Uyazi ngomdlavuza webele one-HER2-Negative? Ake sixoxe!

Cishe uke wezwa okuningi ngomdlavuza webele. Kodwa ingabe uyazi ngempela ukuthi lolu hlobo lomdlavuza lubizwa ngokuthi 'i-HER2-negative'? Luziphatha ngendlela ehlukile kancane kunezinye izinhlobo zomdlavuza webele, futhi ukwelashwa kungase kuhluke. Ungakhathazeki, namuhla sizoxoxa ngalo mdlavuza webele 'i-HER2-Negative' ngendlela elula ongayiqonda, kulungile?

Iyini i-HER2-Negative Breast Cancer?

Kalula nje, `umdlavuza webele ongemuhle we-HER2` usho ukuthi amangqamuzana omdlavuza esifubeni sakho awanawo amaprotheni amaningi noma amancane kakhulu abizwa ngokuthi `i-human epidermal growth factor 2 (HER2). Ubuwazi ukuthi umdlavuza webele uvame ukwenzeka ngenxa yama-hormone (ikakhulukazi i-estrogen ne-progesterone) noma ngenxa yale protein `HER2`? Isibonelo, kumdlavuza webele `ongemuhle we-HER2`, iphrotheni `HER2` ikhona ebusweni bamaseli, okubangela ukuthi amangqamuzana omdlavuza ahlukane ngokushesha futhi akhe amathumba.

Kodwa ezimweni ze-'HER2-negative', umdlavuza awukhuli ngoba kuneprotheni ye-'HER2' eningi kakhulu. Okusho ukuthi, kunezinye izici ezihilelekile.

Uma udokotela wakho ekuxilonga ukuthi unomdlavuza webele, uzobheka isimo sakho se-'HER2' (okungukuthi, esihle noma esibi). Lezi yizici ezikhethekile zamaseli omdlavuza, esiwabiza ngokuthi 'ama-biomarker' , futhi uma eqondwa kahle, odokotela banganquma ukuthi yikuphi ukwelashwa okufanele kakhulu futhi okusebenzayo kuwe. Uyakwazi?

Yiziphi izinhlobo eziyinhloko zomdlavuza webele we-HER2-negative?

Iningi lomdlavuza webele otholakale njengamanje ungowohlobo lwe-'HER2-negative'. Kunezinhlobo ezimbili eziyinhloko zalokhu, ake sibheke ukuthi ziyini:

1. Umdlavuza webele one-hormone receptor kanye ne-HER2-negative (HR+/HER2-) :

Lolu uhlobo oluvame kakhulu lomdlavuza webele, olubalelwa cishe kumaphesenti angama-70 (70%) azo zonke izinhlobo zomdlavuza webele. Kulesi simo, amangqamuzana omdlavuza anezitho zokwamukela ezizwela i-estrogen hormone (ER+), i-progesterone hormone (PR+), noma kokubili. Kalula nje, lapho la ma-hormone ebopha kula ma-receptor, amangqamuzana omdlavuza aqala ukukhula. Kodwa-ke, lezi zinhlobo zomdlavuza azinawo amazinga aphezulu eprotheyini ye-HER2. Yingakho zibizwa ngokuthi i-HR+/HER2-.

2. Umdlavuza webele one-hormone receptor kanye ne-HER2-negative (HR-/HER2-) :

Lolu hlobo luhlanganisa cishe amaphesenti ayi-11 (11%) azo zonke izinhlobo zomdlavuza webele. Lawa maseli omdlavuza awanazo i-receptor ze-estrogen noma i-progesterone. Futhi, njengoba kushiwo ngaphambili, iphrotheni ethi 'HER2' ayiphezulu. Lokhu kusho ukuthi ama-hormone noma iphrotheni ethi 'HER2' awekho anegalelo ekukhuleni kwalomdlavuza . Elinye igama lalokhu yi -'Triple-Negative Breast Cancer' . Lokhu kungenxa yokuthi i-estrogen receptor, i-progesterone receptor, kanye nephrotheni ethi 'HER2' konke 'akunawo' kulokhu.

Ziyini izimpawu zomdlavuza webele we-HER2-negative?

Eqinisweni, izimpawu zomdlavuza webele we-HER2-negative zifana kakhulu nezanoma yimuphi omunye umdlavuza webele. Kufanele uqaphele okulandelayo:

• Uma ubona ushintsho olungavamile ngobukhulu noma ngesimo sebele elilodwa noma womabili akho.
• Uma ubona iqhubu elisha, iqhubu, noma ukuqina ebeleni lakho noma ekhwapheni, ikakhulukazi uma iqhubu lingashintshi ngomjikelezo wakho wokuya esikhathini wanyanga zonke.
• Izinguquko esikhumbeni sebele noma ingono. Isibonelo:
• Ukufiphala kwesikhumba, njengekhasi le-orange
• Isikhumba siyashwabana, siyaqhuma
• Isikhumba esinamaqhubu
• Ukulunywa okuqhubekayo
• Umbala wesikhumba uyashintsha (obomvu, onsomi, onsundu, noma omnyama ngokungavamile).
• Ukuphuma kwezingono . Lokhu kungaba bomvu njengegazi, uketshezi olucacile, noma umbala omhlophe njengobisi (uma ungakhulelwe noma ungancelisi).
• Ukuguqulwa kwezingono (uma bekungenjalo ngaphambili).

Kubalulekile ukuqaphela ukuthi umdlavuza webele awuhlali ubangela izinguquko ezisobala endleleni obukeka ngayo . Futhi, eziningi zalezi zinguquko zingabonakala nasezimweni ezingengozi nezivamile (isib. ama-cysts, i-fibroadenoma). Yingakho kubaluleke kakhulu ukuqapha amabele akho njalo futhi uthole ukuhlolwa komdlavuza webele okuhambisana nobudala . Uma unenkinga ngoshintsho, qiniseka ukuthi ubona udokotela ukuze uthole ukuthi luyisibonakaliso somdlavuza noma esinye isimo.

Yini ebangela umdlavuza webele we-HER2-negative?

Kalula nje, umdlavuza webele we-HER2-negative ubangelwa izinguquko ezakhiweni zofuzo, noma i-DNA, emaseli ebele, okuthiwa yi-mutations , ezibangela lawo maseli ukuba abe amaseli omdlavuza. Lawa maseli omdlavuza abe esehlukana futhi ande ngokushesha ngaphandle kokulawula, akhe amathumba.

Izinto Eziyingozi

Ochwepheshe abakaqiniseki ukuthi iyini imbangela yangempela yalezi zinguquko zofuzo kumdlavuza webele we-HER2-negative. Kodwa-ke, bathole izici eziningana ezingandisa ingozi yokuba nomdlavuza webele. Lezi zifaka:

• Ukuguqulwa kwezakhi zofuzo okuzuzwe njengefa : Akukho ukuguqulwa kwezakhi zofuzo okuqondile okuhlotshaniswa nomdlavuza webele ohlobene ne-HER2. Kodwa-ke, uma umuntu ezuza ukuguquka kwezakhi zofuzo njenge-BRCA1 noma i-BRCA2, usengozini enkulu yokuba nomdlavuza webele (kanye neminye imidlavuza) ngokujwayelekile.
• Wena noma othile emndenini wakho uke waba nomdlavuza webele ngaphambili.: Uma wake waba nomdlavuza webele ngaphambili, unengozi ethile yokuthi ubuye. Futhi, uma izihlobo zakho zegazi (ikakhulukazi umama wakho, ubaba, izingane zakini, izingane) sezike zaba nomdlavuza webele, nawe unengozi ephezulu kancane.
• Ukuchayeka isikhathi eside kuma-hormone e-estrogen noma e-progesterone : Uma uqale ukuya esikhathini kwakho kokuqala usemncane (isib., ngaphambi kweminyaka eyi-12), noma uma uke wanqamuka ukuya esikhathini sekwephuzile (isib., ngemva kweminyaka engama-55), umzimba wakho ubulokhu uchayeka kula ma-hormone ocansi isikhathi eside. Lokhu kungaba yisici esiyingozi futhi. Ezinye izindlela zokwelapha esikhundleni sama-hormone nazo zingandisa ingozi yakho uma zithathwa isikhathi eside.
• Ukusetshenziswa kotshwala : Ucwaningo luthole ukuthi ukuphuza iziphuzo ezingaphezu kwesisodwa ezijwayelekile ngosuku kwandisa nengozi yomdlavuza webele.

Ngaphezu kwalokhu, izici ezinjengokukhula ngeminyaka, ukukhuluphala ngokweqile, kanye nokuntuleka kokuzilolonga nakho kungandisa ingozi yomdlavuza webele ngokujwayelekile.

Umdlavuza webele we-HER2-negative utholakala kanjani?

Odokotela bavame ukuxilonga umdlavuza webele ongemuhle we-HER2 nge- biopsy yebele . Lokhu kuhilela ukuthatha isampula encane (ucezu) lwezicubu esigaxeni noma endaweni esolisayo bese beyithumela elabhorethri. Lapho, udokotela wezifo uhlola isampula ngaphansi kwe-microscope ukuze abone ukuthi kukhona yini amangqamuzana omdlavuza.

Uma amangqamuzana omdlavuza eqinisekiswa, kwenziwa izivivinyo ezikhethekile ukuze kubonakale ukuthi ingakanani iphrotheni ethi `HER2` ekhona ebusweni balawo maseli omdlavuza, noma ukuthi mangaki amakhophi esakhi sofuzo esithi `HER2` akhona.

• Uma unenani elijwayelekile (eliphansi) leprotheni noma i-gene ethi `HER2`, unomdlavuza webele othi `HER2-negative`.

Ukuhlolwa okubili okuyinhloko kwelebhu okwenziwe ngale njongo yile:

1. I-Immunohistochemistry (IHC) : Lolu vivinyo lusebenzisa ama-antibodies athile kanye namadayi ukuthola iphrotheni ye-HER2 ebusweni bamaseli omdlavuza. Uma umphumela we-IHC ungu-0 noma u-1+, umdlavuza ubhekwa njengo-HER2-negative. Uma umphumela ungu-2+ (ngezinye izikhathi ubizwa ngokuthi "ongalingani" noma "umngcele"), ukuhlolwa okubizwa ngokuthi i-FISH kwenziwa futhi ukuqinisekisa isimo se-HER2.

2. I-Fluorescence in situ hybridization (FISH) : Lokhu kuhlola kubheka ukuthi mangaki amakhophi esakhi sofuzo se-HER2, esenza iphrotheni ye-HER2, akhona kumaseli omdlavuza. Lokhu kusebenzisa i-microscope ekhethekile kanye nama-fluorescent (light-emitting markers). Ezimweni lapho umphumela wokuhlolwa kwe-IHC ungaphelele, njengo-2+, ukuhlolwa kwe-FISH kungaqinisekisa ngokuqinisekile isimo se-HER2 (esibi noma esihle).

Ngaphezu kwalezi zivivinyo ze-`HER2`, udokotela wezifo uzohlola nesampula ye-biopsy futhi abheke ukuthi kukhona yini ama-estrogen receptors (ETU) kanye nama-progesterone receptors (PR) kumdlavuza.

Kungase kudingeke futhi ukuthi ube nezinqubo zokuthwebula izithombe ezifana ne-mammogram, i-ultrasound, i-CT scan, noma i-MRI scan ukuze uthole isigaba somdlavuza wakho (okungukuthi, ukubona ukuthi isimila sikhulu kangakanani nokuthi sesisakazekele yini kuma-lymph node noma kwezinye izingxenye zomzimba ezikude).

Udokotela wakho uzohlanganisa lonke lolu lwazi (isimo se-HER2, isimo se-HR, isigaba somdlavuza, kanye nezici zomdlavuza) ukuze adale uhlelo lokwelashwa olufanele kakhulu kuwe.

Yiziphi izindlela zokwelapha umdlavuza webele we-HER2-negative?

Ukwelashwa okungcono kakhulu komdlavuza webele one-HER2-negative kungahluka kumuntu nomuntu. Kuncike ezintweni eziningi, okuhlanganisa nesigaba somdlavuza wakho, kungakhathaliseki ukuthi une-hormone receptor-positive noma negative (HR+/HER2- noma HR-/HER2-), kanye nempilo yakho iyonke.

Ngokuvamile, ukwelashwa kungafaka:

• Ukuhlinzwa komdlavuza webele : Ukususwa kwesimila esinomdlavuza kanye nezicubu ezithile ezinempilo ezizungezile. Lokhu kungaba ukususwa kwe-lumpectomy, okususa ingxenye yebele, noma ukususwa kwe-mastectomy, okususa lonke ibele.
• Ukwelashwa ngemisebe : Imisebe enamandla aphezulu isetshenziselwa ukubhubhisa noma yimaphi amangqamuzana omdlavuza angase asale ngemva kokuhlinzwa, noma ukunciphisa isimila ngaphambi kokuhlinzwa.

Ngaphezu kwalezi zindlela zokwelapha eziyisisekelo, kunezinye izindlela zokwelapha ezithile kuye ngohlobo lomdlavuza:

Ukwelashwa komdlavuza webele we-HR+/HER2- (i-hormone receptor-positive, i-HER2-negative)

Ngenxa yokuthi lolu hlobo lomdlavuza luxhomeke kuma-hormone, lokhu kwelashwa kubalulekile futhi ngaphezu kokuhlinzwa kanye/noma ukwelashwa ngemisebe:

• Ukwelashwa ngama-hormone : Lokhu kwelashwa kusebenza ngokunciphisa amazinga ama-hormone i-estrogen noma i-progesterone esiza ukukhula komdlavuza, noma ngokuvimbela lawo ma-hormone ukuthi angabi yingxenye yamaseli omdlavuza. Isibonelo:
• Ama-inhibitor e-Aromatase (isib. i-Anastrozole, i-Letrozole, i-Exemestane)
• Ama-agonist e-Gonadotropin-releasing hormone (GnRH) (avimba ukukhiqizwa kwama-hormone avela kuma-ovary)
• `Ama-modulator e-estrogen receptor akhethiwe (ama-SERM)` (isib. i-Tamoxifen, i-Raloxifene)

Kwezinye izimo, kungadingeka ukuthi uhlinzwe (oophorectomy) ukuze kususwe ama-ovari akho, akhiqiza i-estrogen. Ukwelashwa ngama-hormone kunganikezwa kodwa noma kuhlanganiswe nokwelashwa okuqondiwe iminyaka eminingana.

• Ukwelashwa okuqondiwe : Lokhu kwelashwa kuhlose ubuthakathaka obuthile kumaseli omdlavuza futhi kuwahlasele ukuze kumiswe ukukhula nokusabalala kwamaseli omdlavuza. Kumdlavuza we-HR+/HER2, imithi ebizwa ngokuthi i-CDK4/6 inhibitors (isib. i-Palbociclib, i-Ribociclib, i-Abemaciclib) isetshenziswa kanye nokwelashwa ngama-hormone. Lokhu kuvimbela i-enzyme elawula ukuhlukana kwamaseli omdlavuza.
• Ukwelashwa ngamakhemikhali: Kwabanye umdlavuza webele we-HR+/HER2-, ikakhulukazi uma umdlavuza ususakazeke noma unolaka, odokotela bangase batuse ukwelashwa ngamakhemikhali kanye nokwelashwa ngama-hormone kanye/noma ukwelashwa okuqondiwe.

Ukwelashwa komdlavuza webele we-HR-/HER2- (triple-negative)

Ngenxa yokuthi umdlavuza webele onemiphumela emithathu awuxhomekile kuma-hormone, ukwelashwa ngama-hormone akusebenzi. Ngaphezu kokuhlinzwa kanye/noma ukwelashwa ngemisebe, kusetshenziswa kakhulu izindlela zokwelapha ezilandelayo:

• Ukwelashwa ngamakhemikhali : Ukwelashwa ngamakhemikhali kuyindlela ebaluleke kakhulu yokwelapha umdlavuza onemiphumela emithathu emibi. Odokotela basebenzisa izinhlobo ezahlukene zemithi yamakhemikhali. Bangase banikeze umuthi owodwa noma inhlanganisela yemithi eminingana.
• Ukwelashwa Ngezifo Ezithathelwana Ngomzimba : Lokhu ukwelashwa okusha kakhulu. Kusebenza ngokuvuselela amasosha omzimba wakho ukuze aqaphele futhi abhubhise amangqamuzana omdlavuza. I-Pembrolizumab (Keytruda®) umuthi wokwelapha ngezifo ezithathelwana ngomzimba ovunyelwe yi-Food and Drug Administration (FDA) futhi unikezwa kanye ne-chemotherapy kwezinye izinhlobo zomdlavuza webele one-triple-negative.
• Ukwelashwa okuqondiwe : Kumdlavuza onemiphumela emithathu emibi one-BRCA gene mutation, kusetshenziswa imithi eqondiwe ebizwa ngokuthi i-PARP inhibitors (isb., i-Olaparib, i-Talazoparib). Futhi, esifweni esisabalalayo, izinhlobo ezintsha zokwelapha eziqondiwe (isb., ama-antibody-drug conjugates) seziyatholakala manje.

Iyini imiphumela emibi yokwelashwa?

Nakuba ukwelashwa komdlavuza kungalwa ngempumelelo nomdlavuza, zonke izindlela zokwelapha, okuhlanganisa i-chemotherapy, ukwelashwa ngemisebe, ukwelashwa ngama-hormone, ukwelashwa okuqondiwe, kanye ne-immunotherapy, kungabangela imiphumela emibi ethile. Lokhu kungaba okwesikhashana noma isikhathi eside. Isibonelo, ukukhathala, isicanucanu, ukuhlanza, ukulahlekelwa izinwele, ukulahlekelwa isifiso sokudla, izilonda emlonyeni, izinguquko zesikhumba, isifo sohudo noma ukuqunjelwa, kanye nokubalwa kwamaseli egazi aphansi.

Qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi imiphi le miphumela emibi, izohlala isikhathi esingakanani, nokuthi ungayiphatha kanjani. Bangase bakuthumele kochwepheshe bokunakekelwa kobuhlungu . Ukunakekelwa kobuhlungu akugcini nje ngezigaba zokugcina zomdlavuza, kodwa futhi kukusiza ukuthi ugcine ikhwalithi yempilo yakho ngokulawula izimpawu nemiphumela emibi kulo lonke ukwelashwa.

Lingakanani izinga lokwelashwa komdlavuza webele we-HER2-negative?

Kuzo zonke izinhlobo zomdlavuza webele ze-HER2-negative, izinga lokusinda liphezulu kakhulu uma umdlavuza ugcinwe esifubeni futhi ungasakazekanga (isigaba sendawo) kunalapho umdlavuza ususakazeke ezithweni ezikude emzimbeni (isib., isibindi, amaphaphu, ubuchopho, amathambo) (umdlavuza osakazeka noma isigaba esikude).Izinga lokusinda komdlavuza osakazeke kuma-lymph node aseduze kuphela kodwa ongasakazekanga ezithweni ezikude (isigaba sesifunda) liphakathi nendawo.

Kodwa-ke, kubalulekile ukukhumbula ukuthi amathuba akho okululama, noma ukubikezela, ancike ezintweni ezithile ekuxilongweni kwakho. Lokhu kufaka phakathi ukuthi umdlavuza ususakazeke kangakanani (isigaba), ukuthi umdlavuza unesimo se-hormone receptor (HR+/HER2- noma HR-/HER2-), ukuthi amangqamuzana omdlavuza anolaka kangakanani (ibanga), iminyaka yakho, impilo iyonke, nokuthi usabela kanjani ekwelashweni. Lezi yizinto udokotela wakho angakhuluma nawe ngazo futhi akuchazele ukuthi yini ongayilindela. Izibalo ziyisilinganiso nje, futhi ngeke zifane kuwo wonke umuntu.

Ngizinakekela kanjani? (Ukuzinakekela)

Kungakhathaliseki ukuthi ungumuntu onomdlavuza webele we-HER2-negative osesigabeni sokuqala noma umuntu ophila nomdlavuza osuthuthukile, kubalulekile ukuzinika isikhathi sokuzinakekela. Lokhu kuzokusiza kokubili ngokomzimba nangokwengqondo. Nazi ezinye izinto ongazenza:

• Phumula uma udinga : Kujwayelekile ukuzizwa ukhathele futhi ukhathele, kokubili ngenxa yomdlavuza kanye nokwelashwa komdlavuza. Uma uzizwa ukhathele, thatha ikhefu uphumule. Lalela umzimba wakho.
• Yidla ukudla okunempilo nokunomsoco : Eminye imithi yokwelapha umdlavuza ingathinta isifiso sakho sokudla kanye nomuzwa wokunambitha. Kodwa zama ukudla ukudla okunempilo ukuze uthole izakhamzimba ezidingwa ngumzimba wakho. Faka izithelo, imifino, i-fiber, kanye nokudla okucebile ngamaprotheni. Uma ungaqiniseki ngokuthi yikuphi ukudla okufanele ukudle noma okungadli, khuluma nodokotela wezokudla ukuze uthole iseluleko.
• Ukuzivocavoca (kodwa ungakwenzi ngokweqile) : Kubalulekile ukwenza ukuzivocavoca njalo ezingeni elikufanele, njengoba kunconywa udokotela wakho. Ngisho nokuhamba kancane noma i-yoga kungaba kuhle. Kungakhulisa amandla akho, kuthuthukise imizwa yakho, futhi kusize ekunciphiseni imiphumela emibi. Kodwa-ke, buza udokotela wakho ukuthi hlobo luni lokuzivocavoca olukufanele nokuthi kufanele ukwenze okungakanani, ngokusekelwe ekuxilongweni kwakho kanye nokwelashwa kwakho.
• Lawula ukucindezeleka : Kuvamile ukuzizwa ucindezelekile, ukhathazekile, futhi wesaba ngenxa yesifo esinjengalesi. Thola izindlela zokusilawula esikusebenzelayo. Nakuba ukuzindla nokuzivocavoca ngokuphefumula kusebenza kwabanye, abanye bangase bakhethe ukuzibandakanya emisebenzini yokudala njengokufunda incwadi, ukulalela umculo, ukudweba, noma ukulima ingadi. Beka eceleni isikhathi esithile usuku ngalunye sanoma yimuphi umsebenzi okusiza uzizwe uzolile futhi ukhululekile.
• Thola ukwesekwa kwengqondo: Kubalulekile ukukhuluma ngemizwa yakho nomndeni nabangane abaseduze. Kungaba namandla kakhulu ukuxhumana nabanye ababhekene nokuxilongwa komdlavuza nokwabelana ngolwazi lwabo. Buza udokotela wakho ngamaqembu okusekela noma izinhlelo zokusinda kumdlavuza.

Kufanele ngimbone nini udokotela?

Kubaluleke kakhulu ukuhlala uxhumana nodokotela wakho njalo, kokubili ngesikhathi sokwelashwa nangemva kwalokho.

• Uma uba nezimpawu ezintsha (isib. ubuhlungu obuqhubekayo, iqhubu elisha, ubunzima bokuphefumula, ukwehla kwesisindo okungachazeki), noma uma izimpawu zakho zamanje zibonakala ziba zimbi kakhulu , bona noma wazise udokotela wakho ngokushesha .
• Ngemva kokwelashwa, udokotela wakho uzohlela ama-aphoyintimenti okulandelela ngezikhathi ezithile . Qiniseka ukuthi uyawagcina la ma-aphoyintimenti. Lokhu kuhloswe ukuhlola ukuthi aphinde abuye yini, ukuphatha imiphumela emibi yesikhathi eside yokwelashwa, nokuhlola inhlalakahle yakho iyonke. La ma-aphoyintimenti okulandelela abaluleke kakhulu eminyakeni emihlanu yokuqala ngemva kokwelashwa . Yilapho umdlavuza uvame ukuphinda ubuye khona.

Yimiphi imibuzo okufanele ngiyibuze udokotela wami?

Uma ukhuluma nodokotela wakho, ungesabi ukubuza noma yimiphi imibuzo onayo, kungakhathaliseki ukuthi mincane kangakanani. Nansi eminye imibuzo ongayibuza ukuze ikusize:

• Ingabe i-receptor yami ye-cancer hormone inhle noma ayinhle?
• Iyini uhlobo oluthile kanye nesigaba somdlavuza wami?
• Yiluphi uhlobo lokwelashwa ongincomayo? Kungani?
• Yimiphi imiphumela emibi yesikhathi esifushane neyesikhathi eside ongayilindela kulezi zindlela zokwelapha? Yini engenziwa ukuze incishiswe?
• Kuthatha isikhathi esingakanani ukwelashwa?
• Yini ongangitshela yona ngesibikezelo sami?
• Ngingaqhubeka nemisebenzi yami yansuku zonke (umsebenzi, imisebenzi yasekhaya) ngesikhathi sokwelashwa?
• Ingabe kukhona izinto ezikhethekile okudingeka ngizinake mayelana nokudla kwami ​​​​nokuzivocavoca umzimba?
• Yini engingayenza ukuze nginciphise ingozi yokubuya komdlavuza?
• Uma ngidinga izinsizakalo zokusekela noma ukwelulekwa, ngingayithola yini i-referral for it?

Kungumqondo omuhle ukubhala phansi le mibuzo bese uyibuza, ukuze ungakhohlwa lutho.

Kungcono yini ukuba ne-HER2-positive noma i-negative?

Lona umbuzo obuzwa abantu abaningi. Kodwa kunzima ukunikeza impendulo elula kulokhu, ngoba iqiniso liwukuthi 'kuya' .

Isibonelo, umdlavuza webele one-HER2 uvame ukukhula ngokushesha futhi ube nolaka kakhulu kunomdlavuza one-HER2. Kodwa-ke, kukhona inzuzo kulokhu. Kunezindlela zokwelapha ezithile ezingahlasela amaprotheni e-HER2, isibonelo, i-Herceptin, i-Perjeta, futhi zisebenza kahle kakhulu kumdlavuza one-HER2. Lezi zindlela zokwelapha azisebenzi kumdlavuza one-HER2, ngoba lawo mdlavuza awunawo amaprotheni amaningi e-HER2 okufanele uwahlasele.

Ngakolunye uhlangothi, uma umdlavuza we-`HER2-negative` ungowe-`HR+` (i-hormone receptor-positive), okungukuthi, uhlobo lwe-`HR+/HER2-`, khona-ke kunezindlela zokwelapha zama-hormone ezisebenza kahle kakhulu kanye nezindlela zokwelapha eziqondiwe njenge-`CDK4/6 inhibitors`. Eqinisweni, umdlavuza webele we-`HR+/HER2-` ubhekwa njengonesimo esihle kakhulu phakathi kwezinhlobo zomdlavuza webele ezikhona.

Kodwa uma umdlavuza u-`HER2-negative` (HR-) (i-hormone receptor-negative), okungukuthi, u-triple-negative, uvame ukuba nolaka kakhulu kunezinye izinhlobo, futhi ukwelashwa kungaba nzima kakhulu. Kodwa manje kukhona i-chemotherapy, i-immunotherapy, kanye nezindlela ezintsha zokwelapha eziqondiwe zalokho futhi.

Ngakho-ke, akunakwenzeka ukusho ukuthi enye "ingcono" noma "imbi kakhulu" kunenye. Into ebaluleke kakhulu ukuhlonza ngokunembile uhlobo oluthile lomdlavuza wakho bese uthola ukwelashwa okuphumelelayo kakhulu okufanele wona.

Ekugcineni, kufanele ngikutshele... (Umyalezo Wokuya Ekhaya)

Uma kutholakala ukuthi unomdlavuza webele othi `HER2-negative`, kuyinto evamile ukuzizwa wesaba futhi ukhathazekile. Kodwa khumbula, lokhu akusikho ukuphela komhlaba. Isayensi nobuchwepheshe bezokwelapha sekuthuthuke kakhulu namuhla, futhi kunezindlela eziningi zokwelapha eziphumelelayo zalolu hlobo lomdlavuza.

Into ebaluleke kakhulu yile:

• Ukwaziswa kahle ngalesi simo.
• Hlala uqaphele izinguquko emzimbeni wakho, ikakhulukazi amabele akho.
• Uma unemibuzo, bonana nodokotela ngesikhathi bese uhlolwa.
• Khuluma nodokotela wakho ngokukhululekile nangokwethembeka, ubuze yonke imibuzo yakho, futhi uthole ukuqonda okuhle ngezinketho zokwelapha.

Khumbula, awuwedwa kulolu hambo. Kukhona odokotela abanamakhono, abahlengikazi, umndeni wakho, kanye nabangane bakho abaseduze abakhona ukukusiza nokukusekela. Gcina isimo sengqondo esihle, landela imiyalelo yodokotela bakho ngqo, futhi uthole ukwesekwa okudingayo, futhi uzokwazi ukubhekana nalesi simo ngempumelelo futhi ululame. Kwangathi ungaqina!

Umdlavuza webele , i-HER2-negative, izimpawu zomdlavuza, ukwelashwa komdlavuza, impilo yabesifazane, ukwelashwa ngamahomoni, i-triple-negative