Uma unesifo sikashukela, cishe uyazi ukuthi ngokuhamba kwesikhathi, kungathinta amehlo akho. Ukubona okufiphele, ukuntanta, kanye nokungaboni imibala kuyizimpawu ezivamile zalesi simo. Kungenzeka ukuthi uke wezwa ngomjovo wamehlo njengokwelashwa kwalesi simo. Le mijovo ingathuthukisa ukubona futhi ivimbele ukulimala okwengeziwe emehlweni akho. Namuhla, sizokhuluma ngomuthi omusha onjalo, ongaba usizo olukhulu kuwe.
Lo muthi weVabysmo usebenza kanjani emehlweni?
Kalula nje, uma umuntu onesifo sikashukela enamazinga aphezulu kashukela egazini isikhathi eside, imithambo yegazi ebucayi engaphakathi kweso iqala ukonakala. Lo monakalo wenzeka ku-retina, ungqimba lweso olucubungula izithombe. Lesi simo sibizwa ngokuthi i-diabetesic retinopathy .
Le mithambo yegazi eyonakele kancane kancane ivuza uketshezi kanye negazi ku-retina. Njengoba isimo siba sibi kakhulu, iso lizama ukwakha imithambo yegazi emisha ukuze ithathe indawo yaleyo eyonakele. Kodwa le mithambo emisha ibuthakathaka kakhulu, futhi ivuza uketshezi olwengeziwe.
Ngakho-ke kuyini i-macular edema?
Kukhona indawo ekhethekile ku-retina ebizwa ngokuthi i-macula . Yilokhu okusisiza sibone izinto phambi kwamehlo ethu, okungukuthi, umbono wethu oqondile, ngokucacile. Njengoba kushiwo ngaphambili, lapho uketshezi luvuza emithanjeni yegazi, le macula iqala ukuvuvukala. Lokhu sikubiza ngokuthi i -diabetic macular edema .
Yilapho ukubona kuba mfushane, ukubona okuphindwe kabili, kuvela amabala amnyama, nemibala ibonakala ifiphele. Abanye abantu bangase balahlekelwe ngisho nokubona kwabo ngokuphelele.
Yini ekhethekile ngeVabysmo?
Umgomo oyinhloko wokwelapha lesi simo ukuvimba umonakalo ku-retina. Kunezinhlobo eziningana zemithi efakwa esweni ngenxa yalokhu. Iningi lale mithi lisebenza ngokuvimba iphrotheni ebizwa ngokuthi i-VEGF . Kalula nje, i-VEGF iyisici esibalulekile esisiza ukwakheka kwemithambo yegazi emisha engafuneki futhi ebuthaka. Ngakho-ke lapho i-VEGF ivinjiwe, ukwakheka kwemithambo yegazi emisha kuyalawulwa.
Isithako esisebenzayo ku-Vabysmo yi -Faricimab . Lo muthi, njengeminye imithi, uvimba i-VEGF. Kodwa ngaphezu kwalokho, lo muthi wenza okunye. Okusho ukuthi, uvimba enye iphrotheni ebizwa ngokuthi i-Ang-2 (angiopoietin-2) . Lapho le phrotheni ye-Ang-2 ikhula esweni, imithambo yegazi iyaba engazinzile futhi ivuza uketshezi oluningi.
Ngakho-ke, ngenxa yokuthi iVabysmo ivimba kokubili i-VEGF kanye ne-Ang-2 ngesikhathi esisodwa, imisa ukwakheka kwemithambo yegazi emisha futhi izinzise imithambo yegazi ekhona, inciphise ukuvuza koketshezi. Lesi senzo esiphindwe kabili yisona esenza iVabysmo ibe ngeyingqayizivele.
Ucwaningo ngalesi sidakamizwa lwembule ini?
Kuye kwenziwa izivivinyo ezimbili ezinkulu zemitholampilo ukuze kutholakale ukuphepha nokusebenza kahle kwe-Vabysmo, okubandakanya inani elikhulu labantu abanesifo sikashukela kanye nokuwohloka kwe-macular abavela emazweni ahlukahlukene nasezizweni ezahlukene emhlabeni jikelele.
Kulezi zivivinyo, iVabysmo yaqhathaniswa nomuthi osuvele ukhona obizwa ngokuthi i-Aflibercept (Eylea) , ovimba i-VEGF kuphela. Abahlanganyeli ocwaningweni babengazi ukuthi yimuphi umuthi abawutholayo. Wonke umuntu wathola imijovo eminingana, kodwa abanye abantu bathola imijovo embalwa kunabanye.
Iyini imiphumela yocwaningo?
Imiphumela iyakhuthaza ngempela.
Ukuthuthukiswa kwamehlo
Ngemva konyaka wokwelashwa, umbono walabo abathatha i-Vabysmo kanye ne-Aflibercept wawuthuthuke kakhulu kunangesikhathi kufundwa. Lokhu kusho ukuthi yomibili le mithi yayisebenza kahle ngokulinganayo ekuthuthukiseni umbono .
Inani lemijovo edingekayo (lena yinto ebaluleke kakhulu!)
Yilapho umehluko omkhulu wabonakala khona.
Ezinyangeni ezimbalwa zokuqala zocwaningo, wonke umuntu wayegonywa kanye ngenyanga, kodwa-ke uhlelo lokugoma lwashintshwa.
- Labo abathola i-Aflibercept baqhubeka nokuthola umuthi wokugoma njalo emavikini ayi-8 (okungukuthi, njalo ezinyangeni ezi-2) ngemva kwezinyanga ezi-5 zokuqala.
- Labo abathola i-Vabysmo belashwa ngokwesimiso "somuntu siqu sokulinganisa," okusho ukuthi isimo samehlo somuntu ngamunye sahlolwa futhi umuthi wokugoma wanikezwa njalo emavikini angu-4, 8, 12, noma 16, njengoba kufanele.
Imiphumela ikhombisile ukuthi abangaphezu kuka-70% balabo abathole i-Vabysmo babedinga umjovo njalo emavikini angu-12-16 (okungukuthi, njalo ezinyangeni ezingu-3-4) . Futhi, bekungekho mehluko ekuthuthukisweni kokubona phakathi kwalabo abathole umuthi njalo ezinyangeni ezingu-3-4 nalabo abathole umuthi njalo ezinyangeni ezimbili.
Lokhu kusho ukuthi ukwelashwa nge-Vabysmo kunganciphisa kakhulu inani lokuvakashela esibhedlela ukuze kutholakale imijovo , kuyilapho kugcinwa ukuthuthukiswa kombono. Yeka ukuthi kulula kangakanani ukungadingi ukuya esibhedlela njalo, akunjalo?
| Ukwelashwa | Isikhawu Sokujova Okuvamile |
|---|---|
| I-Vabysmo (i-Faricimab) | Amaviki ayi-12 kuya kwangu-16 (njalo ezinyangeni ezi-3-4) |
| I-Aflibercept (Eylea) | Kanye njalo emavikini ayi-8 (kanye njalo ezinyangeni ezi-2) |
Ingabe umuthi uzoqhubeka nokusebenza ngemva konyaka wokuqala?
Yebo. Lolu cwaningo lwenziwe iminyaka emibili. Abakutholile ukuthi ngemva kweminyaka emibili, cishe abantu abangu-78% abathatha iVabysmo babedinga umuthi njalo ezinyangeni ezingu-3-4 . Futhi umbono wabo wahlala umuhle njengoba wawunjalo ngonyaka wokuqala.
Njengoba ukulimala kwamehlo okubangelwa isifo sikashukela kuqhubeka ngokuhamba kwesikhathi, le miphumela isikisela ukuthi kokubili i-Vabysmo ne-Aflibercept kungasiza ekuvimbeleni ukulimala kwesikhathi eside kwamehlo. I-Vabysmo ingaphinde ifinyelele lo mphumela ngokwelashwa okumbalwa.
Ungayithola kanjani le ndlela yokwelashwa?
I-Vabysmo iwuketshezi. Iwumjovo wangaphakathi kwe-vitreal ofakwa ngqo esweni ngudokotela oqeqeshiwe . Awukwazi ukwenza lokhu ekhaya.
Uma uqala ukwelashwa, uzoqala uthole imijovo emi-4 njalo emavikini ama-4 . Udokotela wakho uzobe esehlola amehlo akho bese enquma ukuthi uzoqhubeka yini nokujova ngemva kwezinsuku ezi-4, 8, 12, noma 16, kuye ngesimo samehlo akho. Iningi labantu lizodinga imijovo njalo ezinyangeni ezi-3-4.
Ngesikhathi somjovo, udokotela uzosebenzisa ithuluzi elincane ukuze abambe iso lakho livulekile. Ngemuva kwalokho, bazofaka amaconsi esweni lakho ukuze aliqede ukuvuvukala futhi bavimbele ukutheleleka. Ngemuva kwalokho, umjovo unikezwa ngenaliti encane kakhulu. Ngeke uzwe ubuhlungu phakathi nalesi sikhathi.
Imiphumela emibi nokuthi ungayiphatha kanjani?
Njenganoma yimuphi umuthi, lo ungaba nemiphumela emibi emincane.
- Imiphumela emibi evamile: Ukubona kwakho kungase kufiphale isikhathi esifushane ngemva komjovo. Lokhu kuvamile. Gwema ukushayela noma ukusebenzisa imishini phakathi nalesi sikhathi. Ukubona kwakho kuzobuyela esimweni esijwayelekile ngesikhathi esifushane.
- Izimpawu ezinkulu okufanele uziqaphele: Akuvamile kakhulu ukuthi kube nezimpawu zezimo ezithile ezimbi. Kufanele nakanjani uziqaphele lezi.
- Amabala amnyama noma imicu ibonakala sengathi iyantanta phambi kwamehlo.
- Ukukhanya okunjengombani .
- Ukuzizwa sengathi ikhethini lidonswa phambi kwamehlo.
- Ubuhlungu obukhulu bamehlo .
Uma uhlangabezana nanoma yiziphi zalezi zimpawu, ungalibali . Funa iseluleko sezokwelapha ngokushesha. Uma kungenzeka, iya e -ETU (Emergency Treatment Unit) yesibhedlela ukuze uthole ukwelashwa. Lezi zingaba izimpawu zesimo esibucayi.
Ingabe zikhona izinkinga ngeminye imithi?
Okwamanje akukho ukuxhumana okwaziwayo phakathi kweVabysmo neminye imithi.
Kodwa, lokhu kubaluleke kakhulu: Qiniseka ukuthi utshela udokotela wakho nganoma yimiphi eminye imithi oyithathayo, okuhlanganisa imithi kadokotela, amavithamini, imikhiqizo yamakhambi, kanye nemithi yendabuko.
Umlayezo Wokuya Nawe Ekhaya
- I-Vabysmo iwumuthi wokugomela omusha, osebenza kabili owelapha i-diabetic macular edema.
- Lokhu kuvimbela amaprotheni amabili (i-VEGF kanye ne-Ang-2) alawula ukwakheka kwemithambo yegazi emisha kanye nokuvuza koketshezi.
- Lokhu kuvumela abantu abaningi ukuthi banciphise ukuvama kokugoma kube njalo ezinyangeni ezi-3-4 ngenkathi begcina umbono uthuthuka.
- Lona umjovo onikezwa iso ngudokotela, futhi kubaluleke kakhulu ukuthola ukwelashwa ngesikhathi.
- Uma uzwa ubuhlungu obukhulu bamehlo, ukukhanya okukhanyayo, noma ukumbozwa okufana nesembozo sombono wakho ngemva kokuthola umuthi wokugomela, funa iseluleko sezokwelapha ngokushesha.
- Xoxa njalo nodokotela wakho wamehlo ukuthi yikuphi ukwelashwa okungcono kakhulu esimweni sakho.
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