Iyini i-Gastrin? Ingabe iyathinta izinkinga zesisu sakho?

Wake wazibuza ukuthi zingaki izinto ezenzeka emizimbeni yethu, ikakhulukazi ngemva kokudla? Sineqembu lezithunywa ezincane zamakhemikhali emizimbeni yethu ezisiza konke lokhu kwenzeke. Sibiza lawa ma-hormone. Namuhla sizokhuluma nge-hormone eyodwa ekhethekile. Leyo yi-gastrin. Le gastrin ibaluleke kakhulu ekusebenzeni kwesistimu yethu yokugaya ukudla.

Yini ngempela eyenziwa yiGastrin?

Kulungile, manje ake sibone ukuthi lo mngane obizwa ngokuthi uGastrin wenzani emizimbeni yethu. Unemisebenzi eminingana eyinhloko.

• Ukukhiqizwa kwe-asidi yesisu: Into ebaluleke kakhulu ukutshela isisu sakho ukuthi sikhiphe i-asidi yesisu. Le-asidi yesisu yilokho esikubiza ngokuthi i-hydrochloric acid. Ngaphandle kwalokhu, kunzima kakhulu ukugaya ukudla.
• Ukusebenza kwemisipha yesisu: I-Gastrin iphinde isize imisipha esiswini sakho ukuthi isebenze kahle, okusho ukuthi ibangela ukunyakaza kwesisu, okusiza ukuxuba nokuphula ukudla.
• Vuselela Udonga Lwesisu: Ulwelwesi oluthambile lwesisu sethu, i-mucosa, ludinga ukuvuselelwa njalo. I-Gastrin iyasiza nalokhu.
• Ukukhuthazwa kwe-gallbladder kanye ne-pancreas: I-Gastrin, kanye nenye i-hormone ebizwa ngokuthi i-cholecystokinin, isiza i-gallbladder yakho kanye ne-pancreas ukuthi zinciphe futhi zikhiphe ujusi wokugaya ukudla.

Uyini umehluko phakathi kwe-Gastrin ne-Gastric acid?

Ingabe lokhu kuzwakala kudida kancane? Kalula nje, kunje. I-Gastrin iyi -hormone . Kufana nencwadi. Le ncwadi itshela isisu ukuthi, "Kulungile, manje khipha i-asidi yesisu." Bese le-asidi yesisu ivuselela i-enzyme yokugaya ukudla i-pepsin. Ndawonye, ​​lezi ezimbili zakha ujusi wesisu esiswini sethu. Uyaqonda?

Ikhiqizwa kuphi i-gastrin?

I-Gastrin ikhiqizwa ngokuyinhloko yizitho zomzimba ohlelweni lwethu lokugaya ukudla. Le hormone ivela ohlotsheni olukhethekile lweseli olubizwa ngokuthi ama-G-cell. Uhlamvu "G" lumelela "i-gastrin."

Iningi le-gastrin livela esiswini sakho , ikakhulukazi engxenyeni engezansi yesisu sakho (siyibiza ngokuthi i-antrum). Lawa ma-G-cell atholakala ezindlaleni zesisu odongeni lwesisu sakho. Ngaphezu kwalokho, i-gastrin ethile ikhiqizwa yi-duodenum, ingxenye yokuqala yamathumbu akho amancane, kanye ne-pancreas.

Yiziphi izici ezithinta ukukhishwa kwe-gastrin?

Kuyamangalisa ukuthi i-gastrin ikhishwa kanjani uma ucabanga ngokudla! Wazi kanjani lokho? Ubuchopho bethu kanye nohlelo lokugaya ukudla kuxhunyaniswe njalo ngenethiwekhi ekhethekile yezinzwa ebizwa ngokuthi imizwa ye-vagal. Ulwazi luhamba luye phambili naphambili ngalezi zinzwa.

Ngakho-ke, uma ucabanga ngokudla, imizwa yesitho sangasese sobuchopho bakho ithumela umlayezo esiswini, ithi, "Kulungile, ukudla kuyeza, khipha i-gastrin bese ulungiselela ukugaya ukudla." Bese kuthi, uma uqala ukudla, imizwa esesiswini sakho iqaphele ukuthi ukudla sekungene futhi ikhiphe i-gastrin eyengeziwe.

Ezinye izinto ezikhuthaza ukukhishwa kwe-gastrin:

• Ukwanda kwe-pH yesisu (okungukuthi, lapho i-acidity yehla).
• Izindonga zesisu ziyadonseka lapho ukudla kungena.
• Ukudla okuthile, ikakhulukazi okuqukethe amaprotheni, kungena esiswini.

I-Gastrin ibangela ukukhishwa kwe-asidi yesisu, evuselela i-pepsin. Uma ihlangene, lokhu kuyaphula futhi kugaye amaprotheni esiswini. I-Gastrin iphinde ivuselele ukunyakaza kwemisipha esiswini.

Ukuvimbela kanjani ukukhishwa kwe-gastrin?

Njengoba ukudla kuphuma esiswini sakho bese kudlulela engxenyeni yokuqala yamathumbu amancane, i-duodenum, isigaba esilandelayo sokugaya ukudla siqala. Yilapho ukukhishwa kwe-gastrin kuqala ukwehla. Njengoba ukudla kuhamba amazinga e-asidi esiswini nasesiswini ayanda, i-gastrin iyancipha.

Uma ukudla kungena e-duodenum, i-gallbladder yakho kanye ne-pancreas kukhipha ujusi wokugaya ukudla. Bese, uhlelo lwethu lokugaya ukudla lukhipha enye i-hormone ebizwa ngokuthi i-somatostatin. Le-somatostatin ivala amanye ama-hormone (njenge-gastrin). Kufana nokuvala iswishi.

Ungahlola kanjani amazinga e-gastrin?

Kukhona ukuhlolwa kwegazi okukhethekile ukuhlola amazinga e-gastrin yakho. Sikubiza ngokuthi ukuhlolwa kwe-gastrin. Umhlinzeki wezempilo, njengodokotela noma umhlengikazi, uthatha isampula encane yegazi emthanjeni osengalweni yakho bese elithumela elabhorethri ukuze lihlolwe.

Kungani izinga lami le-gastrin libalulekile?

Odokotela bahlola amazinga e-gastrin yakho ukuze babone ukuthi aphezulu kakhulu yini. Amazinga aphansi e-gastrin awavamile, kodwa amazinga aphezulu e-gastrin angabonisa izifo ezithile zesisu kanye nezimo.

Kusho ukuthini amazinga aphezulu e-gastrin (i-Hypergastrinemia)?

Uma amazinga e-gastrin ephakeme, sikubiza ngokuthi i-hypergastrinemia. Ngezinye izikhathi, i-hypergastrinemia ingasho ukuthi unamathumba akhiqiza i-gastrin emzimbeni wakho, abizwa ngokuthi ama-gastrinoma. Lokhu kungenzeka ku-pancreas noma i-duodenum yakho.

Ngezinye izikhathi, i-hypergastrinemia ingasho ukuthi kukhona okuthile esiswini sakho okusivimbela ekukhiqizeni i-asidi yesisu. Lapho i-asidi yesisu incipha, kukhishwa i-gastrin eningi. Futhi, izimpawu ezivame ukuvimba ukukhiqizwa kwe-gastrin ziyaphazamiseka.

Kwenzekani uma amazinga e-gastrin enyuka?

Uma amazinga akho e-gastrin ephezulu, inani le-asidi yesisu esiswini sakho kanye ne-duodenum lingaba phezulu kakhulu. I-asidi eningi kakhulu ingalimaza ulwelwesi oluvikelayo lwesisu sakho kanye ne-duodenum, okubangela izilonda, ezaziwa nangokuthi isifo sesilonda se-peptic.

Futhi, ukuba ne-asidi eningi esiswini kungabangela isimo esibizwa ngokuthi i-GERD (Gastroesophageal Reflux Disease), okuyisimo sesikhathi eside lapho i-asidi ikhuphukela emphinjeni. Uma unesifo sesilonda se-peptic noma i-GERD futhi ingapholi ngemithi, udokotela wakho angase ahlole amazinga e-gastrin yakho.

Yiziphi izimo zezokwelapha ezingase zihlotshaniswe namazinga aphezulu e-gastrin?

Uma une-gastrinomas, amazinga e-gastrin yakho kanye ne-gastric acid angase akhuphuke. Ama-gastrinomas uhlobo lwesimila se-pancreatic neuroendocrine (PET) esikhipha i-gastrin. Angaba nomdlavuza noma angabi nomdlavuza.

Izimo ezibangela i-gastrinomas:

• I-Zollinger-Ellison syndrome.
• I-Multiple endocrine neoplasia uhlobo 1 (MEN1).

Izimo lapho i-gastrin kanye ne-asidi yesisu kukhuphuka khona ngaphandle kwe-gastrinomas:

• Ukwehluleka kwezinso okungapheli.
• Ukuvaleka kokuphuma kwesisu (GOO).

Uma ukukhiqizwa kwe-asidi esiswini sakho kuphansi, ungase ube namazinga aphezulu e-gastrin kodwa amazinga aphansi e-asidi esiswini. Lokhu kungase kubangelwe yi-atrophic gastritis, okuyisimo lapho amangqamuzana akhiqiza i-asidi esiswini ebhujiswa khona.

Izimbangela eziyinhloko ze-atrophic gastritis:

• Ukutheleleka kwe-H. pylori.
• Izifo ezihlasela amasosha omzimba (isib. i-atrophic gastritis ye-autoimmune).

Ezinye izimbangela zokwehla kokukhiqizwa kwe-asidi esiswini:

• Imithi yokuvimbela i-asidi, njenge-H2 blockers noma i-proton pump inhibitors (PPIs).
• Ukususwa kwe-Vagotomy (ukususwa ngokuhlinzwa noma ukunqunywa kwenzwa yesitho sangasese sowesifazane).

Yini okufanele ngiyenze uma nginezimpawu zamazinga aphezulu e-gastrin?

Uma unezimpawu zesisu, ikakhulukazi uma zivela njalo noma sezikhona isikhathi eside, kubalulekile ukubona udokotela. Nazi ezinye izimpawu ezingase zihlotshaniswe nokwanda kwe-gastrin:

• Ubuhlungu besisu noma ukuqaqamba kwesisu.
• Ubuhlungu besifuba obuqhubekayo kanye nokungagayeki kahle kokudla.
• Ukuvuvukala kwe-asidi noma ukudla okunamathela emphinjeni.
• Umphimbo obuhlungu ongapheli kanye nokushoshozela.
• Uhudo oluqhubekayo.
• Izinkinga zokugaya ukudla.

Lezi zimpawu zingase zibonise ukuthi unezinga eliphezulu le-asidi esiswini, noma ukuthi une-gastritis engaphelele, isifo sesilonda se-peptic, noma i-GERD. Lokhu kungase kuhlobane noma kungahlobene ne-gastrin. Kodwa-ke, kubalulekile ukuxilonga nokwelapha lezi zimo ngendlela efanele.

Khumbula, uma unezimpawu ezinjengalezi, ungazami ukuzixilonga ngokubheka ulwazi ku-inthanethi. Kungcono ukubona udokotela bese uthola iseluleko.

Umlayezo Wokuya Nawe Ekhaya

Kulungile, ake sibheke izinto ezilula okufanele sizikhumbule nge-gastrin esikhulume ngayo.

• I-Gastrin iyi -hormone ebalulekile ohlelweni lwethu lokugaya ukudla .
• Umsebenzi wayo oyinhloko ukutshela isisu ukuthi sikhiphe i-asidi esiswini .
• Uma i-asidi yesisu sakho iphezulu kakhulu noma iphansi kakhulu , ingase ihlobane ne-gastrin.
• Uma unezimpawu zesisu, noma izimo ezingathuthuki ngokwelashwa, udokotela angase ahlole amazinga e-gastrin yakho.
• Amazinga aphezulu e-gastrin ngezinye izikhathi angaba uphawu lwesimo sempilo, ngakho-ke kubalulekile ukufuna iseluleko sezokwelapha uma unezimpawu.

Ngakho-ke, i-Gastrin iyinto encane kodwa enamandla esebenza buthule emizimbeni yethu. Ukuqaphela lokhu kuzobaluleka kakhulu empilweni yakho. Uma uneminye imibuzo, ungangabazi ukubuza udokotela wakho.

Isisu , ama-hormone, ukugaya ukudla, i-asidi yesisu, isilonda se-peptic, i-GERD, i-hypergastrinemia