Isandla esincedisayo ekulweni nomhlaza: Masifunde ngeepilisi zeVemurafenib

Namhlanje siza kuthetha ngamayeza akhethekileyo anikwa umntu olwa nomhlaza. Wena okanye umntu omaziyo usenokuba unikwe eli yeza, elibizwa ngokuba yiVemurafenib , ngugqirha wakho. Ngoko ke, namhlanje siza kuthetha ngokweenkcukacha malunga nokuba loluphi uhlobo lweyeza, indlela elisetyenziswa ngayo kanye kanye, kunye nento ekufuneka siyilumkele ngakumbi.

Lithini eli yeza libizwa ngokuba yiVemurafenib?

Ngamafutshane, iVemurafenib liyeza elijolise kwiiproteni ezithile ngaphakathi kwiiseli zomhlaza kwaye lizithintele ekukhuleni kwazo. Ngokuchanekileyo, isebenza njengonyango olujoliswe kulo . Isetyenziswa kakhulu ukunyanga uhlobo lomhlaza wolusu olubizwa ngokuba yimelanoma . Ikwasetyenziselwa ukunyanga imeko engaqhelekanga ebizwa ngokuba sisifo se-Erdheim-Chester .

Khumbula, oogqirha ngamanye amaxesha banokulisebenzisa eli yeza kwezinye iimeko, ngoko ke ukuba unemibuzo, kungcono ukubuza ugqirha wakho okanye ingcali yezemithi.

Igama lophawu oluqhelekileyo lwale mithi yiZelboraf .

Zeziphi izinto ekufuneka ndizixelele ugqirha ngaphambi kokuba ndiqalise eli yeza?

Ngaphambi kokuba uqale ukusebenzisa iVemurafenib, kubaluleke kakhulu ukuxelela ugqirha wakho ngembali yakho yempilo. Kubaluleke kakhulu ukuxelela ugqirha wakho ukuba unenye yezi meko zilandelayo:

• Ukuba unesifo samehlo okanye iingxaki zokubona
• Ukuba unesifo sentliziyo
• Ukuba ukhe waba nentliziyo engaqhelekanga ngaphambili
• Ukuba sele ufunyenwe une-calcium ephantsi egazini, i-magnesium, okanye amanqanaba e-potassium aphantsi
• Ukuba unesifo sezintso
• Ukuba unesifo sesibindi
• Ukuba usandul' ukufumana okanye okwangoku ufumana unyango lwe-radiation
• Ukuba ukhe waba ne-allergy ngaphambili okanye i-reaction engaqhelekanga kwi-Vemurafenib, amanye amayeza, ukutya, iidayi, okanye izithinteli.
• Ukuba uzama ukukhulelwa okanye ukhulelwe okwangoku (oku kubaluleke kakhulu)
• Ukuba ungumama oncancisayo (oku kubalulekile)

Kuphela kukukuxelela ezi zinto ngokuchanekileyo apho ugqirha enokukwazi ukugqiba ukuba eli yeza likulungele okanye alikulungele, kunye namanyathelo okhuseleko ekufuneka uwathathe.

Ndingayisebenzisa njani kanye kanye le yeza?

Eli yeza liza likwimo yeepilisi. Ufanele ulisele ngomlomo neglasi yamanzi. Landela imiyalelo ekwileyibhile kagqirha okanye yekhemisti oyinikwe ngugqirha wakho.

• Musa ukuphula, ukutyumza, okanye ukuhlafuna ezi pilisi. Ginya ipilisi yonke.
• Ungayithatha le nto nokuba utya okanye ungenalo. Nangona kunjalo, ukuba uziva isisu sibuhlungu, kungcono ukuyithatha nokuba utya.
• Sela amayeza ngexesha elifanelekileyo, kuphela ngomlinganiselo ochazwe ngugqirha wakho. Musa ukuthatha ngaphezu komlinganiselo omiselweyo.
• Eyona nto ibalulekileyo kukuba, ungayeki ukuthatha eli yeza ngequbuliso ngaphandle kwengcebiso kagqirha wakho.
• Uninzi lwexesha, la mayeza athathwa malunga neeyure ezili-12 phakathi kwawo. Oko kuthetha ukuba ukuba uwathatha kusasa, kuya kufuneka uthathe idosi elandelayo ebusuku.

Xa ufumana amayeza akho, ikhemesti iya kukunika incwadana ekhethekileyo yesikhokelo (iMedGuide) . Funda le ncwadana ngononophelo ngalo lonke ixesha ufumana amayeza amatsha. Iqulethe ulwazi oluninzi olubalulekileyo kuwe.

Ukuba unika abantwana eli yeza, kufuneka uthethe nogqirha wabantwana ngalo kwaye uluthathele ingqalelo ekhethekileyo.

Ungenza ntoni ukuba uthatha amayeza amaninzi kakhulu?

Ukuba ucinga ukuba usele eli yeza kakhulu ngempazamo, fowunela iziko lokulawula ityhefu okanye igumbi likaxakeka elikufutshane ngokukhawuleza.

Eli yeza limiselwe wena wedwa. Musa ukwabelana ngalo nabanye abantu.

Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?

Ukuba uphoswe yidosi, yithathe ngokukhawuleza xa ukhumbula. Nangona kunjalo, ukuba kungaphantsi kweeyure ezi-4 ngaphambi kwedosi yakho elandelayo ecwangcisiweyo, yitsibe idosi oyiphosileyo. Endaweni yoko, thatha idosi yakho elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe idosi ephindwe kabini.

Ziziphi ezinye izinto ezinokusebenzisana nale mithi?

Eli linqaku elibaluleke kakhulu. I-Vemurafenib inokusebenzisana namanye amayeza owasebenzisayo. Ukuba oku kuyenzeka, iziphumo ebezingalindelekanga zinokwanda okanye ukusebenza kakuhle kwamayeza kunokuncipha.

Musa ukuthatha iVemurafenib kunye namayeza alandelayo:

• I-Cisapride
• I-Dronedarone
• I-Fluconazole
• I-Pimozide
• I-Posaconazole
• I-Saquinavir
• I-Thioridazine

Ukongeza, la mayeza alandelayo anokusebenzisana neVemurafenib:

• Amayeza okulwa nentsholongwane kaGawulayo okanye i-AIDS
• Izinto eziqulethe i-caffeine (buza ugqirha wakho ngale nto)
• Amanye amayeza okubulala iintsholongwane, umzekelo: i-clarithromycin, i-erythromycin, i-telithromycin
• Amanye amayeza osulelo lwefungus, umzekelo: itraconazole, iketoconazole, ivoriconazole
• Amanye amayeza okuthintela iingxaki zesingqisho sentliziyo
• Amanye amayeza asetyenziswa ukunyanga izifo ezifana nokuxhuzula (ukuphazamiseka), umzekelo: i-carbamazepine, i-phenobarbital, i-phenytoin
• Amanye amayeza athintela okanye anyanga amahlwili egazi, umzekelo: i-warfarin
• I-Dextromethorphan
• I-Digoxin
• I-Nefazodone
• I-Midazolam
• Amanye amayeza anokubangela isigqi sentliziyo esingaqhelekanga, oko kukuthi, ukwandisa ixesha le-QT , umzekelo: i-dofetilide, i-ziprasidone
• I-Rifabutin
• I-Rifampin
• I-Rifapentine
• Isongezelelo semifuno iSt. John's wort (Hypericum perforatum)
• I-Tizanidine

Olu luhlu alubandakanyi zonke iindlela onokuthi usebenzise ngayo amayeza. Ngoko ke, xelela ugqirha wakho ngawo onke amayeza (abhalwe ngugqirha nathengiswa ngaphandle kwemvume kagqirha), iimveliso zemifuno, iivithamini, kunye nezongezo zokutya ozithathayo. Qiniseka ukuba uxelela ugqirha wakho ukuba uyatshaya, usela utywala, okanye usebenzisa iziyobisi ezingekho mthethweni. Ezi zinokuchaphazela amayeza akho.

Zeziphi izinto ekufuneka uzilumkele ngakumbi xa usebenzisa eli yeza?

Kubaluleke kakhulu ukuba uhlale uqaphela impilo yakho ngelixa usela iVemurafenib.

• Bona ugqirha wakho rhoqo: Qhubeka usiya kuhlolwa njengoko ugqirha wakho ekuxelela. Kusenokufuneka wenze umsebenzi wegazi ngelixa usebenzisa eli yeza.
• Iimpendulo ezinzulu zesikhumba: Eli yeza ngamanye amaxesha linokubangela iimpendulo ezinzulu zesikhumba. Ezi zinokwenzeka kwiiveki okanye kwiinyanga emva kokuba uqale ukusela iyeza. Xelela ugqirha wakho ngoko nangoko ukuba ufumana irhashalala eneempawu ezifana nomkhuhlane okanye ukubanda. Irhashalala inokuba bomvu okanye ibe mfusa, ize iphuphuke kwaye ulusu lunokuqhekeka. Okanye unokufumana irhashalala ebomvu enokuvuvukala kobuso okanye imilebe, okanye ii-lymph nodes ezivuvukileyo entanyeni okanye emakhwapheni. Ukuba ubona into efana nale , xelela ugqirha wakho ngoko nangoko.
• Thetha ngengozi yomhlaza: Ukuba usela eli yeza, usenokuba sengozini enkulu yokuhlaselwa zezinye iintlobo zomhlaza. Thetha nogqirha wakho ngale nto.
• Utshintsho embonweni: Ukuba ubona naluphi na utshintsho embonweni wakho, njengokubona izinto ngendlela engaqondakaliyo okanye ukubona izinto ngendlela eyahlukileyo kunesiqhelo, kufuneka uxelele ugqirha wakho ngoko nangoko.
• Uvakalelo kwiLanga: Le yingxaki ebaluleke kakhulu. Xa usela iVemurafenib, ulusu lwakho luba novakalelo kakhulu elangeni. Oku kuthetha ukuba nokuba lixesha elifutshane elangeni kunokubangela ukuba ulusu lwakho lutshise, lube bomvu, kwaye lube namaqhubu.
• Ngoko ke, phepha ilanga kangangoko kunokwenzeka.
• Ukuba kufuneka uye elangeni,Nxiba impahla egquma ulusu lwakho kakuhle, nxiba umnqwazi obanzi, kwaye usebenzise isithambisi selanga esicetyiswa ngugqirha wakho.
• Musa ukusebenzisa izibane zelanga okanye iibhedi/iibhuthi zokuthambisa ilanga.
• Ukukhulelwa kunye nokuncancisa:
• Musa ukukhulelwa ngelixa usebenzisa eli yeza kwaye emva kweeveki ezimbini emva kokuyeka ukusebenzisa eli yeza.
• Ukuba uceba ukukhulelwa okanye ucinga ukuba ukhulelwe, xelela ugqirha wakho ngoko nangoko. Eli yeza linokubangela ingozi enkulu kusana olungekazalwa. Buza ugqirha wakho okanye ikhemisti ukuze ufumane ulwazi oluthe kratya.
• Musa ukuncancisa umntwana wakho ngelixa usebenzisa eli yeza kwaye kangangeeveki ezimbini emva kokuba uyekile ukusebenzisa eli yeza.

Zithini iziphumo ebezingalindelekanga ezinokubakho?

Njengalo naliphi na iyeza, iVemurafenib inokubangela ezinye iziphumo ebezingalindelekanga. Ezinye zimbi kakhulu, ezinye azimbi kangako.

Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha wakho okanye kwingcali yezempilo ngokukhawuleza:

Ukuba ufumana naziphi na kwezi mpawu, xelela ugqirha wakho ngokukhawuleza:

• Iimpendulo ze-allergy: ukurhawuzelela kwesikhumba, ukurhawuzelela okanye ukurhawuzelela, ukudumba kobuso, imilebe okanye ulwimi
• Ubunzima bokuphefumla
• Utshintsho lombono
• Umchamo onombala omnyama
• Intlungu okanye ukudumba kwamehlo
• Ukubetha kwentliziyo okukhawulezayo okanye okungaqhelekanga
• Ukuquleka, isiyezi, kunye nokuwa
• Ukungakhululeki ngokubanzi okanye iimpawu ezifana nokubanda
• Izitulo ezinombala okhanyayo
• Umnqweno wokutya
• Kuvela intsumpa entsha; iqhuma elibuhlungu eluswini okanye elibomvu eliphuma igazi okanye elingapholiyo; utshintsho kubungakanani okanye umbala wentsumpa okanye ibala
• Intlungu, ukungaziva, okanye ukulahlekelwa luvakalelo kwimilenze
• Urhawuzelelo, umkhuhlane, kunye nokudumba kweempundu
• Ulusu olubomvu, olunamadyungudyungu, ulusu oluxobukayo (kuquka ulusu oluxobukayo ngaphakathi emlonyeni)
• Intlungu kwicala eliphezulu lasekunene lesisu
• Uvakalelo elangeni okanye ukutshiswa lilanga
• Ukuqina kolusu ezintendeni nasezinyaweni zeenyawo
• Iminwe igobile ngaphakathi kwaye iqinile
• Ukuziva ubuthathaka okanye udiniwe ngokungaqhelekanga
• Ukuhlanza
• Ukutyheli kwamehlo okanye ulusu

Iziphumo ebezingalindelekanga ezihlala zingadingi nyango (xelela ugqirha wakho ukuba ezi zinto ziyaqhubeka okanye ziyakukhathaza):

• Utshintsho kwincasa
• Ukulahlekelwa ngumdla wokutya
• Urhudo (intlungu yesisu)
• Isiyezi
• Ulusu olomileyo
• Ukulahleka kweenwele
• Intloko ebuhlungu
• Intlungu yamalungu
• Intlungu yemisipha
• Isicaphucaphu (ukuziva ugula)
• Ukudumba kwamaqatha, iinyawo, izandla
• Ukudinwa

Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ufumana ezinye iimpawu ezingaqhelekanga, qhagamshelana nogqirha wakho. Ukuba unqwenela, ungaxela iziphumo ebezingalindelekanga kwi- FDA (Food and Drug Administration) ngokufowunela ku-1-800-FDA-1088.

Ndingazigcina njani ezi pilisi?

• Gcina kude nabantwana. Oku kubaluleke kakhulu.
• Gcina kubushushu begumbi (phakathi kwama-20 nama-25 degrees Celsius / ama-68 nama-77 degrees Fahrenheit).
• Gcina iyeza kwibhotile yokuqala ebelifike ngayo, livaliwe kakuhle.
• Lahla amayeza aphelelwe lixesha ngaphandle kokuwasebenzisa.

Okokugqibela, izinto ekufuneka uzikhumbule (Umyalezo Wokuya Ekhaya)

I-Vemurafenib liyeza elidlala indima ebalulekileyo kunyango lomhlaza. Kukho izinto ezimbalwa ekufuneka uzazi xa ulisebenzisa.

• Landela imiyalelo kagqirha ngqo. Yenza yonke into kanye njengoko ekuxelela, kuquka ixesha lokusela iyeza, ubungakanani, kunye nendlela yokuyeka ukulisebenzisa.
• Xelela ugqirha wakho ngazo zonke ezinye iindlela ozithathileyo kunye nezinye izifo onazo. Oku kuya kunceda ukuthintela iziphumo ebezingalindelekanga.
• Ukuba ubona naziphi na iimpawu ezintsha, ingakumbi utshintsho lolusu okanye utshintsho embonweni, xelela ugqirha wakho ngokukhawuleza.
• Lumka ilanga. Ungalibali oku.
• Ukuba ukhulelwe, uceba ukukhulelwa, okanye uncancisa, qiniseka ukuba uxelele ugqirha wakho ngaphambi kokuba usebenzise eli yeza.

Eli nqaku lishwankathelo nje ngokubanzi. Ukuba unemibuzo engaphezulu malunga nale yeza, nceda ungathandabuzi ukubuza ugqirha wakho, ikhemisti, okanye omnye umboneleli wezempilo. Baya kukwazi ukukunceda.

Sikunqwenelela okuhle kodwa kuhambo lwakho lwempilo!

I- Vemurafenib, iZelboraf, amayeza omhlaza, umhlaza wolusu, i-melanoma, iziphumo ebezingalindelekanga, amayeza, unyango lomhlaza