziphumo ebezingalindelekanga. Ezinye ziyingozi, ngelixa ezinye zixhaphakile.
| Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha ngoko nangoko | |
|---|---|
| Imiphumela | Inkcazo |
| Iimpendulo ze-Allergic | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi okanye umqala. |
| I-Cytokine Release Syndrome (CRS) | Le yimeko embi kakhulu ebangelwa kukuhlaselwa ngequbuliso okukhulu kwenkqubo yomzimba yokuzikhusela. Iimpawu zingabandakanya umkhuhlane, ukugodola, ubuthathaka, intloko ebuhlungu, isiyezi, ubunzima bokuphefumla, kunye nokubetha kwentliziyo ngokukhawuleza . |
| Iimpawu zosulelo | Umkhuhlane, ukubanda, ukukhohlela, umphimbo obuhlungu. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga (kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka) | |
| Urhudo | Ukuvuvukala kwesisu. |
| Intloko ebuhlungu | Intloko ebuhlungu. |
| Isicaphucaphu | Ukuziva ngathi uhlanza. |
| Ukuqhambuka kwesikhumba | Amadyungudyungu amancinci okanye ukubomvu eluswini. |
Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ufumana nantoni na engaqhelekanga, nceda unxibelelane nogqirha wakho ukuze akunike ingcebiso kwezonyango.
Umyalezo Wokuya Ekhaya
- I-Teplizumab ayilonyango lwesifo seswekile sohlobo loku-1, kodwa liyeza elinokulibazisa kakhulu ukuqala kwaso.
- Olu lunyango olukhethekileyo olunikwa umthambo esibhedlele, phantsi kweliso likagqirha.
- Ngaphambi kokuba uqale unyango, nika ugqirha wakho inkcazo epheleleyo yazo zonke iimeko zakho zempilo, amayeza owasebenzisayo, kwaye ingakumbi naluphi na ugonyo olufumeneyo.
- Ngexesha lonyangoLumka kakhulu kwiimpawu zosulelo ezifana nomkhuhlane, ukukhwehlela, okanye iCytokine Release Syndrome (CRS) . Ukuba kukho nayiphi na kwezi, yazisa ugqirha wakho ngoko nangoko.
- Ukuba unemibuzo malunga nale yeza, umntu ofanelekileyo onokumbuza ngugqirha wakho. Musa ukukhathazeka ngokubuza abanye abantu.
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