Ngaba uphethwe ziintlungu ezinzima kangangokuba awukwazi nokuzicingela? Mhlawumbi ziintlungu zomqolo, iintlungu zomhlaza, okanye iintlungu zemithambo-luvo. Ngokwesiqhelo, kunzima kakhulu ukulawula iintlungu ezinzima kangaka ngeentlungu ezifana nePanadol kunye ne-ibuprofen. Ngamanye amaxesha, nokuba kunikwa iintlungu ezinamandla, abanye abantu baneziphumo ebezingalindelekanga. Ngoko ke, namhlanje siza kuthetha ngamayeza akhethekileyo oogqirha abaphendukela kuwo xa zonke ezinye iindlela zonyango zingaphumeleli. Leyo yinaliti yeZiconotide.
Kalula nje, yintoni iZiconotide?
I-Ziconotide liyeza elikhethekileyo elisetyenziselwa ukunyanga iintlungu ezinzima nezingapheliyo . Ayifani neyeza eliqhelekileyo lokubulala iintlungu. Ngokwesiqhelo, ipilisi esiyithathayo xa sineentlungu isebenza ngokuya kwindawo apho iintlungu zikhoyo emzimbeni. Kodwa i-Ziconotide isebenza ngendlela eyahlukileyo.
Ngamafutshane, xa sisiva iintlungu emzimbeni wethu, kuxa isignali ihamba ukusuka kwindawo yentlungu ukuya ebuchotsheni ngemithambo-luvo. Into eyenziwa yiZiconotide kukuthintela ezi mpawu zentlungu ezihamba ngomqolo ukuya ebuchotsheni . Kufana nokuba umyalezo wentlungu uyekwa phakathi ngaphambi kokuba ufike ebuchotsheni. Yiyo loo nto inokulawula neentlungu ezinzima ezingenakukwazi ukulawuleka ngamanye amayeza.
Okubaluleke kakhulu, oku kunikwa kuphela xa zonke ezinye iintlungu zingasebenzi okanye iziphumo zazo ezinganyamezelekiyo, kwaye phantsi kweliso elibukhali lengcali.
Linikwa njani eli yeza? Ingaba liyeza eliqhelekileyo?
Hayi. Oku akusiyonto yokujova njengoko sidla ngokujova egxalabeni okanye empundu. Oku kunikwa ngendlela ekhethekileyo.
Eli yeza lifakwa ngqo kulwelo olujikeleze umqolo wakho (ulwelo lwe-cerebrospinal) . Oku kubizwa ngokuba yi-intrathecal injection. Ngenxa yokuba kunzima ukunika eli jelo yonke imihla, oogqirha baza kufaka ipompo ekhethekileyo (ipompo efakwayo) phantsi kolusu lwakho, ngesiqhelo esiswini sakho.
Le pump ifana nekhompyutha encinci. Ingakhupha amayeza ngexesha elithile, ngedosi ethile. Ugqirha uyayicwangcisa le pump aze ayizalise ngamaxesha athile. Iqela lezonyango liya kukufundisa nendlela yokusebenzisa le pump.
Kutheni le nkqubo inzima kangaka?
Le ndlela isetyenziswa kuba iyeza kufuneka liye ngqo kwinkqubo yemithambo-luvo. Ngaphandle koko, ukuba lingeniswa egazini njengesiqhelo, aliyi kusebenza kakuhle kwaye libe nemiphumo emibi emininzi.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale unyango
Ngenxa yokuba eli liyeza elinamandla kakhulu, kubalulekile ukuxelela ugqirha wakho ngembali yakho epheleleyo yempilo ngaphambi kokuba uqale unyango. Qiniseka ukuba uyamxelela ukuba unayo nayiphi na kwezi meko zilandelayo:
- Iingxaki zempilo yengqondo: Ngaba wakha waba nesifo esifana nokudakumba, ixhala, isifo sengqondo , okanye ngaba wena okanye umntu kusapho lwakho wakha wazama ukuzibulala?
- Iingxaki zokopha: Ngaba unengxaki yokuba igazi lakho lingajiyi lula?
- Iintsholongwane: Sixelele ngazo naziphi na izifo ezikhoyo emzimbeni wakho, ingakumbi izifo ezichaphazela umqolo.
- Ukuvaleka komqolo: Ngaba ugqirha wakhe wakuxelela ngokuvaleka komqolo?
- Ii-Allergies: Ukuba une-allergy kule mithi ye-ziconotide okanye naliphi na elinye iyeza, ukutya, okanye idayi.
- Ukukhulelwa: Ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa, qiniseka ukuba wazise ugqirha wakho.
Zithini iziphumo ebezingalindelekanga ezinokubakho xa usebenzisa eli yeza?
Njengalo naliphi na iyeza, i-ziconotide inokubangela iziphumo ebezingalindelekanga. Ezinye ziyingozi, ngelixa ezinye zixhaphakile. Kubalulekile ukuzazi ezi zinto.
| Iziphumo ebezingalindelekanga kunye nento omawuyenze | |
|---|---|
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kwiqela lakho lezonyango ngoko nangoko | |
| Iimpendulo ze-Allergic | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi okanye umqala. |
| Utshintsho lwengqondo kunye nokuziphatha | Ukungazinzi okukhulu, ukuphazamiseka, ukudideka, ukubona okanye ukuva izinto ezingezizo zokwenyani (imibono), iingcinga zokuzibulala, ukudakumba okwandileyo. |
| Iimpawu zeMeningitis | Umkhuhlane, intamo eqinileyo, ubunzima bokujonga ukukhanya, intloko ebuhlungu, isicaphucaphu, kunye nokuhlanza. (Ezi zisenokuba ziimpawu zosulelo engqondweni okanye emgogodleni). |
| Ukonakala kwemisipha (iRhabdomyolysis) | Ubuthathaka obungaqhelekanga, iintlungu zemisipha, umchamo otyheli okanye omdaka, ukuncipha kokuphuma komchamo. |
| Ubunzima bokucinga nokukhumbula | Ubunzima bokugxila, ukulahlekelwa yinkumbulo, ubunzima bokuthetha. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| Ukudideka | Ukudideka okuncinci. |
| Isiyezi | Ukudinwa, ukulahlekelwa yibhalansi. |
| Isicaphucaphu | Ukuza kuhlanza. |
| Ukungakwazi ukulawula amehlo | Iintshukumo zamehlo ezingalawulekiyo. |
Amanqaku akhethekileyo ekufuneka uwalumkele
Utywala nezinye iziyobisi
Musa ukusela utywala ngelixa usebenzisa eli yeza nangasiphi na isizathu . I-Ziconotide inokuphazamisa ukuphaphama kwakho, ukulinganisela, kunye nexesha lokuphendula. Ukusela utywala kunokwenza le meko ibe mandundu ngakumbi.
Kwakhona, kufuneka ulumke kakhulu xa usebenzisa amanye amayeza abangela ukozela (umz., ezinye iziraphu zokukhwehlela, amayeza okungezwani komzimba, iipilisi zokulala). Xelela ugqirha wakho ngawo onke amayeza owasebenzisayo, kuquka neevithamini kunye namayeza emifuno.
Ukuqhuba nokusebenzisa oomatshini
Kuphephe ukuqhuba okanye ukusebenzisa oomatshini abayingozi de wazi kakuhle indlela eli yeza elikuchaphazela ngayo. Kwakhona, ukuze uphephe isiyezi okanye ukuquleka, musa ukuvuka ngequbuliso kwindawo ohleli kuyo okanye olele kuyo. Sukuma kancinci.
Kuthekani ukuba idosi iyanda?
Ekubeni oku kunikwa ngepompo, idosi ayidli ngokwandiswa. Nangona kunjalo, ukuba ukrokrela ukuba uthathe amayeza amaninzi ngenxa yokungasebenzi kakuhle kwepompo okanye esinye isizathu, qhagamshelana ngokukhawuleza neZiko loLwazi lweePoison kwiSibhedlele sikaZwelonke saseColombo, okanye uye kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
Gcwalisa kwakhona ii-Appointments
Ugqirha wakho uza kukunika umhla wokugcwalisa ipompo yakho ngamayeza. Musa ukuwutsiba la maxesha. Ukuba ngesizathu esithile awukwazi ukufika, fowunela iqela lakho lezonyango ngoko nangoko uze uhlengahlengise ixesha.
Umyalezo Wokuya Ekhaya
- I-Ziconotide liyeza elinamandla elisetyenziselwa kuphela iintlungu ezinzima kakhulu, ezingapheliyo ezingasabelanga kwezinye iindlela zonyango.
- Oku kuhanjiswa kulwelo olujikeleze umqolo ngepompo ekhethekileyo efakelweyo phantsi kolusu.
- Ufanele uxelele ugqirha wakho ngazo zonke iimeko zakho zempilo, ingakumbi iingxaki zempilo yengqondo kunye nee-aleji, ngaphambi kokuba uqale unyango.
- Funa uncedo lwezonyango ngokukhawuleza ukuba ufumana iziphumo ebezingalindelekanga ezinzulu ezifana nokudideka, utshintsho kwindlela oziphatha ngayo, umkhuhlane, kunye nokuqina kwentamo.
- Kuphephe ukusela utywala ngokupheleleyo ngelixa usebenzisa olu nyango. Lumka kakhulu xa uqhuba okanye usebenzisa oomatshini.
- Ukuba kukho naluphi na utshintsho, ukwanda, okanye intlungu entsha kwintlungu yakho, yazisa ugqirha wakho.
👩🏽⚕️ Imibuzo eyongezelelweyo (Ii-FAQ)
💬 Isetyenziselwa ntoni i-Ziconotide / Prialt vaccine?
Lo asiloyeza liqhelekileyo lokuthomalalisa iintlungu! Eli liyeza elinamandla kakhulu (elingeyo-opioid) elinikwa esibhedlele nge-'Intrathecal pump' efakwe ngugqirha ngaphakathi kwi-spinal cord/spinal cord yesigulana ukuze kupheliswe i-100% ye-'Severe Chronic Pain' enganyamezelekiyo engancediyo nakweliyeza linamandla kakhulu (iMorphine) kwizigulane ezinomhlaza kunye nabo baneengxaki ezinkulu zemithambo-luvo!
💬 Lenziwe ngantoni eli yeza (iZiconotide), elinamandla kune morphine?
Ibali elimangalisayo! Eli yeza lifunyenwe kwaye lenziwe ngetyhefu ebulalayo (iConotoxin) eveliswa 'yinkumba eyingozi kakhulu/enobuthi (iConus magus / iCone snail)'! Nje ukuba le tyhefu ifikelele kumqolo, ivala/ivala i-100% yamasango e-calcium (iindlela ze-calcium zohlobo lwe-N) kwimithambo-luvo ethwala iintlungu eziya engqondweni. Oku kuyinqumla ngokupheleleyo isigidimi sentlungu esiya engqondweni.
💬 Zeziphi iziphumo ebezingalindelekanga eziyingozi zokunika eli yeza likhethekileyo kwi-spinal cord (Intrathecal)?
Iziphumo ebezingalindelekanga zoku zimbi kakhulu! (Isilumkiso seBlack Box). Ngenxa yokuba eli yeza liya ngqo kwingqondo/umqolo, abanye abaguli baba ne-schizophrenia/ukuphambana okunganyamezelekiyo (Hallucinations). Kwakhona, ixhala elinzima, i-paranoia, kunye 'neengcinga zokuzibulala' ezitshabalalisayo zenzeka ngoko nangoko! Enye inkxalabo enkulu kukuba isigulana sinethuba elikhulu lokungakhumbuli nto (i-Cognitive impairment).
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