Isifo sikashukela sesibe yisifo esivame kakhulu kubantu abaningi ezweni lethu. Mhlawumbe omunye wamalungu omndeni wakho, umngane, noma ngisho nawe uqobo uthintwa yilesi simo. Isifo sikashukela sohlobo lwesibili ikakhulukazi siyinkinga enkulu yezempilo ethinta abantu abangaphezu kwezigidi ezingu-400 emhlabeni jikelele. Uma singalawulwa kahle, singaholela ezinkingeni eziyingozi njengokulimala kwezinso, ukulahlekelwa umbono, isifo senhliziyo, kanye nokukhubazeka. Nakuba kunezinhlobo ezingaphezu kuka-30 zemithi yokulawula lesi sifo, akekho kubo ongasilapha ngokuphelele. Kodwa... ucwaningo olusha lubonisa ukuthi lesi simo singashintsha. Ake sibone ukuthi kanjani.
Lokho ebesikucabanga ngesifo sikashukela isikhathi eside kangaka
Eminyakeni engaba amashumi amabili edlule, uma ubungabuza uchwepheshe ngesifo sikashukela, ubengathi imbangela eyinhloko yalokhu 'ukumelana ne-insulin'. Kalula nje, i-insulin iyi-hormone ekhiqizwa yi-pancreas yethu. Umsebenzi wayo oyinhloko ukuthatha i-glucose (ushukela) evela ekudleni esikudlayo bese uyifaka emaseli emizimba yethu. Yilapho-ke amaseli ethola khona amandla.
Cabanga nge-insulini njengesihluthulelo, namaseli njengomnyango. I-insulini iyisihluthulelo esivula umnyango ukuze i-glucose ingene emaseli.
Kodwa, amangqamuzana omuntu omelana ne-insulin awasabeli kahle kule insulin. Kufana nokuthi imbobo yokhiye emnyango igqwalile. Ngemuva kwalokho, ngenxa yokuthi umnyango awukwazi ukuvulwa, ama-pancreas kufanele enze izihluthulelo ezengeziwe ze-insulin. Ngokuhamba kwesikhathi, ama-pancreas aba buthakathaka ngenxa yokusebenza kanzima kangaka. Yilapho-ke kuvela khona isifo sikashukela sohlobo lwesibili. Lena indaba esesiyazi isikhathi eside.
Ukutholwa okusha okubaluleke kakhulu: Indaba yamaseli e-beta
Manje ososayensi bathole ukuthi inkinga akuyona nje ukumelana ne-insulin. Ingxenye yesibili yenkinga isemaseli ethu e-beta . Lawa ngamaseli ahlala ngaphakathi kwama-pancreas futhi afana nezimboni ezincane ezikhiqiza i-insulin.
Iningi lamaseli e-beta imizimba yethu ewadingayo akhiqizwa eminyakeni embalwa yokuqala yokuphila kwethu. Kodwa abanye abantu bazalwa benamaseli e-beta amaningi kunabanye. Ngakho-ke, noma ngabe bathuthukisa ukumelana ne-insulin kamuva ekuphileni, izimboni zabo zamaseli e-beta zingenza i-insulin eyengeziwe ukuze zibuyisele.
Kodwa-ke, lapho umuntu onesifo sofuzo samaseli e-beta azalwa naso eba nokumelana ne-insulin, amaseli asele kufanele asebenze kanzima kunalokho angakuthwala. Ekugcineni, lawo maseli ayakhathala futhi afe. Labo ngabantu abathola isifo sikashukela sohlobo lwesibili.
Ngakho-ke, umgomo omkhulu manje ukuthola umuthi ongavuselela la maseli e-beta afayo noma wandise inani lamaseli akhona. Uma lokho kungenziwa, isifo sikashukela sohlobo lwesibili singelapheka, hhayi nje ukulawulwa.
Imithi yakamuva eletha ithemba
Njengoba ososayensi babecwaninga ngalokhu, bathole umuthi ongasiza ekukhuliseni la maseli e-beta. Ubizwa ngokuthi i-harmine . Kuyinhlanganisela etholakala ngokwemvelo ezitshalweni ezahlukahlukene emhlabeni jikelele.
Lo muthi, obizwa ngokuthi i-harmine, usebenza ngokuvimba i-enzyme ebizwa ngokuthi i-DYRK1A ngaphakathi kwamaseli e-beta. Uma lokhu kuvinjiwe, amaseli e-beta aqala ukuhlukana, ukwanda, nokukhula ngobukhulu. Ekuhlolweni kwamagundane, amagundane anesifo sikashukela anikezwe lo muthi abe nokwanda okuphindwe kathathu ngobukhulu bamaseli e-beta! Ngesikhathi esifanayo, amazinga awo kashukela egazini nawo abuyele esimweni esijwayelekile.
Kodwa, ukuze lokhu kuphumelele kubantu, ososayensi baqaphela ukuthi kwakudingeka okunye. Ngakho-ke, bahlola umuthi we-harmine ngolunye uhlobo lwemithi esivele isetshenziswa isifo sikashukela. Lelo hlobo lwemithi lubizwa ngokuthi ama-agonist e-GLP1R . Uma ungumuntu othatha imithi yesifo sikashukela, kungenzeka ukuthi uke wezwa ngala magama: `(exenatide)`, `(liraglutide)`, `(lixisenatide)` ezinye zezidakamizwa ezikulesi sigaba. Zisebenza ngokuvuselela amaseli e-beta nokukhuthaza ukukhiqizwa kwe-insulin.
Ngakho-ke, kwenzekani lapho le mithi emibili ihlanganiswa? Imiphumela yayimangalisa!
| Ukwelashwa okusetshenzisiwe | Ukukhula kwamaseli e-beta (kungakapheli amahora angama-24) |
|---|---|
| I-Harmine kuphela | Ukukhula okungaba ngu -2% |
| Isidakamizwa se-agonist se-Harmine + GLP1R | Ukukhula kufikela ku -8% ! |
| Kwezinye izimo, izinombolo zamaseli e-beta ziye zabonakala zikhuphuka ngamaphesenti angama- 40 ezinsukwini ezi-4 nje kuphela. | |
Le miphumela inikeze ithemba elikhulu lokuthi le ndlela yokwelapha izophumelela nakubantu.
Inselele ezayo futhi kungani lokhu kubalulekile?
Inselele enkulu manje ukuthi ungayihambisa kanjani le ngxube yemithi ngqo kumaseli e-beta. Ososayensi bathi, "Sinephakheji yokwelapha amaseli e-beta, kodwa asazi ikheli eliqondile okufanele silithumele kulo." Njengesixazululo, bacabanga ukusebenzisa into ebizwa ngokuthi ama-antibody e-monoclonal . Lokhu kufana nensizakalo yokuthumela ehlakaniphile engaletha iphakheji yethu yemithi ngqo kumaseli e-beta.
Kungani lokhu kubaluleke kangaka?
Cabanga nje, imithi yesifo sikashukela yamanje ilawula amazinga kashukela egazini kuphela. Uma uyeka ukuthatha imithi, lesi sifo sizophinde sivele.
Okuwukuphela kwento esondele esixazululweni esihlala njalo kuze kube manje ukuhlinzwa kwe-bariatric . Okusho ukuthi, ukuhlinzwa ukuze wehlise isisindo. Lokhu kuvame ukufaka isifo sikashukela esimeni esingcono. Kodwa kubantu abayizigidi ezingu-400 emhlabeni, ukuhlinzwa akusebenzi. Kubiza kakhulu, kuyingozi, futhi kuthatha isikhathi eside ukuphulukiswa.
Kodwa uma le nhlanganisela yemithi emisha iphumelela, ingashintsha izimpilo zezigidi zabantu emhlabeni jikelele. Ayigcini nje ngokucindezela izimpawu, ibuyisela imbangela yesifo, okuwukulahlekelwa amaseli e-beta.
Umlayezo Wokuya Nawe Ekhaya
- Isifo sikashukela sohlobo lwesibili asibangelwa nje kuphela ukumelana ne-insulin. Ukwehla kwenani lamaseli e-beta akhiqiza i-insulin nakho kuyimbangela enkulu.
- Ososayensi manje bazama ukuthola umuthi ongakhulisa kabusha la maseli e-beta alahlekile.
- Ucwaningo lukhombisile ukuthi ukuhlanganisa i-harmine nomuthi we-agonist we-GLP1R osuvele usetshenzisiwe kubangela ukuthi amaseli e-beta akhule ngokushesha okukhulu.
- Nakuba lokhu kusesesigabeni socwaningo, kunethemba elikhulu lokwelashwa okungakwelapha ngokuphelele isifo sikashukela esikhathini esizayo.
- Nakuba konke lokhu kuyithemba lesikhathi esizayo, kubalulekile ukulawula isifo sikashukela sakho okwamanje. Landela iseluleko sikadokotela wakho.
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