Ngiyazi ukuthi kunzima ukusho ngamazwi ukuthi uzizwa kanjani lapho udokotela wakho ekutshela ukuthi unomdlavuza webele. Kuvamile ukuba nemibuzo eminingi nokwesaba okufika engqondweni yakho. Kodwa enye yezinto ezibaluleke kakhulu ezingakusiza kulolu hambo olunzima ukuqonda uhlobo oluqondile lomdlavuza wakho. Ukwazi isigaba somdlavuza, uhlobo lwawo, ubukhulu bawo, kanye namanye amaprotheni asemaseli akho omdlavuza kubaluleke kakhulu ekunqumeni ukwelashwa.
Kalula nje, kuyini i-HER2-Negative?
Masiqonde lokhu ngale ndlela. Amaseli emzimbeni wethu afana nezindlu ezincane. Lezi zindlu zine-'antenna' ekhethekile ethola imiyalezo evela ngaphandle. Kwezokwelapha, sibiza lawa ma-receptor. Kukulezi zi-antenna lapho iseli lithola khona imiyalezo efana nokuthi 'ukukhula' nokuthi 'ukwahlukanisa'.
I-HER2 (Human Epidermal Growth Factor Receptor 2) ingenye ye-antenna ekhethekile. I-HER2 isiza ukulawula ukukhula kwamaseli anempilo. Kodwa-ke, amaseli omdlavuza ngezinye izikhathi enza kakhulu le-antenna ye-HER2, okungaphezu kakhulu kokujwayelekile. Ngemuva kwalokho umdlavuza uthola umyalezo oqhubekayo othi 'ukhule', bese umdlavuza uqala ukusabalala ngokushesha okukhulu. Lesi simo sibizwa ngokuthi i-HER2-Positive .
Ngakho-ke, uma udokotela wakho ethi umdlavuza wakho webele awunayo i-HER2 , lokho kusho ukuthi amangqamuzana akho omdlavuza awanalo lolu hlobo lwe-HER2. Kalula nje, umdlavuza wakho awunayo into ebalulekile ewenza ukhule ngokushesha.
Empeleni lokhu kuyizindaba ezinhle ngezinga elithile, ngoba umdlavuza we-HER2-negative uvame ukuba nolaka oluncane kunemidlavuza ye-HER2-positive. Iningi lomdlavuza webele emhlabeni lihlukaniswa njenge-HER2-negative.
Ukwazi kanjani kahle isimo se-HER2 somdlavuza wakho?
Izimpawu zomdlavuza we-HER2-negative kanye nowe-HER2-positive ziyafana. Udokotela wakho akakwazi ukukutshela ukuthi uluhlobo luni onalo ngokukuhlola nje. Uzodinga ukuthatha isampula encane yesimila sakho (i-biopsy) bese esihlola. Lokhu kuhlolwa kuzonquma ukuthi ingakanani iphrotheni ye-HER2 esemaseli omdlavuza.
Kudingeka sibheke okungaphezu nje kwe-HER2!
I-HER2 akuyona yodwa into ethinta ukukhula komdlavuza. Kunezinye izinhlobo ezimbili zama-receptor ( ama-hormone receptors - i-HR) emzimbeni wethu ezizwela ama-hormone.
- Ama-Estrogen Receptors (ER)
- Ama-Progesterone Receptors (PR)
Uma la ma-receptor ekhona kumaseli omdlavuza, ama-hormone i-estrogen ne -progesterone angasiza umdlavuza ukuthi ukhule. Odokotela baxoxa ngazo zonke lezi zi-receptor ndawonye. Lokhu kusho ukuthi umdlavuza wakho we-HER2-negative ungahlukaniswa ngezinhlobo ezimbili:
1. HR-Positive / HER2-Negative: Lokhu kusho ukuthi umdlavuza awuzweli ku-HER2, kodwa uzwela kuma-hormone. Lolu uhlobo oluvame kakhulu lomdlavuza webele.
2. I-HR-Negative / I-HER2-Negative: Lokhu kusho ukuthi umdlavuza awuzweli ku-HER2 noma kuma-hormone. Ngenxa yokuthi wonke la ma-receptor amathathu (i-HER2, i-ER, i-PR) awatholakali, lolu hlobo lubizwa nangokuthi i-Triple Negative .
Ukwazi zonke lezi zici kuzokusiza wena nodokotela wakho nithole isithombe esicacile ngokuziphatha komdlavuza wakho, okuzokusiza ukuthi ukhethe indlela yokwelapha efanele futhi ephumelelayo kakhulu kuwe.
Yiziphi izindlela zokwelapha umdlavuza we-HER2-negative?
Ngenxa yokuthi umdlavuza wakho awunayo i-HER2, ngeke unikezwe ukwelashwa okuqondiwe, okuqondiswe kuphrotheni ye-HER2. Lokho kungenxa yokuthi imithi idinga ukuba ne-antenna ye-HER2 kumaseli omdlavuza ukuze isebenze. Esikhundleni salokho, ezinye izindlela zokwelapha zizokhethwa ngokusekelwe esigabeni somdlavuza wakho nokuthi ngabe uyazwela yini kuma-hormone.
- Ukuhlinzwa kanye nemisebe: Uma umdlavuza utholakala kusenesikhathi, ukuhlinzwa kungawususa ngokuphelele. Ukwelashwa ngemisebe nakho kunganconywa ngaphambi noma ngemva kokuhlinzwa.
- Ukwelashwa nge-Endocrine/ Hormone : Lokhu kwelashwa kubaluleke kakhulu uma umdlavuza wakho une-HR-Positive/HER2-Negative. Kusebenza ngokunciphisa amazinga ama-hormone afana ne-estrogen emzimbeni. Uma ama-hormone engasekho, amangqamuzana omdlavuza alahlekelwa umyalezo wokukhula, futhi umdlavuza ungase unciphe noma uyeke ukukhula.
- Ukwelashwa ngamakhemikhali: Ukwelashwa ngamakhemikhali ngezinye izikhathi kunganikezwa kanye nokwelashwa ngama-hormone komdlavuza one-HR-positive/HER2-negative. Lokhu kuncike ezicini ezifana nesigaba kanye nezinga lomdlavuza, iminyaka yakho, kanye nempilo yakho iyonke. Ngezinye izikhathi imiphumela emibi ye-chemotherapy ingadlula izinzuzo, ngakho -ke kubalulekile ukukhuluma nodokotela wakho ngalokho okungcono kakhulu kuwe.
- Ukwelashwa Ngezifo Ezingalawuleki: Uma umdlavuza wakho ungemuhle kathathu futhi usuthuthuke kakhulu, futhi unenye iphrotheni ebizwa ngokuthi i-PD-L1, lokhu kwelashwa kungaba yindlela ongakhetha kuyo. Kusebenza ngokuvuselela amasosha omzimba wakho ukuze alwe nomdlavuza.
Umbono kanye Nokubikezela
Into ebaluleke kakhulu ngomdlavuza webele ukuwuthola ngaphambi kokuba usakazekele kwezinye izingxenye zomzimba. Uma umdlavuza wakho we-HER2-negative utholakala ebeleni, izinga lokusinda kweminyaka emihlanu liphezulu kakhulu. Lokhu kuyiqiniso ikakhulukazi uma umdlavuza wakho une-HR-positive.
Umdlavuza onemiphumela emithathu kunzima kakhulu ukuwuphatha ngoba awusabeli ekwelashweni ngama-hormone noma ekwelashweni okuqondiswe ku-HER2. Ungaba nolaka kakhulu.
Ngezansi amazinga okusinda eminyaka emihlanu asekelwe esigabeni somdlavuza. Lokhu kumane kuyisilinganiso, khumbula ukuthi isimo sakho singase sihluke.
| Uhlobo lomdlavuza | Indlela okusabalale ngayo | ukusinda okuhlobene kweminyaka emihlanu |
|---|---|---|
| I-HR-Positive / HER2-Negative (Uhlobo oluvame kakhulu) | Kunqunyelwe ebeleni (Okwenziwe endaweni ethile) | 100% |
| Sabalalisa kuma-lymph node aseduze (esifunda) | 90% | |
| Kude | 31% | |
| Okubi Kathathu (HR-Negative / HER2-Negative) | Kunqunyelwe ebeleni (Okwenziwe endaweni ethile) | 91% |
| Sabalalisa kuma-lymph node aseduze (esifunda) | 65% | |
| Kude | 12% |
Ungakhathazeki ngalezi zinombolo. Lezi yizilinganiso nje ezivela ezinkulungwaneni zabantu. Umbono wakho ngamunye uzoncika ezintweni eziningi, okuhlanganisa nendlela umzimba wakho osabela ngayo ekwelashweni kanye nempilo yakho iyonke. Ngakho-ke, vuleleka kudokotela wakho ngesimo sakho kanye nanoma yiziphi izivivinyo ezengeziwe ongase uzidinge.
Umlayezo Wokuya Nawe Ekhaya
- I-HER2-Negative isho ukuthi amangqamuzana akho omdlavuza awanalo iphrotheni ebalulekile ewenza akhule ngokushesha. Lokhu kuvame ukwenza la magciwane angabi nolaka.
- Ngisho noma umdlavuza wakho ungenayo i-HER2, ukwazi ukuthi uyazwela yini kuma-hormone (HR-positive) noma cha (HR-negative) kubalulekile ekunqumeni ukwelashwa.
- Izinketho zokwelapha zincike ohlotsheni kanye nesigaba somdlavuza, kanye nempilo yakho. Ukuhlinzwa, ukwelashwa ngemisebe, ukwelashwa ngama-hormone, kanye ne-chemotherapy yizona zindlela zokwelapha eziyinhloko.
- Le mpi nomdlavuza akuyona into okufanele uyenze wedwa. Khuluma nodokotela wakho ngayo yonke imibuzo yakho kanye nokwesaba kwakho. Ukuba nolwazi olufanele kungamandla akho amakhulu kulolu hambo.
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