Kuyini i-Cholecystokinin? Ake sixoxe ngakho kalula!

Sawubona! Unjani? Namuhla sizokhuluma ngesithunywa samakhemikhali esincane kodwa esibaluleke kakhulu emzimbeni wethu. Sibizwa ngokuthi i-cholecystokinin. Nakuba igama lingase libonakale lide kancane, libalulekile enqubweni yethu yokugaya ukudla. Ake sibone ukuthi lenzani, lisebenza kanjani, nokuthi libaluleke kangakanani emzimbeni wethu?

Iyini le cholecystokinin?

Kalula nje, i-cholecystokinin iyi -hormone . Uyazi ukuthi ayini ama-hormone? Afana nezithunywa ezincane ezithwala imiyalezo ukusuka endaweni kuya endaweni emizimbeni yethu. Le hormone ebizwa ngokuthi i-cholecystokinin ikhiqizwa kakhulu ngamaseli asemathunjini akho amancane , ikakhulukazi ngemva kokudla. Yingakho ngezinye izikhathi ibizwa ngokuthi i-pancreozymin. Iqanjwe kanjalo ngoba isebenza kuma-pancreas. Kodwa ngokumangazayo, le cholecystokinin ikhona nasebuchosheni bethu kanye nasesimisweni sezinzwa esiyinhloko . Ososayensi basathola ukuthi yenzani lapho. Kodwa indima yayo ekugayweni kokudla inkulu kakhulu.

I-cholecystokinin iqala kanjani ukukhishwa?

Cabanga ukuthi udle ukudla okumnandi. Mhlawumbe i-curry yenyama nelayisi, noma ucezu lwenhlanzi, amalentili, i-sambol kakhukhunathi... Ukudla okudlayo kuqala kuya esiswini. Kugaywa lapho isikhashana, bese kancane kancane kuqala ukufinyelela engxenyeni yokuqala yamathumbu amancane, i-duodenum . Kufana nesitimela esiza esiteshini. Bese kuba namaseli akhethekile ezindongeni ze-duodenum yakho, njengabaphenyi. Abizwa ngokuthi ama-I-cell . Lawa ma-I-cell anekhono elimangalisayo lokubona amaprotheni namafutha (okungukuthi, inyama, inhlanzi, amaqanda, ubisi, amafutha) ekudleni okudlayo. Lapho nje ewabona, lawa '(ama-I-cell)' acabanga, "O, manje sekuyisikhathi sokuqala ibhizinisi! Sidinga ukukhipha umngane wethu i-cholecystokinin ngokushesha," futhi bayayenza futhi bayikhiphe ngqo egazini. Ukusuka lapho, uhambo lwayo olubalulekile luqala.

Yini eyenziwa yi-cholecystokinin emizimbeni yethu?

Yilapho umsebenzi wangempela wenzeka khona ngemva kokuba i-cholecystokinin ingene egazini. Ayihlali nje lapho. Ihamba egazini, iya esithweni ngasinye, futhi yenza imisebenzi eminingi ebalulekile.

Lokho ekwenzayo ngesikhathi sokugaya ukudla

Ake sibone ukuthi ibaluleke kangakanani indima edlalwa yi-cholecystokinin ekugayweni kokudla:

• Kubangela ukuba inyongo ifinyele: Kutshela inyongo yakho ukuthi, "Kulungile, manje usunayo inyongo ngaphakathi kuwe."Faka okunye emathunjini amancane. Sekuyisikhathi sokuqala ukusebenza!" Ungamangali, igama elithi 'cholecystokinin' lisho 'ukuhambisa inyongo'. Le nyongo yiyo esiza ekuncibilikiseni amafutha, noma amafutha, esiwadlayo, bese siwaphula abe amaconsi amancane. Njengoba nje sisebenzisa insipho ukugeza izitsha.
• Ivuselela i-pancreas: Iphinde ithumele isignali ku-pancreas, ithi, "Kufanele futhi uthumele ama-enzyme akho okugaya ukudla emathunjini amancane. Kunomsebenzi omkhulu okufanele wenziwe lapha." Elinye igama, "i-pancreozymin," lisuselwa kulo msebenzi ohlobene ne -pancreas .
• Ukuqhekeka kwamaprotheni namafutha: I-bile evela enyongweni kanye nama-enzyme avela e-pancreas asebenza ndawonye ukuphula amaprotheni namafutha ekudleni esikudlayo abe yizicucu ezincane ukuze akwazi ukumuncwa ngumzimba. Lokhu kufana nokuphula itshe elikhulu libe yizicucu ezincane.
• Ilawula ukukhishwa kwesisu : Ngesikhathi lo msebenzi uqhubeka emathunjini amancane, i-cholecystokinin itshela isisu ukuthi, "Ungakhathazeki, linda umzuzu. Ungathumeli ukudla okusha emathunjini amancane kuze kube yilapho ukudla kwangaphambilini sekugayiwe." Lokhu kubizwa ngokuthi ukucindezelwa kokukhishwa kwesisu . Lokhu kusho ukuthi ithumbu elincane alitholi inani elikhulu lokudla ngesikhathi esisodwa, kodwa linesikhathi sokukugaya kahle.
• Yehlisa isifiso sokudla : Ngesikhathi sokugaya ukudla, i-cholecystokinin yenza isisu sethu sizizwe sigcwele. Iphinde ivuselele imizwa yesitho sangasese sowesifazane odongeni lwesisu, ithumele isignali ebuchosheni, "Sekwanele, sengigcwele, ungabe usadla." Yingakho sizizwa sigcwele ngemva nje kokudla.
• I-peristalsis iyaqala: Ekugcineni, lokhu kudla okugayiwe kudinga ukuthuthwa kuye emathunjini . Lokhu kusizwa ukufinyela kwesigqi kanye nokukhululeka kwemisipha emathunjini, okubizwa ngokuthi i-peristalsis . Kufana nokusunduza ukudla emathunjini .

Cabanga ukuthi le hormone eyodwa isiza kanjani inqubo yethu yokugaya ukudla isebenze kahle!

Imiphumela ebuchosheni kanye nasesimisweni sezinzwa

Ngaphezu kokusiza ekugayeni ukudla, i-cholecystokinin itholakale futhi inendima ebuchosheni bethu kanye nasesimisweni sezinzwa esiyinhloko. Lokhu kusacwaningwa, kodwa lokho okutholakale kuze kube manje kubaluleke kakhulu. Ikakhulukazi, kungasiza ekukhathazekeni kanyeKubonakala sengathi kuhlotshaniswa nezimo zempilo yengqondo njengokuhlaselwa uvalo . Ezinye izifundo zikhombisile ukuthi amazinga aphezulu e-cholecystokinin ebuchosheni andisa ukukhathazeka. Lokhu kuyinkimbinkimbi kancane, kodwa kusobala ukuthi kunomthelela nasekulawuleni kwethu ngokomzwelo. Kubikwe nokuthi kuhilelekile ekulawuleni izinga lokushisa lomzimba, noma ukulawulwa kokushisa komzimba . Kuthiwa uma kujovwa ebuchosheni, kuzobangela umkhuhlane, futhi uma kujovwa kwezinye izingxenye zomzimba, kuzobangela i-hypothermia, isimo lapho izinga lokushisa lomzimba lehla khona. Kodwa-ke, kudingeka ucwaningo olwengeziwe ukuze kuqondwe lokhu ngqo.

Itholakala kuphi i-cholecystokinin emzimbeni wethu?

Njengamanye ama-hormone, i-cholecystokinin ihamba emizimbeni yethu yonke egazini lethu. "Ikhuluma" nezitho ezahlukene ngokusebenzisa ama-receptor akhethekile kumaseli alezo zitho. La ma-receptor afana neminyango. Iminyango ivuleka kuphela uma kukhona ukhiye obizwa ngokuthi i-cholecystokinin, bese iseli lithola umyalezo. Esimiso sethu sokugaya ukudla, ama-receptor e-cholecystokinin (CCK) atholakala emisipheni yenyongo, ulwelwesi lwesisu namathumbu, kanye ne-pancreas. La ma-receptor angatholakala nasezingxenyeni ezahlukene zobuchopho kanye nohlelo lwezinzwa oluphakathi.

Yiziphi izifo ezihambisana ne-cholecystokinin?

Kunezifo ezithile lapho kutholakale khona amazinga aphansi e-cholecystokinin. Kodwa-ke, akukacaci ukuthi lokhu kuwumphumela wesifo noma imbangela yalesi sifo. Ucwaningo lusaqhubeka ngalokhu. Isibonelo, amazinga aphansi e-cholecystokinin angase ahlotshaniswe nezimo ezifana ne -gastroparesis , isimo lapho isisu singakhiphi kahle futhi ukudla kubhajwe, kanye ne -biliary dyskinesia, isimo lapho i-gallbladder ingasebenzi kahle futhi i-bile ingeke ikhishwe kahle. Ngaphezu kwalokho, ososayensi baphenya ukuthi ukuhlukahluka okuhlukahlukene kwezakhi zofuzo ezihilelekile ekukhiqizweni kwe-cholecystokinin kuhlotshaniswa kanjani nezinye izinkinga zokukhathazeka kanye nezinkinga ze-metabolic. Olunye ucwaningo lubonisa ukuthi lokhu kuhlukahluka kwezakhi zofuzo kungashintsha indlela i-cholecystokinin exhumana ngayo nobuchopho futhi ilawula izimpawu zokukhathazeka noma indlala.

Buyini ubudlelwano phakathi kwe-cholecystokinin nokukhuluphala ngokweqile?

Ukukhuluphala ngokweqile, noma ukukhuluphala ngokweqile, kuyinkinga kubantu abaningi namuhla. Ososayensi baphenya ngenkuthalo ukuthi kukhona yini ukuxhumana phakathi kokukhuluphala kanye ne-cholecystokinin. Okunye okutholakele kuyamangaza impela. Isibonelo, kutholakale ukuthi abantu abanohlobo oluthile (ushintsho) ku-gene ye-cholecystokinin banamathuba angaba ngu-60% okuba nokukhuluphala kunabanye. Kukhona nobufakazi bokuthi abantu abanokukhuluphala okukhulu (ukukhuluphala kwesigaba sesi-3), okungukuthi, abantu abakhuluphele kakhulu, banokuzwela okunciphile ku-cholecystokinin. Lokhu kusho ukuthi yize bene-cholecystokinin emizimbeni yabo, bangase bangakwazi ukuzwa kahle isignali 'yokugcwala' ebanika yona. I-Cholecystokinin isebenza nenye i-hormone ebizwa ngokuthi i-leptin ukulawula indlala. Abantu abanokukhuluphala bangase babe nokungalingani phakathi kwezimpawu zendlala kanye nokugcwala ebuchosheni babo. Ngakho-ke, ukuqonda i-cholecystokinin kungasiza nasekutholeni ukwelashwa kokukhuluphala.

Iyini le cholecystokinin test?

Ukuhlolwa kwe-cholecystokinin kuhilela ukunikeza inyongo yakho umuthi obizwa ngokuthi i-cholecystokinin ukuze uyishukumise. Ngezinye izikhathi lokhu kwenziwa njengengxenye ye -HIDA scan, okuwuhlobo olukhethekile lokuhlolwa kwe-nuclear medicine imaging . Ungakhathazeki ngegama, lokhu kuhlolwa kuphephile kakhulu. Nakhu okwenzekayo: 1. Okokuqala, uchwepheshe ufaka inani elincane le-radioactive isotope, noma i-tracer, emthanjeni wakho. Kufana nokudweba imigwaqo embalwa emzimbeni wakho bese ubheka ukuthi kwenzekani kuyo. 2. Lo mshini wokulandelela uhamba uye esibindini sakho kanye nohlelo lwe-biliary (i-gallbladder, i-bile ducts). 3. Ngemuva kwalokho, kusetshenziswa ikhamera ekhethekile (i-scanner) ukuthwebula imisebe ekhishwa yilo mshini wokulandelela bese ubonisa izithombe esikrinini sekhompyutha. Lezi zithombe zivumela udokotela ukuthi abone ukuthi inyongo yakheka kanjani nokuthi ihamba kanjani. Uma udokotela wakho efuna ukubona ukuthi kwenzekani lapho inyongo yakho iqina, angase afake i-cholecystokinin ku-HIDA scan njengesinyathelo esengeziwe. Ngaleso sikhathi, uchwepheshe uzofaka i-cholecystokinin emthanjeni wakho. Ngemuva kwalokho, kuthathwa izithombe ezengeziwe. Njenge-cholecystokinin ekhiqizwa ngokwemvelo emathunjini akho, i-cholecystokinin ejoviwe ivuselela i-gallbladder ukuthi inciphe. Odokotela bayala lolu vivinyo ukuze babone ukuthi kukhona yini inkinga ngokusebenza kwe-gallbladder yakho nokuthi ngabe ikhipha i-bile kahle yini.

Ingabe kukhona ukwelashwa kwe-cholecystokinin?

Kuze kube manje, akukho ukwelashwa kwezokwelapha okusebenzisa ngqo i-cholecystokinin. Okusho ukuthi, i-cholecystokinin ayinikezwa njengokwelapha isifo. Kodwa-ke, isetshenziswe ukuthola nokuhlola imithi emisha. Isibonelo, abacwaningi bazama ukudala imithi efana ne-cholecystokinin ekunciphiseni isifiso sokudla nokusiza ekunciphiseni isisindo. Futhi, i-cholecystokinin inengxenye ekhethekile ebizwa ngokuthi i-CCK-4 . Le CCK-4 yaziwa ngokubangela abantu ukuba bazizwe bekhathazekile futhi besaba. Ngakho-ke, ososayensi ngezinye izikhathi basebenzisa i-CCK-4 ukuhlola ukuthi imithi emisha yokulwa nokukhathazeka isebenza kahle kangakanani.

Izinto ezibaluleke kakhulu okudingeka sizikhumbule (Umyalezo Wokuya Ekhaya)

Ngakho-ke, kusukela kulokho esikhulume ngakho nge-cholecystokinin, ungakhumbula ezinye zezinto ezibaluleke kakhulu. Manje usuyaqonda ukuthi le hormone encane yenza umsebenzi omkhulu kangakanani emizimbeni yethu, akunjalo?

• I-Cholecystokinin iyi -hormone ebalulekile enqubweni yokugaya ukudla . "Ikhuluma" nazo zonke izitho ezihilelekile ekugayweni kokudla, njenge-gallbladder kanye ne-pancreas, futhi izisize zenze umsebenzi wazo ngendlela efanele.
• Odokotela bayisebenzisa futhi njengesikhuthazi esithembekile sokuhlola ukusebenza kwenyongo.
• Kuphinde kusize ekulawuleni indlala . Kutholakale nokuthi ukusebenza okungasebenzi kahle kwe-cholecystokinin kungahlotshaniswa nezimo ezifana nokukhuluphala ngokweqile.
• Ososayensi bayaqhubeka nokufunda ngendima yayo ebuchosheni nasesimisweni sezinzwa, ikakhulukazi ubudlelwano bayo nezimo ezifana nokukhathazeka kanye nezinkinga zokwethuka.

Ngakho-ke, imizimba yethu iyimishini emangalisayo ngempela! Kuyamangalisa ukuthi lezi zinto ezincane zingawenza umehluko ongakanani empilweni yethu, akunjalo? Nakekela umzimba wakho, futhi laba bangane abancane bazokunakekela!

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I-Cholecystokinin, i-Cholecystokinin, i-Hormone, Ukugaya ukudla, i-Gallbladder, i-Pancreas, indlala, ukukhuluphala ngokweqile, i-HIDA scan