Ithemba elisha kulabo abane-Hemophilia A: Funda nge-Altuviiio!

Ingabe wena noma othile emndenini wakho une-Hemophilia A? Uma kunjalo, cishe uyazi kahle ubunzima bokuyeka ukopha ngisho noma unesilonda esincane, kanye nesidingo sokujova njalo. Lokhu kuyinselele eshintsha impilo ngempela. Kodwa manje sekukhona umuthi omusha ongasetshenziswa ukwelapha lesi simo, futhi ungasetshenziswa kanye ngesonto. Namuhla, sikhuluma ngalowo muthi obizwa ngokuthi i-Altuviiio.

Iyini i-Hemophilia A? I-Altuviiio ingasiza kanjani?

Kalula nje, i-hemophilia A yisimo sofuzo esidluliselwa kusuka kumzali kuya enganeni. Umuntu onalesi simo unamazinga aphansi kakhulu e-Factor VIII, iphrotheni ebalulekile esiza ukujiya kwegazi.

Cabanga ngegazi lethu njengodaka oluhlanganisa udonga ndawonye. Uma kuvela inxeba, lodaka kudingeka luhlangane ukuze luvalwe. I-Factor VIII ifana nesamente ehlanganisa lodaka ndawonye. Ngenxa yokuthi umuntu one-hemophilia A akanalo 'usimende' (Factor VIII), kuthatha isikhathi eside ukuyeka ukuphuma kwegazi enxebeni.

Lesi simo singaba sincane, siphakathi nendawo, noma sibe sibi kakhulu, kuye ngezinga le-factor VIII. Ngenxa yokuthi lesi sifo sizuzwe njengefa (X-linked), sivame kakhulu kwabesilisa, futhi amacala anzima kakhulu abonakala kubo. Abesifazane nabo bangathinteka, kodwa izimpawu zivame ukuba zincane kakhulu.

Umuntu one-hemophilia enzima angase ophe emalungeni, emisipheni, noma ezithweni zangaphakathi ngaphandle kwesizathu esibonakalayo, hhayi nje ngenxa yokusikeka okuncane. Lokhu sikubiza ngokuthi "ukopha okuzenzakalelayo." Uma lokhu kungelashwa kahle, kungabangela umonakalo wesikhathi eside futhi kube yingozi ngisho nokuphila.

Ukwelashwa okuvamile ukufaka i-recombinant factor VIII protein, eyenziwa elabhorethri. Lokhu kusetshenziswa ngezindlela ezimbili:

1. Ukwelashwa "ngesikhathi esifunwayo": Ukunikeza umjovo kuphela uma kuvela ukopha ukuze kumiswe.

2. Ukwelashwa kokuvimbela: Ukuze kuvinjelwe ukopha ezigulini ezinezimo ezinzima, imijovo eqhubekayo inikezwa ngesheduli emisiwe (isibonelo, kabili noma kathathu ngesonto).

Yilapho i-Altuviiio ingena khona. Nakuba imithi eminingi ye-factor VIII ekhona idinga imithamo emibili noma emithathu ngesonto, i-Altuviiio iyimithamo ethathwa kanye ngesonto. Lokhu kungenxa yokuthi isakhiwo sayo esikhethekile seprotheyini (`Fc-VWF-XTEN`) sivumela i-factor VIII ukuthi ihlale izinzile futhi isebenza emzimbeni isikhathi eside.

Uyisebenzisa kanjani le mithi?

I-Altuviiio umuthi owuketshezi ofakwa emthanjeni. Okungukuthi, ukumnika nge-IV (efakwa ngemithambo yegazi). Lokhu kuvame ukunikezwa uchwepheshe wezempilo esibhedlela noma emtholampilo.

Ibhokisi lemithi liqukethe ibhodlela lempuphu, i-syringe yoketshezi, kanye neminye imishini edingekayo. Okokuqala, udinga ukuxuba i-powder noketshezi ukuze uvuselele umuthi. Ukuze wenze lokhu, udinga ukusebenzisa i-adaptha ekhethekile ukuze ufake kancane kancane uketshezi oluvela kwi-syringe ungene ebhodleleni. Ngemuva kwalokho, udinga ukuzungeza ibhodlela kancane kancane ukuze uncibilikise ngokuphelele i-powder. Okulandelayo, udinga ukudonsa uketshezi lubuyele e-syringe.

Okubaluleke kakhulu: Bheka ngokucophelela ngaphambi kokusebenzisa umuthi. Uketshezi olulungisiwe kufanele lucace, lungabi nambala noma lube phuzi kancane . Ungalusebenzisi uma lunamabala noma izinhlayiya. Umuthi olungisiwe kufanele usetshenziswe zingakapheli amahora amathathu.

Ungadinga amabhodlela angaphezu kwelilodwa ukuze uthole umthamo wakho owunqunyiwe. Uma kunjalo, kuzodingeka uhlanganise umuthi ovela emabhodleleni amaningana ube yisirinji enkulu udokotela wakho azokunika yona.

Uma umthamo usulungile, kufakwa ithubhu ekhethekile esirinjini, exhunywe enalitini efakwe emthanjeni. Isirinji ibe isicindezelwa kancane kancane ukuze kufakwe umuthi emzimbeni. Lokhu kungathatha noma yikuphi kusukela kumzuzu owodwa kuya kweyishumi.

Yiziphi izingozi eziqondile zalo muthi?

Ngezinye izikhathi, imizimba yethu yenza into efana 'nezilwi' ngokumelene nale phrotheni ye-Factor VIII enikezwa ngaphandle. Ngokwezokwelapha, lezi zibizwa ngokuthi izithiyo noma ama-antibodies. Uma lezi zithiyo zakhiwa, zibhubhisa i-Factor VIII, okwenza umuthi ungasebenzi kahle kakhulu.

Akukacaci ukuthi lokhu kuvame kangakanani kubantu abasebenzisa i-Altuviiio. Kodwa ungakhathazeki, udokotela wakho uzohlola igazi lakho njalo ukuze abone ukuthi lezi zithiyo sezivele zikhona.

• Uma izivimbeli zisezingeni eliphansi, udokotela angase andise umthamo womuthi.
• Uma amazinga akho okuvimbela eba phezulu kakhulu, ungase ungasakwazi ukusebenzisa i-Altuviiio. Uma lokhu kwenzeka, udokotela wakho uzokuchazela ezinye izindlela zokwelapha ezenzelwe ngqo abantu abanezithibelo.

Yini etholwe yilezi zifundo?

Izifundo ezenziwe ukuze kubonwe ukusebenza kahle kwe-Altuviiio ziveze imiphumela emihle kakhulu. Ake sikubheke etafuleni elilula.

Le miphumela ikhombisa ukuthi i-Altuviiio iwumuthi osebenza kahle kakhulu ekuvimbeleni ukopha kanye nokulawula ukopha uma kwenzeka.

Ezinye izinto ezimbalwa okufanele uzazi

• Umuthi usebenza ngokushesha kangakanani?

I-Altuviiio inyusa amazinga akho e-factor VIII ngokushesha ngemva kokujova. Lokhu kunciphisa ingozi yokopha ngokushesha. Kodwa-ke, ungayeki ukuthatha umuthi ngaphandle kweseluleko sikadokotela wakho . Ukuze ugcine amazinga akho e-factor VIII ephezulu, udinga ukuthatha umuthi njengoba kuhleliwe njalo ngeviki.

• Ingabe iyasebenzisana neminye imithi?

Ngokwazi kwethu, i-Altuviiio ayibikwanga ukuthi isebenzisana neminye imithi. Kodwa-ke, kubalulekile ukutshela udokotela wakho ngayo yonke imithi oyithathayo, ngisho namavithamini.

• Ingabe lo umuthi okhethekile?

Yebo. I-Altuviiio umuthi 'okhethekile'. Lokhu kusho ukuthi ungase ungatholakali ekhemisi elivamile, futhi kungadingeka ukuthi utholakale ekhemisi elikhethekile lesibhedlela noma ngohlelo olunikezwe uhulumeni. Udokotela wakho uzokuqondisa kulokhu.