Ingabe unomfutho wegazi ophakeme, noma lokho sonke esikwazi ngokuthi 'umfutho wegazi ophakeme'? Noma ingabe ugcina uketshezi futhi uvuvukele imilenze ngenxa yesimo esifana nokuhlaselwa yinhliziyo? Khona-ke udokotela wakho kungenzeka ukuthi ukunike umuthi okhethekile. Lona uhlobo lomuthi esizokhuluma ngawo kulesi sihloko namuhla, kalula nangendlela enesizotha. Sibiza laba ngokuthi ama-Aldosterone Antagonists.
Kalula nje, bayini laba bantu abaphikisana ne-Aldosterone?
Kulungile, ake sikuqonde lokhu ngale ndlela. Sinezitho ezimbili ezincane emzimbeni wethu ezibizwa ngokuthi izindlala ze-adrenal. Lezi zikhiqiza i-hormone ebizwa ngokuthi i-aldosterone. Umsebenzi oyinhloko waleli hormone ukulawula umfutho wegazi ngokugcina usawoti namanzi emzimbeni uma kudingeka. Lokhu akuyona inkinga kumuntu ojwayelekile.
Kodwa ake ucabange, uma umuntu esevele enomfutho wegazi ophakeme, noma uma enokuqongelela kwamanzi okungadingekile emzimbeni wakhe ngenxa yesifo senhliziyo, le hormone ye-aldosterone izokwenza isimo sibe sibi kakhulu.
Yilapho uhlobo lwemithi ebizwa ngokuthi ama-Aldosterone Antagonists lusiza khona. Le mithi isebenza ngokuvimbela isenzo se-aldosterone hormone (umphikisi usho ukusebenza ngokumelene nayo). Yingakho lolu hlobo lwemithi lubizwa nangokuthi 'ama-diuretics asindisa i-potassium'.
Yiziphi izinhlobo eziyinhloko zemithi kulesi sigaba?
Kunezinhlobo eziningana zemithi ye-Aldosterone Antagonist evame ukunqunywa odokotela. Kungenzeka ukuthi uke wawabona la magama.
| Igama lomuthi | Ulwazi olubalulekile |
|---|---|
| I-Spironolactone (i-spironolactone) | Lona umuthi omdala kakhulu futhi osetshenziswa kakhulu kuleli klasi. Uza njengephilisi noma uketshezi. Ngokuvamile uthathwa kanye ngosuku. Ngezinye izikhathi unikezwa kanye nomunye umuthi wokukhipha isisu, i-hydrochlorothiazide. |
| I-Eplerenone (Eplerenone) | Leli futhi liyiphilisi. Linqunyelwe ukuthi liphuzwe kanye noma kabili ngosuku. Kucatshangwa ukuthi linemiphumela emibi embalwa uma kuqhathaniswa ne-Spironolactone. |
| I-Finerenone (I-Finarenone) | Lona umuthi omusha kakhulu. Uvame ukunconywa kubantu abanesifo sezinso esingamahlalakhona, ikakhulukazi labo abanesifo sikashukela sohlobo lwesibili. |
Lo muthi usebenza kanjani emzimbeni?
Kulula kakhulu. Uma uthatha umuthi i-Aldosterone Antagonist, uyahamba uvimbe ama-receptor avumela i-aldosterone hormone ukuthi ibophezele kumaseli emzimbeni. Kwenzekani-ke?
I-hormone i-aldosterone ayikwazi ukugcina usawoti namanzi emzimbeni. Ngakho-ke, izinso zethu ziqala ukukhipha usawoti namanzi amaningi ngomchamo. Into ekhethekile ngalokhu ukuthi ngenkathi kukhishwa usawoti namanzi anjalo, kuvikela umzimba ekulahlekelweni yi-potassium ebalulekile.
Kalula nje, kunciphisa inani lamanzi nosawoti okuqongelela emzimbeni ngokungadingekile, futhi kunciphisa nomfutho wegazi. Lokhu kunciphisa nomthwalo enhliziyweni.
Yiziphi izimo eziyinhloko ezisetshenziswa kuzo ama-Aldosterone Antagonists?
Odokotela batusa lolu hlobo lomuthi njengokwelapha hhayi isifo esisodwa kuphela, kodwa nezimo eziningana.
- Ukwehluleka Kwenhliziyo: Uma inhliziyo ibuthakathaka, uketshezi luyanqwabelana emzimbeni (i-edema) futhi lubangele ukuvuvukala emilenzeni nasemaphashini. Lo muthi usiza ukususa uketshezi oluningi futhi unciphise ukucindezeleka enhliziyweni.
- Umfutho Wegazi Ophakeme: Lo muthi usiza ukulawula umfutho wegazi ophakeme okunzima ukuwulawula ngeminye imithi.
- Isifo Sezinso Esingapheli: Lezi zisetshenziselwa ukwelapha izifo zezinso, ikakhulukazi lezo ezihambisana nesifo sikashukela.
- I-Hyperaldosteronism: Lesi yisimo lapho umzimba ukhiqiza khona i-aldosterone eningi kakhulu. Lo muthi ubalulekile ekwelapheni lokhu.
- Ukuvuvukala okubangelwa yisifo sesibindi: Lokhu kunikezwa futhi ukulawula ukugcinwa koketshezi ngenxa yesifo sesibindi.
- Izinga eliphansi le-potassium egazini: Lo muthi unikezwa nalesi simo ngoba usiza ekugcineni izinga le-potassium emzimbeni.
- I-acne: Abanye odokotela besikhumba batusa ne-Spironolactone ye-acne ngoba ilawula umsebenzi wama-hormone athile.
Izinzuzo kanye nemiphumela emibi engaba khona yale mithi
Njenganoma yimuphi umuthi, lokhu kungaba nezinzuzo kanye nemiphumela emibi.
Izinzuzo eziyinhloko
- Yandisa isikhathi sokuphila kweziguli ezinesifo senhliziyo.
- Banamandla engeziwe okuzivocavoca nokwenza imisebenzi yansuku zonke.
- Kunciphisa isidingo sokulaliswa esibhedlela.
- Kunciphisa kakhulu ingozi yokufa ngokuzumayo okuhlobene nesifo senhliziyo.
Imiphumela emibi engaba khona
Uma uthatha lo muthi, ungase uchame kaningi kunokujwayelekile ngoba uwumuthi wokukhipha isisu. Lokhu kujwayelekile. Ngaphezu kwalokho, ezinye izinto zingase zenzeke.
- Ukukhwehlela
- Isiyezi (i-vertigo)
- Ikhanda elibuhlungu (ikhanda elibuhlungu)
- Uhudo
- Amazinga aphezulu e-potassium egazini: Lena yinto eyinhloko okufanele uyikhathalele. Le ngozi iphezulu kakhulu kubantu abanesifo sezinso. Ngakho-ke, udokotela uzohlola njalo amazinga e-potassium ngokwenza ukuhlolwa kwegazi.
Imiphumela emibi ethile ku-Spironolactone
Ngenxa yokuthi umuthi i-Spironolactone uxhumana ngezinga elithile namanye ama-hormone emzimbeni (i-androgen ne-progesterone), abanye abantu bangase babhekane nalokhu okulandelayo:
- Ukukhulisa amabele (i-Gynecomastia) kokubili kwabesilisa nabesifazane.
- Ukungasebenzi kahle kocansi kwabesilisa (Izinkinga zokwakheka kwesidoda).
- Ukopha kwesitho sangasese sowesifazane ngemva kokunqamuka kokuya esikhathini.
Ngenxa yalezi zizathu, abanye abantu bangase bafune ukushintshela ku-Eplerenone. Kodwa khumbula, udokotela wakho kuphela onganquma ukuthi yimuphi umuthi ofanele wena .
Nini ukukhuluma nodokotela wakho
Uma uhlangabezana nanoma yimiphi imiphumela emibi ngenkathi uthatha lo muthi, ungalokothi uyeke ukuwuthatha wedwa. Khuluma nodokotela wakho ngokushesha. Angase akwazi ukulungisa umthamo noma akushintshele komunye umuthi.
Futhi, uma izimpawu zakho zingathuthuki ngemva kokusebenzisa umuthi amasonto ambalwa, yazisa udokotela wakho ngalokho.
Futhi, uma uthatha lo muthi, qiniseka ukuthi ubuza udokotela wakho ngaphambi kokuphuza ijusi likaphayiphu noma ukusebenzisa ezinye izindlela zikasawoti, njengoba ezinye zazo zingase zibe ne-potassium.
Umlayezo Wokuya Nawe Ekhaya
- Imithi elwa ne-Aldosterone iyiqembu elibalulekile lemithi elapha izimo ezifana nomfutho wegazi ophakeme, isifo senhliziyo, kanye nesifo sezinso.
- Lokhu kususa usawoti namanzi amaningi emzimbeni futhi kugcina amazinga e-potassium adingekayo emzimbeni.
- Thatha umuthi owunikezwe udokotela wakho njengoba nje ekutshela, ngesikhathi esifanele, ngomthamo ofanele. Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ubuyisele umthamo ongawusebenzisi.
- Uma uzwa noma yikuphi ukungakhululeki noma imiphumela emibi evela emithini, ungenzi izinqumo ngokwakho bese uthintana nodokotela wakho ngokushesha.
- Kubaluleke kakhulu ukuhlolwa kwegazi njalo, ikakhulukazi ukuhlola amazinga e-potassium.
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