Ingabe uhlala ukhathele? Ingabe lokhu kungaba inkinga ngendlala yakho ye-pituitary? (Ukungabi naso isifiso sokudla)

Ingabe ngezinye izikhathi uzizwa sengathi umzimba wakho ubuthakathaka, sengathi kukhona okushodayo? Mhlawumbe isizathu salokhu inkinga encane kwenye yezindlala ezincane kakhulu, kodwa ezibaluleke kakhulu emzimbeni wakho. Namuhla sizokhuluma nge -hypopituitarism , isimo esingavamile esenzeka endlaleni ye-pituitary . Ungakhathazeki, sizokhuluma ngalokhu kalula, ngendlela ongayiqonda.

Kuyini i-hypopituitarism?

Kalula nje, i-hypopituitarism yilapho i-pituitary gland yakho ingakhiqizi ama-hormone anele. Manje cishe uyazibuza ukuthi lawa ma-hormone ayini. Ama-hormone afana nezithunywa zamakhemikhali ezithwala imiyalezo yokwenza imizimba yethu isebenze kahle. Ama-hormone e-pituitary alawula izinto eziningi, okuhlanganisa i-metabolism yethu, ukukhula komzimba, intuthuko yocansi, kanye nokuzala.

Cabanga ngakho njengesikhungo esincane somyalo emzimbeni wethu, i-pituitary gland. Kodwa ayisebenzi yodwa. Isizwa enye ingxenye ebalulekile yobuchopho ebizwa ngokuthi i-hypothalamus . I-hypothalamus itshela i-pituitary gland ukuthi, "Kulungile, khipha i-hormone manje." I-hypothalamus ilawula nezinto ezifana nomfutho wegazi, ukushaya kwenhliziyo, izinga lokushisa komzimba, kanye nokugaya ukudla. Ngakho-ke, uma kukhona umonakalo noma isifo ku-pituitary gland noma ku-hypothalamus, ungahlakulela i-hypopituitarism.

Lesi simo singavela ngokuzumayo, ngisho nangemva kwengozi. Noma singakhula kancane kancane ezinyangeni noma eminyakeni. Ngokuvamile, laba bantu kuzodingeka baphuze imithi impilo yabo yonke ukuze balawule izimpawu zabo. Kodwa ungakhathazeki, udokotela wakho uzokuqapha eduze futhi akunikeze ukwelashwa okudingekayo.

Ingabe kunezinhlobo ezahlukene ze-hypopituitarism?

Yebo, ingahlukaniswa ngezinhlobo ezimbili eziyinhloko. Enye isekelwe ekutheni ingakanani i-hormone entulekayo .

• Ukuntuleka kwe-pituitary okuhlukanisiwe: Kulokhu, i-hormone eyodwa kuphela ye-pituitary iyantula.
• Ukuntuleka kwama-hormone amaningi e-pituitary: Lokhu kwenzeka lapho ama-hormone amabili noma ngaphezulu e-pituitary entula.
• I-Panhypopituitarism: Lesi yisimo esingesibi kangako lapho wonke ama-hormone akhiqizwa yi-pituitary gland encishiswa khona.

Okulandelayo, zihlukaniswa ngokwembangela kanye nendlela i-pituitary gland ethinteka ngayo :

• I-hypopituitarism eyinhloko: Lokhu kubangelwa umonakalo noma isifo esithinta ngqo indlala ye-pituitary.
• I-hypopituitarism yesibili: Lokhu kubangelwa umonakalo noma isifo ku-hypothalamus. Khumbula, i-hypothalamus yiyo enikeza iziyalezo ku-pituitary gland.
• Idiopathic hypopituitarism: Ngezinye izikhathi imbangela ayitholakali.

Ziyini izimpawu ze-Hypopituitarism?

Izimpawu ziyahlukahluka kuye ngokuthi i-hormone ayisebenzi kahle yini . Izici ezilandelayo nazo zidlala indima:

• Ubulili bakho.
• Uneminyaka yakho lapho lesi simo saqala khona .
• Imbangela ye-hypopituitarism.
• Indlela ama-hormone ancipha ngayo ngokushesha .

Manje ake sibone ukuthi yiziphi izimpawu ezibonakala lapho i-hormone ngayinye iphansi.

Izimpawu Zokuntuleka Kwe-hormone Yokukhula (GH)

Kwabasanda kuzalwa:

• Amazinga kashukela aphansi egazini (i-Hypoglycemia) .
• Ukuba nepenis yowesilisa encane ngendlela engavamile (Micropenis) .

Kwabantwana abancane:

• Ukukhula kuhamba kancane noma cishe akukho nhlobo. Isibonelo, uma ingane yakho ibonakala ingakhuli isikhathi eside uma iqhathaniswa nezinye izingane ezineminyaka yayo, lokhu kungaba uphawu lwalokhu.
• Ukuphakama okufushane .
• Ukukhula kocansi okubambezelekile noma okungekho ngesikhathi sokuthomba.

Kwabantu abadala:

• Ukukhathala okukhulu okuqhubekayo . Ukuzizwa sengathi ibhethri liphelile.
• Ukuzizwa ungajabule futhi unganelisekile ngempilo.
• Ukuncipha komsebenzi wobulili kanye nesifiso .
• Ukwanda kokugcwala kwamafutha, ikakhulukazi eduze kwesinqe .
• Ukuncipha kokubekezelela ukubanda nokushisa .
• Ukuncipha kwesisindo semisipha .
• Ukuncipha kwamandla nokukhuthazela lapho uzivocavoca.

Izimpawu zokuntuleka kwe-thyroid-stimulating hormone (TSH)

Kwabasanda kuzalwa:

• Ukuncipha kwethoni yemisipha (imilenze izizwa ingenampilo).
• Izinga lokushisa lomzimba eliphansi (i-Hypothermia) .
• Ukuzizwa uvuvukele .
• Ekhala ngezwi elihoshozelayo nelingenasithelo .

Kwabantwana abancane kanye nabantu abadala:

Izimpawu zalokhu zifana neze- hypothyroidism , ngoba i-hormone ye-TSH ivuselela i-thyroid gland ukuthi ikhiqize ama-hormone ayo.

• Ukukhathala okukhulu .
• Isikhumba esomile kanye nokuncipha/ukulahlekelwa izinwele .
• Ukuqunjelwa .
• Ukwanda kwesisindo .
• Ubuthakathaka bemisipha .
• Ukwehla kwamandla okubekezelela umkhuhlane .
• Izimo zengqondo ezifana nokucindezeleka .
• Abesifazane bangase babe nokuya esikhathini okungajwayelekile noma ukopha okukhulu kunokuvamile .

Izimpawu zokuntuleka kwe-Follicle-Stimulating Hormone (FSH) kanye/noma i-Luteinizing Hormone (LH)

I-FSH ne-LH ama-hormone abizwa ngokuthi ama-gonadotropin . Lawa athinta ngqo uhlelo lwethu lokuzala .

Kwabafana abasanda kuzalwa:

• Ukuba nepenis yowesilisa encane ngendlela engavamile (Micropenis) .
• Amasende angakafiki phansi .

Kwabantwana abancane:

• Ukuntuleka kokukhula kwamabele emantombazaneni.
• Amasende abafana awakhuli .
• Umzimba awubi nokukhula okusheshayo (ukukhula okusheshayo) ngesikhathi sokuthomba.

Kwabesilisa:

• Ukuncipha kwesifiso socansi .
• Ukukhathala okukhulu .
• Ukungazali .
• Ukungasebenzi kahle kwe-Erectile .
• Ukulahlekelwa izinwele ebusweni noma emzimbeni .

Kwabesifazane:

• Isifiso sobulili esiphansi .
• Ukukhathala okukhulu .
• Ukungazali .
• Ukushisa komzimba - Ukuzwa ukushisa okungazelelwe emzimbeni.
• Ukuya esikhathini okungajwayelekile noma ukuyeka ngokuphelele ukuya esikhathini (i-Amenorrhea) .
• Ukulahlekelwa izinwele esiswini esingezansi .
• Ukwehluleka ukukhiqiza ubisi lwebele ngemva kokubeletha umntwana .

Izimpawu Zokuntuleka Kwe-Adrenocorticotropic Hormone (ACTH noma i-Corticotropin)

Kwabasanda kuzalwa:

• Amazinga kashukela aphansi egazini (i-Hypoglycemia) .
• Ukukhuluphala kancane kakhulu (Ukwehluleka ukukhula kahle) . Kufana nokuthi ingane ayinceli ngisho noma iphuza ubisi olwanele.
• Ukuquleka .
• Ukuphuzi kwesikhumba (i-Jaundice) .

Kwabantwana abancane kanye nabantu abadala:

• Ukukhathala okukhulu .
• Ukwehlisa isisindo ngaphandle kwesizathu .
• Umfutho wegazi ophansi (i-Hypotension) .
• Isicanucanu nokuhlanza .
• Amazinga kashukela aphansi egazini (i-Hypoglycemia) .
• Ukudideka, ukulahlekelwa ukwazi .

Izimpawu zokuntuleka kwe-Prolactin

Isici esiyinhloko salokhu ukuntuleka kokukhiqizwa kobisi lwebele ngemva kokubeletha umntwana .

Izimpawu Zokuntuleka kwe-Oxytocin

• Izinkinga zokuncelisa ngemva kokuzalwa komntwana.
• Ubunzima bokusondelana nomntwana ngemva kokuzalwa.
• Ukuntuleka kozwela ngokuhlupheka kwabanye.
• Ubunzima bokuxhumana nabanye.

Izimpawu Zokuntuleka Kwe-Antidiuretic Hormone (ADH noma i-Vasopressin noma i-Arginine Vasopressin)

Kwabasanda kuzalwa:

• Ukuhlanza .
• Umkhuhlane ongaziwa imbangela .
• Ukukhala ngokweqile .
• Ukwehlisa isisindo .
• Ukuqunjelwa .
• Ukumanzisa njalo ama-napkin (Ama-napkin amanzi kakhulu) .

Kwabantwana abancane:

• Ubunzima ekuqeqesheni indlu yangasese .
• Ukuchama Embhedeni .
• Ukukhathala ngokushesha .

Kwabantu abadala:

• Ukuchama njalo .
• Ukoma ngokweqile .
• Ukungalingani kwe-electrolyte .

Okubalulekile: Ungakhathazeki uma unesinye noma ezimbili zalezi zimpawu, kodwa uma ziqhubeka, kungcono ukufuna iseluleko sezokwelapha.

Ziyini izimbangela ze-hypopituitarism?

Kungaba nezizathu eziningi zalesi simo. Ngezinye izikhathi ngisho nodokotela abakwazi ukukhomba imbangela eqondile. Ngokuvamile, ingabangelwa izinto ezintathu eziyinhloko:

1. Ukucindezela i-pituitary gland noma i-hypothalamus.

2. Ukulimala kwendlala ye-pituitary noma i-hypothalamus.

3. Ukuba nesimo sezokwelapha esingavamile noma esinye isifo esibangela i-hypopituitarism.

Izimo ezithinta i-pituitary gland noma i-hypothalamus

Izimo ezingabeka ingcindezi kulezi zingxenye zobuchopho futhi zibangele i-hypopituitarism zifaka:

• Ama-adenoma e-pituitary: Lawa amathumba angenabungozi akha endlaleni ye-pituitary. Angashintsha indlela ama-hormone akhiqizwa ngayo.
• Izimila zobuchopho: Izimila ezikhula eduze kwe-hypothalamus noma i-pituitary gland zingaphazamisa ukukhiqizwa kwama-hormone.
• I-Lymphocytic hypophysitis (LH): Lesi yisimo esingavamile. Lapha, amaseli abizwa ngokuthi ama-lymphocyte ahlasela i-pituitary gland. (Le LH akufanele ididaniswe ne-Luteinizing Hormone okukhulunywe ngayo ngaphambili, akunjalo?!)
• I-pituitary noma i-hypothalamus sarcoidosis: I-Sarcoidosis yisifo esibangela ukuvuvukala.

Izehlakalo ezilimaza i-pituitary gland noma i-hypothalamus

• Ukuhlinzwa: Izinkinga ngesikhathi sokuhlinzwa kobuchopho (ikakhulukazi ukuhlinzwa kokususa ama-adenoma e-pituitary).
• Ukwelashwa ngemisebe: Ukwelashwa ngemisebe okwakusetshenziswa ekwelapheni ukwelashwa komdlavuza kwangaphambilini noma ama-pituitary adenomas.
• Ukulimala okukhulu ekhanda (Ukulimala kobuchopho okubuhlungu - i-TBI):Izinto ezifana nezingozi zezimoto, ukuwa, kanye nokulimala kwezemidlalo.
• I-pituitary apoplexy: Ukubhujiswa okungazelelwe kwezicubu ze-pituitary gland.

Izimo zezokwelapha ezingavamile

• I-hemochromatosis ezuzwe njengefa: Lesi yisimo sofuzo. Sibangela ukuthi i-iron eningi iqongeleleke egazini. Lokhu kungalimaza i-pituitary gland.
• I-meningitis yamabhaktheriya: Nakuba ingavamile, i-hypopituitarism ingenzeka njengenkinga ye-meningitis yamabhaktheriya.
• Ukuguquka kwezakhi zofuzo: Ezinye izimo zezakhi zofuzo ezingavamile zingabangela ukuntuleka kwamahomoni e-pituitary.

Yiziphi izinto ezibangela ingozi?

Izimo noma izehlakalo ezilandelayo zingaba yizinto ezibangela i-hypopituitarism:

• Njengoba ngike ngabhekana nokwelashwa komdlavuza kanye nemisebe ngaphambilini.
• Ukulimala ekhanda noma ebuchosheni: Phakathi kuka -27% no-32% wabantu abaye balimale ekhanda ngenxa yokulimala okubuhlungu (i-TBI) bahlakulela i-hypopituitarism.
• I-anemia ye-sickle cell: Lesi sifo singabangela ukuntuleka kwama-hormone e-pituitary.
• Isifo sikashukela sohlobo 1: Ukulimala kwemizwa nemithambo yegazi okubangelwa isifo sikashukela sohlobo 1 esingalawuleki kungaba nomthelela kulesi simo.
• Ukukhulelwa Nokubeletha: Ukopha ngokweqile ngemva kokubeletha kungalimaza indlala ye-pituitary. Lesi simo sibizwa ngokuthi i-Sheehan syndrome .

Izinkinga ezingaba khona

Ukuntuleka kwama-hormone okuhambisana ne-hypopituitarism kungaholela ekuthuthukisweni kwezinye izimo. Le miphumela iyahlukahluka kuye ngokuthi i-hormone ayiphelele. Nazi ezinye izibonelo:

• Ukuntuleka kwe-GH (i-hormone yokukhula) kungabangela ukukhuluphala , i-cholesterol ephezulu , kanye nesifo se-metabolic syndrome .
• Ukuntuleka kwama-hormone e-estrogen (ngenxa yokuntuleka kwe-FSH) kungabangela i-osteoporosis ( ukuncipha kwamathambo) kwabesifazane.
• Ukuntuleka kwe-ACTH kungabangela inkinga yezindlala ze-adrenal , isimo esiphuthumayo esisongela impilo.

Yiziphi izivivinyo ezenziwayo ukuze kutholakale lesi simo?

Udokotela wakho angayala noma yikuphi kwalokhu kuhlolwa ukuze ahlole i-hypopituitarism:

• Ukuhlolwa kwegazi kwamazinga ama-hormone: Kuye ngezimpawu zakho, udokotela wakho angase akuyalele ukuhlolwa kwegazi okulinganisa amazinga ahlukahlukene ama-hormone.
• Ukuhlolwa kokukhuthazwa kwama-hormone: Kulokhu kuhlolwa, udokotela wakho uzokunikeza umuthi wokuvuselela i-pituitary gland yakho ukuthi ikhulule i-hormone ehlolwayo. Ngemuva kwalokho, kuthathwa isampula yegazi bese ithunyelwa elabhorethri ukuze ihlolwe.
• Ukuhlolwa kokubekezelela i-insulin: Lokhu kungabona ukuntuleka kwe-hormone yokukhula (GH) kanye ne-ACTH.
• Ukuhlolwa kwe-Osmolality kwegazi nomchamo: Lokhu kuhlolwa kokuntuleka kwe-antidiuretic hormone (ADH).
• I-MRI (Magnetic Resonance Imaging) Scan: I-MRI scan ithatha izithombe ezinemininingwane zengaphakathi lomzimba wakho. I-MRI scan yobuchopho ibhekwa njengendlela engcono kakhulu yokuthola izimila ze-pituitary ezibangela i-hypopituitarism.
• Iskeni se-Brain CT (Computed Tomography): Lokhu kuhlolwa kungasetshenziswa ukubona ukuthi kukhona yini isimila sobuchopho noma i-pituitary adenoma ebangela lesi simo.

Iphathwa kanjani i-hypopituitarism?

Nakuba kungekho ikhambi, lingelashwa . Ukwelashwa kuncike ekutheni yimaphi ama-hormone antulayo nokuthi yini ebangela isimo sakho . Ithimba lakho lezokwelapha lizokusiza ukuthi wakhe uhlelo lokwelashwa olukulungele kangcono. Izinketho zokwelapha ezivamile zifaka:

• Ukwelashwa kokushintsha ama-hormone: Umgomo walokhu ukubuyisela ama-hormone e-pituitary anciphile emazingeni ajwayelekile. Ezimweni eziningi, imithi kumele ithathwe impilo yakho yonke.
• Ukuhlinzwa: Abantu abane-pituitary adenomas bangadinga ukuhlinzwa ukuze basuswe.
• Ukwelashwa ngemisebe: Ukwelashwa ngemisebe kungasiza ekunciphiseni ama-adenoma e-pituitary.

Udokotela wakho angase futhi akuncome ukuthi uphathe ikhadi le-ID yezokwelapha noma isongo ngaso sonke isikhathi, uma kwenzeka isimo esiphuthumayo.

Iyini iphrojekthi ye-hypopituitarism?

Umbono uyahlukahluka, kuye ngalezi zici:

• Ubudala bakho lapho izimpawu zakho zaqala khona .
• Isizathu sesimo sakho .
• Ukuthi ama-hormone aphansi kangakanani .
• Indlela umzimba wakho osabela ngayo ekwelashweni .

Abantu abaningi abane-hypopituitarism baphila impilo enempilo. Kodwa-ke, uma kukhona ukulimala kwe-pituitary kwesikhathi eside, isikhathi sokuphila singase sibe sifushane kancane kunesomuntu oneminyaka efanayo ongenaso lesi simo. Kodwa-ke, isikhathi sokuphila ngokuvamile asinciphisi kulabo abalandela uhlelo lokwelashwa olufanele .

Kuthiwani uma kukhona isimo esiphuthumayo? Uma i-hypopituitarism ikhula ngokuzumayo, iba nkulu, futhi ingelashwa, kungaba yisimo esiphuthumayo sezokwelapha futhi iholele ngisho nasekufeni. Ngakho-ke uma ubona izimpawu, bona udokotela ngokushesha.

Kufanele ngimbone nini udokotela?

Ezimweni eziningi, i-hypopituitarism idinga ukuqapha ngokucophelela impilo yonke kwama-hormone athintekile. Bona udokotela wakho njalo ukuqinisekisa ukuthi uhlelo lwakho lokwelashwa luyasebenza.Uma unezimpawu ezintsha noma ezikhathazayo, xhumana nodokotela wakho ngokushesha okukhulu.

Yimiphi imibuzo okufanele ngiyibuze udokotela wami?

Uma kutholakale ukuthi une-hypopituitarism, ungase ufune ukubuza udokotela wakho le mibuzo:

• Uhlobo luni lwe-hypopituitarism enginalo?
• Yimaphi ama-hormone aphansi kimi?
• Iyini imbangela yalokhu?
• Yiziphi izindlela zokwelapha enginazo?
• Ingabe ikhona imiphumela emibi evela ekwelashweni kwami?
• Ngidinga ukuthatha umuthi isikhathi esingakanani?
• Ingabe lokhu kuzothinta ukuzala kwami?
• Ingabe lokhu kuzothinta ukukhulelwa kwami?
• Ingabe lokhu kungenzeka nasezinganeni zami?

Okokugcina, khumbula (Umyalezo Wokuya Ekhaya)

Ukuxilongwa okusha kungaba yinto esabekayo, kodwa ungesabi ukubuza udokotela wakho imibuzo mayelana ne-hypopituitarism. Ezimweni eziningi, ukwelashwa impilo yonke kanye nokuqapha ama-hormone kuyadingeka. Yingakho kubalulekile ukubona udokotela wakho njalo. Uma unezimpawu ezintsha noma ezikhathazayo, xhumana nodokotela wakho. Bakhona ukukusiza. Ngokuphathwa okufanele, ungaphila impilo enempilo nesebenzayo.

i- hypopituitarism, i-pituitary gland, ama-hormone, ukuntuleka kwama-hormone, i-hypothalamus, i-growth hormone, i-thyroid, i-adrenal, i-Sri Lanka Health, i-pituitary gland, ukuntuleka kwama-hormone