Ingabe ingane yakho ithola umkhuhlane, izilonda emlonyeni, noma umphimbo obuhlungu ngezinsuku ezifanayo njalo ngenyanga? Ingabe isifo esisodwa siyaphela, bese sibuya ngemva kwamasonto amabili noma amathathu? Ungase ucabange, "Isimiso somzimba sokuzivikela sengane yami sibuthakathaka." Yebo, lokho kungaba yiqiniso. Kodwa isizathu salesi sifo esijikelezayo singaba yisimo esingavamile kakhulu. Namuhla, sikhuluma ngesinye salezi zimo, i-cyclic neutropenia.
Kalula nje, kuyini i-cyclic neutropenia?
Ukuze siqonde lokhu, sidinga ukwazi ngesosha elisegazini lethu. Igama lalelo sosha yi -neutrophil . Le neutrophil uhlobo lweseli elimhlophe legazi elisivikela ezifweni ngokulwa namagciwane, ikakhulukazi amagciwane, angena emizimbeni yethu. Kufana nebutho elingaphakathi emizimbeni yethu.
I-Neutropenia yilapho inani lamasosha e-neutrophil egazini lehla ngaphansi kwamazinga ajwayelekile. Njengoba nje ibutho liba buthaka lapho amasosha alo eba mancane, lapho ama-neutrophil eba mancane, amasosha omzimba wethu aba buthaka futhi siqala ukuthola izifo kalula.
Manje ake sibheke incazelo yegama elithi cyclic . I-Cyclic isho ukuthi "i-cyclical." Lokhu kusho ukuthi izinga le-neutrophil alihlali liphansi. Liyakhuphuka futhi lehle ngesimiso esivamile, ngomjikelezo. Ukuze kube sobala, ngokuvamile njalo emavikini amathathu (cishe izinsuku ezingu-21) , izinga le-neutrophil lehla kakhulu izinsuku ezintathu kuya kwezinhlanu. Bese libuyela esimweni esijwayelekile, bese lehla futhi emavikini amathathu alandelayo. Lo mjikelezo wenzeka ngendlela ebikezelwayo kakhulu.
Kalula nje, i-cyclic neutropenia yisimo lapho inani lamaseli e-neutrophil, avikela imizimba yethu ezifweni, lehla khona ngokwemijikelezo yansuku zonke ebekiwe, okwandisa ingozi yokutheleleka.
Lesi simo asivamile neze. Abacwaningi bathi umuntu oyedwa kuphela kwabayisigidi emhlabeni unalesi sifo.
Ziyini izimpawu zalesi sifo?
Isici esikhethekile salesi sifo ukuthi izimpawu zivela ngokuhambisana nomjikelezo wokwehla kwamazinga e-neutrophil. Okusho ukuthi, lezi zimpawu zivela zingakapheli izinsuku ezintathu kuya kwezine zokwehla kwama-neutrophil, futhi lapho amazinga e-neutrophil ebuyela esimweni esijwayelekile, izimpawu ziyanyamalala.
| Isibonakaliso | Incazelo |
|---|---|
| Umkhuhlane nokukhathala | Uma ama-neutrophil ephansi, uphawu lokuqala lokutheleleka emzimbeni kungaba umkhuhlane. Kanye nalokhu, umzimba ungase uzizwe ungaphili. |
| Izilonda zomlomo kanye nomphimbo obuhlungu | Lolu uphawu oluvame kakhulu. Lungabangela izilonda ezibuhlungu emlonyeni nasezinsinini. Lungabangela nomphimbo obuhlungu. |
| Isifo se-periodontal | Kungase kube nokopha njalo kanye nokuvuvukala kwezinsini. |
| Ukutheleleka okuphindaphindiwe | Ukutheleleka kwemigudu yokuphefumula (umkhuhlane, ukukhwehlela), ukutheleleka kwemigudu yokugaya ukudla (ubuhlungu besisu), kanye nokutheleleka kwesikhumba (i-cellulitis) kungavela njalo. |
Uhlobo lwalezi zimpawu lungashintsha impilo yonke. Kubantu abaningi, ubukhali bezimpawu buyehla njengoba befika ebudaleni . Izilonda zomlomo nezinkinga zamazinyo zivame kakhulu kubantu abasha, kuyilapho ikhanda elibuhlungu kanye nokutheleleka kwama-sinus (sinusitis) kuvame kakhulu kubantu abadala.
Kungani lokhu kwenzeka?
I-cyclic neutropenia ibangelwa ukuguquka kwezakhi zofuzo . Imbangela eyinhloko ushintsho ku- ELANE gene emzimbeni wethu.
Cabanga ngesakhi sofuzo njengeqoqo lemiyalelo etshela amaseli emzimbeni wethu ukuthi asebenze kanjani. Isakhi sofuzo se-ELANE siqukethe imiyalelo yokwenza i-enzyme esiza ama-neutrophil ukuthi asebenze kahle. Uma kukhona iphutha noma ukuguquka kwalesi sakhi sofuzo, ama-neutrophil awakwazi ukusebenza kahle.
Lesi simo singadluliselwa kubazali siye ezinganeni, noma singakhula ngesikhathi sokukhulelwa.
Ngenxa yalesi sici sofuzo,
- Umzimba ungase ungakhiqizi ama-neutrophil anele.
- Ngaphandle kwalokho, ama-neutrophil angafa ngokushesha.
- Noma ama-neutrophil angase angasebenzi kahle.
Dokotela, ukuxilonga kanjani lokhu?
Lezi zimpawu zivame ukubonakala kusukela ekuzalweni, ngakho-ke lesi sifo sivame ukutholakala ebuntwaneni. Udokotela uzocabangela izinto eziningana ukuqinisekisa lesi sifo.
- Umlando womndeni walesi sifo: Njengoba lesi kuyisimo sofuzo, kuyahlolwa ukuthi ngabe kukhona yini omunye emndenini (abazali, izingane zakubo) onalesi sifo.
- Ukuhlolwa kwegazi: Lokhu kubaluleke kakhulu. Udokotela wakho uzohlola amazinga akho e-neutrophil egazini lakho kabili noma kathathu ngesonto cishe amasonto ayisithupha . Lokhu kuzokwenziwa ukuze kubonakale ukuthi amazinga akho e-neutrophil ayancipha yini ngokujikeleza kwegazi.
- Iphethini yezimpawu: Udokotela uzofunda ngokucophelela imvamisa yezimpawu (cishe njalo emavikini ama-3). Le phethini yokujikeleza isiza ukuhlukanisa lokhu kwezinye izinhlobo ze-neutropenia.
- Ukuhlolwa kwezakhi zofuzo: Ngezinye izikhathi ukuhlolwa kwezakhi zofuzo kunganconywa ukuqinisekisa ukuthi kukhona yini ukuguquka kwezakhi zofuzo ze-ELANE.
Lapho exilonga lesi simo, udokotela kumele akhiphe ezinye izinhlobo ze-neutropenia ezinezimpawu ezifanayo, njenge-'Severe congenital neutropenia' (eyayaziwa ngokuthi i-'Kostmann syndrome'), i-'Autoimmune neutropenia', kanye ne-'Idiopathic neutropenia'.
Yiziphi izindlela zokwelapha lokhu?
Kunemigomo emibili eyinhloko yokwelapha. Eyokuqala ukwelapha izifo ezikhona kakade. Eyokuqala ukukhulisa amazinga e-neutrophil nokuvimbela izifo zesikhathi esizayo.
| Indlela yokwelapha | Ukusebenza kahle |
|---|---|
| Ama-antibiotic | Lokhu kunikezwa ukulwa nokutheleleka ngamagciwane okwenzeka ngezikhathi zama-neutrophil aphansi. |
| Ukwelashwa kwe-G-CSF | Lona ukwelashwa okuyinhloko nokuphumelela kakhulu. I-G-CSF (i-Granulocyte colony-stimulating factor) umuthi ovuselela umongo wethu wamathambo ukuthi ukhiqize ama-neutrophil engeziwe (isib. i-filgrastim (i-Neupogen®)). Inikezwa njengomjovo futhi iyindlela yokwelapha ephephile engasetshenziswa isikhathi eside. |
| Ukufakelwa kweseli lesiqu | Lena indlela esetshenziswa kuphela kulabo abanesifo esibi kakhulu futhi abangasabeli ekwelashweni kwe-G-CSF. Kule ndlela, amaseli okuqala aphilile ayatshalwa ukuze athathe indawo yamaseli anesifo. |
Ingabe ikhona imiphumela emibi yokwelashwa?
Ukwelashwa kwe-G-CSF kungabangela imiphumela emibi emincane. Kodwa-ke, odokotela bavame ukuqala ukwelashwa kwalesi sifo ngomthamo ophansi, ngakho imiphumela emibi mincane.
- Ikhanda elibuhlungu
- Ubuhlungu emathanjeni nasemalungeni
- Isicanucanu kanye nesifo sohudo
Izinto ezinjengalezi zingenzeka. Khuluma nodokotela wakho ngokucophelela mayelana nokwelashwa okutholayo kanye nemiphumela yako emibi.
Ngingashayela nini udokotela ucingo?
Uma wena noma ingane yakho ninesifo se-cyclic neutropenia, kubaluleke kakhulu ukufuna iseluleko sezokwelapha ngokushesha nje lapho nibona noma yiziphi izimpawu zokutheleleka .
Naka kakhulu izici ezilandelayo:
* Imfiva
* Ubuhlungu endaweni ethile emzimbeni
* Ukuvuvukala noma ukubomvu kwesikhumba
Uma ubona noma yiziphi zalezi zimpawu, bona udokotela wakho ngokushesha. Unganqikazi ukuya eMnyangweni Wezimo Eziphuthumayo (ETU) uma kudingeka.
Yini okufanele siyenze ukuze sizivikele ezifweni?
Ngaphezu kokuzivikela ezifweni, udinga futhi ukuqaphela uma inani lakho lama-neutrophil liphansi.
- Geza izandla zakho kahle njalo, ikakhulukazi ngaphambi kokudla nangemva kokusebenzisa indlu yangasese.
- Gcina impilo yomlomo iphilile. Hlanza amazinyo akho nsuku zonke futhi ubonane nodokotela wamazinyo njalo .
- Thola yonke imijovo enconyiwe ngesikhathi.
- Gwema ukuthinta ubuso bakho, amehlo, kanye nekhala lakho ngaphandle kokugeza izandla zakho.
- Thatha imithi yakho njengoba nje udokotela wakho ekuyalele futhi uhlolwe igazi lakho ngesikhathi.
Nakuba lesi simo singesokuphila konke, ukwelashwa okuphumelelayo njenge-G-CSF manje sekuvumele abantu abaningi abane-cyclic neutropenia ukuba baphile impilo evamile ngokuphelele . Okubalulekile, nakuba ezinye izinhlobo ze-neutropenia zinengozi yokuba nomdlavuza, njenge-leukemia, i-cyclic neutropenia ayinayo.
Umlayezo Wokuya Nawe Ekhaya
- I-neutropenia ye-cyclic yisimo esingavamile sofuzo lapho inani lamaseli e-neutrophil alwa nokutheleleka lehla khona ngokujikeleza.
- Izimpawu (umkhuhlane, izilonda zomlomo) zivame ukuvela cishe kanye njalo emavikini amathathu.
- Ukuze kutholakale ukuthi unegciwane, ukuhlolwa kwegazi kufanele kwenziwe njalo amasonto amaningana ukuqinisekisa ukujikeleza kwamazinga e-neutrophil.
- Ngenxa yokuthi kunezindlela zokwelapha eziphumelela kakhulu njenge-G-CSF, iziguli zingaphila impilo evamile.
- Kubaluleke kakhulu ukufuna iseluleko sezokwelapha ngokushesha nje lapho ubona noma yiziphi izimpawu zokutheleleka (umkhuhlane, ubuhlungu, ukuvuvukala).
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