Lapho odokotela beqinisekisa ukuthi unomdlavuza webele, ngingacabanga ukuthi kumelwe ukuba wazizwa wesaba, ushaqekile, futhi udabuke kangakanani. Kunemibuzo eminingi efika engqondweni ngaleso sikhathi. Kodwa lapho udokotela wakho esho igama elifana nelithi 'HER2-Positive', kumelwe ukuthi lenza ingqondo yakho ikhathazeke kakhulu. "Lithini lelo gama? Lisho ukuthi isimo sami sibi kakhulu?" Kuvamile ukuba izinto eziyinkulungwane zifike engqondweni. Yingakho namuhla sizokhuluma ngokuthi uyini lo mdlavuza webele othi 'HER2-Positive', ukuthi usho ukuthini, nokuthi yiziphi izindlela zokwelapha wona ngendlela elula kakhulu ongayiqonda.
Kuyini 'i-HER2'?
Kalula nje, i-HER2 iyiprotheni esiza ukukhula kwamaseli ebele emzimbeni wethu. Igama layo eliphelele yi-``Human Epidermal Growth Factor Receptor 2``. Le protheni ikhona kumaseli ebele omuntu ophilile ngesilinganiso esithile, esilawulwayo. Isiza amaseli ukuthi ahlukane futhi akhule ngendlela ehlelekile.
Kodwa-ke, kweminye imidlavuza yebele, ngenxa yephutha ku-gene eyenza i-HER2 protein, le protein ikhiqizwa ngokweqile. Kufana nokunyathela i-accelerator yemoto. Bese kuthi, sengathi imoto ihamba ngokushesha, la maseli omdlavuza aqale ukuhlukana futhi akhule ngokushesha okukhulu, ngaphandle kokulawula. Isizathu esiyinhloko esenza umdlavuza ube mubi kakhulu ukukhiqizwa ngokweqile kweprotheni.
Ngakho-ke, uma umdlavuza wakho 'une- HER2-positive ', kusho ukuthi kukhona iphrotheni yokukhula ebizwa ngokuthi i-HER2 engaphezulu ebusweni bamaseli akho omdlavuza.
Ngingazi kanjani ukuthi ine-HER2-positive?
Uma usola ukuthi unomdlavuza webele, udokotela wakho cishe uzoncoma ukuthi kwenziwe i-biopsy. Njengoba ungase ukhumbule, lokhu kuhilela ukuthatha ingxenye encane yezicubu bese uyithumela elabhorethri ukuze ihlolwe. Leli sampula lezicubu liyahlolwa ukuze kutholakale uhlobo oluqondile lomdlavuza.
Into eyinhloko ebhekwayo kulesi sivivinyo isimo se-HER2. Futhi, kuhlolwa enye into ebalulekile. Okungukuthi, ukuthi umdlavuza uyazwela yini kuma-hormone. Okungukuthi, ukuthi umdlavuza ukhula ngenxa yama-hormone `(Estrogen)` kanye `(Progesterone)`. Ngemva kokubheka konke lokhu, udokotela unquma ukuthi iyiphi indlela yokwelapha efaneleka kakhulu futhi ephumelelayo kuwe.
Ake sichaze kabanzi ngalokho esikuhlolayo.
| Umaka | Kusho ukuthini lokho? |
|---|---|
| Isimo se-HER2 | Amaseli omdlavuza ayahlolwa ukuze kubonakale ukuthi anamaprotheni amaningi e-HER2 (ahle) noma cha (ahle). Uma ehle, kusho ukuthi le phrotheni isiza amaseli omdlavuza ukuba akhule ngokushesha. |
| Isimo Sokwamukela Ama-hormone | Babheka ukuthi amangqamuzana omdlavuza anama-receptor ama-hormone i-estrogen noma i-progesterone. Uma lawa ebonakala elungile, lawo ma-hormone asiza umdlavuza ukuthi ukhule. |
Imiphumela yalezi zivivinyo izonquma uhlobo lomdlavuza onawo. Isibonelo, i-HER2-positive noma i-Hormone Receptor-negative. Lonke lolu lwazi lubalulekile ekukusizeni ukuthi uthuthukise uhlelo lwakho lokwelashwa .
Ubani othola umdlavuza one-HER2? Ingabe uyingozi?
Umdlavuza webele one-HER2 ungavela kwabesifazane kanye nakwabesilisa, futhi akuvamile kakhulu kwabesilisa. Uvame kakhulu kwabesifazane abangaphansi kweminyaka engu-50. Imbangela eqondile ayaziwa okwamanje.
Manje ake sifinyelele embuzweni omkhulu engqondweni yakho: Ingabe lokhu kuyingozi?
Iqiniso liwukuthi, umdlavuza we-HER2-positive ungase ube nesilinganiso sokukhula esiphezulu kancane. Lokhu kusho ukuthi la maseli omdlavuza anomkhuba ophakeme kancane wokuhlukana noma ukusabalala ngokushesha okukhulu.
Kodwa, ungesabi! Yilokhu okudingeka ukukhumbule. Yebo, lolu hlobo lomdlavuza lungashesha. Kodwa namuhla kuye kwasungulwa izindlela zokwelapha ezisebenza kahle kakhulu neziqondiwe ezilungele lona. Ngakho-ke, asikho isizathu sokwesaba igama elithi "ukushesha".
Ukwelashwa nethemba lokululama
Lezi yizindaba ezinhle kakhulu kulesi sihloko. Eminyakeni engaba ngu-20 eyedlule, umdlavuza webele one-HER2 wawubhekwa njengesimo esinzima nesibucayi ukwelapha. Kodwa ngokuthuthuka kwesayensi yezokwelapha, isimo sishintshe ngokuphelele namuhla.
Ososayensi bathole imithi eminingana ekhethekile engahlasela futhi ivimbele umsebenzi wale phrotheni ye-HER2. Lokhu kubizwa ngokuthi " ukwelashwa okuqondiwe.")`. Ukuze kube sobala, le mithi iya ngqo kuphrotheni ye-HER2 ekhona ngokweqile, ivimba isignali etholwa amangqamuzana omdlavuza ukuze "akhule ngokushesha." Lokhu kufana nokufaka amabhuleki emotweni egijima ngesivinini esikhulu.
Ngenxa yalezi zindlela zokwelapha eziqondiwe, ithuba lokuthi umuntu onomdlavuza webele one-HER2 aphulukiswe ngokuphelele manje liphezulu kakhulu, lilingana namazinga okuphulukiswa komdlavuza ovame kakhulu oxhomeke kuma-hormone.
Kwenzekani ngemva kokwelashwa?
Ngemva kokuqeda ukwelashwa, udokotela wakho uzoqhubeka nokukuqapha. Akuvamile ukuthi umdlavuza ubuye noma usakazekele kwezinye izingxenye zomzimba. Uma lokhu kwenzeka, udokotela wakho uzokwenza olunye uhlolo lwegazi. Lokhu kungenxa yokuthi uhlobo lomdlavuza lungashintsha ngezinye izikhathi ngokuhamba kwesikhathi. Isibonelo, umdlavuza owawune-HER2-positive ngaphambili ungabuya futhi ube yi-HER2-negative. Ngakho-ke, ukwelashwa kusekelwe njalo esimweni sakamuva.
Ngakho-ke, susa ukwesaba kwakho. Yebo, igama elithi umdlavuza liyesabeka. Kodwa i-HER2 -Positive iyisimo esingelapheka kakhulu futhi esingelapheka namuhla.
Umlayezo Wokuya Nawe Ekhaya
- Umdlavuza webele one-HER2-positive ulapho amangqamuzana omdlavuza ekhiqiza ngokweqile iphrotheni (HER2) esheshisa ukukhula.
- Lesi simo sitholakala ngokuhlola isampula yezicubu ezivela ku-biopsy yakho.
- Nakuba lolu hlobo lomdlavuza luvame ukukhula ngokushesha, asikho isidingo sokulwesaba.
- Kulezi zinsuku, kunezindlela zokwelapha ezihlosiwe eziphumelela kakhulu ezenzelwe le njongo. Ngenxa yalokho, amathuba okululama aphezulu kakhulu.
- Khuluma nodokotela wakho ngokukhululekile nganoma yimiphi imibuzo, ukwesaba, noma ukungabaza ongase ube nakho. Yilapho uzothola khona ulwazi olunembile kakhulu kanye nempumuzo engcono kakhulu.
- Awuwedwa. Ngomqondo oqinile kanye nokwelashwa okufanele, unganqoba le nselele.
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