Wake wadla ukudla okunamafutha amaningi, njenge-biryani, noma into efana ne-curry ebabayo enobisi lukakhukhunathi, noma ucezu lwenhlanzi olunamafutha? Uma uqeda ukudla, ucabanga ukuthi, "O, sekwanele, isisu sami sigcwele." Wake wazibuza ukuthi ubani otshela ubuchopho bakho ukuthi isisu sakho sigcwele nokuthi kufanele uyeke ukudla? Omunye wemisebenzi ebaluleke kakhulu yale hormone esikhuluma ngayo namuhla yi-cholecystokinin. Kalula nje, ifana nomphathi obaluleke kakhulu ohlelweni lwethu lokugaya ukudla.
Kalula nje, iyini i-cholecystokinin?
I-Cholecystokinin iyi -hormone esebenza njengengxenye yesimiso sethu sokugaya ukudla. I-hormone iyisithunywa samakhemikhali esikhiqizwa endaweni eyodwa emzimbeni wethu, sihambe ngegazi, futhi sithwale umyalezo kwenye indawo. Njengomuntu othumelayo. Le cholecystokinin, noma i-CCK ngamafuphi, ikhishwa yimizimba yethu ngemva kokudla, lapho lokho kudla kugaywa.
Ikhiqizwa kakhulu futhi ikhishwe emathunjini ethu amancane . Kodwa into emangalisayo ukuthi, le hormone ye-CCK ikhona nasebuchosheni bethu kanye nasesimisweni sezinzwa esiyinhloko. Kodwa odokotela basazama ukuthola okuningi ngomsebenzi wayo lapho. Ngezinye izikhathi ibizwa nangokuthi i-pancreozymin . Kodwa igama elivame ukusetshenziswa kakhulu yi-cholecystokinin.
Le hormone ye-CCK iqala kanjani ukukhishwa emzimbeni?
Ake sithi udla ukudla. Lokho kudla kuqala kuya esiswini. Ngemva kokugaya okuthile esiswini, lokho kudla kuya engxenyeni yokuqala yamathumbu amancane. Sikubiza ngokuthi i-duodenum .
Yilapho umsebenzi wangempela uqala khona. Uma udle ukudla okucebile ngamaprotheni (isib. inyama, inhlanzi, amaqanda, udali) namafutha (isib. uwoyela, ubisi lukakhukhunathi, ibhotela), uhlobo olukhethekile lweseli ezindongeni ze-duodenum (olubizwa ngokuthi 'amaseli e-I') "luyawaqaphela" la maprotheni namafutha. Kufana nonogada obona isivakashi esikhethekile.
Uma ethola amaprotheni namafutha ngale ndlela, la maseli akhiqiza ngokushesha i-hormone i-CCK bese eyikhipha egazini lethu. Leso 'yisignali' sokuthi i-CCK iqale ukusebenza.
Yiziphi izinto eziyinhloko ezenzeka emzimbeni ngenxa ye-CCK hormone?
Uma i-CCK isisegazini, ayihlali nje lapho. Kufana nomphathi wohlelo lonke lokugaya ukudla, okwenza imisebenzi eminingana ngesikhathi esisodwa. Lena inqubo emangalisayo kakhulu. Ake sibone ukuthi iyini.
| Umsebenzi we-hormone ye-CCK | Incazelo elula |
|---|---|
| Ukufinyela kwenyongo | I-CCK iyahamba iyotshela inyongo ukuthi, "Kulungile, manje uzocindezela yonke inyongo onayo emathunjini amancane." Igama elithi 'cholecystokinin' lisho ukuthi "ukuhambisa inyongo." Le nyongo yilokho okusisiza ukugaya amafutha esiwadlayo. |
| Ukuvuselela i-pancreas | Ngesikhathi esifanayo, i-CCK ithumela umyalezo kuma-pancreas, ithi, "Thumela ama-enzyme akho e-pancreas manje." La ma-enzyme aphula amaprotheni namafutha abe yizinhlayiya ezincane ukuze akwazi ukumuncwa ngumzimba. |
| Ukulawula ukuphuma kwesisu | Ngesikhathi le nqubo yokugaya ukudla iqhubeka emathunjini amancane, i-CCK itshela isisu ukuthi, "Linda kancane, ungathumeli ukudla okwengeziwe kuze kube yilapho lokhu kudla sekugayiwe." Kufana nephoyisa lomgwaqo elilawula ithrafikhi. Lokhu kuvumela inqubo yokugaya ukudla ukuthi ithathe isikhathi esifanele. |
| Ukuncipha kwesifiso sokudla (ukuzizwa usuthi) | Yilokhu esikuzwayo isikhathi esiningi. I-CCK isenza sizizwe sigcwele ngezindlela ezimbili. Enye iwukwenza isisu sizizwe sigcwele ngokomzimba. Enye iwukuvuselela imizwa yesitho sangasese sowesifazane ezindongeni zesisu, ithumele isignali ebuchosheni ethi, "Sekwanele, sengigcwele." |
| Ukukhuthaza i-peristalsis (ukunyakaza kwamathumbu) | Okokugcina, i-CCK iyasiza futhi ekuqaliseni i-peristalsis, ukufinyela kwemisipha okufana namagagasi okudingekayo ukuhambisa ukudla okugayiwe emathunjini. |
Imiphumela ye-CCK ebuchosheni nasohlelweni lwezinzwa
Ngaphezu kokugaya ukudla, ucwaningo luthole ukuthi i-CCK ithinta nesimo sethu sengqondo. Ikakhulukazi, ukukhathazeka kanye nezinkinga zokwethuka.Kubonakala sengathi i-CCK ihlobene nokukhathazeka. Izifundo zikhombisile ukuthi amazinga e-CCK akhuphukile ebuchosheni angandisa ukukhathazeka. Ucwaningo olwengeziwe luyaqhubeka ngalokhu.
Yiziphi izimo zezokwelapha ezingase zihlotshaniswe ne-CCK?
Odokotela baqaphele ukuthi abantu abanezimo ezithile zezokwelapha banamazinga aphansi e-CCK. Kodwa-ke, akukacaci ukuthi lokhu kuyimbangela yesifo noma uphawu lwesifo.
- I-Gastroparesis: Kulesi simo, imisipha yesisu ayisebenzi kahle, okwenza ukudla kubambezeleke ekuhambeni kusuka esiswini kuya emathunjini amancane. Amazinga aphansi e-CCK angase ahileleke.
- I-Biliary Dyskinesia: Lokhu kwenzeka lapho inyongo ingafinyeleli kahle futhi ikhiphe inyongo. Lokhu kungenzeka ukuthi kungenxa yokuthi inyongo ayiphenduli kahle ku-CCK.
- Ukukhathazeka nokukhuluphala: Abanye abantu banezakhi zofuzo ezishintsha indlela i-CCK hormone exhumana ngayo nobuchopho. Lokhu kungaholela ekushintsheni kwezimpawu zokulawula isifiso sokudla noma izimpawu zokulawula ukukhathazeka.
Ubudlelwano phakathi kwe-CCK nokukhuluphala ngokweqile
Lesi yisihloko esibalulekile kubantu abaningi. Ososayensi benza ucwaningo oluningi ngobudlelwano phakathi kwe-CCK nokukhuluphala ngokweqile.
Ezinye izifundo zibonise ukuthi abantu abanezakhi zofuzo ezithile bangaba nengozi eyengeziwe engu-60% yokukhuluphala ngokweqile.
Kutholakale nokuthi abanye abantu abakhuluphele ngokweqile banokuzwela okuncane esignalini "yokugcwala" ethunyelwa yi-hormone ye-CCK. Lokhu kusho ukuthi noma begcwele, ubuchopho babo bungase bungakwazi ukukuzwa ngokunembile. Lokhu kungaholela ekutheni badle kakhulu kunalokho abakudingayo. I-CCK kanye nenye i-hormone ebizwa ngokuthi i-leptin basebenza ndawonye ukulawula izimpawu zethu zendlala nokugcwala.
Kuyini ukuhlolwa kwe-Cholecystokinin?
Ngezinye izikhathi, uma udokotela wakho esola ukuthi inyongo yakho ayisebenzi kahle, angase acele ukuhlolwa okukhethekile ukuze abone ukuthi isebenza kahle yini. Yilapho-ke ukuhlolwa kwe-CCK kwenziwa khona.
Lokhu kuvame ukwenziwa kanye ne- HIDA scan . I-HIDA scan iwukuskena okukhethekile okubheka ukusebenza kwezinto ezifana ne-gallbladder kanye ne-bile ducts yethu.
Nansi indlela yokukwenza:
1. Umjovo Wokujova: Okokuqala, uchwepheshe uzofaka inani elincane kakhulu lento ekhipha imisebe (i-tracer) emthanjeni wakho. Ungakhathazeki, lokhu akulimazi umzimba. Le nto ihamba ngegazi futhi iqoqeke esibindini sakho kanye nenyongo.
2. Ukuskena kokuqala:Ngemuva kwalokho, uchungechunge lwezithombe zenyongo yakho luthathwa kusetshenziswa isithwebuli sekhompyutha.
3. Umjovo we-CCK: Okulandelayo yingxenye ebaluleke kakhulu. Uma udokotela efuna ukubona ukuthi kwenzekani lapho inyongo yakho iqina, uzokufaka inani elincane le-hormone i-CCK ngomthambo.
4. Ukuskena kwesibili: Ngemva komjovo we-CCK, okwenzekayo kufana nalapho udla ukudla okunamafutha. Okusho ukuthi, inyongo yakho iqala ukufinyela. Ngaleso sikhathi, bathatha olunye uchungechunge lwezithombe.
Ngokuqhathanisa lezi zithombe, udokotela angakwazi ukuthola ukuthi inyongo yakho isebenza kahle kangakanani, ukuthi ikhipha inyongo kahle yini, nokuthi kukhona yini ukuvinjelwa.
Ingabe i-CCK isetshenziselwa ukwelashwa kwezokwelapha?
Njengamanje, i-hormone ye-CCK ayisetshenziswa ngqo njengokwelapha noma yisiphi isimo sezokwelapha. Kodwa-ke, isibe yinto ebaluleke kakhulu ekutholeni nasekuhloleni imithi emisha.
Ngokwesibonelo:
- Imithi yokwehlisa isisindo: Ngenxa yokuthi i-CCK inekhono lokuzwa ukugcwala, abacwaningi bazama ukuthuthukisa imithi yokunciphisa isifiso sokudla engalingisa leyo nqubo.
- Ukwelashwa kokukhathazeka: Ingxenye ethile ye-CCK (CCK-4) ingadala ukukhathazeka nokwesaba kubantu ngaphansi kwezimo ezilawulwayo. Ososayensi basebenzisa le ndlela ukuhlola ukusebenza kahle kwemithi emisha ehloselwe ukunciphisa ukukhathazeka.
Ngakho-ke, i-CCK akuyona nje enye i-hormone emizimbeni yethu. Iyisithunywa samakhemikhali esimangalisayo esithinta izinto eziningi, kusukela ohlelweni lwethu lokugaya ukudla kuya empilweni yethu yengqondo, futhi kuningi okusazotholakala esikhathini esizayo.
Umlayezo Wokuya Nawe Ekhaya
- I-Cholecystokinin (CCK) iyi-hormone ebalulekile ekhiqizwa amathumbu amancane esiza ekugayeni amaprotheni namafutha esiwadlayo.
- Lokhu kuvuselela i-gallbladder kanye ne-pancreas, kukhulula i-bile nama-enzyme adingekayo ekugayweni kokudla.
- Le hormone ye-CCK yiyo enikeza ubuchopho isignali ebaluleke kakhulu esisitshela ukuthi, "Sisuthi, sesidlile ngokwanele." Lokhu kubaluleke kakhulu ekulawuleni isisindo.
- I-CCK isetshenziswa nasezivivinyweni zezokwelapha, njenge-HIDA scan, ehlola ukusebenza kwenyongo.
- Ososayensi basacwaninga ngobudlelwano phakathi kwe-CCK nezimo ezifana nokukhuluphala ngokweqile nokukhathazeka. Uma unenkinga ngalokhu, kungcono ukukhuluma nodokotela wakho.
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