Umdlavuza Webele: Masingesabi kodwa siqaphele!

Uma sizwa igama elithi umdlavuza webele, sonke siyasaba kancane. Kodwa bewazi ukuthi akuzona zonke izinhlobo zomdlavuza webele ezifanayo? Kunezinhlobo ezithile, uma zitholakala kusenesikhathi futhi zelashwa kahle, okungenzeka kakhulu ukuthi zelapheke. Ngakho-ke, uhlobo olulodwa lomdlavuza webele esizokhuluma ngalo namuhla, oluyimpumuzo kancane, kodwa okufanele siluqaphele nakanjani, lubizwa ngokuthi 'i-Luminal A'. Ngakho-ke, ingabe kufanele sixoxe ngalokhu ngokuningiliziwe?

Uyini umdlavuza webele we-Luminal A?

Kalula nje, lolu uhlobo lomdlavuza webele oluxhomeke kuma-hormone (i-Hormone Receptor-Positive noma i-HR+) . Manje ucabanga ukuthi, "Iyini le nto yama-hormone?" Sinama-hormone amabili emizimbeni yethu abizwa ngokuthi i-estrogen ne-progesterone. Ngaphakathi kwala maseli omdlavuza, kunamaprotheni akhethekile angabopha kula ma-hormone, njengengidi efanelana nokhiye. Siwabiza lawa ma-receptor ngokuthi. Ngakho-ke, lapho la ma-hormone efika futhi ebopha kulawo ma-receptor, asiza amangqamuzana omdlavuza ukuba akhule. Igama elithi 'luminal' libhekisela ongqimbeni lwamaseli ngaphakathi kwemisele yobisi yebele. Yilapho iningi lomdlavuza webele liqala khona.

Amaseli omdlavuza we-Luminal A anezici eziningana ezikhethekile:

• I-Estrogen Receptor-Positive (ER+): Lokhu kusho ukuthi la maseli anezinga eliphezulu lama-estrogen receptors (ERs), akwazi ukubopha ne-hormone estrogen. Lokhu kusho ukuthi amaseli omdlavuza angakhula esuka ku-hormone estrogen.
• I-Progesterone Receptor-Positive (PR+): Lawa maseli anama-receptor amaningi (PR) abopha i-hormone i-progesterone. Lokhu kusiza futhi amangqamuzana omdlavuza ukuba akhule.
• I-HER2-Negative noma i-HER2-: Lokhu kujule kakhulu. I-HER2 (i-Human Epidermal Growth Factor Receptor 2) ingenye iphrotheni ekhethekile. Ingatholakala ngobuningi obukhulu ebusweni bamanye amangqamuzana omdlavuza, okungasiza umdlavuza ukusabalala ngokushesha. Kodwa-ke, amangqamuzana e-Luminal A ngokuvamile anephrotheni encane ye-HER2 noma awanayo nhlobo . Lokho kuyinto enhle. (Ezinye izinhlobo zomdlavuza webele, njenge-Luminal B, zingaba ne-HER2-positive noma zibe negative.)
• Iphrotheni ye-Ki-67 ephansi: I-Ki-67 iyiphrotheni etholakala kuphela kumaseli ahlukana ngokushesha. Umdlavuza we-Luminal A unamazinga aphansi kakhulu ale phrotheni. Lokhu kusho ukuthi la maseli omdlavuza ahlukana ngesivinini esiphansi, okusho ukuthi umdlavuza ukhula kancane . Lona umehluko omkhulu phakathi kwalolu hlobo lomdlavuza nezinye izinhlobo ezifana ne-Luminal B.
• Izinga Eliphansi: Kalula nje, amaseli e-Luminal A ngokuvamile awanamandla njengezinye izinhlobo zomdlavuza. Amathuba okuphinde avele ngemva kokwelashwa aphansi kunamaseli e-Luminal B.

Lolu lwazi lungase lubonakale luyinkimbinkimbi kancane kuwe. Ungase uzibuze, "Yini i-ER, i-PR, i-HER2, i-Ki-67?" Kodwa lokhu kubaluleke kakhulu .Lezi yizinto ezinikeza ulwazi olusezingeni lama-molecule mayelana namaseli omdlavuza esifubeni sakho. Ngokusekelwe kulolu lwazi, udokotela wakho angakha uhlelo lokwelashwa oluqondene nawe futhi abikezele ukuthi uzosabela kanjani ekwelashweni okuhlukene.

Uvame kangakanani umdlavuza webele we-Luminal A?

Eqinisweni, lolu uhlobo lomdlavuza webele oluvame kakhulu . Kubikwa ukuthi phakathi kuka -50% no-60% wabo bonke abaguli abanomdlavuza webele banalolu hlobo, olubizwa ngokuthi i-Luminal A. Lokhu kusho ukuthi uma kukhulunywa ngomdlavuza webele, kubaluleke kakhulu ukwazi ngalolu hlobo.

Ziyini izimpawu zomdlavuza webele we-Luminal A?

Ngezinye izikhathi lo mdlavuza ungavela ngaphandle kwezimpawu. Yingakho odokotela behlala bencoma ukuhlolwa kwamabele njalo (Ukuhlolwa Komdlavuza Okuvamile). Uma kutholakale kusenesikhathi, kulula ukukwelapha. Kodwa-ke, abanye abantu bangase babe nezimpawu ezinjengalezi:

• Iqhubu noma i-cyst ebeleni: Lolu uphawu oluvame kakhulu. Kungase kuzwakale sengathi yiqhubu elizwakala kalula futhi lingekho ngaphambili.
• Ubuhlungu bebele: Abanye abantu bangase babe nobuhlungu ebeleni noma ekhwapheni.
• Ukuphuma kwengono: Ngezinye izikhathi, ukuphuma kwengono okungenalo ubisi kodwa okubonakala sengathi igazi lingaphuma engono.
• Ukuqina kwesikhumba sesifuba noma ukufiphala: Izinguquko esikhumbeni sesifuba, njengokubonakala okufiphele kwezinye izindawo, noma ukubukeka okufana nekhasi le-orenji.
• Ukuvuvukala kwebele noma kwekhwapha: Ibele elilodwa lingase libonakale likhulu kunelinye, noma indawo yekhwapha nayo ingaba uphawu.

Khumbula, ukuba nalezi zimpawu akusho ukuthi unomdlavuza webele. Kodwa-ke, uma uhlangabezana nanoma yiziphi zalezi zimpawu, kuhlale kuwukuhlakanipha ukubona udokotela ukuze akuhlole.

Yini ebangela umdlavuza webele we-Luminal A?

Eqinisweni, umdlavuza webele uvela lapho amaseli ebele aphilile eshintsha ngokuzumayo futhi eqala ukukhula ngokungalawuleki. Ochwepheshe abakakazi kahle ukuthi kungani lokhu kwenzeka. Kodwa-ke, bathole ezinye izinto eziyingozi ezandisa ingozi yokuba nomdlavuza webele. Zihlanganisa:

• Umlando womndeni womdlavuza webele noma wesibeletho: Uma umama wakho, udadewenu, noma indodakazi yakho ike yaba nomdlavuza webele, nawe usengozini enkulu kancane.
• Ukuba neminyaka engaphezu kwengu-50 ubudala: Le ngozi iyanda njengoba iminyaka ikhula.
• Ukuba nezicubu zebele eziqinile: Labo abanezicubu zebele eziqinile ku-mammogram basengozini enkulu.
• Ukusetshenziswa kotshwala: Abantu abaphuza utshwala njalo basengozini enkulu.
• Njengoba ngike ngathola ukwelashwa ngemisebe endaweni yesifuba:Uma uke wathola ukwelashwa ngemisebe endaweni yesifuba ngenxa yesinye isifo.
• Ukuchayeka isikhathi eside kuma-hormone afana ne-estrogen noma i-progesterone: Kunezimbangela eziningana ezingaba khona zalokhu. Isibonelo, ukuya esikhathini ekuqaleni (ukuya esikhathini kokuqala) , ukuya esikhathini sekwephuzile (ukuya esikhathini sekwephuzile) , noma ukuthatha imithi ethile yokushintsha ama-hormone (HRT) isikhathi eside.

Akuwona wonke umuntu onalezi zici eziyingozi ozoba nomdlavuza. Futhi, umuntu ongenazo lezi zici angawuthola. Yingakho ukuhlolwa njalo kubalulekile.

Umdlavuza webele we-Luminal A utholakala kanjani?

Umdlavuza webele uvame ukutholakala okokuqala ngokuhlolwa kwe-mammogram . Uma i-mammogram yakho ikhombisa noma yini esolisayo, udokotela wakho uzoyala ukuhlolwa okwengeziwe. Lokhu kungafaka:

• I-Diagnostic Mammogram: I-mammogram ebheka indawo esolisayo ngokucacile.
• Ukuhlolwa kwe-MRI (Magnetic Resonance Imaging): Lokhu kungaveza izithombe ezicacile zebele.
• Ukuhlolwa kwe-Ultrasound: Lokhu kungasiza futhi ekuboneni izinto ezifana namaqhubu kangcono.

Ngemva kwalezi zivivinyo, cishe kuzodingeka wenze i-biopsy yebele . Lokhu kuhilela ukuthatha isampula encane yezicubu endaweni esolisayo yebele, uyithumele elebhu bese uyihlola ngaphansi kwe-microscope. Lokhu kuhlolwa kungabonisa ngokuqinisekile ukuthi amangqamuzana omdlavuza akhona noma cha.

Uma udokotela wezifo ethola amangqamuzana omdlavuza, uzokwenza ezinye izivivinyo ukuqinisekisa ukuthi lawa maseli angowohlobo lwe-Luminal A. Lokho kusho ukuthi bazohlola izinto ezifana ne-ER, i-PR, i-HER2, kanye ne-Ki-67 okukhulunywe ngayo ngaphambili.

Ukwazi kahle ukuthi hlobo luni lomdlavuza onalo kungasiza udokotela wakho womdlavuza ukuthi anqume ukuthi yiziphi izindlela zokwelapha ezisebenza kahle kakhulu . Kungakunikeza nombono wamathuba okuthi umdlavuza uphinde ubuye ngemva kokwelashwa.

I-Luminal A isetshenziswa kanjani ukwelapha umdlavuza webele?

Umdlavuza webele uzwela kuma-hormone (HR+), ngakho-ke uvame ukusabela kahle kakhulu ekwelashweni okuvimba ama-hormone . Lena enye yezinzuzo eziyinhloko zalolu hlobo lomdlavuza. Kunezindlela eziningana zokwelapha:

• Ukwelashwa Ngokuvimba Ama-hormone: Lokhu kuhilela ukunikeza imithi evimba ukusebenza kwama-hormone (i-estrogen, i-progesterone) esiza amangqamuzana omdlavuza ukukhula. Imithi efana ne -Tamoxifen kanye ne-Aromatase Inhibitors ivame ukusetshenziswa kulokhu.Ukwelashwa Kokucindezela Ama-Ovarian Kungenziwa ngisho.
• Ukuhlinzwa: Kulokhu, amangqamuzana omdlavuza ayasuswa ebeleni. Lokhu kungenziwa ngezindlela ezimbili:
• Ukususwa kwe-Lumpectomy: Ukususwa kwesimila esinomdlavuza kanye nenani elincane lezicubu ezinempilo ezisizungezile.
• Ukususwa kwebele: Ukususwa kwebele lonke.

Ukuthi yikuphi ukuhlinzwa okufanele kuncike ezintweni ezifana nosayizi kanye nokusabalala komdlavuza.

• Ukwelashwa Ngemisebe: Ngemva kokuhlinzwa, ukwelashwa ngemisebe kungase kunikezwe ukuze kubhujiswe noma yimaphi amangqamuzana omdlavuza angase ahlale endaweni.
• Ukwelashwa ngamakhemikhali: Imithi yokwelapha ngamakhemikhali ivame ukusebenza kahle kakhulu kumdlavuza okhula ngokushesha. Umdlavuza we-Luminal A ukhula kancane, ngakho akuwona wonke umuntu odinga ukwelashwa ngamakhemikhali. Kodwa-ke, abanye abantu (isibonelo, uma umdlavuza ususakazekele kuma-lymph node noma uma umdlavuza umkhulu kakhulu) bangase bazuze kukwelashwa ngamakhemikhali. Udokotela wakho womdlavuza uzokutshela ukuthi uyakudinga lokhu.

Ngokuvamile, kunikezwa inhlanganisela yokwelashwa okukodwa noma ngaphezulu kwalokhu. Ngokusekelwe kolwazi olusembikweni wakho we-biopsy, udokotela wakho uzokwakha uhlelo lokwelashwa olufanele wena.

Kuyini ukubikezela kulabo abanomdlavuza webele we-Luminal A?

Nazi izindaba eziduduzayo. Uma kuqhathaniswa nezinye izinhlobo zomdlavuza webele, umdlavuza webele i-Luminal A unesimo sengqondo esihle kakhulu .

Kodwa-ke, ukubikezela kwakho kuncike ngobukhulu bomdlavuza lapho utholakala, ukuthi ukhula ngokushesha kangakanani, nokuthi ngabe ususakazekele kwezinye izingxenye zomzimba. Uma ukwelashwa kuqalwa ngokushesha, kulapho ukubikezela kwakho kuba ngcono khona.

I-Luminal Umdlavuza webele ungelapheka ngokuphelele ngokwelashwa (ukuxolelwa). Futhi, uma utholakale usesesigabeni sokuqala (amacala asesigabeni sokuqala), ungelapheka ngokuphelele (ungelapheka).

Amazinga Okusinda Kwabasindile Kumdlavuza Webele we-Luminal A

Izinga lokusinda iminyaka emihlanu yalolu hlobo lomdlavuza webele licishe libe ngu -95% . Lokho kusho ukuthi abantu abangu-95 kwabayi-100 abatholakale benalesi sifo bazophila ngemva kweminyaka emihlanu.

Kodwa-ke, la mazinga okusinda ayizilinganiso ezisekelwe emiphumeleni yabanye abake baba nalesi sifo esikhathini esidlule. Aziqondile ngesimo sakho. Khuluma nodokotela wakho ukuze uthole ukuthi la mazinga asebenza kanjani esimweni sakho.

I-Luminal A iyinciphisa kanjani ingozi yokuba nomdlavuza webele?

Asikwazi ukuvimbela ezinye izinto eziyingozi, njengomlando womndeni womdlavuza. Kodwa-ke, ukwenza lezi zinto kungasiza ekunciphiseni ingozi yakho iyonke yomdlavuza:

• Gwema ukubhema nokubhema ugwayi.
• Yidla izithelo eziningi, imifino, kanye nokudla okusanhlamvu okuphelele.
• Khulisa umsebenzi womzimba. Kuhle ukuzivocavoca okungenani imizuzu engama-30 ngosuku.
• Nciphisa ukusetshenziswa kotshwala.
• Gcina isisindo sakho siphilile.

Ngizinakekela kanjani?

Kuvamile ukuba nemizwa ehlukahlukene uma unomdlavuza. Kulungile ukuzwa noma yini oyizwayo. Ngezinye izinsuku ungase uzizwe uphilile. Ngezinye izinsuku ungase ungafuni nokuvuka embhedeni. Kubalulekile ukulalela umzimba wakho. Lezi ziphakamiso zingakusiza:

• Yidla izithelo eziningi, imifino, kanye nokudla okusanhlamvu okuphelele.
• Bhala kahle.
• Lawula ukucindezeleka ngezinto ezifana ne-yoga, ukuzindla, noma ukwelashwa ngobuciko.
• Phumula uma udinga ukuphumula.
• Funa usizo kuzinhlelo zokusinda kumdlavuza.
• Khuluma nabanye abanesifo esifana nesakho. Lokhu kungaba umthombo omkhulu wamandla.

Kufanele ngimbone nini udokotela wami?

Uzobona udokotela wakho njalo ukuze ahlolwe njalo. Kodwa-ke, uma uthola izimpawu ezintsha , noma uma izimpawu zakho zamanje ziba zimbi kakhulu, qiniseka ukuthi wazisa udokotela wakho.

Yimiphi imibuzo okufanele ngiyibuze udokotela wami?

Uma unomdlavuza webele we-Luminal A, ungase ufune ukubuza udokotela wakho le mibuzo:

• Nginasiphi isigaba (ibanga noma isigaba) somdlavuza?
• Ingabe umdlavuza usabalale kwezinye izindawo?
• Yikuphi ukwelashwa ongincomayo ngohlobo lomdlavuza webele enginalo?
• Ukwelapha kuzothatha isikhathi esingakanani?
• Kukangaki lapho kuzodingeka ngize khona ukuzohlolwa?
• Ingabe ikhona imiphumela emibi yokwelashwa?

Yimuphi umyalezo esifuna ukuwuthatha ekhaya kule ndaba?

I-Luminal Umdlavuza webele uhlobo lomdlavuza olunesimo esihle kakhulu sokwelashwa . Kuyiqiniso lokho. Kodwa-ke, ukutholakala unomdlavuza kuyisenzakalo esishintsha impilo. Ngaleso sikhathi, ungase ube nemizwa ehlukahlukene, okuhlanganisa ukwesaba nokudabuka. Konke kuvamile.

Into ebaluleke kakhulu ukuhlala uzolile, uthole ulwazi olufanele, futhi ulandele iseluleko sikadokotela wakho. Thola ukwesekwa emndenini wakho nakubangane bakho, abakuthandayo. Khuluma nodokotela wakho nganoma yikuphi ukwesaba noma ukukhathazeka ongase ube nakho. Angachaza uhlobo lomdlavuza onalo kanye nezinketho zokwelashwa ezingcono kakhulu kuwe.

Khumbula, awuwedwa. Uma utholakale kusenesikhathi futhi welashwa kahle, umdlavuza webele we-Luminal A unethuba elikhulu kakhulu lokwelashwa!

'I-Luminal A, Umdlavuza Webele, Ukwelashwa Ngama-hormone, Izimpawu Zomdlavuza, Ukwelashwa Komdlavuza, Impilo Yabesifazane, Ukuqwashisa Ngomdlavuza