Wake wazisika umunwe wakho? Noma walunywa yisinambuzane futhi indawo yaba bomvu, yavuvukala, futhi yaba buhlungu? Sonke sike saba nokuhlangenwe nakho okunje. Futhi, uma ungowesifazane, cishe uyazi kahle ubuhlungu obuzwayo ngesikhathi sakho sokuya esikhathini. Namuhla, sizokhuluma ngesithunywa samakhemikhali esincane kodwa esinamandla kakhulu esingemuva kwakho konke lokhu, kodwa asikhulumi kakhulu ngakho, futhi yilokho esizokhuluma ngakho. Kubizwa ngokuthi ama-Prostaglandins . Nakuba igama lingase lizwakale lingavamile, lihilelekile emisebenzini eminingi yansuku zonke yemizimba yethu.
Kalula nje, ayini lawa ma-prostaglandin?
Ama-Prostaglandin ayiqembu lama-lipid (uhlobo lwamafutha) akhiqizwa emzimbeni wethu lapho izicubu zonakele, zithelelekile, noma ezimweni ezikhethekile. Nakuba esebenza njengama-hormone, empeleni awawona ama-hormone.
Manje ungase ucabange, "Ngakho-ke umehluko uyini phakathi kwama-hormone nalawa?" Cabanga ngakho, ama-hormone emizimbeni yethu afana nenkonzo yeposi yezwe. Ama-hormone, akhiqizwa endaweni eyodwa, njenge-pituitary gland ebuchosheni, ahamba emzimbeni wonke ngegazi futhi alethe imiyalezo ezingxenyeni ezahlukene zomzimba.
Kodwa ama-Prostaglandin awanjalo. Afana nomuntu osedolobheni ohambisa umyalezo endlini elandelayo. Okusho ukuthi, akhiqizwa lapho edingeka khona futhi athinta kuphela amangqamuzana aseduze . Awahambi emzimbeni wonke ngegazi. Ngakho-ke, isenzo sawo sihlala isikhathi esifushane kakhulu. Lawa ma-Prostaglandin akhiqizwa yi-fatty acid ebizwa ngokuthi i-arachidonic acid, etholakala emaseli omzimba wethu.
Uyini umsebenzi oyinhloko wama-prostaglandin?
Kunezinhlobo eziningana zama-prostaglandin. Futhi, kunezinhlobo eziningana zama-receptor ezibopha kuzo. Ngakho-ke, imisebenzi yazo ihlukile. Kuya ngesitho, izicubu ezizithintayo, kanye nezidingo zomzimba ngaleso sikhathi.
Nazi ezinye zezinto eziyinhloko abazenzayo:
| Inqubo | Umsebenzi we-prostaglandins |
|---|---|
| Ukwelashwa kwenxeba | Uma kukhona ukulimala, ama-platelet ayaqoqwa futhi alawulwe ukuze kwakheke ihlule legazi ukuze kumiswe ukopha. |
| Ukuvuvukala | Ukuze kuvikelwe izicubu ezonakele, ukugeleza kwegazi endaweni kuyanda, okubangela ukuvuvukala, ukubomvu, nobuhlungu. |
| Ubuhlungu nomkhuhlane | Izwela imizwa ezwa ubuhlungu. Iphinde ithinte isikhungo sokulawula izinga lokushisa ebuchosheni, okubangela umkhuhlane. |
| Uhlelo lokuzala lwabesifazane | Kusiza isibeletho ukuthi sifinyele futhi kukhiphe ulwelwesi lwesibeletho (i-endometrium) ngesikhathi sokuya esikhathini. Kusiza umlomo wesibeletho ukuthi uvuleke futhi isibeletho sifinyele ngesikhathi sokubeletha. |
| Ukushaya kwegazi | Ukuqinisa imithambo yegazi noma ukuqinisa imithambo yegazi kusiza ukulawula umfutho wegazi. |
| Isisu | Kunciphisa ukukhishwa kwe-asidi esiswini futhi kwandisa ulwelwesi lwamafinyila oluvikela udonga lwesisu. |
| Uhlelo lokuphefumula | Izindlela zokuphefumula ziyancishiswa (i-bronchoconstriction) noma zibanzi (i-bronchodilation). |
Ake siqonde lokhu ngesibonelo sangempela.
Cabanga usekhishini usika imifino bese umunwe wakho usikwa ngommese. Hawu! Kwenzekani manje? Nansi indlela ama-prostaglandin asebenza ngayo:
1. Ukuyeka ukopha: Ama-prostaglandin akhishwa ngokushesha ezicutshini zomunwe ezilimele. Lawa abonisa ama-platelet egazini ukuthi "aze lapha ngokushesha futhi anamathele ndawonye ukuze akhe ihlule legazi." Lelo hlule legazi livala inxeba futhi limise ukopha. Ngesikhathi esifanayo, ama-prostaglandin nawo asiza ekunciphiseni imithambo yegazi kuleyo ndawo.
2. Ukuvuvukala: Okulandelayo, olunye uhlobo lwe-prostaglandin luyangena futhi lubangele ukuthi imithambo yegazi ivuleke. Lokhu kubangela ukuthi igazi eliningi ligeleze. Yingakho inxeba liba bomvu futhi livuvuke kancane . Lokhu kuvuvukala kuvimbela izinto ezifana namagciwane angangena enxebeni ukuthi zingafiki kwezinye izingxenye zomzimba.
3. Ukungeniswa kwamaseli okuphepha:Lawa ma-prostaglandin athumela esinye isignali kumaseli okuzivikela omzimba wethu, amaseli amhlophe egazi. Ama-phagocyte, ikakhulukazi, asabela kulesi signali futhi "adle" futhi ahlanze noma yimaphi amagciwane namaseli alimele angene ngenxeba.
4. Ubuhlungu: Kanye nakho konke lokhu, ama-Prostaglandin enza iziphetho zemizwa lapho zizwele kakhulu. Yingakho sizwa ubuhlungu . Lobuhlungu busitshela ukuthi, "Umunwe wakho ulimele, nakekela."
5. Ngemva kokuphulukiswa: Ngemva kokuba inxeba selipholile ngokuphelele, olunye uhlobo lwe-prostaglandin luyangena bese luncibilikisa ihlule legazi elakheka ngaphambilini, ngoba alisadingeki.
Uke wabona ukuthi uhlelo oluyinkimbinkimbi kangakanani oluqhubeka ngaphakathi emizimbeni yethu ngisho noma kukhona ukulimala okuncane? Ama-Prostaglandin adlala indima enkulu ekuhlanganiseni konke lokhu.
Ngakho-ke, ingabe ama-prostaglandin amahle noma amabi?
Lona umbuzo obaluleke kakhulu. Ama-prostaglandin empeleni abalulekile futhi angokwemvelo emizimbeni yethu. Abalulekile ekwelapheni amanxeba, ekuvikeleni amagciwane, nasekulawuleni umjikelezo wokuya esikhathini. Ukuvuvukala, inqubo ebizwa ngokuthi ukuvuvukala, kuyindlela umzimba ozivikela ngayo.
Kodwa inkinga iphakama lapho umzimba wethu uqala ukukhiqiza ama-prostaglandin amaningi kunalawo owadingayo . Yilapho izinkinga ziqala khona.
Isibonelo, ama-prostaglandin ayadingeka ukuze isibeletho sinciphe ngesikhathi sokuya esikhathini. Kodwa-ke, uma ekhiqizwa ngokweqile, isibeletho sincipha ngokweqile nangokubuhlungu. Lokhu yilokho esikubiza ngokuthi ubuhlungu bokuya esikhathini . Ngezinye izikhathi lesi simo singabangela nokopha okukhulu (i-menorrhagia).
Futhi, isizathu esenza abantu abanezifo ezingamahlalakhona njenge-arthritis babe nobuhlungu obungapheli kanye nokuvuvukala kwamalunga abo kungenxa yokuthi la mazinga e-prostaglandin ahlala ephezulu.
Ama-prostaglandin asetshenziswa kanjani kwezokwelapha?
Uma umsebenzi wama-prostaglandin usuqondwa, odokotela bawasebenzisa ekwelashweni okuhlukahlukene. Basebenzisa nemithi evimba ukusebenza kwawo.
Ama-Prostaglandin Okwenziwa
Imithi efana ne-prostaglandins, eyenziwe elabhorethri, isetshenziselwa ukwelapha izimo ezahlukene zezokwelapha.
- Uma bebeletha: Omama abakhulelwe ababambezeleka ekuqaleni kokubeletha banikezwa imithi efana ne -Dinoprostone yokwandisa umlomo wesibeletho futhi ifinyeze isibeletho.
- I-Glaucoma: Amaconsi amehlo afana ne -Travoprost asetshenziselwa ukwelapha i-glaucoma, isimo lapho ukucindezeleka kwamehlo kukhula khona.
- Ukungasebenzi kahle kocansi kwabesilisa (Ukungasebenzi kahle kwe-Erectile):I-Alprostadil, i-dilator yegazi, isetshenziselwa ukwelapha lesi simo.
- Izilonda Zesisu: Amanye amaphilisi obuhlungu angalimaza ulwelwesi lwesisu uma ethathwa njalo. Ukuvimbela lokhu, kunikezwa imithi efana ne -Misoprostol ehlisa i-asidi yesisu.
Imithi evimbela isenzo se-prostaglandin
Iningi lemithi yokubulala izinhlungu esiyisebenzisayo nesiyithola njalo isebenza ngokuvimbela ukukhiqizwa kwama-prostaglandin. Leli qembu lemithi libizwa ngokuthi imithi elwa nokuvuvukala engeyona eye-steroidal , noma ama-NSAID ngamafuphi.
Ama-painkiller afana ne -Ibuprofen, i-Naproxen, i-Diclofenac, i-Mefenamic Acid oyisebenzisayo yonke ingaphansi kwaleli qembu (ama-NSAID). Uma uwasebenzisa ngenxa yobuhlungu bokuya esikhathini, ikhanda elibuhlungu, kanye nobuhlungu bamalunga, ubuhlungu buyancipha ngoba le mithi ivimba ukukhiqizwa kwama-prostaglandin.
Yiziphi izinkinga ezingahlotshaniswa nama-prostaglandin?
Ngezinye izikhathi, imizimba yethu ikhiqiza ama-prostaglandin amaningi kakhulu, noma anganele. Kuzo zombili izimo, kungavela izinkinga ezahlukene zempilo.
Izimo ezenzeka lapho ukwanda kwama-prostaglandin:
- Ubuhlungu obungapheli: Bungabangela ubuhlungu obuqhubekayo emzimbeni.
- Ukuzwela kakhulu ebuhlungwini: Ukuzwa ubuhlungu obukhulu ngisho noma buvela entweni encane kakhulu.
- Ukuya esikhathini okubuhlungu (i-Dysmenorrhea): Ubuhlungu bokuya esikhathini esikhulume ngabo ekuqaleni.
- Ukopha okukhulu kokuya esikhathini.
- Ucwaningo luthole ukuthi amazinga aphezulu e-prostaglandin nawo anegalelo ekukhuleni kwezinye izinhlobo zomdlavuza .
Uma ama-prostaglandin enganele:
Lokhu akuvamile ukuhlotshaniswa nesimo esingamahlalakhona. Kodwa-ke, kungase kube nezimo lapho inani lama-prostaglandin adingekayo ukuze kupholiswe inxeba linganele. Futhi, ezimweni lapho umzimba ungakhiqizi ama-prostaglandin anele ukuqala ukubeletha, odokotela banikeza ama-prostaglandin okwenziwa avela ngaphandle.
Kufanele ubonane nini nodokotela?
Uma unobuhlungu obungapheli noma ukuvuvukala emzimbeni wakho, qiniseka ukuthi ubona udokotela wakho bese uxoxa ngakho. Kungaba nezimbangela eziningi zalokhu, kodwa ukungalingani emsebenzini wama-prostaglandin kungenzeka kube yimbangela.
Ikakhulukazi, kukhona okufanele kukhulunywe ngakho ngobuhlungu bokuya esikhathini.
Uma ubuhlungu bakho bokuya esikhathini bukhulu kangangokuthi abukwazi ukulawulwa ngama-painkillers athengiswa ngaphandle kwemithi kadokotela (ama-NSAID), ungamane nje ubuthathe njengento "eyenzeka emantombazaneni." Ngezinye izikhathi lobu buhlungu obukhulu bungabangelwa yi-endometriosis nomaKungaba ngenxa yesimo sezempilo esiyimfihlo, njenge-uterine fibroids. Ngakho-ke, qiniseka ukuthi ukhuluma nodokotela wakho ngakho futhi uthole iseluleko nokwelashwa okudingekayo.
Ama-Prostaglandin angamakhemikhali amangalisayo asebenza buthule kodwa ngamandla emizimbeni yethu. Nakuba ebalulekile ekusindeni kwethu, lapho ibhalansi yawo iphazamiseka, ingathinta kakhulu ikhwalithi yezimpilo zethu. Ngakho-ke naka umzimba wakho. Uma unezinhlungu eziqhubekayo noma izimpawu ezingavamile, ungalokothi unqikaze ukufuna iseluleko sezokwelapha.
Umlayezo Wokuya Nawe Ekhaya
- Ama-prostaglandin angamakhemikhali asebenza njengama-hormone futhi akhiqizwa emizimbeni yethu, lapho kudingeka khona.
- Lokhu kuhileleke ngqo ezinqubweni eziningi ezifana nobuhlungu, ukuvuvukala (ukuvuvukala), umkhuhlane, ukujiya kwegazi, kanye nokuya esikhathini.
- Nakuba lokhu kubalulekile emzimbeni, ubuningi obukhulu bungabangela izinkinga ezifana nobuhlungu obungapheli kanye nobuhlungu obukhulu bokuya esikhathini.
- Ama-painkiller (ama-NSAID) afana ne-ibuprofen asebenza ngokuvimbela ukukhiqizwa kwama-prostaglandin.
- Uma unezinhlungu ezinzima zokuya esikhathini ezingalawuleki noma ezihlala isikhathi eside, ungakuzibi futhi ubone udokotela wakho ngokushesha.
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