Iyini i-AA Amyloidosis? Ake sifunde ngayo kalula!

Wake wazibuza ukuthi yini engenzeka uma amaprotheni athile emizimbeni yethu eba yinkinga encane? Namuhla sizokhuluma ngesimo esisodwa esingavamile, kodwa esibalulekile okufanele sisiqaphele. Sibizwa ngokuthi i-AA Amyloidosis.

Kuyini i-AA Amyloidosis? Masiyiqonde kalula!

Kalula nje, i-AA Amyloidosis uhlobo olulodwa lweqembu elikhulu lezifo ezibizwa ngokuthi i-amyloidosis. Manje ungase ubuze, 'Kuyini lokhu ku-amyloidosis?' Imizimba yethu inohlobo lweprotheni ebizwa ngokuthi i-amyloid. Lawa maprotheni anesimo esithile esinobukhulu obuthathu (isakhiwo se-3D). Yileyo ndlela asebenza ngayo. Kodwa-ke, ngezinye izikhathi lawa maprotheni ashintsha isimo sawo, ahlangane njengebhola lentambo, bese enza imicu emincane (ama-fibrils). Yilokhu esikubiza ngokuthi 'ama-amyloid deposits'. Ukuqongelela kwalawa ma-deposit ezithweni nasezicutshini zethu ezahlukene kubizwa ngokuthi i-amyloidosis.

Ku-AA amyloidosis, izinga leprotheyini ye-serum A egazini likhuphuka kakhulu ngenxa yokuvuvukala okweqile emzimbeni wethu. Uma unesifo sokutheleleka isikhathi eside noma isifo sokuvuvukala, leli zinga leprotheyini ye-serum A lingakhuphuka. Ngandlela thile, i-AA amyloidosis iyinkinga enkulu yalezi zifo zokuvuvukala. Odokotela bayayelapha ngokwelapha isifo sokuvuvukala esiyisisekelo.

I-AA amyloidosis iyithinta kanjani imizimba yethu?

Manje ake sibone ukuthi le-AA amyloidosis ithinta kanjani imizimba yethu. Ingalimaza kakhulu izinso zethu . Hhayi lokho kuphela, kodwa ingalimaza nesibindi, ubende, isisu, namathumbu. Akuvamile ukuthinta inhliziyo. Enye into ukuthi lesi simo singathinta inani lamaprotheni emchameni wakho kanye nezinga le-cholesterol egazini lakho.

Ingabe lesi yisimo esibulalayo?

Yebo, lokhu kuyinkinga enkulu ngempela. Uma i-AA Amyloidosis ingelashwa kahle, ingaba yingozi . Khumbula, ngithe lokhu kubangelwa yisifo esibangela ukuvuvukala kwesikhathi eside. Ngakho-ke, lapho odokotela belapha lesi sifo esiyisisekelo, nabo baphatha i-AA amyloidosis. Ngakho-ke akukho okufanele ukhathazeke ngakho, kodwa into ebaluleke kakhulu ukuyibona kusenesikhathi bese uthola ukwelashwa .

Ubani okungenzeka kakhulu ukuthi athole i-AA amyloidosis?

Uma ucabanga ngokuthi ubani ongaba nalokhu, noma ubani onesifo sokuvuvukala esingamahlalakhona usengozini yokuthola i-AA amyloidosis . Lokho kusho ukuthi, uma unesifo esinjalo, kuhle ukuqaphela lokhu futhi.

Yini ebangela i-AA amyloidosis?

Ake sibheke kabanzi ukuthi yini ebangela lokhu. I-AA amyloidosis uhlobo lwe-amyloidosis. Odokotela babiza le amyloidosis ngokuthi "ukuphazamiseka kokugoqeka kwamaprotheni." Cabanga ngakho, amaprotheni ethu angama-molecule amade anezimo ezikhethekile ezintathu-ntathu (3D). Lawa maprotheni enza umsebenzi omningi emizimbeni yethu - kusukela ekuhlinzekeni amandla, ekulinganiseni uketshezi, ekusizeni ngokuzivikela komzimba, ekunikezeni isakhiwo somzimba, ekuhambiseni izinto, ekulawuleni izinqubo zomzimba, njalo njalo.

Ngokuvamile, lawa maprotheni asuswa egazini uma umsebenzi wawo usuqediwe. Kodwa-ke, ezinkingeni lapho lawa maprotheni egoqeka khona ngendlela engafanele, amaprotheni ashintsha isimo futhi athathe izimo ezingavamile umzimba ongakwazi ukuzisebenzisa noma ukuzisusa. Ku-AA amyloidosis, lawa maprotheni angavamile ayahlangana futhi akhe 'ama-amyloid deposits', noma 'ama-fibrils', ezithweni zethu zomzimba.

Izifundo zamuva nje zikhombe izimo eziningana ezingabangela i-AA amyloidosis. Lezi zifaka phakathi izinhlobo ezithile zomdlavuza wegazi, izifo ezibangelwa amagciwane njengezilonda ezingamahlalakhona, izifo zamathambo ezifana ne-rheumatoid arthritis, noma izifo zamathumbu ezivuvukalayo njengesifo sikaCrohn noma i-ulcerative colitis. Ngezinye izikhathi, kungabangelwa nezimo zofuzo ezifana nezifo zomkhuhlane ezivamile njenge-familial Mediterranean fever.

Ziyini izimpawu ze-AA amyloidosis?

Kulungile, manje ake sibone ukuthi yiziphi izimpawu ze-AA amyloidosis. Ngokuvamile, ithinta izinso. Ingathinta nezitho zomzimba ezifana nesibindi, ubende, kanye nesisu. Bheka ukuthi unazo yini lezi zimpawu:

• Ukuvuvukala emilenzeni noma emaqakaleni . Lokhu kungaba uphawu lwenkinga yezinso. Kungaba futhi uphawu lwesifo sezinso esingamahlalakhona.
• Umchamo onegwebu noma onamagwebu.
• Ukuphuma komchamo okuncane kunokujwayelekile.
• Uhudo olungapheli.
• Ukwanda kwezinso.
• Ukwanda kwesibindi.
• Umfutho wegazi ophansi.
• Isicanucanu nokuhlanza.

Odokotela bayixilonga kanjani i-AA amyloidosis?

Odokotela basithola kanjani lesi sifo? Benza uchungechunge lwezivivinyo. Eyokuqala ukuhlolwa kwe-biopsy.

• I-biopsy ethi "Fat pad" : Lokhu kuhilela ukuthatha inani elincane lamafutha ngaphansi kwesikhumba sesisu bese ulihlola. Kulula kakhulu.
• I-biopsy yesitho : Kuthathwa isampula encane yezicubu esithweni okucatshangwa ukuthi sithintekile bese sihlolwa.

Ngaphezu kwalokho, ezinye izivivinyo zingenziwa ukuqinisekisa ukuthi unenye uhlobo lwe-amyloidosis olubizwa ngokuthi "AL amyloidosis." Ngenxa yokuthi izimpawu ze-AL amyloidosis kanye ne-AA amyloidosis zifana kakhulu, i-AL amyloidosis uhlobo olubi kakhulu futhi olukhula ngokushesha .

Iphathwa kanjani i-AA amyloidosis?

Manje ake sibone ukuthi yiziphi izindlela zokwelapha lokhu. I-AA amyloidosis ibangelwa yisimo sokuvuvukala isikhathi eside esibangela ukwakheka kwamaprotheni angajwayelekile ezithweni zakho zomzimba. Ngakho-ke, odokotela bayayelapha ngokwelapha isimo sokuvuvukala esiyisisekelo . Uma welapha isimo esiyisisekelo futhi wehlisa ukuvuvukala, isimo se-AA amyloidosis naso siyalawulwa. Njengoba izinga lokuvuvukala lehla, izimpawu ziyancipha kancane kancane.

Kukhona nemithi etholakala njengamanje yokwelapha i-AA amyloidosis. Odokotela nabacwaningi bayaqhubeka nokuhlola izindlela ezintsha zokwelapha. Isibonelo, baphenya ngezindlela zokususa lawa ma-fibril e-amyloid egazini ngaphambi kokuba anqwabelane ezithweni zomzimba, futhi baphenya nangamasosha omzimba enziwe elebhu angahlasela futhi asuse ama-fibril e-amyloid asevele akhene ezithweni zomzimba.

Ingabe i-AA amyloidosis ingavinjelwa?

Ingabe lokhu kungavinjelwa? Eqinisweni, uma unesifo sokuvuvukala esingamahlalakhona njenge-rheumatoid arthritis, kungabangela ukwanda kwamaprotheni athile egazini futhi kubangele i-AA amyloidosis. Ngakho-ke, okuwukuphela kwendlela yokuvimbela lokhu ukuthola ukwelashwa okusheshayo nokufanelekile kwesifo sokuvuvukala esingamahlalakhona esiyisisekelo onaso .

Ingabe i-AA amyloidosis ingelapheka?

Yebo, ingelapheka. Odokotela belapha i-AA amyloidosis ngokwelapha isimo sokuvuvukala esiyisisekelo esibangele lokho. Njengezifo eziningi, indlela engcono kakhulu yokuphatha i-AA amyloidosis ukuxilonga lesi sifo bese uqala ukwelashwa ngokushesha okukhulu .

Ngizinakekela kanjani?

Uma une-AA amyloidosis, indlela engcono kakhulu yokuzinakekela ukusebenzisana nodokotela wakho ukuze welaphe kahle isimo sokuvuvukala esibangele lokhu. Abacwaningi bathole izifo eziningi nezimo ezibangela ukuvuvukala kwesikhathi eside ezihlotshaniswa ne-AA amyloidosis. Buza udokotela wakho ukuthi isimo sakho siyibangele kanjani i-AA amyloidosis nokuthi basiphatha kanjani leso simo sokuvuvukala.

Kalula nje, i-AA amyloidosis iyinkinga engavamile, kodwa engathi sína, yezifo noma izimo eziningi ezivamile zokuvuvukala. Ngenhlanhla, odokotela bangayilapha ngokwelapha isimo esiyisisekelo. Ngokuvamile, izimpawu ze-AA amyloidosis zingase zibonakale njengezinkinga ezivamile ojwayelene nazo ngesifo sakho sokuvuvukala. Kodwa, njengezinye izifo ezingathi sína, odokotela banamathuba amaningi okuyelapha uma itholakale kusenesikhathi.Uma ubona noma yiziphi izinguquko noma izimpawu ezintsha ku-arthritis yakho, tshela udokotela wakho ngokushesha . Bazohlola izimpawu zakho futhi bachaze ukuthi zisho ukuthini.

Ngakho-ke, yiziphi izinto ezibaluleke kakhulu okudingeka sizikhumbule kule ndaba?

Igama elithi AA Amyloidosis liyesabeka kancane, kodwa kubaluleke kakhulu ukuliqonda kahle.

Khumbula, lokhu kuvame ukwenzeka njengenkinga yesinye isifo sokuvuvukala isikhathi eside.

• Uma unesifo sokuvuvukala esingamahlalakhona, njenge-rheumatoid arthritis, kubalulekile ukufuna ukwelashwa okufanele .
• Uma uba nezimpawu ezintsha, njengezinkinga zezinso (ukuvuvukala emilenzeni, izinguquko emchameni), uhudo oluqhubekayo, noma isibindi noma ubende okhuphukile, yazisa udokotela wakho .
• Uma i-AA amyloidosis iqashelwa futhi yelashwa kusenesikhathi, imiphumela emihle ingatholakala . Ukwelashwa okuyinhloko ukwelapha isifo sokuvuvukala esiyisisekelo.
• Ungesabi, kodwa qaphela . Khuluma nodokotela wakho ngokukhululekile, mtshele izinkinga zakho. Bazokusiza.

Ngakho-ke, sithemba ukuthi lolu lwazi lube wusizo kuwe. Hlala uphilile!

I- Amyloidosis, i-AA amyloidosis, iphrotheni, ukuvuvukala, isifo sezinso, isifo esingamahlalakhona, isifo samathambo esibizwa ngokuthi i-rheumatoid arthritis