Xa wena okanye umntu osondeleyo kuwe efunyaniswa ukuba unomhlaza webele, kuyinto eqhelekileyo ukuziva uxinezelekile kwaye udidekile xa kuxoxwa ngeendlela zonyango. Kunokuba nzima ngakumbi ukukhumbula amagama amayeza amatsha xa oogqirha bethetha ngawo. Namhlanje, siza kuthetha ngelinye lamayeza anjalo, i-abemaciclib. Masithethe ngokulula nangokucacileyo malunga nokuba yintoni le yeza, indlela esebenza ngayo, kunye nento ekufuneka uyiqaphele xa ulisebenzisa.
Luhlobo luni lweyeza iVerzenio kwaye lisebenza njani?
Ngamafutshane, iVerzenio luhlobo lweyeza elithintela ukukhula kweeseli zomhlaza. Ngokwezonyango, likwiqela leziyobisi ezibizwa ngokuba yi-"kinase inhibitors".
Ngoku khawucinge ukuba ngaphakathi kwiiseli zomzimba wethu kukho izithunywa ezincinci ezithumela imiyalezo omnye komnye. Olu tshintshiselwano lwemiyalezo lulo olugqiba ukuba iseli kufuneka yahlulwe okanye ikhule na. Sibiza ezi zithunywa ngokuthi zii-enzymes. Kumhlaza, ezinye zezi zithunywa ziba nomdla kakhulu kwaye ziqhubeka zithumela umyalezo ongalunganga kwiiseli zomhlaza, zisithi "zahlulwe ngokukhawuleza, zikhule ngokukhawuleza."
IVerzenio ijolise kwizithunywa ezimbini ezikhethekileyo ezibizwa ngokuba yi-'cyclin-dependent kinases 4 kunye ne-6`, okanye i-CDK4 kunye ne-CDK6 ngamafutshane. Ezi zimbini zezona zimbini ezinceda kakhulu iiseli zomhlaza ukukhula nokwahlukana. IVerzenio yenza kanye oku "ngokuthintela" isenzo sezi zithunywa zimbini. Iyawuthintela loo myalezo ukuba ungayi kwiseli yomhlaza. Emva koko iiseli zomhlaza zilahlekelwa luphawu lokukhula nokwahlukana. Oku kubangela ukuba iiseli zomhlaza ziyeke ukukhula okanye ubungakanani bethumba bunciphe.
Loluphi uhlobo lomhlaza webele olunikwa iVerzenio?
I-Verzenio ayilonyango lwazo zonke iintlobo zomhlaza wamabele. Isetyenziselwa ngokukodwa iintlobo zomhlaza ezineempawu ezithile.
Bazi:
- I-Hormone Receptor (HR)-positive: Oku kuthetha ukuba ezi seli zomhlaza zisebenzisa iihomoni, ezifana ne-estrogen, ukuze zikhule. Oku kuthetha ukuba iihomoni "zikukutya" kwezi ntlobo zomhlaza.
- I-HER2-negative: Kwakhona, olu hlobo lomhlaza aluvelisi iproteni ebizwa ngokuba yi-'HER2' kumphezulu walo.
I-Verzenio idla ngokunikwa abantu abanezi mpawu zombini, abanomhlaza webele okwinqanaba lokuqala , kwaye abasengozini enkulu yokuba umhlaza ubuye emva konyango. "Inqanaba lokuqala" lithetha ukuba umhlaza awusasazekanga ngaphaya kwebele okanye ii-lymph nodes ezikufutshane.
Okubaluleke kakhulu, iVerzenio ayiloyeza elizimeleyo. Inikwa kunye nonyango lwehomoni emva kokuba unyango oluphambili olufana notyando kunye ne-chemotherapy lugqityiwe.
Ndingayisebenzisa njani le yeza?
I-Verzenio yipilisi oyiginyayo. Zilumkele ezi zinto xa uyisebenzisa.
- Idosi: Ngokwesiqhelo imiselwe ukuba ithathwe kabini ngemini.
- Ixesha lemini: Zama ukusela amayeza akho ngexesha elifanayo yonke imihla, kungcono kusasa nangokuhlwa. Oku kuya kunceda ukugcina amanqanaba afanayo amayeza emzimbeni wakho.
- Ukusela nokutya: Le pilisi ingasetyenziswa nokutya okanye ngaphandle kokutya. Akukho ngxaki ngaloo nto.
- Indlela yokuginya: Oku kubaluleke kakhulu! Ithebhulethi mayiginywe yonke . Ungaze uyityumze, uyihlafune, okanye uyiqhekeze ithebhulethi. Ukuba unayo nayiphi na ithebhulethi ephukileyo okanye eqhekekileyo, ungayisebenzisi kwaye xelela ugqirha wakho.
- Ukuba uyahlanza: Ukuba uyahlanza emva nje kokusela iyeza, yiyeke loo dosi . Musa ukuthatha elinye ipilisi. Thatha idosi yakho elandelayo ngexesha elicwangcisiweyo.
Unyango lweVerzenio lomhlaza webele okwinqanaba lokuqala ludla ngokunikezelwa ukuya kuthi ga kwiminyaka emi-2. Oku kuthetha ukuba unyango luyayekiswa ukuba umhlaza ubuya, ukuba uneziphumo ebezingalindelekanga ezinzulu, okanye ukuba ixesha leminyaka emi-2 liphelile. Ukuba uneziphumo ebezingalindelekanga ezithile, ugqirha wakho unokunciphisa umthamo wakho okanye ayeke ukuthatha iyeza okwethutyana aze aliqalise kwakhona.
Isebenza kangakanani iVerzenio?
Impumelelo yeVerzenio iqinisekisiwe ngezilingo ezinkulu zeklinikhi. Eyona ibalulekileyo kwezi luvavanyo lweklinikhi olubizwa ngokuba yi-'monarchE'.
Kolu phononongo, kusetyenziswe izigulane ezingama-5,637 ezineentlobo zomhlaza wamabele ezikhankanyiweyo apha ngasentla. Zahlulwe zaba ngamaqela amabini.
1. Elinye iqela lanikwa unyango lwe-hormone ngeVerzenio .
2. Elinye iqela lanikwa unyango lweehomoni kuphela .
Emva koko babalandela aba bantu iminyaka emine. Bajonga ukuba bangaphi abantu abasindayo ngaphandle kokuba umhlaza ubuyile, bavelise umhlaza omtsha, okanye bafe. Le ndlela yokulinganisa ibizwa ngokuba yi-invasive disease-free survival (IDFS).
Iziphumo emva kweminyaka emi-4 zezi zilandelayo:
- I-IDFS yabo bafumana unyango lwe-hormone ngeVerzenio yayiyi -85.5% .
- I-IDFS yabo bafumana unyango lwe-hormone kuphela yayiyi -78.6% .
Oku kubonisa ngokucacileyo ukuba ukongeza iVerzenio kunciphisa kakhulu umngcipheko wokuphinda umhlaza nge-6.9%.Le yinkqubela phambili enkulu kunyango lomhlaza olukwinqanaba lokuqala.
Uza kubekwa esweni njani ngexesha lonyango?
I-Verzenio iqala ukusebenza emzimbeni wakho ukususela ngomhla oqala ukuwusebenzisa. Ugqirha wakho uya kwenza izinto ezahlukeneyo ukujonga inkqubela yonyango lwakho.
- Iiskeni: Ngokwesiqhelo, malunga neeveki ezi-6 emva kokuqala unyango, uya kwenziwa iskeni ukuze ubone ukuba umhlaza usabela njani kunyango. Nangona kunjalo, eli xesha linokulungiswa ngugqirha wakho kuxhomekeke kwimeko yakho.
- Uvavanyo lweGazi: Oku kubaluleke kakhulu. I-Verzenio ngamanye amaxesha inokubangela ukwehla kwenani leeseli ezimhlophe zegazi emzimbeni. Le meko ibizwa ngokuba yi-"neutropenia." Iiseli ezimhlophe zegazi zifana namajoni emzimbeni wethu, zisikhusela kwizifo. Ukuba ziphantsi, izifo ezinzulu zinokwenzeka. Ke ngoko, ugqirha wakho uya kwenza uvavanyo lwegazi rhoqo ukujonga amanqanaba eeseli ezimhlophe zegazi, ii-neutrophils, kunye neeplatelets. Oku kuya kuqinisekisa ukuba kukhuselekile ukuqhubeka nokusela iyeza.
Ungayilawula njani imiphumo emibi?
Kuqhelekile ukuba neziphumo ebezingalindelekanga xa unyangwa umhlaza. Eyona nto ibalulekileyo kukungaxhalabi kwaye uxele ugqirha wakho naziphi na iziphumo ebezingalindelekanga ngokukhawuleza . Banokubona ukuba zimbi na baze bakunike iingcebiso ezifanelekileyo.
Nazi iziphumo ebezingalindelekanga eziqhelekileyo kunye nendlela yokujongana nazo.
| Iziphumo ebezingalindelekanga eziqhelekileyo | Indlela yokulawula |
|---|---|
| Urhudo | Oku kuqhelekile kakhulu. Buza ugqirha wakho kwaye ugcine iyeza (umz. iLoperamide) likufutshane norhudo. Kuphephe ukutya okuneziqholo nokunamafutha. Sela ulwelo oluninzi kunye nolwelo. Xelela ugqirha wakho ngoko nangoko ukuba urhudo olukhulu. |
| Isicaphucaphu kunye nokuhlanza | Endaweni yokutya isidlo esikhulu ngaxeshanye, yitya ukutya okuncinci amaxesha amaninzi ngemini. Izinto ezifana neti yejinja kunye neecrackers zinokunceda. Ukuba kuyimfuneko, ugqirha wakho uya kukunika amayeza okuhlanza. |
| Ukudinwa | Phumla kangangoko unako. Ukuzilolonga kancinci (umz. ukuhamba) ngamanye amaxesha kunokukunika amandla. Yitya ukutya okunesondlo. |
| Ukulahlekelwa yiChalaha | Nokuba kunzima ukutya, zama izinto ezifana nesuphu, ijusi yeziqhamo, kunye neziselo ezinesondlo ukuze ufumane amandla. |
Ukongeza, ugqirha wakho uza kukufundisa ngeempawu zeziphumo ebezingalindelekanga ezinzulu, ezifana neengxaki zemiphunga (ukukhwehlela, ubunzima bokuphefumla) okanye amahlwili egazi (ukudumba, iintlungu emilenzeni). Ukuba ufumana nayiphi na kwezi, kubalulekile ukufuna ingcebiso kagqirha ngoko nangoko.
Yintoni endifanele ndiyiphephe xa ndisebenzisa iVerzenio?
Xa usebenzisa iVerzenio, ukunxibelelana nokutya okuthile kunye namanye amayeza kunokubakho. Oku kunokutshintsha indlela amayeza asebenza ngayo okanye konyuse iziphumo ebezingalindelekanga.
| Izinto ekufuneka uziphephe | Isizathu |
|---|---|
| I-grapefruit | Kuphephe ukutya i-jumbo shrimp okanye ukusela ijusi ye-jumbo shrimp. Izithako ezikwi-jumbo shrimp zinokuthintela umzimba ukuba ungaqhekeki (ukuguqula i-metabolize) iVerzenio. Oku kunokukhokelela kumanqanaba aphezulu angeyomfuneko eziyobisi emzimbeni, nto leyo eyonyusa umngcipheko weziphumo ebezingalindelekanga. |
| Iyeza iKetoconazole | Eli liyeza losulelo lwefungus. Oku kukwabangela into efanayo neebhola ezinkulu. Linokunyusa ngokuyingozi izinga leVerzenio emzimbeni. |
Ngoko ke, ngaphambi kokuba uqale ukusebenzisa iVerzenio, xelela ugqirha wakho ngawo onke amayeza owasebenzisayo ngoku (kuquka iivithamini, amayeza esintu, kunye nezongezo) . Kwakhona, xelela ugqirha wakho ukuba unezinye izifo, ezifana nesifo sesibindi. Ugqirha wakho unokumisela idosi ekhuselekileyo kuwe.
Umyalezo Wokuya Ekhaya
- I-Verzenio liyeza elinikwa kunye nonyango lwehomoni kuhlobo oluthile lomhlaza webele olukwinqanaba lokuqala olubizwa ngokuba yi-HR-positive, i-HER2-negative .
- Oku kuthintela imiqondiso ebangela ukuba iiseli zomhlaza zikhule kwaye zahlukane, nto leyo elawula umhlaza.
- Ungaze uyityumze okanye uyihlafune ipilisi. Yiginye yonke.
- Iziphumo ebezingalindelekanga ezifana norhudo, isicaphucaphu, kunye nokudinwa zinokwenzeka ngexesha lonyango, ngoko ke yazisa ugqirha wakho ngoko nangoko malunga nokungonwabi.
- Kuphephe ukutya igrapefruit ngokupheleleyo ngexesha lonyango.
- Kubalulekile ukwazisa ugqirha wakho malunga nazo zonke ezinye iziyobisi ozisebenzisayo kunye nazo naziphi na ezinye iimeko zempilo onokuba nazo.
- Ukuqinisekisa ukhuseleko, qiniseka ukuba ugqirha wakho unika uvavanyo lwegazi ngexesha elifanelekileyo.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho