Cishe uke wezwa ngemithi efana ne-Viagra. Iningi labantu liyazi ukuthi le mithi inikezwa ukungasebenzi kahle kocansi. Kodwa bewazi ukuthi imithi esesigabeni esihlukile, ebizwa ngokuthi i-Phosphodiesterase Inhibitors, isetshenziselwa ukwelapha izimo ezahlukahlukene, kusukela esifweni senhliziyo kuya esifweni samaphaphu, isifo sesikhumba, kanye nesifo samalunga? Namuhla, ake sixoxe ngaleli klasi elimangalisayo lemithi. Ake siqonde ukuthi iyini, isebenza kanjani, nokuthi yiziphi izinzuzo nezingozi.
Kalula nje, ayini ama-Phosphodiesterase Inhibitors (ama-PDE inhibitors)?
Lolu uhlobo lomuthi olwandisa imithambo yegazi emzimbeni wethu, lunciphise ukuqina kwayo, futhi lwenze ukugeleza kwegazi kube lula. Cabanga ukuthi uma ipayipi lamanzi livalekile, uma ulikhulisa kancane, amanzi ageleza kalula. Lokhu kunciphisa umfutho wegazi futhi kuthuthukise ukugeleza kwegazi ezingxenyeni ezahlukene zomzimba. Ngenxa yaleli khono, lolu hlobo lomuthi lusetshenziswa njengokwelapha izifo eziningi ezahlukene.
Lomuthi usebenza kanjani?
Ukuze siqonde lokhu, sidinga ukwazi kuqala ngesithunywa esincane samakhemikhali emzimbeni wethu. Igama laso yi -Phosphodiesterases , noma i-PDE ngamafuphi. Le PDE uhlobo lwe -enzyme . Ama-enzyme afana nabasizi abancane abasheshisa futhi basize ezinye izinqubo zamakhemikhali emzimbeni wethu.
Kunezinhlobo eziningana zala ma-enzyme e-PDE emizimbeni yethu. Ososayensi basebenzise izinombolo ukuze bahlukanise. Into ekhethekile ukuthi uhlobo ngalunye lwe-PDE lusebenza kakhulu ezindaweni ezithile zomzimba.
- I-PDE-3: Lolu hlobo lutholakala kakhulu enhliziyweni yakho kanye nasesimisweni sokujikeleza kwegazi . Luphinde luhileleke enqubweni yokujiya kwegazi.
- I-PDE-4: Lokhu kutholakala kakhulu emaphashini . Kusebenza ngokuqinisa imisipha emigudwini yomoya.
- I-PDE-5: Lolu hlobo lutholakala emaphashini nasezithweni zangasese zabesilisa .
Ngakho-ke, izidakamizwa ezibizwa ngokuthi ama-Phosphodiesterase Inhibitors (ama-PDE inhibitors) zisebenza ngokuvimbela umsebenzi wama-enzyme e-PDE okukhulunywe ngawo ngenhla. Kufana nokuvala umnyango. Eminye imithi yokuvimbela i-PDE isebenza ngokukhetha kakhulu. Okusho ukuthi, ihlose uhlobo oluthile kuphela, njenge-PDE-5. Kuneminye imithi esebenza ngokungakhethi . Okusho ukuthi, ingathinta zonke izinhlobo ze-PDE ngezinga elithile.
Yiziphi izimo eziphathwa ngalo muthi?
Uhlobo lwemithi ebizwa ngokuthi i-PDE inhibitors luvunyelwe yizikhungo ezifana ne-U.S. Food and Drug Administration (FDA) ukwelapha izimo zezokwelapha ezingaphezu kweshumi nambili. Nazi ezinye zazo.
| Isigaba sesifo | Isimo sezokwelapha kanye nencazelo elula |
|---|---|
| Ukujikeleza kwegazi nenhliziyo |
|
| Izifo zokuvuvukala |
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| Izifo zesimiso sokuzala sabesilisa |
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| Izifo zesistimu yokuphefumula |
|
Yiziphi izinzuzo zama-PDE Inhibitors?
Lolu hlobo lomuthi luwusizo kakhulu ekwelapheni izimo ezithile zezokwelapha. Kunezizathu eziningana zalokhu.
- Kulula ukuyisebenzisa: Le mithi iza ngezindlela eziningi. Itholakala njengamaphilisi omlomo, okhilimu bokugcotshwa, kanye nemijovo ye-IV. Eminye imithi idinga ukuthathwa nsuku zonke, kanti eminye ingathathwa kuphela uma kudingeka.
- Ukwelashwa okuqondiwe: Njengoba ngishilo ekuqaleni, eminye imithi ihlose uhlobo oluthile lwe-PDE kuphela, ngakho-ke mancane amathuba okuba nemiphumela engafuneki (imiphumela emibi) kwezinye izingxenye zomzimba. Kufana nokuthi umuthi usebenza lapho isifo sikhona khona.
- Izinzuzo eziningana zomuthi owodwa: Ngezinye izikhathi izimo ezimbili ezihlobene zingenzeka kumuntu oyedwa. Isibonelo, i-benign prostatic hyperplasia (BPH) kanye nokungasebenzi kahle kwe-erectile (ED) kungenzeka kokubili ndawonye. I-PDE-5 inhibitor tadalafil ivunyelwe ukwelapha zombili lezi zimo. Ngokufanayo, kunemithi engelapha kokubili i-gout kanye nesifo samathambo esihambisanayo.
Iyini imiphumela emibi kanye nezingozi zalo muthi?
Into ebaluleke kakhulu ukuthi yonke le mithi kufanele ithathwe ngaphansi kweseluleko sikadokotela kuphela. Amathuba okuba nemiphumela emibi angahluka kuye ngemithi kanye nomuntu ngamunye.
Imiphumela emibi eyinhloko incike ekutheni umuthi ungowaluphi uhlobo lwe-PDE inhibitor.
| Uhlobo Lokuvimbela i-PDE | Imiphumela emibi emincane nephakathi | Imiphumela emibi engaba mibi kakhulu (tshela udokotela wakho ngokushesha) |
|---|---|---|
| Izithibi ze-PDE-3 (kuthinta inhliziyo nemithambo yegazi) | Ikhanda elibuhlungu, ubuthakathaka, ukuvuvukala, isicanucanu, ukuhlanza, ubuhlungu besisu, isiyezi, ukuqubuka kwesikhumba. | Ukungahambi kahle kwesigqi senhliziyo (i-arrhythmia), ubuhlungu besifuba, umfutho wegazi ophansi, ukopha noma ukuminyana okungavamile, ukulimala kwesibindi. |
| Izithibi ze-PDE-4 (kuthinta amaphaphu nokuvuvukala) | Ukwehla kwesisindo, isicanucanu, ukuhlanza, isifo sohudo, izifo zomgudu wokuphefumula ophezulu, ikhanda elibuhlungu, ukuqwasha, ukuvuvukala endaweni yomjovo. | Ukuwohloka kokucindezeleka okukhona, imicabango yokuzibulala, ukusabela kwe-hypersensitivity (ukulunywa, ukuvuvukala, ukuqubuka). |
| Izithibi ze-PDE-5 (kuthinta ukungabi namandla ocansi kanye nomfutho wegazi ophezulu emaphashini) | Ikhanda elibuhlungu, ukusha, ikhala elicijile, ubuhlungu bomhlane, ubuhlungu bemisipha, isicanucanu, isiyezi, futhi mhlawumbe ukubona ukukhanya okuluhlaza okwesibhakabhaka (okwesikhashana). | Ukuqabula: Ukuqina kobulili okubuhlungu okuhlala isikhathi esingaphezu kwamahora ama-4 ngaphandle kokukhuthazwa ngokocansi. Lesi yisimo esiphuthumayo sezokwelapha. Izinguquko/ukulahlekelwa umbono noma ukuzwa ngokuzumayo, ukulimala kwesibindi. |
| Izithibi Ezingakhethi (isib. i-caffeine, i-theophylline) | Ukungaphumuli, ukuqwasha, ukuthuthumela, isicanucanu, ukuhlanza, uhudo, isiyezi, ikhanda elibuhlungu. | Ukushaya kwenhliziyo okusheshayo, ukushaya kwenhliziyo okungajwayelekile, ubuhlungu besifuba, ukuxhuzula. |
Isexwayiso esikhethekile: Uma uthatha umuthi onjenge- nitroglycerin ngaphansi kolimi ngenxa yobuhlungu besifuba, futhi uba nobuhlungu besifuba zingakapheli amahora angama-24 uthatha i-PDE-5 inhibitor (isib. iSildenafil, iTadalafil), hamba uye emnyangweni wezimo eziphuthumayo wesibhedlela (i-ETU) ngokushesha. Ukuhlanganisa le mithi emibili kungabangela umfutho wegazi ophansi ngendlela eyingozi.
Ubani okungafanele athathe lo muthi?
Kwabanye abantu, lolu hlobo lomuthi olubizwa ngokuthi ama-PDE inhibitors lungase lungafaneleki ngenxa yezinye izimo zabo zezokwelapha noma eminye imithi abayithathayo. Lokhu sikubiza ngokuthi yi -contraindications . Kunezinhlobo ezimbili zalokhu:
1. Iziphazamiso eziphelele:
- Kunoma yimuphi umuthi ovimbela i-PDE: Uma uke waba nokusabela okukhulu kokungezwani komzimba (ukuzwela ngokweqile) kulo muthi noma ofanayo.
- I-Cilostazol: Uma unesifo senhliziyo.
- Kwabavimbela i-PDE-5 (njenge-Sildenafil, i-Tadalafil): isifo senhliziyo esibi, ubuhlungu besifuba obungazinzile (i-angina engazinzile), ukuhlaselwa yinhliziyo noma isifo sohlangothi muva nje.
2. Izimo ezihlobene:
- Kwabavimbela i-PDE-5: Uma uthatha ama-nitrate noma ama-alpha-blockers, kufanele ukhulume nodokotela wakho ngoba angabangela ukwehla komfutho wegazi lakho ngendlela eyingozi.
- I-Cilostazol: Uma unenkinga yokopha.
- Nge-Pentoxifylline: Uma usanda kuba nokopha ebuchosheni noma esweni.
Uma ukhulelwe, uzama ukukhulelwa, noma uncelisa, khuluma nodokotela wakho njalo ngaphambi kokuthatha noma yimuphi umuthi. Kunobufakazi bokuthi ezinye izithibi ze-PDE zingathinta umbungu ezifundweni zezilwane.
Kufanele ubonane nini nodokotela?
Uma izimpawu zakho zishintsha noma zithinta imisebenzi yakho yansuku zonke, kungcono ukutshela udokotela wakho. Kodwa-ke, uma uhlangabezana nanoma yikuphi kwalokhu okulandelayo , iya esibhedlela noma egumbini lezimo eziphuthumayo (ETU) ngokushesha.
- Izimpawu zokuhlaselwa yinhliziyo: ubuhlungu besifuba, ukuphelelwa umoya, ukujuluka, isiyezi, isicanucanu.
- Ukuqabulana: Ukuqina kobulili okubuhlungu okuhlala amahora angaphezu kwamane ngaphandle kokuvusa inkanuko yobulili. Lokhu kungabangela umonakalo ohlala njalo uma kungelashwa ngokushesha.
- Ukulahlekelwa umbono noma ukuzwa ngokuzumayo: Uma ulahlekelwa umbono ngokuzumayo, ukulahlekelwa umbono, noma ukulahlekelwa ukuzwa, funa usizo lwezokwelapha ngokushesha. Ukubambezeleka kungabangela umonakalo ongapheli.
Umlayezo Wokuya Nawe Ekhaya
- Ama-Phosphodiesterase inhibitors (ama-PDE inhibitors) ayiqembu lemithi eliwusizo kakhulu elingasetshenziswa hhayi kuphela ekuphazamisekeni kocansi, kodwa futhi nasezifweni eziningana ezihlobene nenhliziyo, amaphaphu, isikhumba, kanye namalunga.
- Yonke le mithi kufanele ithathwe kuphela ngokunconywa ngudokotela.Tshela udokotela wakho nganoma yiziphi ezinye izifo onazo kanye nanoma yimiphi eminye imithi oyiphuzayo.
- Imiphumela emibi ingenzeka, ngakho-ke yazi ngayo ngaphambi kokuqala umuthi.
- Uma uzwa izimpawu ezinzima njengobuhlungu besifuba, ukuphelelwa umoya okuhlala isikhathi esingaphezu kwamahora ama-4, noma ukulahlekelwa umbono/ukuzwa ngokuzumayo, hamba uye eMnyangweni Wezimo Eziphuthumayo (ETU) ngokushesha.
- Ukusebenzisa lo muthi ngaphandle kwencwadi kadokotela, ngokubuza abanye noma ngokubuza emakhemisi, kungaba nemiphumela emibi kakhulu, ngisho nesongela ukuphila.
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