Ingabe udokotela wakho ukunikezile wena noma othile omaziyo iphilisi elibizwa ngokuthi i-Guanidine? Ungase ube nesithakazelo esincane, noma wesabe kancane, uma uzwa leli gama. Ngoba lokhu akuyona imithi esivame ukuzwa ngayo. I-Guanidine umuthi osetshenziselwa ukwelapha isimo esithile sezokwelapha esingavamile. Ngakho-ke, kubaluleke kakhulu ukuqaphela lokhu. Ngakho-ke, namuhla sizokhuluma ngala maphilisi e-Guanidine, izimo zezokwelapha azelaphayo, indlela yokuwasebenzisa, kanye nezinto okufanele uziqaphele.
Iyini i-Guanidine futhi yelapha siphi isifo?
Kalula nje, i-Guanidine iyisidakamizwa esivuselela imizwa futhi sithuthukise ukusebenza kwemisipha. Ngokwezokwelapha, ingeyesigaba semithi ebizwa ngokuthi 'izikhuthazi zemisipha ze-cholinergic'.
Lo muthi usetshenziswa kakhulu ekwelapheni isimo esingavamile sokuzivikela komzimba esibizwa ngokuthi i-Lambert-Eaton Myasthenic Syndrome (LEMS) .
Ake siqonde kancane ngokuthi iyini i-LEMS.
Cabanga nje, ukunyakaza kwemizimba yethu kulawulwa imiyalezo evela ebuchosheni. Lapho le miyalezo ihamba ngemizwa futhi ifinyelela emisipheni, siyakwazi ukuhambisa izingalo nemilenze yethu nokuhamba. Lapho kuhlangana khona imizwa nemisipha, ikhemikhali ebizwa ngokuthi 'i-Acetylcholine' iyakhishwa eziphethweni zemizwa. Lapho le khemikhali ifika emisipheni, imisipha iyafinyela, okungukuthi, iyasebenza.
Kodwa kumuntu one-LEMS, amasosha omzimba ahlasela ngephutha lezo ziphetho zemizwa. Ngenxa yalokho, inani le-'Acetylcholine' elidingekayo alikhishwa. Umphumela uba ubuthakathaka obukhulu nokukhathala okubangelwa yimisipha engawutholi kahle umyalezo. Ubuthakathaka bemisipha buvame kakhulu emilenzeni nasezinqeni.
I-Guanidine isebenza ngokuvuselela ukukhululwa kwesithunywa samakhemikhali (i-Acetylcholine) eziphethweni zemizwa. Lokhu kusho ukuthi inika amandla ukugeleza komyalezo ovinjiwe futhi isiza imisipha ukuthi isebenze kahle futhi.
Izinto okudingeka uzitshele udokotela wakho ngaphambi kokuqala imithi
I-Guanidine umuthi okufanele usetshenziswe ngokuqapha. Ngakho-ke, kubaluleke kakhulu ukwazisa udokotela wakho ngomlando wakho wezokwelapha ophelele ngaphambi kokumnikeza lo muthi. Qiniseka ukuthi uyamtshela uma unezinye zezimo ezilandelayo:
- Isifo sezinso: Kufanele utshele udokotela wakho uma unezinkinga ezihlobene nezinso, njengoba izinso zidlala indima enkulu ekususeni lo muthi emzimbeni.
- Isifo sesibindi: Uma kukhona ubuthakathaka ekusebenzeni kwesibindi, khuluma ngakho futhi.
- Izinkinga zamaseli egazi: Uma kubikwe ukuthi unamaseli amhlophe egazi aphansi, amaseli abomvu egazi, noma ama-platelet egazini lakho, lokho kuwulwazi olubaluleke kakhulu.
- Isifo Sengqondo: Uma welashwa noma unomlando wanoma yisiphi isifo sengqondo, sicela usazise.
- Ukungezwani komzimba: Uma une-allergy ku-guanidine noma kunoma yimuphi omunye umuthi, ukudla, noma idayi.
- Ukukhulelwa noma ukulindela umntwana: Uma ukhulelwe noma uhlela ukukhulelwa, lokhu kuyinto okumele uyisho.
- Ukuncelisa: Yazisa udokotela futhi uma ungumama oncelisayo.
Ngingawusebenzisa kanjani lo muthi?
Into ebaluleke kakhulu ukulandela imiyalelo kadokotela wakho ngqo lapho usebenzisa lo muthi.
- Gwinya leli philisi ngengilazi yamanzi.
- Sebenzisa umuthi njengoba nje kuqondiswe kulebula kadokotela. Ungathathi okungaphezu noma okungaphansi kwenani udokotela wakho akutshele ukuthi ulithathe.
- Lokhu kungathathwa ngaphambi noma ngemva kokudla. Kodwa-ke, uma uzwa ubuhlungu besisu, ukubuphuza kanye nokudla kungasiza ekunciphiseni.
- Zijwayeze ukuphuza imithi yakho ngesikhathi esifanayo nsuku zonke, ngesikhathi.
- Okubaluleke kakhulu: Ungayeki ukuphuza imithi yakho nganoma yisiphi isizathu ngaphandle kweseluleko sikadokotela wakho. Ukuyeka ngokuzumayo kungabangela ukuthi izimpawu zakho zibuye futhi zibe zimbi kakhulu.
- Uma kunikezwa izingane: Uma kunikezwa lo muthi ezinganeni, kubalulekile ukubonisana nodokotela wezingane.
Kuthiwani uma ngiphuza umuthi omningi kakhulu? (Ukudlula umthamo)
Uma ucabanga ukuthi kungenzeka ukuthi ngephutha uthathe umuthi omningi kunalokho ocabanga ukuthi unakho, ungalibali. Shayela ngokushesha iNational Poisons Information Centre eColombo National Hospital , noma uye e-Emergency Treatment Unit (ETU) yesibhedlela esiseduze.
Ake sifunde nangemiphumela emibi kanye nokusebenzisana kwayo.
Njenganoma yimuphi umuthi, i-Guanidine ingabangela imiphumela emibi. Ingaphinde ihlangane neminye imithi.
Imiphumela emibi engaba khona
Ezinye zalezi zingaba zimbi kakhulu, ezinye zivamile. Kubalulekile ukuzazi.
| Uhlobo lomphumela ongemuhle | Izici |
|---|---|
| Imiphumela emibi kakhulu edinga usizo lwezokwelapha ngokushesha | |
| Ukusabela kokungezwani komzimba | Ukucasuka kwesikhumba, ukulunywa, ukuvuvukala |
| Ubunzima bokuphefumula | Ubunzima bokuphefumula |
| Izinguquko ekushayeni kwenhliziyo | Ukushaya kwenhliziyo okusheshayo noma okungajwayelekile |
| Izimpawu zokutheleleka | Umkhuhlane, umphimbo obuhlungu |
| Izinguquko zengqondo | Ukubona noma ukuzwa izinto ezingezona ezangempela (i-Hallucinations) |
| Izinkinga zomchamo | Ubunzima bokuchama noma ushintsho enanini lomchamo owukhiqizayo |
| Ubuthakathaka obungavamile | Ukuzizwa ukhathele kakhulu futhi ubuthakathaka emzimbeni |
| Imiphumela esibindini | Ukuphuzi kwamehlo noma isikhumba (njenge-jaundice) |
| Imiphumela emibi evamile okufanele ibikwe kudokotela uma iqhubeka | |
| Izici ezijwayelekile | Umlomo owomile, isiyezi, ikhanda elibuhlungu, isisu esibuhlungu, isicanucanu/ukuhlanza, isifo sohudo, ukulahlekelwa yisifiso sokudla |
| Imiphumela ohlelweni lwezinzwa | Ukuba ndikindiki, ukuqaqamba, noma ubuhlungu ezithweni, ukushintsha kwemizwelo |
Eminye imithi esebenzisana ne-Guanidine (Ukusebenzisana Kwezidakamizwa)
Eminye imithi oyithathayo ingathinta indlela esebenza ngayo i-Guanidine. Ngakho-ke tshela udokotela wakho ngayo yonke imithi oyithathayo (kufaka phakathi amavithamini nemikhiqizo yamakhambi), ikakhulukazi uma uthatha noma yikuphi kwalokhu okulandelayo:
- Eminye imithi esetshenziswa umdlavuza
- Imithi enikezwa ukulawula amasosha omzimba ngemva kokufakelwa isitho
- Eminye imithi yokwelapha isithuthwane (isib., `iCarbamazepine`)
- Imithi yokwelapha izifo zengqondo efana ne-"Clozapine"
- Ama-Phenothiazine (isib. i-Chlorpromazine)
- Imithi yohlobo lwe-steroid (isib. `i-Prednisone`, `i-Cortisone`)
- 'I-Sulfinpyrazone'
Khumbula ukuthi lolu hlu aluphelele, ngakho-ke ukuze uphephe, kungcono ukutshela udokotela wakho ngakho konke okuthathayo.
Umlayezo Wokuya Nawe Ekhaya
- I-Guanidine umuthi osetshenziselwa ukwelapha isifo esingavamile, esithile semisipha esibizwa ngokuthi i-Lambert-Eaton Myasthenic Syndrome (LEMS).
- Qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyithathayo, ikakhulukazi uma unezinkinga zezinso, zesibindi, noma zegazi.
- Akufanele uqale, uyeke, noma ushintshe umthamo wemithi ngaphandle kweseluleko sikadokotela wakho.
- Uma uhlangabezana nanoma yimiphi imiphumela emibi efana nobunzima bokuphefumula, izinguquko ekushayeni kwenhliziyo, ukuphuzi kwamehlo, noma umkhuhlane, funa iseluleko sezokwelapha ngokushesha.
- Uma usola ukuthi uphuze ngokweqile, iya eNational Poison Information Centre noma eMnyangweni Wezimo Eziphuthumayo wesibhedlela (ETU) ngokushesha.
- Gcina umuthi endaweni ephephile ekamelweni lokushisa, kude nezingane.
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