Ithumba elingenamsebenzi emzimbeni? Masithethe ngale (Undifferentiated Pleomorphic Sarcoma - UPS)!

Ngaba wakha waziva into efana neqhuma elikhula lize libe likhulu emzimbeni wakho? Ngamanye amaxesha, ngaphandle kwesizathu esicacileyo, unokufumana ukudumba okanye ukuba ndindisholo engalweni okanye emlenzeni. Nangona singazinaki kangako ezi zinto, kusenokuba kukho into enzulu efihliweyo emva kwazo. Namhlanje, siza kuthetha ngohlobo oluthile lomhlaza abantu abaninzi abangaluva rhoqo, kodwa kubaluleke kakhulu ukuba sonke siluqaphele. Musa ukoyika, masiqonde oku ngokulula.

Yintoni i-"Undifferentiated Pleomorphic Sarcoma - UPS"?

Ngamafutshane, i-"Undifferentiated Pleomorphic Sarcoma" okanye i-"UPS" njengoko siyibiza ngokufutshane, luhlobo lomhlaza olubizwa ngokuba yi -soft tissue sarcoma . Oku kuxa iiseli zomhlaza zibumba kwizicubu ezithambileyo zomzimba wethu, ezifana nezihlunu, izicubu ezinamafutha, kunye nemithambo yegazi.

Amaxesha amaninzi, le `(UPS)` iqala kwizicubu ezithambileyo zeengalo okanye imilenze yakho . Ngamanye amaxesha inokwenzeka nakwinxalenye enzulu yomva wesisu, ebizwa ngokuba yi-`retroperitoneum` . Amaxesha amaninzi, le `(UPS)` ichaphazela amathambo. Into ebuhlungu kukuba, olu luhlobo lomhlaza oludla ngokuba nolaka . Ngoko ke kunokwenzeka ukuba lusasazeke kwezinye iindawo zomzimba, ingakumbi imiphunga okanye ii-lymph nodes .

Ngaphambili, le `(UPS)` yayibizwa ngokuba yi -`malignant fibrous histiocytoma` . Isizathu soku kukuba abaphandi babecinga ukuba lo mhlaza uvela kwiiseli ezikhethekileyo zokuzikhusela zomzimba ezibizwa ngokuba yi-`histiocytes` . Nangona kunjalo, uphando lwamva lufumanise ukuba kusenokwenzeka ukuba uqala kwiiseli ezibizwa ngokuba yi-`mesenchymal cells`, ezenza izicubu ezinxibelelanayo emzimbeni wethu.

Ngoku makhe sijonge intsingiselo yala magama mabini kweli gama.

"Ukungahlukani" kuthetha ukuba ezi seli zomhlaza zibonakala zingaqhelekanga kwaye zingacwangciswanga . Njengezinto zokudlala ezisasazeke ngaphandle kocwangco. Ziye zahluka kakhulu kwaye azikhuli kangangokuba akunakwenzeka ukwazi ukuba zeziphi iiseli eziphilileyo eziqale kuzo okanye ukuba zeziphi umsebenzi ezazicetyelwe ukuzenza.

Igama elithi "pleomorphic" lithetha ukuba ezi seli zahlukile ngesimo, ubungakanani, okanye inucleus, iziko lolawulo lweseli . Cinga ngayo njengefenitshala engenziwanga ngesikhunta esifanayo, nganye yahlukile ngesimo nangobukhulu. Ezinye iiseli zincinci, ezinye zinkulu. Ezinye zingqukuva, ezinye zinde. Kwanenucleus, equlethe iichromosomes ngaphakathi kweeseli, yahlukile kwiseli nganye. Yingakho ezi seli zomhlaza zikhula ngokungacwangciswanga nangokukhawuleza ngaphandle kolawulo.

I-UPS ngokwenene luhlobo lomhlaza olungaqhelekanga kakhulu . Umzekelo, eMelika, esi sifo sichaphazela abantu abangaphantsi kwama-5,000 ngonyaka. Nangona kunjalo, phakathi kweentlobo zee-sarcomas zezicubu ezithambileyo,Kunye ne-liposarcoma (umhlaza okhula kwizicubu ezinamafutha) kunye ne-leiomyosarcoma (umhlaza okhula kwimisipha egudileyo), (i-UPS) lolona hlobo lwesithathu oluxhaphakileyo lwe-soft tissue sarcoma .

Zithini iimpawu ze-`(UPS)`?

Iimpawu ze-`Undifferentiated Pleomorphic Sarcoma (UPS)` zinokwahluka kumntu nomntu. Abanye abantu basenokungabi nazo naziphi na iimpawu. Nangona kunjalo, kukho ezinye iimpawu eziqhelekileyo:

• Iqhuma okanye ubunzima obukhula kancinci kancinci: Olu luphawu oluphambili. Ingavakala ngathi liqhuma naphi na emzimbeni, ingakumbi engalweni, emlenzeni, okanye esiswini.
• Iqhuma elingenabuhlungu elinokunyakaza okanye elingashukumi xa lichukunyiswa: Uninzi lwexesha, la maqhuma awabangeli ntlungu kwasekuqaleni. Ngenxa yoko, abanye abantu basenokungawahoyi kangako.
• Ukungaziva okanye ukutsha ngenxa yethumba elicinezela umthambo: Ngamanye amaxesha, njengoko eli thumba likhula, linokucinezela umthambo okufutshane. Oku kunokubangela ukungaziva ezandleni okanye ezinyaweni, ukurhawuzelelwa, okanye ukutsha.
• Ukudumba engalweni okanye emlenzeni: Ukuba ingalo okanye umlenze uvuvukala ngaphandle kwesizathu esicacileyo, oko kufanele kuthathelwe ingqalelo.

Okubalulekileyo kukuba, i-UPS ayisoloko ibonisa iimpawu ezicacileyo. Azisoloko zibuhlungu , kwaye akukho tshintsho eluswini phezu kweqhubu (njengokutshintsha kombala okanye izilonda). Kwakhona, iimpawu eziqhelekileyo ezifana nomkhuhlane, ukwehla kobunzima, kunye nokungakhululeki azibonakali rhoqo.

Zithini izizathu ze-`(UPS)`?

Iingcali azikayazi kakuhle into ebangela i-UPS. Into eziyaziyo kukuba ibangelwa lutshintsho (utshintsho) kwi -DNA (imolekyuli equlethe ulwazi lwethu lwemfuza) kwiiseli eziphilileyo. Nangona kunjalo, into ebangela olo tshintsho kwi-DNA ayikacaci.

Izinto Ezibangela Umngcipheko Owonyusa Umngcipheko Wokuphuhlisa I-UPS

Into enobungozi yinto eyonyusa amathuba okuba nesifo. Kukho izinto ezininzi ezinobungozi eziye zachongwa njenge-`(UPS)`. Kodwa khumbula, ayinguye wonke umntu onezi zinto ezinobungozi oza kukhula abe yi-`(UPS)`, kwaye akunakuthiwa abantu abangenazo ezi zinto ezinobungozi abayi kukhula babe yi-`(UPS)`.

Izinto ezinobungozi ezichongiweyo ngoku zezi:

• Ukuba yindoda: Amadoda anamathuba amaninzi okufumana esi sifo kunabafazi, kwaye umngcipheko uphezulu kakhulu phakathi kwamadoda amhlophe.
• Ngaphezulu kweminyaka engama-50 ubudala: Ukuxhaphaka kwesi sifo kuyanda njengoko iminyaka ikhula.
• Iimeko ezithile zonyango: Umzekelo, abantu abanezifo ezifana ne -neurofibromatosis (imeko ebangela ukuba iithumba zenzeke kwinkqubo yemithambo-luvo) okanye isifo sePaget samathambo (isifo esibangela ukukhula okungaqhelekanga kwamathambo) basengozini enkulu yokukhula (UPS).
• Ezinye iimeko zemfuza:Abantu abaneengxaki zemfuza ezingaqhelekanga ezifana ne-Li-Fraumeni syndrome basengozini enkulu yokuhlaselwa ziintlobo ezahlukeneyo zomhlaza, kuquka (i-UPS).
• Ukuvezwa kwiikhemikhali ezithile: Ukuvezwa ixesha elide kwiikhemikhali ezithile, ezifana ne -arsenic okanye i-vinyl chloride, nako kunokuba ngumngcipheko.
• Unyango lwe-radiation lwangaphambili kwindawo echaphazelekayo: Ukuba ufumene unyango lwe-radiation kwindawo ethile yesifo esithile, kukho umngcipheko omncinci wokufumana i-sarcoma (UPS) kuloo ndawo kamva.
• Ukuchatshazelwa yimitha emsebenzini: Ukuba kufuneka uchatshazelwe yimitha kwimisebenzi ethile, oko kungaba ngumngcipheko.

Kuyamangalisa ukuba abantu abaninzi abafumana i-UPS abanazo naziphi na ezi zinto ziyingozi . Ngoko ke ukuba ubona into ebonakala ngathi liqhuma elingaqhelekanga emzimbeni wakho, musa ukuyityeshela ngokucinga, "Andinazo naziphi na kwezi zinto ziyingozi."

Oogqirha bayibona njani i-`(UPS)`?

Xa ubona ugqirha oneqhuma elinje, uza kuqala akubuze ngempilo yakho , nokuba kukho umntu kusapho lwakho okhe waba nezifo ezifana nomhlaza (imbali yosapho), njl. Emva koko uza kubuza ngeempawu zakho. Eli qhuma lihlale ixesha elingakanani? Ngaba liyakhula? Ngaba libuhlungu? Ukongeza, uza kwenza olu vavanyo lulandelayo:

1. Uvavanyo lomzimba: Ugqirha uza kuhlola indawo enesimila, ubungakanani baso, kunye nendlela esivakalelwa ngayo xa sichukunyiswa (siqinile okanye sithambile).

2. Uvavanyo lomfanekiso: Olu vavanyo lunceda ekuboneni ukuba ithumba libonakala njani ngaphakathi kwaye lisasazeke kangakanani. Ngokwesiqhelo, uvavanyo olunye okanye ngaphezulu, olufana ne -X-ray, i-ultrasound scans, kunye/okanye i-MRI scans, lunokwenziwa.

3. I-Biopsy: Olu lolona vavanyo lubalulekileyo lokufumanisa isifo ngokuqinisekileyo . Oku kuquka ukuthatha iqhekeza elincinci lesicubu sethumba (mhlawumbi ngesixhobo esincinci esifana nenaliti) size silihlolwe phantsi kwe-microscope yingcali yezifo (ugqirha ochwephesha ekuxilongeni izifo). Kulapho kuphela apho sinokuqiniseka khona ukuba yi-UPS okanye yenye imeko.

Ziziphi iindlela zonyango ze-`(UPS)`?

Unyango lwe-UPS luxhomekeke kwizinto ezifana nobukhulu bethumba kunye nokuba umhlaza usasazeke na. Unyango oluphambili lwe-UPS yenqanaba lokuqala lutyando lokususa ithumba . Oku kudla ngokwenziwa kunye nonyango lwemitha . Nangona kunjalo, ngamanye amaxesha unyango olongezelelweyo lomhlaza lunokufuneka.

Utyando

Injongo ephambili yotyando lwe-UPS kukususa ngokupheleleyo ithumba elinomhlaza.. Oogqirha bazama ukususa kungekuphela nje umhlaza, kodwa kunye nenani elincinci lezicubu eziphilileyo ezijikeleze wona (oku kubizwa ngokuba "ngumda") . Kanye njengokuba sisusa ukhula emyezweni, asisusi isityalo kuphela, kodwa kunye nomaleko omncinci womhlaba ojikeleze wona. Emva koko akusekho neqhekeza elincinci leengcambu zokhula. Ngendlela efanayo, xa oogqirha besusa lo mhlaza, bayawususa kunye nenani elincinci lezicubu eziphilileyo ezijikeleze wona. Kulapho kuphela apho sinokuqiniseka ukuba zonke iiseli zomhlaza zisusiwe ngaphandle kwezinye eziseleyo. Ukuba kukho iiseli zomhlaza emaphethelweni ethumba elisusiweyo, kuthetha ukuba kunokubakho iiseli zomhlaza ezingaphezulu ezisele emzimbeni.

Ukuba ithumba lisengalweni okanye emlenzeni wakho, ugqirha wakho uya kuzama ukususa umhlaza aze agcine ukusebenza kangangoko kuloo ngalo okanye emlenzeni. Nangona kunjalo, kwezinye iimeko ezinzima, ukususwa kwesilonda kunokufuneka . Ke ngoko, kubalulekile ukuthetha nogqirha wakho we-oncologist ukuze agqibe ukuba loluphi unyango olulungele imeko yakho.

Unyango olongezelelweyo lomhlaza

Iingcali zomhlaza zingasebenzisa unyango olongezelelweyo ngaphambi okanye emva kotyando. Nangona olu nyango ludla ngokungalunciphisi umhlaza, lunokunceda ekwenzeni utyando lukhuseleke ukususa umhlaza, okanye ukubulala naziphi na iiseli zomhlaza ezinokuthi zihlale emva kotyando.

Olu nyango longezelelweyo lulandelayo:

• Unyango lweKhemotherapy: Ukunika amayeza abulala iiseli zomhlaza.
• Unyango lwe-Immunotherapy: Ukuvuselela amajoni omzimba ukuze alwe neeseli zomhlaza.
• Unyango lwemitha: Ukutshabalalisa iiseli zomhlaza kusetyenziswa imitha enamandla aphezulu.

Isicwangciso sakho sonyango sihlukile kuwe. Sisenokungafani nesomnye umntu. Ngoko ke thetha nogqirha wakho we-oncologist malunga neendlela onokukhetha kuzo. Uhlala unyangwa liqela elinolwazi oluhlukeneyo . Eli qela linokuquka ugqirha wotyando, ugqirha we-radiation oncologist, kunye nogqirha we-oncologist wezonyango. Nangona ingcali nganye inendima eyahlukileyo, bonke basebenzisana ukukunyanga. Baza kukunceda ugqibe ukuba yintoni efanelekileyo kwimeko yakho.

Ndifanele ndimbone nini ugqirha?

Ukuba ubona iqhuma okanye ukukhula naphi na emzimbeni wakho okukhula kancinci kancinci , ingakumbi ukuba kuhamba neempawu ezifana nentlungu, ukudumba, okanye ukungakwazi ukuhambisa ilungu lakho ngokufanelekileyo , kufuneka ubone ugqirha ngoko nangoko .

Ukuba sele ubonile ukuba unayo `(UPS)`, wenaUkuba ufumanisa iimpawu ezintsha, okanye ukuba iimpawu zakho ziya zisiba mandundu, xelela ugqirha wakho we-oncologist ngoko nangoko .

Zeziphi izinto ezinokulindelwa ngumntu one-(UPS)`?

Ixesha lokuphila liyahluka kumntu nomntu. Kuxhomekeke kubukhulu be-sarcoma kunye nesigaba sesifo . Ngokubanzi, izinga lokusinda kweminyaka emihlanu kwi-high-grade (UPS) limalunga nama-60% . Oku kuthetha ukuba malunga nama-60% abantu abafunyaniswe benesifo basaphila emva kweminyaka emihlanu. Izinga lokusinda kweminyaka eli-10 limalunga nama-48% .

Kodwa khumbula, la mazinga okusinda ziingqikelelo nje eziqhelekileyo . Azikuxeleli ngokuthe ngqo ukuba uza kuphila ixesha elingakanani okanye loluphi unyango oluza kusebenza kakhulu kuwe. Ukuze ufunde okungakumbi ngamazinga okusinda kunye nendlela akuchaphazela ngayo, kungcono ukuthetha neqela lakho le-oncology.

Ngaba `(UPS)` inokunyangeka ngokupheleleyo?

(UPS) iyanyangeka ngokupheleleyo, ingakumbi ukuba ifunyaniswe kwangethuba . Nokuba isifo sisasazeke kangakanani na, kukho iindlela zonyango ezinokukunceda ukuphucula umgangatho wobomi bakho kwaye zandise ubomi bakho. Njengalo naluphi na uhlobo lomhlaza, ukufunyanwa kwangethuba kunye nonyango lwe-(UPS) yeyona ndlela ilungileyo yokufumana iziphumo eziphumelelayo .

Izinto ekufuneka ziqwalaselwe

Xa ufunyaniswa ukuba unomhlaza, unokuchaphazela yonke into ebomini bakho. Ukuba ngumhlaza ongaqhelekanga ofana ne-Undifferentiated Pleomorphic Sarcoma (UPS), ungaziva uwedwa kakhulu kwaye ngathi akukho mntu ukuyiqondayo. Ngamaxesha anje, kunokuba luncedo ukujoyina iqela lenkxaso apho kukho abanye abadlula kumava afanayo nawe . Ukuthetha nabo kunokukunceda uqonde iimvakalelo zakho kwaye uzilawule.

Kwakhona, iqela lakho lezonyango lihlala likhona ukukunceda . Banokukuthetha nawe malunga neendlela zakho zonyango, bakuxhase, kwaye bakunike ulwazi kunye nezixhobo ozidingayo ukuze wenze izigqibo zempilo ezisekelwe kulwazi. Ungoyiki ukubabuza nayiphi na imibuzo onayo . Hlala ukhumbula ukuba awuwedwa.

I - Sarcoma ye-Pleomorphic engahlukanisiweyo, i-UPS, i-sarcoma, umhlaza wezicubu ezithambileyo, umhlaza, ithumba, iimpawu zomhlaza, unyango lomhlaza