Ingabe uqala usuku lwakho ngokuqina komhlane nobuhlungu ngokushesha nje lapho uvuka ekuseni? Ingabe lobu buhlungu buyancipha uma uhamba kancane, wenze okuthile okuwusizo, futhi buyanda futhi uma umile? Lezi zingaba izimpawu ezivamile zesifo esibizwa ngokuthi i-Ankylosing Spondylitis (AS). Lesi yisimo esicasulayo ngempela esiphazamisa impilo yansuku zonke. Njengokwelashwa kwalokhu, odokotela baqale bakunike imithi yobuhlungu (ama-NSAID). Uma lokhu kungalawuli lesi sifo, bangakudlulisela emijovweni ebizwa ngokuthi i-biologics. Kodwa-ke, abanye abantu abatholi impumuzo kulezi zindlela zokwelapha, noma imiphumela yazo emibi kunzima ukuyibekezelela. Ingabe ubhekene nento efanayo? Uma kunjalo, ungakhathazeki. Ngokuthuthuka kwesayensi yezokwelapha, sekuvele okunye ukwelashwa okusha nokuphumelelayo. Lokho yi -Janus Kinase (JAK) inhibitors . Ake sixoxe ngalokhu namuhla.
Ayini ama-JAK Inhibitors?
Ama-JAK inhibitors ayiqembu elisha lemithi yokwelapha i-ankylosing spondylitis. Njenge-biologics, angaphansi kweqembu lemithi ebizwa ngokuthi izidakamizwa ezilwa namathambo eziguqula izifo (DMARDs). "Ukuguqula izifo" kusho ukuthi le mithi ayinciphisi ubuhlungu kuphela. Iphinde ilawule umonakalo emgogodleni nakwamanye amalunga, inciphise ukuqhubeka kwesifo.
Kodwa lezi azisetshenziselwa i-Ankylosing Spondylitis kuphela. Lolu hlobo lomuthi luvunyelwe nakwezinye izifo eziningana zokuzivikela komzimba. Okungukuthi, izifo lapho amasosha omzimba ahlasela khona amangqamuzana awo.
- Isifo samathambo esibizwa ngokuthi i-rheumatoid arthritis
- I-polyarticular course juvenile idiopathic arthritis (JIA)
- I-Psoriatic arthritis
- I-ulcerative colitis
Into ekhethekile ukuthi ungawathatha lawa njengamaphilisi esikhundleni sokuthola imijovo efana ne-biologics. Ngakho-ke lokhu kuyimpumuzo enkulu kulabo abesaba imijovo.
Yiziphi izinhlobo ezisetshenziswayo ze-Ankylosing Spondylitis?
Njengamanje, izinhlobo ezimbili zama-JAK inhibitors zivunyelwe ukwelapha i-Ankylosing Spondylitis.
- I-Tofacitinib (igama lomkhiqizo: Xeljanz, Xeljanz-XR)
- I-Upadacitinib (igama lomkhiqizo: Rinvoq)
Lokhu kuvame ukunikezwa iziguli ezinezimpawu ezingalawulwanga ngomuthi owodwa noma ngaphezulu we-biologic obizwa ngokuthi ama-TNF inhibitors, noma ezingakwazi ukubekezelela imiphumela emibi yaleyo mithi. Ngakho-ke, udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ophelele ngaphambi kokukunikeza lo muthi.
Lomuthi usebenza kanjani?
Ukuze siqonde lokhu, ake sithathe isibonelo esincane. Cabanga ukuthi amasosha omzimba wethu ayibutho elikhulu. Esifweni esifana ne-Ankylosing Spondylitis, leli butho lithola umyalezo ongalungile bese liqala ukuhlasela amalunga ezwe lalo (emizimba yethu). Lokhu kuhlasela yikho okubangela ubuhlungu nokuvuvukala (ukuvuvukala).
Kukhona "izithunywa" ezithile ezithumela le miyalezo engalungile. Zibizwa ngokuthi ama-enzyme e-JAK . Lawa ma-enzyme yiwo abonisa amangqamuzana omzimba ukuthi "ahambe ayohlasela," amakhemikhali abizwa ngokuthi ama-cytokine.
Lokho okwenziwa yimithi ebizwa ngokuthi ama-JAK inhibitors ukuvimba lezo zithunywa (ama-enzyme e-JAK). Lokhu kuvimbela ukugeleza kwaleyo miyalezo engalungile futhi kunciphisa ikhono lesimiso somzimba sokuzivikela ekuhlaseleni amalunga.
Imithi ye-biologic isebenza ngendlela ehlukile kancane. Imithi ye-biologic ihlasela futhi ivimbele i-cytokine ethile, njenge-TNF noma i-IL-17. Ama-JAK inhibitors avimba ukukhiqizwa kwama-cytokine amaningi ngesikhathi esisodwa. Kalula nje, avimba inkinga kwasekuqaleni.
Ingabe ikhona imiphumela emibi?
Njenganoma yimuphi umuthi, kunethuba lemiphumela emibi. Kodwa kubantu abaningi, iphephile. Udokotela wakho uzokuqapha ngokucophelela ngaphambi kokuba uqale ukuthatha lo muthi nangesikhathi uwuthatha.
| Uhlobo lomphumela ongemuhle | Incazelo |
|---|---|
| Imiphumela emibi evamile (ngokuvamile ayibi kakhulu) |
|
| Imiphumela emibi engavamile (Isexwayiso Esifakwe Ebhokisini) |
Okunye okwengeziwe ngemiphumela emibi kakhulu
Ngenxa yokuthi le mithi icindezela amasosha omzimba, ikhono lomzimba lokulwa namagciwane afana namagciwane namagciwane liyancipha kancane. Lokhu kwandisa ingozi yokutheleleka.
Ukuhlolwa kwesifo sofuba (TB): Ngaphambi kokuqala lo muthi, udokotela wakho uzokuhlolela isifo sofuba. Abanye abantu bangase babe namagciwane e-TB afihlekile emizimbeni yabo. Uma usebenzisa i-JAK inhibitor, la magciwane angasebenzi angaqala ukusebenza. Ngakho-ke, udokotela wakho uzokuqapha lokhu ngesikhathi sokwelashwa.
Okubalulekile: Ngesikhathi uthatha lo muthi, kufanele ugweme ukuthola imijovo ephilayo. Izibonelo zifaka phakathi isimungumungwane, ukhunta, i-rubella (MMR), kanye ne-rotavirus. Le mijovo ingakwenza ugule ngoba amasosha omzimba wakho asuke ebuthaka ngaleso sikhathi. Qiniseka ukuthi ukhuluma nodokotela wakho ngaphambi kokuthola noma yimuphi umuthi wokugoma.
Yini okufanele ngiyilindele lapho ngiqala imithi?
Abanye abantu baqala ukuzwa impumuzo ezimpawini zabo zingakapheli amasonto amabili nje beqalile lo muthi. Kodwa-ke, kungathatha izinyanga ezifika kweziyisithupha ukuthi abanye abantu bazizwe impumuzo ephelele. Lokhu kuyahlukahluka kuye ngomuntu nomuntu.
Uma ungazizwa ungcono ngemva kokuthatha imithi izinyanga ezimbalwa, ungesabi futhi khuluma nodokotela wakho ngakho bese uthola iseluleko sokuthi yini okufanele uyenze ngokulandelayo.
Umlayezo Wokuya Nawe Ekhaya
- Ama-JAK inhibitors ayiqembu elisha lemithi etholakala njengamaphilisi e-ankylosing spondylitis. Ngokuvamile anikezwa abantu abahlulekile kwezinye izindlela zokwelapha.
- Le mithi ayigcini nje ngokunciphisa ubuhlungu, kodwa futhi ilawula nomonakalo emalungeni.
- Kulula kakhulu ukuzisebenzisa ngoba azidingi imijovo efana ne-biologics.
- Njengayo yonke imithi, lena ingaba nemiphumela emibi. Ngakho-ke, kubalulekile ukuhlolwa kwegazi njalo ngaphansi kokuqondisa kukadokotela.
- Ungalokothi uqale, uyeke, noma ushintshe umthamo walo muthi ngaphandle kweseluleko sikadokotela wakho.
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