Kuyini i-Glycogen? Ake sixoxe ngokugcinwa kwamandla emzimbeni wethu ngamagama alula!

Wake wazibuza ukuthi imizimba yethu iwagcina kanjani amandla esiwathola ekudleni esikudlayo ukuze siwasebenzise kamuva? Yilapho into ekhethekile ebizwa ngokuthi i-glycogen ingena khona. Kufana nebhange lamandla eligcina amafoni ethu eshajekile.

Kuyini i-glycogen?

Kalula nje, i-glycogen uhlobo lukashukela olubizwa ngokuthi i-glucose olugcinwa emizimbeni yethu. Lwakhiwe ngama-molecule amaningi e-glucose ahlanganiswe ndawonye.

Manje ungase uzibuze ukuthi iyini i-glucose. I-glucose inguphethiloli oyinhloko ohlinzeka ngamandla emizimbeni yethu. Sithola le glucose kokunye kokudla esikudlayo, ikakhulukazi lokho okuqukethe ama-carbohydrate. Uma i-glucose ekudleni esikudlayo ingadingeki ngokushesha ukuze ibe namandla, imizimba yethu iyigcina njenge-glycogen esibindini nasemisipheni , ukuze isetshenziswe kamuva.

Inqubo umzimba wethu odala ngayo i-glycogen kusuka ku-glucose ibizwa ngokuthi i-Glycogenesis . Futhi, inqubo lapho le glycogen iguqulwa khona ibe yi-glucose uma kudingeka futhi isetshenziselwa amandla ibizwa ngokuthi i-Glycogenolysis . Zombili lezi zinqubo zisizwa izinhlobo ezahlukene zama-enzyme . Ama-enzyme ayizinhlobo ezikhethekile zamaprotheni atholakala ngaphakathi kwamaseli ethu. Asebenza njengezinto ezibangela ukwakheka kwama-enzyme futhi asiza izinqubo ezahlukene emzimbeni ukuthi zisebenze kahle. Kunezinkulungwane zama-enzyme anjalo emzimbeni wethu wonke, futhi ngalinye lawo lenza umsebenzi obalulekile.

Uyini umehluko phakathi kweGlycogen, Glucose kanye neGlucagon?

Manje ake sibone ukuthi umehluko uyini phakathi kwala magama amathathu: i-Glycogen, i-Glucose, ne-Glucagon. Womathathu ahlobene nendlela imizimba yethu esebenzisa ngayo ama-carbohydrate ukuze ithole amandla, kodwa ngalinye lawo linomsebenzi ohlukile.

I-glucoseLuhlobo lukashukela esiluthola ekudleni esikudlayo, ikakhulukazi ama-carbohydrate. Uhlobo oluyinhloko lukashukela egazini lethu yi-glucose egazini, noma lokho esikubiza ngokuthi ' ushukela egazini'. Lolu shukela lunikeza imizimba yethu amandla, futhi luphinde londle izitho zethu zomzimba, imisipha, kanye nesimiso sezinzwa. I-glucose ibaluleke kakhulu ngoba ingumthombo oyinhloko wamandla ebuchosheni bethu. Eqinisweni, ubuchopho bethu budinga i-glucose njalo, yingakho kunconywa ukuthi umuntu omdala adle okungenani amagremu angu-130 ama-carbohydrate ngosuku.

Manje sesiyazi ukuthi lapho imizimba yethu ingasadingi i-glucose ngokuzumayo, igcinwa esibindini nasemisipheni yethu njenge -glycogen .

I-Glucagon iyi-hormone ekhiqizwa yi-pancreas yethu. Isiza ukuguqula i-glycogen egciniwe ibe yi-glucose bese iyikhulula egazini. Umzimba ungabe ususebenzisa leyo glucose ukuze uthole amandla. I-Glucagon kanye ne -insulin yi-hormone ezimbili ezilawula amazinga kashukela egazini emzimbeni wethu.

Ingabe i-glycogen iyi-carbohydrate?

Ngakho-ke, ingabe i-glycogen iyi-carbohydrate? I-glycogen yenziwe ngama-carbohydrate, okungukuthi, ekudleni okunesitashi esikudlayo. Kodwa-ke, i-glycogen akuyona i-carbohydrate uqobo. Uma sidla ukudla okuqukethe ama-carbohydrate, imizimba yethu iyawaphula bese iwaguqula abe yi-glucose ukuze isetshenziswe njenge-energy. I-Glycogen yindlela i-glucose egcinwa ngayo. Yakhiwe yinqwaba yama-molecule e-glucose axhunywe ndawonye.

Igcinwa kuphi i-glycogen?

Kulungile, pho le glycogen igcinwa kuphi emizimbeni yethu? I-Glycogen igcinwa kakhulu emizimbeni yethu.Itholakala emisipheni yesibindi kanye nemisipha yamathambo . Imisipha iyimisipha enamathele emathanjeni kanye nasemisipha yethu. Ngaphezu kwalokho, inani elincane kakhulu ligcinwa ebuchosheni bethu.

Nakuba isibindi sethu sigcina iphesenti eliphezulu le-glycogen kunemisipha yethu, isisindo semisipha yethu iyonke sikhulu kakhulu kunesibindi sethu, ngakho-ke izingxenye ezintathu kwezine kuphela ze-glycogen iyonke emzimbeni isemisipheni yethu.

Uma sizivocavoca ngamandla, ikakhulukazi isikhathi eside, inani le-glycogen emaseli emisipha asebenzayo lingancipha kakhulu. Inani le-glycogen emaseli esibindi liyashintsha usuku lonke. Lokhu kungenxa yezici eziningana:

• Inani lama-carbohydrate esiwadlayo.
• Isikhathi esisigcinayo phakathi kokudla.
• Ubukhulu kanye nobude bomsebenzi womzimba esiwenze muva nje.

Cabanga nje, uma ungadli amahora ayi-12 kuya kwangu-24 (uzila ukudla), cishe yonke i-glycogen esibindini isuke isiphelile.

Iyiphi inkonzo enikezwa yi-glycogen emizimbeni yethu?

Manje ake sibone ukuthi le glycogen iyinikeza kanjani insizakalo emzimbeni wethu. Kuye ngokuthi igcinwa kuphi - kungaba sesibindini noma emisipheni - umsebenzi wayo nawo uyahlukahluka kancane.

Umsebenzi Wezitolo Ze-Glycogen Zesibindi

Imizimba yethu isebenzisa i-glycogen, ikakhulukazi esibindini , ukusiza ukulawula amazinga ethu kashukela egazini.

Ngokuvamile, imizimba yethu ilawula ngokucophelela amazinga ethu kashukela egazini ngama-hormone abizwa ngokuthi i-glucagon kanye ne-insulin. Uma amazinga ethu kashukela egazini ehla kakhulu, okubizwa ngokuthi i-hypoglycemia , ama-pancreas ethu akhipha i-glucagon eyengeziwe. Enye yezinto ezenziwa yi-glucagon ukuguqula i-glycogen esibindini ibuyele ku-glucose bese iyikhulula egazini. Ungase ukhumbule ukuthi sayibiza ngokuthi le nqubo ngokuthi i-glycogenolysis. Lapho i-glucose ikhishwa egazini, amaseli kuwo wonke umzimba angayisebenzisela amandla.

Izitolo ze-Glycogen esibindini nazo ziyasiza ekusebenzeni kwemisipha kanye nokuzivocavoca ngezinga elithile. Lapho nje uqala ukuzivocavoca, imisipha yakho esebenzayo isebenzisa i-glucose ukuze ithole amandla, ngakho-ke isibindi siqala ukuphula i-glycogen ukuze silondoloze amazinga kashukela egazini. Kodwa-ke, imisipha yakho isebenzisa kakhulu izitolo zayo ze-glycogen.

Umsebenzi Wezitolo Ze-Muscle Glycogen

I-Glycogen emisipheni isebenza ngokuyinhloko njengomthombo wamandla okusebenza kwemisipha yethu.

Ukuze sinyakaze, imisipha yethu idinga amandla amaningi. Cabanga nje, uma imisipha yethu ibingathatha ushukela egazini ukuze ithole la mandla, ushukela emzimbeni ubuzophela ngokushesha okukhulu.

Yingakho imizimba yethu igcina izingxenye ezintathu kwezine ze-glycogen kuyo yonke imisipha yamathambo. Lokhu kuvumela imisipha ukuthi iqhubeke nokuthola amandla ngaphandle kokuthinta kakhulu amazinga kashukela egazini, ikakhulukazi ngesikhathi sokuzivocavoca.

Izinga lokuphelelwa yi-glycogen emisipheni yethu lihlobene kakhulu nokuqina komsebenzi womzimba. Njengoba ukuqina kokuzivocavoca kukhuphuka, izinga lokuphelelwa yi-glycogen emisipheni nalo liyakhula. Ngakho-ke, ngesikhathi semisebenzi enamandla kakhulu, njengokushesha , izitolo ze-glycogen emaseli emisipha asebenzayo zingaphela ngokushesha okukhulu, noma ngabe ubude besikhathi somsebenzi bufushane.

Uma sidla ama-carbohydrate anele, imisipha yethu iphinda igcwale i-glycogen.

Kuyini iGlycogen Storage Disease (GSD)?

Ngezinye izikhathi, izinkinga zingaphakama ngale glycogen. Esinye sezimo ezinjalo isifo sokugcina i-glycogen, noma i-GSD ngamafuphi .

I-GSD iyisimo esingavamile, esizuzwe njengefa.Lokhu kwenzeka lapho umuntu ezalwa engenawo ama-enzyme athile adingekayo ukwenza kanye/noma ukuphula i-glycogen. Ngenxa yokuthi imizimba yethu isebenzisa ama-enzyme amaningi ahlukene ukucubungula i-glycogen, kunezinhlobo eziningi ezahlukene ze-GSD. I-GSD ivame ukubangela ukulimala kwesibindi kanye nobuthakathaka bemisipha . Ezinhlotsheni eziningi ze-GSD, izimpawu ziqala ukubonakala ebuntwaneni noma ebuntwaneni.

Yiziphi izivivinyo ezitholakalayo zokuhlola amazinga e-glycogen?

Ngakho-ke, ingabe kukhona ukuhlolwa okukhethekile ukuhlola amazinga e-glycogen emzimbeni wethu? Empeleni, akukho ukuhlolwa okukhethekile okulinganisa amazinga e-glycogen kuphela. Ngaphezu kwalokho, amazinga ethu e-glycogen ahlala eshintsha kuye ngokuthi sisebenza kangakanani kanye nenani lama-carbohydrate esiwadlayo ngosuku.

Kunalokho, uma unezimpawu, odokotela basebenzisa ezinye izivivinyo ukuze babone ukuthi unenkinga yini ngendlela umzimba wakho okhiqiza futhi ophula ngayo i-glycogen, ebizwa ngokuthi isifo sokugcina i-glycogen (GSD). Lezi zivivinyo yilezi:

• Ukuhlolwa kwegazi: Izinto ezifana nephaneli yokusebenza kwesibindi kanye nephaneli yokusebenza kwezinso zingakusiza ubone ukuthi lezi zitho zisebenza kahle kangakanani. Ukuhlolwa kwezinga likashukela egazini kungakusiza ubone ukuthi umzimba wakho usebenzisa kahle kangakanani i-glycogen. Abantu abane-GSD bavame ukuba noshukela wegazi ophansi.
• I-ultrasound yesisu: Lokhu kuhlolwa kwesithombe kungasiza udokotela wakho ukuthi abone ukuthi isibindi sakho sikhulile yini.
• Ukuhlolwa kwezicubu: Udokotela wakho angase athathe isampula encane yezicubu emisipheni noma esibindini sakho bese elinganisa amazinga e-glycogen noma ama-enzyme akuso.
• Ukuhlolwa kofuzo: Udokotela wakho angase futhi ancome ukuhlolwa kofuzo ukuze abone ukuthi unayo yini i-gene ye-Glycogen Storage Disease.

Yini ebaluleke kakhulu okudingeka siyikhumbule kulesi sihloko?

Kulungile, manje cishe usuyaqonda ukuthi i-glycogen ibalulekile ekulawuleni amazinga ethu kashukela egazini nasekunikezeni amandla okuzivocavoca. Ngenhlanhla, izinkinga ngokukhiqizwa nokusetshenziswa kwe-glycogen emizimbeni yethu azivamile.

Into engcono kakhulu ongayenza ukuze uthole amazinga akho e-glycogen, ikakhulukazi uma ungumsubathi, ukudla ama-carbohydrate anele nsuku zonke. Uma unemibuzo mayelana nokudla kwakho kanye nemigomo yakho yokuzivocavoca, qiniseka ukuthi ukhuluma nodokotela wakho noma isazi sokudla esibhalisiwe. Bangakunikeza iseluleko esifanele wena.